Journal of Affective Disorders Reports最新文献

{"title":"Development and validation of a probability-strength stacking ensemble model for depression risk prediction in college students: A SHAP-based interpretability analysis","authors":"Jiuqi Sun,&nbsp;Chenchen Xu,&nbsp;Guohua Pan,&nbsp;Ming Lu","doi":"10.1016/j.jadr.2026.101135","DOIUrl":"10.1016/j.jadr.2026.101135","url":null,"abstract":"<div><div>Depressive symptoms are common among college students, yet scalable screening tools that adequately capture nonlinear risk patterns remain limited. This study developed and validated a Probability-Strength Stacking (PSS) ensemble framework for depression risk prediction using a publicly available, anonymized college student mental health dataset from Kaggle (n = 27,901). Thirteen sociodemographic, psychological, behavioral, and economic predictors were analyzed. Data were split 80:20 into training and held-out test sets. XGBoost, LightGBM, Random Forest, SVM, CatBoost, hard-label stacking, and PSS Stacking-v2 were compared. PSS Stacking-v2 used continuous probability outputs from four base learners as meta-features for a logistic regression meta-learner, preserving inter-model confidence information discarded by conventional hard-label stacking. Performance was assessed by AUC, accuracy, sensitivity, specificity, F1, and Brier score, with 5-fold cross-validation, 1000-iteration bootstrap resampling, SHAP analysis, and decision curve analysis. On the held-out test set (n = 5581), PSS Stacking-v2 achieved AUC=0.9193 (95% CI: 0.9125–0.9266), accuracy=0.8461, sensitivity=0.8843, specificity=0.7920, F1=0.8706, and Brier score=0.1112, comparable to standalone CatBoost (AUC=0.9197, Brier=0.1098) and substantially outperforming hard-label stacking (AUC=0.8605; Brier=0.1251). SHAP identified suicidal ideation, academic pressure, and financial stress as the strongest predictors. The model showed positive net benefit across decision thresholds from 0.04 to 0.96, indicating good potential for practical risk stratification and early identification of depression among college students.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101135"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148656493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of accelerated transcranial magnetic stimulation induced neuroplasticity in patients with depression","authors":"Tobias Bracht ,&nbsp;Rilana Di Maria ,&nbsp;Niklaus Denier ,&nbsp;Leila M. Soravia ,&nbsp;Kristina Adorjan ,&nbsp;Bogdan Draganski ,&nbsp;Mario Pfammatter ,&nbsp;Gianluca A. Florineth","doi":"10.1016/j.jadr.2026.101108","DOIUrl":"10.1016/j.jadr.2026.101108","url":null,"abstract":"<div><div>Repetitive transcranial magnetic stimulation (rTMS) is an efficient non-pharmacological therapy for patients with depression, including those with treatment resistant depression (TRD). Accelerated treatment TMS-protocols (aTMS) are applied several times a day and hold the promise for rapid and efficient treatment responses superior to conventional rTMS. A better understanding of the neurobiological underpinnings of aTMS-related neuroplasticity is crucial to advance the field. To this aim, we conducted a systematic review of studies investigating neuroplasticity of aTMS-treatment. Two investigators screened the established research literature databases for publications following the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines and using Patient/Population, Intervention, Comparison and Outcome (PICO) acronyms. Among the selected 22 studies assessing 958 participants the following imaging methods were applied: functional MRI (fMRI) (n = 15), structural MRI (n = 1), diffusion tensor imaging (DTI) (n = 1), arterial spin labelling (ASL) (n = 2), ¹⁸F-fluorodeoxyglucose positron emission tomography (18-FDG PET) (n = 1), and multimodal imaging (n = 2). The majority of reported aTMS-induced changes are confined to the anterior cingulate cortex (ACC), more specifically the subgenual ACC (sgACC). Associations between aTMS-induced neuroplasticity and clinical response were not consistent; however, the most frequently reported findings pertained to the sgACC. Future studies, investigating larger samples are required to consolidate the assumption that aTMS-induced plasticity of the sgACC may be associated with treatment response.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101108"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148409485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet, the gut microbiome, and neuroinflammation: nutritional modulation of the gut–brain axis in psychiatric disorders","authors":"Davoud Amiri,&nbsp;Lamberto Briziarelli,&nbsp;Swetang J. Shah,&nbsp;Barry Karlsson,&nbsp;Sara Amiri,&nbsp;Amin Vakili,&nbsp;Anastasia Mustakova","doi":"10.1016/j.jadr.2026.101133","DOIUrl":"10.1016/j.jadr.2026.101133","url":null,"abstract":"<div><h3>Background</h3><div>Evidence suggests that diet and the gut microbiome influence brain function and mental health. The gut–brain axis, a bidirectional network linking the gastrointestinal tract and the central nervous system, integrates neural, endocrine, immune, and metabolic pathways. Dysbiosis has been associated with neuroinflammation, altered neurotransmitter metabolism, and disrupted stress-response systems implicated in psychiatric disorders.</div></div><div><h3>Objective</h3><div>This narrative review examines current evidence on the relationships between diet, the gut microbiome, and neuroinflammatory processes in psychiatric disorders, focusing on depression, anxiety, bipolar disorder, and neurodevelopmental conditions.</div></div><div><h3>Methods</h3><div>Recent literature (2020–2025) was synthesised, focusing on studies investigating gut microbiota, dietary patterns, psychobiotics (probiotics, prebiotics, synbiotics), and their interactions with neuroimmune pathways and psychiatric outcomes.</div></div><div><h3>Results</h3><div>Gut microbiota alterations are associated with psychiatric symptoms and may influence brain function through multiple mechanisms, including microbial metabolite production (e.g., short-chain fatty acids), immune and cytokine modulation, alterations in the tryptophan–kynurenine pathway, and effects on vagal and neuroendocrine signalling. Diets rich in fibre, polyphenols, and fermented foods promote beneficial microbial profiles, whereas Western diets are linked to dysbiosis and low-grade inflammation. Clinical trials of psychobiotic and dietary interventions show promising but heterogeneous effects.</div></div><div><h3>Conclusions</h3><div>The gut–brain axis represents a promising framework for understanding psychiatric disorders and developing novel interventions. Nutritional strategies may complement conventional treatments, although further longitudinal and mechanistic studies are required.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"25 ","pages":"Article 101133"},"PeriodicalIF":3.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148640546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and mental health across family constellations in Germany: Evidence of a stable burden","authors":"Sabine Diabaté ,&nbsp;Pauline Kleinschlömer ,&nbsp;Lisa Kriechel ,&nbsp;Leonie Kleinschrot ,&nbsp;Elizabeth Mohr ,&nbsp;Helena Ludwig-Walz","doi":"10.1016/j.jadr.2026.101033","DOIUrl":"10.1016/j.jadr.2026.101033","url":null,"abstract":"<div><div>Loneliness is a pressing public health issue associated with adverse mental health outcomes, yet its distribution across family constellations and its links to mental health symptoms over time remain understudied. Using longitudinal data from the German Family Demography Panel Study (FReDA; <em>N</em> = 15,994 individuals, respondents aged 18 to 49 in 2020), this study examines how loneliness, as well as depressed and anxious moods, vary across five family constellations over three waves (autumn/winter 2021/22, 2022/23, 2023/24). Our results first indicate that loneliness remained high in Germany in 2023/2024, with approximately one-third of respondents reporting loneliness. Since the end of the COVID-19 pandemic, loneliness has declined on average, whereas depressed mood has increased and anxious mood has slightly decreased. This pattern is consistent across family constellations, and women score consistently higher than men. However, singles - both with and without children - reported the highest levels of loneliness, depressed and anxious mood. These findings suggest that cohabitation with a partner may act as a protective factor. Linear regression analyses suggest a persistent association between loneliness and mental health symptoms across all family constellations. The strength of these associations stays stable over time, particularly between loneliness and depressed mood. The first-difference regressions indicate that within-person increases in loneliness are associated with increases in affective symptoms across all family structures, with particularly strong effects among single parents and stronger associations for depressed than for anxious mood. These findings underscore the need for nuanced public health strategies that consider family constellations when addressing loneliness and mental health.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101033"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from deep learning models on new-onset anxiety in patients following bariatric metabolic surgery","authors":"Hongyi Zou ,&nbsp;Chen Jiang ,&nbsp;Xiguang Qi ,&nbsp;Oshin Miranda ,&nbsp;Tianyi Xie ,&nbsp;Anita P. Courcoulas ,&nbsp;LiRong Wang","doi":"10.1016/j.jadr.2026.101061","DOIUrl":"10.1016/j.jadr.2026.101061","url":null,"abstract":"<div><h3>Background</h3><div>Due to its long-term effectiveness in weight control and cost-efficiency, bariatric metabolic surgery (BMS) has emerged as a promising treatment option for patients with severe obesity. However, its impact on certain mental health disorders remains unclear.</div></div><div><h3>Objective</h3><div>This study aimed to utilize a deep learning (DL) model, DeepBiomarker2, which integrates social determinants of health (SDoH) and electronic health records (EHR), to identify clinical features associated with new-onset anxiety disorder following BMS.</div></div><div><h3>Methods</h3><div>We conducted a case-control study using longitudinal EHR data from the University of Pittsburgh Medical Center (Jan 2004–Oct 2019) on patients who underwent bariatric surgery. DeepBiomarker2, a DL model integrating diagnoses, medications, lab tests, and neighborhood socioeconomic status, predicted new-onset anxiety. Perturbation-based contribution analysis identified key predictive features.</div></div><div><h3>Results</h3><div>A total of 14,856 eligible patients who underwent BMS without a prior history of anxiety disorder were identified. DL models outperformed traditional logistic regression in predicting post-BMS anxiety, yielding area under the curve (AUC) values exceeding 0.89. Key features associated with post-BMS anxiety included abnormal urine and blood lab results, opioid and psychiatric medication use, frequent emergency department (ED) visits, and pre-existing mental health conditions. Potential protective indicators included omega-3 fatty acids, vitamin B12, calcium citrate, and pravastatin. Inclusion of nSES data led to marginal improvements in model performance.</div></div><div><h3>Conclusion</h3><div>Our DL models successfully identified clinical features potentially associated with new-onset anxiety following BMS, offering valuable insights to support early intervention and personalized mental health strategies for postoperative care.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101061"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing professional competencies to tackle depression and suicidal ideation: outcomes of the EAAD 4-level intervention across seven European countries","authors":"Evelien Coppens ,&nbsp;Chantal Van Audenhove ,&nbsp;Piotr Toczyski ,&nbsp;Panagiota Fexi ,&nbsp;Rainer Mere ,&nbsp;Peeter Värnik ,&nbsp;Eva Claeys ,&nbsp;András Székely ,&nbsp;Saiko Allende Leal ,&nbsp;Ella Arensman ,&nbsp;Anvar Sadath Vakkayil ,&nbsp;Albena Drobachka ,&nbsp;Katharina Schnitzspahn ,&nbsp;Kahar Abdulla ,&nbsp;Simge Celik ,&nbsp;Ulrich Hegerl","doi":"10.1016/j.jadr.2026.101026","DOIUrl":"10.1016/j.jadr.2026.101026","url":null,"abstract":"<div><h3>Background</h3><div>Training primary care workers, mental health professionals, and community facilitators is a common strategy to enhance their knowledge, attitudes, and confidence in managing depression and suicidality. This study evaluates the impact of two standardized training programs within the EAAD 4-level intervention on participants’ attitudes, perceived competence, and behavioural intentions across seven European countries.</div></div><div><h3>Method</h3><div>A single-group pre-post-test study was conducted as part of the EU-funded EAAD-Best project. A cohort of 696 primary care and mental healthcare professionals (Level 1) from five countries and 519 community workers (Level 3) from five countries participated in tailored training. A bespoke questionnaire based on the Theory of Planned Behaviour assessed attitudes, perceived competence, and behavioural intention before and immediately after training.</div></div><div><h3>Results</h3><div>Linear mixed models showed significant improvements in <strong>perceived competence</strong> (Level 1: +14.7 %; Level 3: +26.7 %) and <strong>behavioural intention</strong> (Level 1: +25.7 %; Level 3: +53.9 %). Attitudes were already positive at baseline but improved slightly (Level 1: +1.7 %; Level 3: +2.2 %). Positive effects were observed across multiple countries, regardless of group size and training delivery mode. In one country, where training was delivered online to large groups due to the COVID-19 lockdown, training effects were still observed.</div></div><div><h3>Conclusion</h3><div>Our results suggest that the EAAD training program may enhance professionals’ competencies and intentions to apply learned skills. An online version of the training, which enabled training of large groups, also showed promising results, highlighting potential for scalability. Future initiatives should focus on engaging harder-to-reach professionals and considering more robust evaluation designs to better assess impact.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101026"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial characteristics and daily impairment in women with persistent perinatal depressive symptoms: A large-scale cohort study","authors":"Haruna Irino ,&nbsp;Satoko Sasagawa ,&nbsp;Chika Yokoyama ,&nbsp;Aiko Okatsu ,&nbsp;Ayako Kanie ,&nbsp;Chika Kubota ,&nbsp;Yasue Mitamura ,&nbsp;Sayaka Aoyama ,&nbsp;Miyuki Makino ,&nbsp;Aiichiro Nakajima ,&nbsp;Yaeko Kataoka ,&nbsp;Masaru Horikoshi ,&nbsp;Hironori Kuga ,&nbsp;Masaya Ito","doi":"10.1016/j.jadr.2026.101032","DOIUrl":"10.1016/j.jadr.2026.101032","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to determine the prevalence of persistent perinatal depressive symptoms and to identify the psychosocial characteristics associated with persistent symptoms among Japanese women. While persistent perinatal depression significantly impact both mothers and children, evidence from Japan remains limited.</div></div><div><h3>Methods</h3><div>A longitudinal online survey was conducted at three time points: during pregnancy, 1-month postpartum, and 6-month postpartum. Depressive symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS), and daily impairment was measured using the difficulty item of the Patient Health Questionnaire-9. The EPDS cutoff score was 13 during pregnancy and 9 for postpartum. Group differences were examined using chi-square tests and one-way ANOVAs, followed by multivariable logistic regression.</div></div><div><h3>Results</h3><div>Among the 1039 participants (31.85±4.31 years), those who scored over cutoff during pregnancy, 1-month postpartum, and 6-month postpartum were 9.5%, 12.5%, and 11.3%, respectively. Depressive symptoms remained consistently high at all three-time points for 41 women (3.9%), fluctuated for 238 (22.9%), and remained low for 760 (73.2%). Persistent perinatal depressive symptoms were associated with greater daily impairment and were predicted by lower household income, personal psychiatric history, fewer sleeping hours at 1-month postpartum, and fear of COVID-19.</div></div><div><h3>Limitations</h3><div>Data were self-reported via the internet, and daily impairment was assessed using a single item.</div></div><div><h3>Conclusions</h3><div>Persistent perinatal depressive symptoms are associated with greater daily impairment and specific psychosocial vulnerabilities. Given their potential adverse effects on both mothers and children, continuous monitoring and support for depressive symptoms throughout the perinatal period are essential from a public health perspective.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101032"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146080641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What makes good expectation-violating interventions? - A mixed methods exploration of social interactions in the context of bereavement","authors":"Caroline Wanza ,&nbsp;Winfried Rief ,&nbsp;Bettina K. Doering","doi":"10.1016/j.jadr.2026.101056","DOIUrl":"10.1016/j.jadr.2026.101056","url":null,"abstract":"<div><h3>Background</h3><div>Expectations regarding social interactions shape how individuals experience and express grief following the loss of a significant person. When these expectations are negative or dysfunctional, they can impede coping and contribute to prolonged distress. Expectation-violating experiences (i.e., positive social interactions) may promote psychological recovery, but their role in bereavement remains underexplored.</div></div><div><h3>Objective</h3><div>This study qualitatively examined written accounts of grief-related expectation violations in social interactions, exploring how situational factors influence these experiences and identifying parameters relevant for grief-specific psychotherapy.</div></div><div><h3>Method</h3><div>We conducted mixed methods analyses using data from an online controlled trial of an imagery-based expectation violation intervention. Qualitative data were collected from 47 bereaved participants (M_age = 30.69 years, SD=11.32; range=18–55; 87.2 % female) who described situations where their grief-related social expectations were disconfirmed. Responses were analyzed using reflexive thematic analysis and linked to quantitative demographic and symptom measures.</div></div><div><h3>Results</h3><div>Two themes of negative social expectations emerged: expectations about others’ behavior and expectations about one’s own experience. Expectation violations also comprised two themes: behaviors of others and their impact on the bereaved. Most participants described both aspects of expectation violation, which was linked to a greater reduction in negative social expectations. Qualitative themes were not significantly associated with demographic or loss-related variables.</div></div><div><h3>Conclusions</h3><div>Interactions that are validating and reciprocal may foster connectedness and support recovery after loss. The findings underscore the importance of interpersonal interactions and self-awareness for changing expectations. Behavioral experiments should consider how the disconfirming behavior of others impacts the bereaved person’s self-perception.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101056"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study of brain correlates of long-term treatment with transcutaneous vagal nerve stimulation in posttraumatic stress disorder","authors":"J. Douglas Bremner ,&nbsp;Matthew T. Wittbrodt ,&nbsp;Nil Z. Gurel ,&nbsp;Jonathon A. Nye ,&nbsp;Md Mobashir H. Shandhi ,&nbsp;Asim H. Gazi ,&nbsp;Amit J. Shah ,&nbsp;Victoria Amorim ,&nbsp;Bradley D. Pearce ,&nbsp;Viola Vaccarino ,&nbsp;Omer T. Inan","doi":"10.1016/j.jadr.2025.101014","DOIUrl":"10.1016/j.jadr.2025.101014","url":null,"abstract":"<div><h3>Objective</h3><div>Posttraumatic Stress Disorder (PTSD) is a highly prevalent condition, and current treatments have limitations. Vagal Nerve Stimulation (VNS) is a new approach that potentially has promise for PTSD. Understanding the neurobiology of treatment response is important for developing new treatments. The purpose of this study was to assess neural correlations of long-term transcutaneous cervical VNS (tcVNS) in patients with PTSD.</div></div><div><h3>Methods</h3><div>Patients with PTSD underwent randomization to active tcVNS (<em>N</em> = 6) or sham stimulation (<em>N</em> = 5) twice daily for three months. High-Resolution Positron Emission Tomography scanning with radiolabeled water was used to measure brain blood flow measurements before and after treatment during exposure to personalized traumatic scripts paired with active or sham stimulation.</div></div><div><h3>Results</h3><div>Three months of active tcVNS resulted in activation in response to traumatic scripts in the sham stimulation group not seen in the tcVNS group in brain areas mediating the fear response, including posterior cingulate, thalamus, temporal and parietal cortex, and parahippocampal gyrus, with an increase in medial prefrontal cortex with tcVNS, in patients with PTSD.</div></div><div><h3>Conclusion</h3><div>TcVNS affects brain areas mediating fear and emotion which may underlie a therapeutic effect for PTSD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101014"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146079988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripartum psychiatric admissions in Israel: A retrospective cohort study","authors":"V. Bar ,&nbsp;Y. Bilu ,&nbsp;R. Walfisch ,&nbsp;G. Amit ,&nbsp;L. Azani ,&nbsp;R. Yoffe ,&nbsp;M. Weiser","doi":"10.1016/j.jadr.2026.101028","DOIUrl":"10.1016/j.jadr.2026.101028","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize peripartum psychiatric admissions in Israel and identify risk factors associated with postpartum admissions.</div></div><div><h3>Methods</h3><div>A total of 828,374 births between 2016 and 2022 were retrospectively analyzed using Israeli maternal-child health clinics’ data, representing 62% of nationwide births during the study period. Psychiatric admissions before, during and after pregnancy were identified through a national registry. Multivariable logistic regression and Cox proportional hazards models were used to examine risk factors, including: prior psychiatric admissions, Edinburgh Postnatal Depression Scale scores, employment status, marital status, and socioeconomic status.</div></div><div><h3>Results</h3><div>Admission rate spikes in the first month postpartum, and gradually returns to baseline levels after 6 months. Postpartum admissions were considerably more likely among women who had previous psychiatric admissions (OR = 149), and more so due to psychotic disorders (OR = 104) than bipolar disorder (OR = 5.1). However, first time admissions compose 62% of six-months postpartum admissions. Among mothers screened with EPDS a high score was associated with elevated risk for admission (OR = 5.6), especially when considering only mothers with no prior admissions (OR = 8.9).</div></div><div><h3>Conclusion</h3><div>Perinatal psychiatric admissions’ characteristics in Israel resemble those reported elsewhere, both temporally and in associated risk factors. The large number of first-time admissions highlights the need and challenge in identifying mothers at risk. EPDS screening was found useful in identifying mothers at risk for admissions, even beyond those due to postpartum depression and in the postpartum period. Incorporating a more detailed clinical history is likely required to better identify mothers at risk.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101028"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}