加速针灸治疗重度抑郁症患者：一项单盲、随机等候名单对照试验

Q3 Psychology

Journal of Affective Disorders Reports Pub Date : 2025-05-25 DOI:10.1016/j.jadr.2025.100935

Xiao Wei Tan , Yuen Yin Joyce Chee , Yin Jia Lim , Frederick Peiwei Koh , Zheng Jie Jovi Koh , Gulwant Hasvinjit Kaur Singh , Si Yun Rachel Tan , Linda Zhong , Phern Chern Tor

{"title":"加速针灸治疗重度抑郁症患者：一项单盲、随机等候名单对照试验","authors":"Xiao Wei Tan , Yuen Yin Joyce Chee , Yin Jia Lim , Frederick Peiwei Koh , Zheng Jie Jovi Koh , Gulwant Hasvinjit Kaur Singh , Si Yun Rachel Tan , Linda Zhong , Phern Chern Tor","doi":"10.1016/j.jadr.2025.100935","DOIUrl":null,"url":null,"abstract":"<div><h3>Aim</h3><div>To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.</div></div><div><h3>Methods</h3><div>Recruited patients were 1:1 randomly assigned to receive either treatment-as-usual (wait-list controlled group) or with additional acupuncture intervention (treatment group). The acupuncture treatment includes daily scalp acupuncture with manual stimulation for a total of 10 sessions conducted within 2–3 weeks. Blinded raters assessed patients’ depressive symptoms and quality of life at baseline (pre-treatment), immediately after treatment, 2 weeks, and 3 months post-treatment.</div></div><div><h3>Results</h3><div>A total of 84 patients with 59 (70.2 %) Chinese, 17 (20.2 %) Malay and 4 (4.8 %) Indians participated in this trial. There is an overall improvement of depressive symptoms score assessed by Montgomery–Åsberg Depression Rating Scale (MADRS) and Quick Inventory of Depressive Symptomatology- Self report 16 items (QIDS-SR16), and an improvement of subjective Quality of life assessed by EQ5D Visual Analogue Score (VAS) and Utility Score (US) from pre-treatment to 3 months post-treatment for patients in both treatment groups and control group. In addition, compared to patients in control group, acupuncture induced an overall significantly better QIDS-SR16 (effect size <em>η<sup>2</sup></em> = 0.15, <em>p</em> = 0.025) and better EQ-5D Visual Analogue Scale score (<em>η<sup>2</sup></em> = 0.20, <em>p</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>Acupuncture induced an accumulated and delayed antidepressant treatment effect for patients with depression. Our study informed the potential of an accelerated acupuncture treatment as an augmentation antidepressant therapy within a multiethnic South-east Asian population.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100935"},"PeriodicalIF":0.0000,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial\",\"authors\":\"Xiao Wei Tan , Yuen Yin Joyce Chee , Yin Jia Lim , Frederick Peiwei Koh , Zheng Jie Jovi Koh , Gulwant Hasvinjit Kaur Singh , Si Yun Rachel Tan , Linda Zhong , Phern Chern Tor\",\"doi\":\"10.1016/j.jadr.2025.100935\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Aim</h3><div>To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.</div></div><div><h3>Methods</h3><div>Recruited patients were 1:1 randomly assigned to receive either treatment-as-usual (wait-list controlled group) or with additional acupuncture intervention (treatment group). The acupuncture treatment includes daily scalp acupuncture with manual stimulation for a total of 10 sessions conducted within 2–3 weeks. Blinded raters assessed patients’ depressive symptoms and quality of life at baseline (pre-treatment), immediately after treatment, 2 weeks, and 3 months post-treatment.</div></div><div><h3>Results</h3><div>A total of 84 patients with 59 (70.2 %) Chinese, 17 (20.2 %) Malay and 4 (4.8 %) Indians participated in this trial. There is an overall improvement of depressive symptoms score assessed by Montgomery–Åsberg Depression Rating Scale (MADRS) and Quick Inventory of Depressive Symptomatology- Self report 16 items (QIDS-SR16), and an improvement of subjective Quality of life assessed by EQ5D Visual Analogue Score (VAS) and Utility Score (US) from pre-treatment to 3 months post-treatment for patients in both treatment groups and control group. In addition, compared to patients in control group, acupuncture induced an overall significantly better QIDS-SR16 (effect size <em>η<sup>2</sup></em> = 0.15, <em>p</em> = 0.025) and better EQ-5D Visual Analogue Scale score (<em>η<sup>2</sup></em> = 0.20, <em>p</em> = 0.005).</div></div><div><h3>Conclusion</h3><div>Acupuncture induced an accumulated and delayed antidepressant treatment effect for patients with depression. Our study informed the potential of an accelerated acupuncture treatment as an augmentation antidepressant therapy within a multiethnic South-east Asian population.</div></div>\",\"PeriodicalId\":52768,\"journal\":{\"name\":\"Journal of Affective Disorders Reports\",\"volume\":\"21 \",\"pages\":\"Article 100935\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-05-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Affective Disorders Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666915325000654\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Psychology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Affective Disorders Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666915325000654","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}

引用次数: 0

摘要

目的探讨加速针灸治疗作为一种辅助疗法对原发性抑郁症状患者的疗效。方法入选患者按1:1随机分为常规治疗组（等候名单对照组）和针刺干预组（治疗组）。针灸治疗包括每日头皮针刺加手刺激，共10次，疗程2-3周。盲法评分者在基线（治疗前）、治疗后立即、治疗后2周和治疗后3个月评估患者的抑郁症状和生活质量。结果共84例患者，其中华人59例（70.2%），马来人17例（20.2%），印度人4例（4.8%）。治疗组和对照组患者在治疗前至治疗后3个月，采用Montgomery -Åsberg抑郁评定量表（MADRS）和抑郁症状快速量表-自我报告16项（QIDS-SR16）评估抑郁症状评分总体改善，采用EQ5D视觉模拟评分（VAS）和效用评分（US）评估主观生活质量改善。此外，与对照组相比，针刺总体上显著改善了QIDS-SR16（效应大小η2 = 0.15, p = 0.025）和EQ-5D视觉模拟量表评分（效应大小η2 = 0.20, p = 0.005）。结论针刺对抑郁症患者的抗抑郁作用具有累积性和延迟性。我们的研究表明，在东南亚多民族人群中，加速针灸治疗作为一种增强抗抑郁治疗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Accelerated acupuncture therapy for patients with major depressive symptoms: a single blind, randomized wait-list controlled trial

Aim

To test the effectiveness of an accelerated acupuncture treatment as an augmentation therapy for patients with primary diagnosis of major depressive symptoms.

Methods

Recruited patients were 1:1 randomly assigned to receive either treatment-as-usual (wait-list controlled group) or with additional acupuncture intervention (treatment group). The acupuncture treatment includes daily scalp acupuncture with manual stimulation for a total of 10 sessions conducted within 2–3 weeks. Blinded raters assessed patients’ depressive symptoms and quality of life at baseline (pre-treatment), immediately after treatment, 2 weeks, and 3 months post-treatment.

Results

A total of 84 patients with 59 (70.2 %) Chinese, 17 (20.2 %) Malay and 4 (4.8 %) Indians participated in this trial. There is an overall improvement of depressive symptoms score assessed by Montgomery–Åsberg Depression Rating Scale (MADRS) and Quick Inventory of Depressive Symptomatology- Self report 16 items (QIDS-SR16), and an improvement of subjective Quality of life assessed by EQ5D Visual Analogue Score (VAS) and Utility Score (US) from pre-treatment to 3 months post-treatment for patients in both treatment groups and control group. In addition, compared to patients in control group, acupuncture induced an overall significantly better QIDS-SR16 (effect size η² = 0.15, p = 0.025) and better EQ-5D Visual Analogue Scale score (η² = 0.20, p = 0.005).

Conclusion

Acupuncture induced an accumulated and delayed antidepressant treatment effect for patients with depression. Our study informed the potential of an accelerated acupuncture treatment as an augmentation antidepressant therapy within a multiethnic South-east Asian population.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊