Journal of Affective Disorders Reports最新文献

{"title":"Development and psychometric validation of the Italian version of the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS)","authors":"Giulio Emilio Brancati ,&nbsp;Lisa Ventura ,&nbsp;Alessandro Froli ,&nbsp;Samuele Gemignani ,&nbsp;Thomas E. Gift ,&nbsp;Barrie K. Marchant ,&nbsp;Giulio Perugi","doi":"10.1016/j.jadr.2025.100908","DOIUrl":"10.1016/j.jadr.2025.100908","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>In this study we developed and validated the Italian version of the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS), a clinician-rated scale for attention-deficit/hyperactivity disorder (ADHD) in adults. It assesses both observable behavior and subjective experiences and is tailored to address clinical features more directly relevant to adults with the disorder.</div></div><div><h3>Methods</h3><div>50 participants were recruited, including 32 referred to the Psychiatry Unit 2 at Pisa University Hospital, and 18 recruited through snowball sampling. 25 were diagnosed with ADHD, 15 with other psychiatric conditions, and 10 were healthy controls. All participants were evaluated using the WRAADDS and a set of clinician-rated, informant-rated and self-rated instruments. Psychometric characteristics of the WRAADDS were assessed, including inter-rater reliability and internal consistency, as well as concurrent and criterion validity.</div></div><div><h3>Discussion</h3><div>The WRAADDS total and composite domains score showed excellent inter-rater reliability (Spearman's <em>r</em> ≥ 0.815; <em>N</em> = 17) and internal consistency (Cronbach's α ≥ 0.88). Concurrent validity was supported by correlations with measures of inattention, hyperactivity/impulsivity, and emotional dysregulation (<em>r</em> ≥ 0.6). Patients with ADHD scored significantly higher than the other participants on several WRAADDS scores and an ADHD composite score ≥ 8 distinguished patients with ADHD with accuracy = 88 %, sensitivity = 92 %, and specificity = 84 %. In conclusion, the Italian version of the WRAADDS is a valid assessment tool for adult ADHD, facilitating a comprehensive understanding of the disorder within the adult population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100908"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esketamine nasal spray compassionate use program in the Netherlands: An open label, multi-center cohort study in severe treatment-resistant depression","authors":"Abel (K.A.J.) Busz ,&nbsp;Emma (E.J.) Schmidt ,&nbsp;Rob (R.H.S.) van den Brink ,&nbsp;Karen (K.) Foeken ,&nbsp;Marasha (M.) de Jong ,&nbsp;Joost (J.B.C.) Mertens ,&nbsp;Martijn (M.S.) van Noorden ,&nbsp;Etienne (E.J.F.L.) Olivier ,&nbsp;Koen (K.R.J.) Schruers ,&nbsp;Sara (S.I.J.) Schutters ,&nbsp;Joris (J.) van Son ,&nbsp;Wessel (W.J.) Strootker ,&nbsp;Harry (H.C.P.) Venema ,&nbsp;Dieuwertje (D.A.) de Waardt ,&nbsp;Jasper (J.B.) Zantvoord ,&nbsp;Danielle (D.) Cath ,&nbsp;Henricus (H.G.) Ruhe","doi":"10.1016/j.jadr.2025.100905","DOIUrl":"10.1016/j.jadr.2025.100905","url":null,"abstract":"<div><h3>Background</h3><div>Esketamine, a N-methyl-<span>d</span>-aspartate (NMDA) receptor antagonist, used intranasally (IN), is applied as an antidepressant (AD) in treatment-resistant depressed (TRD) patients. Real-world studies with IN esketamine are still scarce.</div></div><div><h3>Objectives</h3><div>To evaluate the effectiveness and potential moderators of response of IN esketamine in real-world TRD patients treated in a compassionate use program (CUP) in the Netherlands.</div></div><div><h3>Method</h3><div>In this multi-center, open label, naturalistic cohort-study 42 patients were treated with 28–84 mg IN esketamine augmenting an oral AD. We used the Montgomery-Asberg rating scale (MADRS) change scores as primary outcome and report response-, remission rates and minimal clinically important difference (MCID) reached after 28 and 90 days of treatment. Potential effect moderators studied were level of treatment resistance and history of electroconvulsive therapy (ECT).</div></div><div><h3>Results</h3><div>Baseline mean MADRS score was 33.6 ± 5.3 and 64.3 % of the population had a history of ≥5 failed AD treatments. At 28 days, a significant decrease of 10.1 (7.3–12.6) MADRS-points was observed (Cohen's d 1.9, 95 % CI: 0.26–0.45, <em>t</em> = 7.20, <em>p &lt;</em> .001). Between 29 and 90 days no additional significant decrease in the MADRS score was observed. Response- and remission rates were 28.6 % and 14.3 % at 28 days and 35.7 % and 19.8 % at 90 days (<em>n</em> = 42), respectively. At 28 days 52.4 % achieved MCID. No clinically relevant moderating effects were found.</div></div><div><h3>Limitations</h3><div>Small sample size and variable time between screening and start of treatment.</div></div><div><h3>Conclusions</h3><div>In this group of TRD patients, IN esketamine treatment showed significant effectiveness, suggesting a valuable treatment option for this group.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100905"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of alliance, the bond with the treatment team, and group cohesion with self-esteem and quality of life in day clinic treatment of depression","authors":"Catherine Irniger ,&nbsp;Johannes Vetter ,&nbsp;Franziska Mürner ,&nbsp;Steffi Weidt ,&nbsp;Erich Seifritz ,&nbsp;Martin grosse Holtforth ,&nbsp;Rainer Krähenmann","doi":"10.1016/j.jadr.2025.100909","DOIUrl":"10.1016/j.jadr.2025.100909","url":null,"abstract":"<div><h3>Introduction</h3><div>In day clinic treatment, patients engage not only with their psychotherapists, but also with fellow patients and other members of the treatment team. Given that interpersonal difficulties are a core component in the treatment of depression, these additional relationships could be of special relevance. However, compared to alliance little is known how other relationships experienced during treatment relate to outcome. Thus, the aim of the analysis was to examine the potentially beneficial association of different types of relationships with outcome in day clinic treatment of depression.</div></div><div><h3>Methods</h3><div>The relationships were assessed with the Inpatient and Day-Clinic Experience Scale (IDES) including the subscales bond with the psychotherapist, bond with the treatment team, and group cohesion. Treatment outcome was assessed by the Rosenberg Self-Esteem Scale (RSE), and the European Health Interview Survey - Quality of Life (EUROHIS-QOL). For both outcome measures, residual gain scores were computed, and a path analysis was conducted.</div></div><div><h3>Results</h3><div>Whereas higher levels of group cohesion were associated with more increase in self-esteem, a stronger bond with the psychotherapist was associated with more increase in quality of life. For the bond with the treatment team no significant association with treatment outcome was observed.</div></div><div><h3>Discussion</h3><div>The results highlight distinct associations of different types of relationships with treatment outcome in depression. Limitations such as the limited sample size, high number of male patients, and high staff turnover are discussed. Future research should further explore the association of different therapeutic relationships with outcome as well as the associated mechanisms of action.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100909"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebrospinal fluid platelet-derived growth factor receptor-beta is negatively correlated with depressive symptom severity in suicide attempters","authors":"A. Bontidean ,&nbsp;D. Lindqvist ,&nbsp;C. Grudet ,&nbsp;L. Träskman-Bendz ,&nbsp;L. Brundin ,&nbsp;F. Ventorp","doi":"10.1016/j.jadr.2025.100906","DOIUrl":"10.1016/j.jadr.2025.100906","url":null,"abstract":"<div><h3>Background</h3><div>Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity.</div></div><div><h3>Methods</h3><div>We measured levels of PDGFR-β in CSF from recent suicide attempters using electrochemiluminescence immunoassays. PDGFR-β was correlated to CSF/serum albumin ratio (Qalb), an established BBB integrity biomarker, and symptom severity according to the Montgomery-Åsberg Depression Rating Scale (MADRS).</div></div><div><h3>Results</h3><div>There was a significant negative correlation between PDGFR-β and total MADRS score in suicide attempters (<em>r</em>=-0.47, <em>p</em> = 0.003, <em>n</em> = 38). PDGFR-β did not correlate significantly with Qalb (<em>r</em> = 0.179, <em>p</em> = 0.268, <em>n</em> = 40).</div></div><div><h3>Conclusions</h3><div>Although PDGFR-β levels may not reflect BBB integrity, low CSF levels of this biomarker were associated with more severe depressive symptoms. We hypothesize that this may be due to mechanisms unrelated to BBB integrity including the effects of PDGFR-β on neurogenesis and cellular proliferation.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100906"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143824066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anhedonia and 24-hour movement behaviours in adulthood","authors":"Anna-Kaisa Karppanen ,&nbsp;Jouko Miettunen ,&nbsp;Tuula Hurtig ,&nbsp;Anna-Maiju Leinonen ,&nbsp;Raija Korpelainen ,&nbsp;Vahid Farrahi","doi":"10.1016/j.jadr.2025.100911","DOIUrl":"10.1016/j.jadr.2025.100911","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aimed to examine the association between self-reported physical and social anhedonia in young adulthood with the composition of movement behaviours in a 24-h cycle, including physical activity, sedentary behaviour, and sleep.</div></div><div><h3>Method</h3><div>Participants from the Northern Finland Birth Cohort 1966 who participated in the 31-year and 46-year follow-up studies were included (<em>n</em> = 2826). Anhedonia was measured at age 31 using the Physical Anhedonia Scale and the Social Anhedonia Scale. At age 46, physical activity and sedentary behaviour were measured using an accelerometer, and sleep was self-reported. Compositional data analysis was used to examine the association between anhedonia and the composition of 24-h movement behaviour.</div></div><div><h3>Results</h3><div>Physical anhedonia at age 31 was significantly associated with the composition of 24-h movement behaviour at age 46. Higher physical anhedonia was associated with lower daily time spent in moderate to vigorous physical activity and light physical activity, as well as more daily time spent in sedentary behaviour in middle-aged females, but not in males. No significant association between social anhedonia and 24-h movement behaviour was found in either gender.</div></div><div><h3>Limitations</h3><div>Anhedonia and sleep were self-reported, which may introduce bias.</div></div><div><h3>Conclusion</h3><div>Findings contribute to the understanding of physical anhedonia as a potential predictor of later 24-h movement behaviour. Anhedonia scales can be used to identify individuals at risk for mental disorders who may benefit from targeted interventions utilizing physical activity. This knowledge can be applied in various sectors of healthcare to enhance 24-h movement behaviour at both individual and population levels.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100911"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143792763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the role of social contact and loneliness in linking intimate partner violence and internalizing distress","authors":"Natasha Joksimovic ,&nbsp;Frédérique Vallières ,&nbsp;Philip Hyland","doi":"10.1016/j.jadr.2025.100915","DOIUrl":"10.1016/j.jadr.2025.100915","url":null,"abstract":"<div><div>Low social support is a well-established risk factor for mental health problems among survivors of intimate partner violence (IPV). Social support includes elements of social contact and loneliness, and in this study, we examined the specific roles social contact and loneliness play in explaining the association between IPV and internalizing distress. We also assessed the psychometric properties of the Composite Abuse Scale Short Form (CASR-SF), a relatively new measure of IPV. Participants (<em>N</em> = 353) were male and female adults living in Ireland with a lifetime history of IPV. The psychometric properties of the CASR-SF were assessed using confirmatory factor analysis and composite reliability analysis. Structural equation modelling (SEM) was used to determine if social contact and loneliness fully or partial accounted for the association between IPV and internalizing distress. The CASR-SF was best explained by a single-factor model that fitted the data well, and had excellent internal reliability (ω = 0.97). The SEM results indicated that there was a direct association between IPV and internalizing distress (β = 0.32), and this association was partially mediated by loneliness (β = 0.06) but not social contact. The CASR-SF operated well as a measure of IPV in this sample, and subjective assessments of the quality and quantity of social interactions (loneliness) was more important than the number of social interactions (social contact) in accounting for the association between IPV and internalizing distress. Reducing loneliness may therefore be an important clinical objective in helping survivors of IPV with mental health problems.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100915"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Notice to “Whole-brain correlates of post-traumatic stress disorder in military-related mild traumatic brain injury: A voxel-wise meta-analysis” [Journal of Affective Disorders Reports 16 (2024) 100770]","authors":"Zachary P. Pierce ,&nbsp;Jessica M. Black","doi":"10.1016/j.jadr.2024.100859","DOIUrl":"10.1016/j.jadr.2024.100859","url":null,"abstract":"","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100859"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Problematic smartphone usage and inadequate mental health literacy potentially increase the risks of depression, anxiety, and their comorbidity in Chinese college students: A longitudinal study","authors":"Changru Wang ,&nbsp;Jie Hu ,&nbsp;Yi Zhou ,&nbsp;Linlin Jiang ,&nbsp;Jing Chen ,&nbsp;Jingjing Xi ,&nbsp;Jun Fang ,&nbsp;Shichen Zhang","doi":"10.1016/j.jadr.2025.100907","DOIUrl":"10.1016/j.jadr.2025.100907","url":null,"abstract":"<div><h3>Background</h3><div>Problematic smartphone usage (PSU) and mental health literacy (MHL) are potential factors to psychological problems, but interactive and mediate effects in this association remains unclear. This study aimed to examine whether MHL mediate associations of PSU with depression, anxiety, and their comorbidity, and the extent of interaction of PSU and MHL with psychological problems in Chinese college students.</div></div><div><h3>Methods</h3><div>Pooled longitudinal data of 6879 participants was collected between November 2019 and June 2020 to assess the MHL, PSU, depression, and anxiety of college students in Anhui province, China. Mediation analyses and multiple logistic regression models were conducted to explore potential associations.</div></div><div><h3>Results</h3><div>PSU was significantly was positively correlated with depression, anxiety, and their comorbidity, and this association mediated by MHL with the mediation ratio of 4.29 %, 5.86 % and 5.00 %, respectively. Furthermore, students with PSU and inadequate MHL had the highest risk of depression (<em>RR</em> = 4.041, <em>95 % CI</em>: 3.132–5.214), anxiety (<em>RR</em> = 2.759, <em>95 % CI</em>: 1.954–3.894), and their comorbidity (<em>RR</em> = 3.805, <em>95 % CI</em>: 2.592–5.584).</div></div><div><h3>Limitations</h3><div>Retrospective design may introduce recall bias.</div></div><div><h3>Conclusions</h3><div>These findings underscore the vulnerability of individuals with PSU and inadequate MHL to longitudinal risks of experiencing depression, anxiety, and their comorbidity. And MHL mediating the association between PSU and psychological problems. In light of these results, interventions aimed at reducing the incidence and progression of mental health issues among college students should prioritize strategies for decreasing smartphone usage and enhancing MHL.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100907"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143777159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrition-focused group intervention was not superior to social support in the treatment of depression: A randomized controlled trial with a strength-based counseling approach","authors":"Aino Kipfer ,&nbsp;Tiina Laatikainen ,&nbsp;Timo Partonen ,&nbsp;Johanna Roponen ,&nbsp;Outi Nuutinen ,&nbsp;Marja-Leena Lamidi","doi":"10.1016/j.jadr.2025.100914","DOIUrl":"10.1016/j.jadr.2025.100914","url":null,"abstract":"<div><h3>Background</h3><div>Depression is a public health challenge, negatively affecting health and work ability. While an association between diet and depression is recognized, only a few randomized controlled trials have been published on the impact of diet counseling on clinical depression.</div></div><div><h3>Methods</h3><div>We conducted an 8-week randomized controlled trial to examine the effectiveness of a strength-based, motivational nutrition group intervention on symptoms of depression among individuals with a moderate to severe major depressive disorder. Participants (<em>n</em> = 93) were recruited from their healthcare units (<em>n</em> = 13) in Kuopio and Siilinjärvi, Eastern Finland, and randomized into the intervention or control arm. Both arms attended six group sessions. The outcomes were assessed at baseline, 8 weeks, and 6 months using the Center for Epidemiological Studies Depression Scale (CES-D), the Index of Diet Quality (IDQ), the Assessment of Quality of Life – 8D (AQoL-8D), and a work ability indicator.</div></div><div><h3>Results</h3><div>In both groups, there were only non-significant improvements in depression symptoms, diet quality, quality of life, and work ability at 8 weeks and 6 months. Based on the AQoL subscales, mental health significantly improved in the intervention but not in the control group. There were, however, no significant differences between the groups in any outcomes. The results were similar at 8 weeks and 6 months.</div></div><div><h3>Limitations</h3><div>Blinding of the study participants was not possible. Only 55 % of the participants completed the follow-up at six months.</div></div><div><h3>Conclusions</h3><div>The intervention was not effective in improving depression status or diet quality, in contrast to previous nutrition interventions for people with depression.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100914"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidepressant effects of exercise: Does mindset matter?","authors":"Kendall Kohnle,&nbsp;Rick Ingram","doi":"10.1016/j.jadr.2025.100901","DOIUrl":"10.1016/j.jadr.2025.100901","url":null,"abstract":"<div><h3>Background</h3><div>Following research by reported by Crum and Langer (2007), perhaps changing a person's mindset (i.e., beliefs and expectations) about exercise could be a key to facilitating the antidepressant effects of exercise without changing the behavior itself.</div></div><div><h3>Methods</h3><div>The experimental group participants were told that their daily activities were considered exercise which would alleviate their depressive symptoms. Control participants read a script that discussed various effective strategies to alleviate depressive symptoms.</div></div><div><h3>Results</h3><div>No preexisting differences in depression between groups approached significance, nor were there differences on any measure administered pre-experiment. A multilevel model analysis indicated a significant difference between the groups’ depression scores over time, with the mindset group's depressive symptoms decreasing more rapidly than those of the control groups. Although not of prime interest, result showed that anxiety scores also decreased more rapidly in the mindset condition.</div></div><div><h3>Conclusion</h3><div>Altering mindset about exercise appears to, accelerates decreases in depressive symptoms. mindfulness-based therapies may quite naturally integrate elements that facilitate a patient's positive mindset and expectations. Broadly speaking, clinicians who are attuned to finding ways to incorporate therapeutic placebos like a positive mindset may find this beneficial to patients. As such, influencing mindset may be an effective aid in the treatment of depression.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"20 ","pages":"Article 100901"},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143687088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}