Journal of Affective Disorders Reports最新文献

{"title":"Childhood maltreatment as a risk factor for depressive symptoms after an unintended pregnancy: The role of emotion regulation difficulties","authors":"Hannah Klusmann ,&nbsp;Caroline Meyer ,&nbsp;Sinha Engel ,&nbsp;Stephanie Haering ,&nbsp;Meike Katharina Blecker ,&nbsp;Elisabeth Conrad ,&nbsp;Franziska Reichmuth ,&nbsp;Sarah Schumacher ,&nbsp;Christine Knaevelsrud","doi":"10.1016/j.jadr.2025.100931","DOIUrl":"10.1016/j.jadr.2025.100931","url":null,"abstract":"<div><h3>Background</h3><div>Individuals who experience an unintended pregnancy are at risk of developing depressive symptoms, regardless of whether the pregnancy is terminated or carried to term. Knowledge about particularly vulnerable individuals after an unintended pregnancy and about potential mechanisms of change is scarce.</div></div><div><h3>Methods</h3><div>This study investigated whether participants with childhood maltreatment after an unintended pregnancy (abortion or delivery), and whether difficulties in emotion regulation contribute significantly to depressive symptoms, beyond the effects of childhood maltreatment. Welch <em>t</em>-tests, chi-square-tests and hierarchical regression analysis were conducted.</div></div><div><h3>Results</h3><div>We included 190 participants, 46.8 % of whom had experienced childhood maltreatment. Participants with childhood maltreatment reported greater depressive symptoms (<em>t</em> = 4.23, df=186, <em>p</em>&lt;.001) and were more likely to fulfill the diagnostic criteria for a depressive episode with onset during or after the pregnancy (χ²=6.5354, df=1, <em>p</em>&lt; .05). The unique contribution of childhood maltreatment to depressive symptoms was 7 % (F(184,1) = 21.52, <em>p</em> &lt; .001), the unique contribution of difficulties in emotion regulation to depressive symptoms was 28 % (F(183,1) = 80.70, <em>p</em> &lt; .001).</div></div><div><h3>Limitations</h3><div>Limitations include the cross-sectional design and self-selected sample. Furthermore, only participants with unintended pregnancies were included, impeding comparisons with intended pregnancies.</div></div><div><h3>Conclusions</h3><div>Individuals with childhood maltreatment are specifically vulnerable to developing depressive symptoms after an unintended pregnancy. Preventive interventions should identify these individuals and provide individualized support as early as possible. Emotion regulation may be a promising intervention target for reducing depressive symptoms after an unintended pregnancy.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100931"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144184300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amygdala subregional functional connectivity in treatment-resistant depression","authors":"Sheryl L. Foster ,&nbsp;Ramon Landin-Romero ,&nbsp;Sarah Lewis ,&nbsp;Ana Rita Barreiros ,&nbsp;Sophie Matis ,&nbsp;Anthony Harris ,&nbsp;Mayuresh S. Korgaonkar","doi":"10.1016/j.jadr.2025.100932","DOIUrl":"10.1016/j.jadr.2025.100932","url":null,"abstract":"<div><h3>Background</h3><div>Treatment resistance impacts almost 50 % of depression patients, with amygdala dysfunction being widely implicated. fMRI studies have typically focussed on identifying whole rather than individual subregional amygdala functional connectivity but this approach, together with cohort heterogeneity, is likely contributing to inconsistent results. This study used high resolution 3T fMRI data to investigate subregional alterations that may differentiate treatment-resistant cohorts from healthy individuals and depressed patients who respond to treatment.</div></div><div><h3>Methods</h3><div>Resting-state fMRI data were obtained in 35 participants diagnosed with Treatment-Resistant Depression (TRD), 38 healthy control participants (HC), and 35 treatment-sensitive participants (TSD). Seed-based functional connectivity analyses of three main subregions bilaterally (laterobasal, centromedial and superficial), as well as the whole amygdala, were performed and comparisons made between groups.</div></div><div><h3>Results</h3><div>We found <strong>c</strong>onnectivity differences in the right laterobasal amygdala subregion in TRD compared to both groups. TRD patients displayed hypoconnectivity to the right fusiform gyrus relative to HC whereas hyperconnectivity to the left inferior frontal gyrus relative to TSD was identified. No connectivity differences were found for the whole amygdala or any of the other subregions bilaterally.</div></div><div><h3>Limitations</h3><div>Modest sample size and cross-sectional study design are limitations. A causal relationship between functional connectivity alterations and treatment resistance cannot be established.</div></div><div><h3>Conclusion</h3><div>Altered connectivity of the right laterobasal subregion is a distinguishing feature of TRD. These alterations may underlie severe impairments in emotion processing and social functioning that are characteristic of TRD. These results emphasise the need for further investigation of the functional role of the amygdala subregions in depression.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100932"},"PeriodicalIF":0.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining alterations in subjective sleep ratings in individuals with major depressive disorder receiving daily theta burst stimulation","authors":"Jennifer Cuda ,&nbsp;David Smith ,&nbsp;Arthur R. Chaves ,&nbsp;Karina L. Fonseca ,&nbsp;Jessica Drodge ,&nbsp;Stacey Shim ,&nbsp;Youssef Nasr ,&nbsp;Maya El-Outa ,&nbsp;Ram Brender ,&nbsp;Ruxandra Antochi ,&nbsp;Lisa McMurray ,&nbsp;Rebecca Robillard ,&nbsp;Sara Tremblay","doi":"10.1016/j.jadr.2025.100933","DOIUrl":"10.1016/j.jadr.2025.100933","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder is often accompanied by sleep disturbances, which have been found to influence response to antidepressant treatments. Repetitive transcranial magnetic stimulation (rTMS), including novel optimized protocols like theta burst stimulation (TBS), is an effective intervention for treatment-resistant depression, although little is known about the relationship between sleep and the antidepressant effects of this treatment.</div></div><div><h3>Methods</h3><div>Sixty-six individuals with treatment-resistant depression received 4 to 6 weeks of daily TBS treatments targeting the left-unilateral or bilateral dorsolateral prefrontal cortex (DLPFC). Depression severity was measured using the Hamilton Rating Scale for Depression (HRSD-17) and subjective sleep using the Leeds Sleep Evaluation Questionnaire (LSEQ). Data was analyzed with linear mixed models and Spearman correlations.</div></div><div><h3>Results</h3><div>TBS significantly reduced HRSD-17 scores and improved LSEQ subscales reflecting sleep quality, ease of awakening from sleep, and behavior following wakefulness. Improvements in symptoms of depression were associated with improvement in behavior following waking after 20 and 30 TBS sessions, but not with sleep quality.</div></div><div><h3>Limitations</h3><div>Limitations include a limited sample size, lack of sham condition, subjective measures of sleep and variable number of treatments (20 or 30 TBS sessions).</div></div><div><h3>Conclusions</h3><div>These findings suggest that TBS treatments concurrently improve subjective sleep quality and depression symptoms. Additionally, changes in depression more closely aligned with changes in sleep-related daytime functioning than with sleep quality per se. Further work is required to delineate how sleep improvements following neuromodulation may contribute to the antidepressant response.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100933"},"PeriodicalIF":0.0,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of mindfulness-based cognitive therapy in regulating cognition and emotion of patients with depression: A systematic review of randomized controlled trials","authors":"Nikapitiye Nandarathana,&nbsp;Jay Kumar Ranjan,&nbsp;Madhubanti Sinha","doi":"10.1016/j.jadr.2025.100929","DOIUrl":"10.1016/j.jadr.2025.100929","url":null,"abstract":"<div><h3>Background</h3><div>A number of reviews report the efficacy of Mindfulness-Based Cognitive Therapy (MBCT) in the treatment of depressive disorders, however, there is a dearth of qualitative reviews examining the efficacy of MBCT in regulating cognitions and emotions.</div></div><div><h3>Objective</h3><div>To systematically review the efficacy of MBCT in alleviating depressive symptoms, preventing relapse in patients with depression (PWD), and identify the different cognitive and affective factors that influence its effectiveness.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in six electronic databases (PubMed, EBSCOhost, Web of Science, JSTOR, Scopus, and Science Direct) up to May 13, 2024 for randomized controlled trials (RCTs) assessing MBCT in adults with depressive disorders. We appraised the methodological quality of the included studies using Cochrane Risk-of-Bias 2.0.</div></div><div><h3>Results</h3><div>The present systematic review followed the PRISMA guideline, and out of 1151 screened studies, 117 were eligible for full-text review. 17 studies were finally included in this review. All included studies utilized RCTs, comparing MBCT vs treatment as usual (TAU) and one study compares MBCT with cognitive behavioral therapy (CBT) and TAU. The results support that MBCT effectively manages the symptoms of depressive disorders and regulates cognition and emotions.</div></div><div><h3>Conclusion</h3><div>MBCT, when implemented with pharmacological treatment, demonstrates significant efficacy in alleviating depressive symptoms, reducing thought rumination, regulating emotions, and enhancing mindfulness. Further, MBCT reduces relapse rates in patients with depression.</div></div><div><h3>PROSPERO registration</h3><div>CRD42024548497</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100929"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of group psychotherapy compared to waiting list or other active intervention on depression and other clinical outcomes in adults with autism spectrum disorder: A systematic review","authors":"Donia Shalabi ,&nbsp;Matilda Plume ,&nbsp;Hanna Berggren ,&nbsp;Hanna Nguyen ,&nbsp;Steinn Steingrimsson ,&nbsp;Tomas Larson ,&nbsp;Jacqueline Borg ,&nbsp;Constanze Wartenberg","doi":"10.1016/j.jadr.2025.100930","DOIUrl":"10.1016/j.jadr.2025.100930","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review evaluates the efficacy of group psychotherapy for adults with autism spectrum disorder (ASD). Symptoms of depression, mortality, drop out due to lack of effect or side effects, complications, anxiety, global functioning, and quality of life were considered as outcomes.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines and pre-registration in PROSPERO, the databases MEDLINE, Cochrane Library, EMBASE, CINAHL, and APA PsycINFO were searched in December 2022 for studies involving adults with ASD that compared group psychotherapy with other individual psychotherapy, pharmacological treatment, other active interventions, or waiting list. The risk of bias of included studies was assessed, and data were extracted and summarized. Meta-analyses were planned if appropriate. The certainty of the evidence was assessed using GRADE.</div></div><div><h3>Results</h3><div>Five studies (<em>n</em> = 261) were included. Four studies (3 randomized controlled trials [RCTs], 1 non-RCT) compared group psychotherapy to waiting list. Given the studies’ heterogeneity no meta-analyses were performed. The studies reported inconsistent findings regarding depressive symptoms and anxiety. None of the studies reported data regarding quality of life, global functioning, mortality or suicide, drop out, or complications. One RCT comparing group psychotherapy to recreational activity found no significant difference in depressive symptoms, global functioning, or quality of life. No study comparing group psychotherapy with other individual psychotherapy or pharmacological treatment was found.</div></div><div><h3>Conclusion</h3><div>Based on five controlled studies it is uncertain whether group psychotherapy compared to waiting list or recreational activity results in differences in depressive symptoms, anxiety, global functioning, or quality of life in adults with ASD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100930"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression prevalence, screening, and treatment rates in adolescents with obesity in ambulatory settings","authors":"Madhuri Molleti ,&nbsp;Jeremy Chu ,&nbsp;Angela Chieh ,&nbsp;Rongbing Xie ,&nbsp;Li Li","doi":"10.1016/j.jadr.2025.100928","DOIUrl":"10.1016/j.jadr.2025.100928","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to describe the prevalence, screening, and treatment rates for depression in adolescents in ambulatory settings in the United States.</div></div><div><h3>Method</h3><div>Physician-reported data on 444,080,295 male and female adolescents ages 13-18 were extracted from the 2008-2018 CDC National Ambulatory Medical Care Survey datasets. Body mass index (BMI) percentiles were calculated using the CDC’s SAS calculator, and particpants were then stratified into weight groups based on their BMI percentiles. Statistical testing included t-test and chi-square to determine association between weight groups and depression, and regression analysis was used to determine predictors of depression. Weighting factors were applied to improve comparability and reduce bias.</div></div><div><h3>Results</h3><div>16.89% of participants had obese BMI percentiles, and 13.81% had overweight, 43.39% had healthy, and 25.91% had underweight BMI percentiles. Depression screening rates in adolescents with obesity is 2.89%, overweight is 3.35%, healthy weight is 3.49%, and underweight is 2.83% (<em>p</em>=0.382). Prevalence of depression in adolescents with obesity is 7.17%, overweight is 6.04%, healthy weight is 6.31%, and underweight is 12.14% (<em>p</em>&lt;0.0001). Prevalence of counseling and psychotherapy in adolescents with obesity is 2.70%, overweight is 2.89%, healthy weight is 2.92%, and underweight is 11.27% (<em>p</em>&lt;0.0001). Patients seen by primary care health workers, age, female sex, number of chronic conditions, and increased visits are significant predictors of depression diagnosis in adolescents.</div></div><div><h3>Conclusion</h3><div>Depression in adolescents with overweight or obese status is under-screened for, under-identified, and under-treated. More mental health counseling and psychotherapy must be offered to those with both depression and obesity.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100928"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“I wish I could work on school stuff.” Investigating the impact of remote learning on undergraduate students’ academic success and mental health during the COVID-19 lockdown","authors":"Joseph P. Nano ,&nbsp;William A. Catterall ,&nbsp;Michael L. Chang ,&nbsp;Mina H. Ghaly","doi":"10.1016/j.jadr.2025.100918","DOIUrl":"10.1016/j.jadr.2025.100918","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate how remote learning has affected undergraduate students' learning abilities, academic success, and mental health during the COVID-19 pandemic.</div></div><div><h3>Methods</h3><div>This cross-sectional study took place between April and June 2020 in the United States. Participants completed a survey consisting of demographic questions, Depression, Anxiety, and Stress Scale-21 Items (DASS-21), and an open-ended question. We used a logistic regression model on objective variables and conducted a systematic thematic analysis of the open-ended response.</div></div><div><h3>Results</h3><div>Our final sample consisted of 1,173 full-time undergraduate students in the United States. Most participants were public university students (<em>n</em>=835, 71.2 %) and reported that moving to remote learning had a negative impact on their school performance (<em>n</em>=802, 68.4 %). Students’ positive experiences in remote learning were associated with moving to their family’s house (<em>p</em>&lt;0.05), living on campus in a dorm (<em>p</em>&lt;0.05), and no internet issues during classes (<em>p</em>&lt;0.0001). From the thematic analysis, we found six common themes among those who reported having a negative experience with remote learning that focused on the following topics: (1) Students had to adjust to an online learning environment; (2) Students had to adjust to the home environment; (3) Students experienced mental health difficulties; (4) Students dealt with political tension; (5) Students felt uncertain about future opportunities; and (6) Students lacked motivation to do work.</div></div><div><h3>Limitations</h3><div>The results of this study may not be generalizable to undergraduate students outside of the United States due to differences in lockdown restrictions.</div></div><div><h3>Conclusion</h3><div>Remote learning during COVID-19 had a negative impact on the majority of undergraduate students’ academic performance and mental health.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100918"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of disordered eating and/or eating disorders in children and adolescents in the Arab World: A systematic review and meta-analysis","authors":"Rana Rizk ,&nbsp;Lara Chamma ,&nbsp;Nour Chamma ,&nbsp;Celine El Khoury ,&nbsp;Lara Saade ,&nbsp;Pia Tohme","doi":"10.1016/j.jadr.2025.100920","DOIUrl":"10.1016/j.jadr.2025.100920","url":null,"abstract":"<div><h3>Introduction</h3><div>The prevalence of disordered eating (DE) among children and adolescents is increasing in Arab countries. This systematic review explores the predictors of DE and eating disorders (EDs) in this demographic.</div></div><div><h3>Methods</h3><div>We searched PUBMED, MEDLINE, CINAHL, EMBASE, PsycINFO, Google Scholar, Web of Science Core Collection, ProQuest, Al Manhal, Al-Masdar, the website of the World Bank, and the grey literature for relevant studies, without language or time restrictions. We extracted data on study characteristics, methods, and results, and assessed the risk of bias using the MMAT tool. We performed an operate narrative synthesis of the studies adopting a bivariate vs. multivariate analysis, and meta-analyzed homogeneous studies adopting a multivariate analysis using RevMan 5.4.</div></div><div><h3>Results</h3><div>We included 36 studies and meta-analyzed 8. The risk of bias was assessed as high to unclear for a large proportion of the included studies. The predictors were categorized across biological, social, and psychological domains, but there was no consistency across studies, except for peer pressure. In the meta-analysis, excess body weight (OR=1.89; 95 %CI: 1.44, 2.49), female sex (OR=1.61; 95 %CI: 1.26, 2.06), urbanicity (OR=3.21; 95 %CI: 2.53, 4.08), perceived media pressure (OR=1.40; 95 %CI: 1.27, 1.54), and body shape dissatisfaction (OR=4.89; 95 %CI: 3.60, 6.66) predicted DE/EDs.</div></div><div><h3>Conclusion</h3><div>Culturally-sensitive prevention and intervention strategies with particular attention to perceived media pressure, are needed to address DE in children and adolescents.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100920"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mood stabilizer adherence patterns among adults with bipolar disorder: A single-center retrospective analysis","authors":"Neel Swamy ,&nbsp;Kelly C. Lee ,&nbsp;Jamie Kneebusch ,&nbsp;Casey Tiefenthaler","doi":"10.1016/j.jadr.2025.100922","DOIUrl":"10.1016/j.jadr.2025.100922","url":null,"abstract":"<div><h3>Background</h3><div>Bipolar disorder (BD) is a severe psychiatric disorder frequently associated with psychotropic non-adherence. Few studies have quantified real-world adherence patterns among people prescribed lithium or valproate for BD.</div></div><div><h3>Methods</h3><div>This single-center retrospective study examined adherence to lithium and valproate among adults hospitalized for BD between January 2017 and January 2022. The primary outcomes were the differences in the 6-month average proportion of days covered (PDC), for months 1 – 6 and 7 – 12 post-discharge, between the lithium and valproate groups. Secondary outcomes included the 12-month psychiatric readmission rate and demographic/comorbid associations with PDC. PDC was calculated by querying SureScripts fill records and confirming dispensing dates with pharmacies.</div></div><div><h3>Results</h3><div>Of 75 eligible adults, 56.0 % were discharged on lithium and 44.0 % on valproate. People discharged on lithium exhibited higher PDC during months 1 – 6 (0.36 versus 0.25 in the valproate group) and 7 – 12 (0.27 versus 0.16); these differences lacked statistical significance. Significant difference in ≥ 1 psychiatric re-admission during months 1 – 12 was observed between people discharged on lithium (9.5 %) and those discharged on valproate (30.3 %) <em>(p</em> = 0.035). Male sex and comorbid substance use disorder were associated with significantly lower PDC.</div></div><div><h3>Conclusion</h3><div>People discharged on lithium or valproate are vulnerable to mood stabilizer non-adherence following psychiatric hospitalization. Future research should examine psychotropic adherence trajectories in larger subpopulations of people with BD.</div></div><div><h3>Limitations</h3><div>Data derived from medication fill records may overestimate adherence in people who miss doses after dispensing and underestimate adherence in people who switch mood stabilizer therapy under a clinician’s direction.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100922"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143886062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does rTMS modulate phenotype of microglia in patients with treatment-resistant depression? A transcriptome analysis using iMG cells","authors":"Hiroshi Tateishi ,&nbsp;Hiroko Kunitake ,&nbsp;Masahiro Ohgidani ,&nbsp;Shogo Inamine ,&nbsp;Yutaka Kunitake ,&nbsp;Toru Murakawa ,&nbsp;Ryohei Kojima ,&nbsp;Jun Kikuchi ,&nbsp;Takumi Shiraishi ,&nbsp;Ken Takada ,&nbsp;Shota Shiba ,&nbsp;Masataka Hirano ,&nbsp;Airi Fukai ,&nbsp;Akira Tomonari ,&nbsp;Takahiro A Kato ,&nbsp;Akira Monji ,&nbsp;Yoshito Mizoguchi","doi":"10.1016/j.jadr.2025.100919","DOIUrl":"10.1016/j.jadr.2025.100919","url":null,"abstract":"<div><div>Background The neuroinflammatory hypothesis has been proposed as the pathophysiology of depression, and microglia are suggested to have crucial roles by modulating neuroinflammatory responses in patients with depression. We have originally developed human blood induced microglia-like (iMG) cells, which are surrogate cells to predict activities of human brain microglia for reverse-translational research. Repetitive transcranial magnetic stimulation (rTMS) is an effective therapeutic method for improving depressive symptoms in patients with treatment-resistant depression (TRD); however, its details remain unknown. The aim of this study was to predict how rTMS alters the phenotype of microglia using iMG cells of patients with TRD.</div><div>Methods Five patients with TRD were enrolled in a frequency (10 Hz) rTMS study. Microarray analysis of the iMG cells of patients with TRD at baseline and the end of the 6-week rTMS treatment was performed in the five domains of immunity, inflammation, phagocytosis, metabolic syndrome, and lipids.</div><div>Results Three of the five were rTMS responders and two were non-responders for depressive symptoms. Microarray analysis of responders showed that rTMS treatment significantly increased the RNA expression of 21 genes, including genes related to neuroinflammation, acting in a direction to promote neuroinflammation, and significantly decreased four genes.</div><div>Limitations The main limitations were the small sample size and the lack of control conditions using the sham rTMS procedure.</div><div>Conclusion This study suggests that rTMS treatment may alter iMG genes, including immune-related genes, in patients with TRD. Future studies should confirm these findings using a larger patient sample size and a sham rTMS procedure.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"21 ","pages":"Article 100919"},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143873889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}