Journal of Affective Disorders Reports最新文献

{"title":"The contributions of mentalizing and impulsivity dimensions to the clinical expressions of attention-deficit hyperactivity disorder during adulthood","authors":"Margaux Bouteloup ,&nbsp;Vincent Besch ,&nbsp;Roland Hasler ,&nbsp;Rosetta Nicastro ,&nbsp;Eléonore Pham ,&nbsp;Karen Dieben ,&nbsp;Martin Blay ,&nbsp;Eva Rüfenacht ,&nbsp;RF-TBM Consortium ,&nbsp;Nader Perroud ,&nbsp;Martin Debbané","doi":"10.1016/j.jadr.2026.101060","DOIUrl":"10.1016/j.jadr.2026.101060","url":null,"abstract":"<div><div>The aim of our study is to characterize how transdiagnostic dimensions of personality trait impulsivity and mentalizing can be related to clinical domains and functional impairments in adults with ADHD. We specifically explore their relationship to 3 levels of expression of psychopathology: number of diagnostic symptoms (1), additional clinical indicators of severity (2), general social functioning (3).</div><div>We included 157 outpatients with ADHD aged to 16 to 77 consulting in a specialized psychiatric center in an University Hospital. Diagnostic procedure was based on the ACE+ and the ASRS. Mentalizing was assessed with the Mentalization Scale and impulsivity was evaluated with the UPPS-P Short Form.</div><div>Several forward stepwise linear and logistic regressions were performed.</div><div>Our results show that independently of gender and age effects, impulsivity facets of personality and especially urgence dimensions are significantly related to ADHD symptoms, clinical severity and quality of life. We also found that mentalizing dimensions, and most prominently self-mentalizing, further contributed to self-rated ADHD symptoms, clinical severity (suicidal history in particular) and quality of life.</div><div>These results suggest that an evaluation of impulsivity and mentalizing dimensions may be worthwhile to enrich evaluation, personalize diagnosis, case formulation, psychoeducation strategies and treatment for adults receiving the diagnosis of ADHD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101060"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Language influences perception of impulsive tendencies of depressed individuals","authors":"Huaixuan “Knox” Huang,&nbsp;Kristi Erdal","doi":"10.1016/j.jadr.2026.101040","DOIUrl":"10.1016/j.jadr.2026.101040","url":null,"abstract":"<div><h3>Background</h3><div>Impulsivity, particularly when triggered by emotions, is a significant predictor of various forms of psychopathology. However, most impulsivity research has been conducted in Western cultures. This study assessed whether culture influences perception of a depressed individual’s impulsive behavioral tendencies.</div></div><div><h3>Methods</h3><div>Vignettes of depressed individuals were used to examine 124 bilingual people’s (English and Japanese or Korean or Mandarin) (<em>M_age</em>=32.37 years; 57% male) perception of a depressed individual’s impulsivity, when language and vignette character name were varied. Impulsivity perception was measured using the five subscales of the UPPS-P Impulsive Behavior Scale - Short Form. Acculturation and self-construal were covaried.</div></div><div><h3>Results</h3><div>Reading and thinking in East Asian languages (compared to English) led to a depressed individual being perceived as more likely to lose control under negative emotion, to seek sensation, and to not think before acting. When the vignette character had a typical English name, participants perceived them as less likely to persevere. Acculturation and self-construal were not significant covariates.</div></div><div><h3>Limitations</h3><div>One impulsivity subscale was dropped due to its poor reliability in two East Asian Languages. Ecological validity was restricted by the vignette methodology, the assessment of impulsivity perception rather than behavior, and the geographical distribution of the sample.</div></div><div><h3>Conclusions</h3><div>Findings support how culture influences perception of impulsive tendencies of depressed individuals differently when thinking about a cultural context (name) and when thinking within a cultural context (language).</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101040"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between service member problematic anger and marital dysfunction in U.S. military couples: Findings from the Millennium Cohort Program","authors":"Travis N. Ray ,&nbsp;Matthew P. Forsstrom ,&nbsp;Rayan Joneydi ,&nbsp;Cynthia A. LeardMann ,&nbsp;Valerie A. Stander ,&nbsp;Hope S. McMaster","doi":"10.1016/j.jadr.2026.101034","DOIUrl":"10.1016/j.jadr.2026.101034","url":null,"abstract":"<div><div>Problematic anger is prevalent among service members and is associated with numerous dysfunctional outcomes. Research is needed to determine whether service member problematic anger has a unique, long-term impact on marital functioning. This study examined problematic anger and its longitudinal associations with marital dysfunction outcomes among 3456 U.S. service member–spouse dyads enrolled in the Millennium Cohort Program. Service members completed a self-report measure of problematic anger at Time 1 (2014–2016); spouses completed self-report assessments of intimate partner violence (IPV), marital quality, marital dissolution, relationship trust, and parenting alliance at Time 2 (2019–2021). Logistic regressions were conducted to examine associations between service member problematic anger and marital dysfunction outcomes using hierarchical adjustment for categories of covariates. Service member problematic anger was associated with IPV experience, low martial quality, marital dissolution, and low relationship trust among spouses after adjusting for demographic characteristics and military contextual variables. However, after adjusting for mental health variables, IPV was the only marital dysfunction outcome associated with service member problematic anger. The association between problematic anger and IPV remained after adjusting for adverse childhood experiences in the final model. Results suggest that mental health conditions, in general, may contribute to marital dysfunction in military couples, but problematic anger appears to be particularly crucial in predicting IPV. Screenings and targeted interventions for problematic anger among service members are needed. Such efforts may help to mitigate the downstream effects of problematic anger on marital dysfunction, thus improving service member readiness.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101034"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world effectiveness of self-administered transcranial direct current stimulation (tDCS) for depression: A retrospective cohort study","authors":"Mu Mu ,&nbsp;Aria Banazadeh ,&nbsp;Michael Cauchi ,&nbsp;Chris Griffiths","doi":"10.1016/j.jadr.2026.101044","DOIUrl":"10.1016/j.jadr.2026.101044","url":null,"abstract":"<div><h3>Background</h3><div>Flow FL-100 is a transcranial direct current stimulation (tDCS) device self-administered by users at home. The retrospective analysis examined real-world usage and effectiveness of Flow tDCS treatment using data from 14,726 users collected by Flow Neuroscience AB between 2020 and 2024.</div></div><div><h3>Methods</h3><div>Self-reported user background information and Montgomery-Åsberg Depression Rating Scale Self (MADRS-S) scores up to week 50 of the treatment were analysed. Effectiveness metrics (remission, response, and relapse rates) were assessed at pre-treatment baseline followed by week 3, 6, 10, 15, 20, and 50. Repeated-measures ANOVA, post-hoc and between-subject analysis were used to examine the change in MADRS-S over time and the influence of user background factors.</div></div><div><h3>Outcomes</h3><div>The reported mean MADRS-S score decreased from a moderate level before treatment to a mild level at week 10 and then plateaued thereafter. Response and remission rates increased between week 3 and week 10, then stabilised through to week 50. A repeated measures ANOVA and post-hoc test reveal statistically significant differences (<em>p</em> &lt; 0.0001) in MADRS-S scores across multiple time points. Reduction in reported depressive symptoms was observed during the initial weeks of treatment, these levels were maintained throughout the subsequent weeks. User adherence and background factors were significantly associated (<em>p</em> ≤ 0.005) with changes in MADRS-S scores during the first 10 weeks of treatment.</div></div><div><h3>Interpretations</h3><div>Users of self-administered Flow tDCS treatment reported a rapid initial improvement and long-term reduction of depressive symptoms. Observed variability in adherence and response across diverse user groups suggests potential benefits from personalised treatment protocols and support.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101044"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting the causal relationship between insomnia, plasma metabolites, and anxiety: A mediated mendelian randomization study","authors":"Qi Fan ,&nbsp;Jiaxin Li ,&nbsp;Yushi Tian ,&nbsp;Qingyuan Meng ,&nbsp;Mingyue Lan ,&nbsp;Xiaoyang Hu","doi":"10.1016/j.jadr.2026.101059","DOIUrl":"10.1016/j.jadr.2026.101059","url":null,"abstract":"<div><h3>Objective</h3><div>This study employed a two-sample Mendelian randomization (MR) approach to investigate the causal relationships among insomnia, plasma metabolites, and anxiety disorders.</div></div><div><h3>Methods</h3><div>Using summary data from genome-wide association studies (GWAS), we examined the associations between insomnia, 1400 plasma metabolites, and anxiety disorders. Bidirectional MR analysis was conducted to explore the causal relationship between insomnia and anxiety, while two-step mediation MR analysis was used to investigate the potential mediating role of plasma metabolites.</div></div><div><h3>Results</h3><div>Based on genetic prediction, this study suggests a potential causal relationship between insomnia and anxiety, and identifies seven plasma metabolites that may be involved in mediation. These findings provide new insights into the mechanism by which insomnia might contribute to the development of anxiety disorders, and offer potential new avenues for early prevention and diagnosis of anxiety. Two-step MR analysis identified causal associations between insomnia and 92 plasma metabolites. Furthermore, seven plasma metabolites were found to mediate the causal link between insomnia and anxiety.</div></div><div><h3>Conclusions</h3><div>This study provides compelling evidence for a causal relationship between insomnia and anxiety and identifies seven plasma metabolites involved in this mediation. These findings offer novel insights into how insomnia may contribute to the development of anxiety and propose new avenues for early prevention and diagnosis of anxiety disorders.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101059"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and evaluation of the psychometric properties of a short Chinese version of the reentry shock scale (RSS) among older adults","authors":"Zenan Wu ,&nbsp;Sai-fu Fung ,&nbsp;Tianjian Pi","doi":"10.1016/j.jadr.2026.101063","DOIUrl":"10.1016/j.jadr.2026.101063","url":null,"abstract":"<div><div>In light of increased international cross-border mobility, especially among older adults, this study aimed to develop a psychometrically robust and culturally appropriate short-form Chinese version of the Reentry Shock Scale (RSS-7) for assessing Reverse Culture Shock (RCS) among returnees. A total of 210 older Hong Kong returnees (M = 82.2 years old, SD = 6.64) with prior cross-border living experiences were recruited. Using a combination of psychometric techniques, including Confirmatory Factor Analysis, the proposed RSS-7 demonstrated satisfactory internal consistency, construct validity, and concurrent validity. Compared to the Chinese full version, the RSS-7 exhibited better psychometric properties while retaining measurement coverage across all conceptual dimensions. This shortened scale offers a reliable and efficient measurement tool for future research on RCS, particularly among aging populations.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101063"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thwarted belongingness as a predictor of suicidal ideation: A question of operationalization?","authors":"J. Eimen ,&nbsp;H. Schiemann ,&nbsp;J.J. Schroers ,&nbsp;I. Höller ,&nbsp;D. Schreiber ,&nbsp;T. Teismann ,&nbsp;T. Forkmann","doi":"10.1016/j.jadr.2026.101025","DOIUrl":"10.1016/j.jadr.2026.101025","url":null,"abstract":"<div><h3>Introduction</h3><div>The Interpersonal Theory of Suicide (ITS) posits that thwarted belongingness (TB), perceived burdensomeness (PB), and hopelessness about the unchangeability of both states predict suicidal ideation, with TB often being a weaker predictor compared to PB. This study evaluates the German version of the Thwarted Belongingness Scale (TBS) as an alternative to the Interpersonal Needs Questionnaire (INQ) for operationalizing TB.</div></div><div><h3>Methods</h3><div>411 participants (75.4% female; <em>M_age</em> = 29.57; <em>SD_age</em> = 11.20) completed an online survey. Factorial validity of the TBS was examined using confirmatory factor analysis. Internal consistency and convergent validity were investigated. Hierarchical linear regression analyses compared TBS and INQ in predicting suicidal ideation, including PB and the interaction of TB×PB as predictors.</div></div><div><h3>Results</h3><div>The TBS demonstrated excellent internal consistency (Cronbach’s α = 0.95), good fit indices, and convergent validity. Both TBS and INQ significantly predicted suicidal ideation, but no interaction effect of TB×PB was found. PB was a significantly stronger predictor of suicidal ideation than TB, regardless of TB measure used.</div></div><div><h3>Conclusion</h3><div>The TBS showed solid psychometric properties and may be a suitable alternative to the INQ for measuring TB. However, TB remains a weaker predictor of suicidal ideation compared to PB, regardless of operationalization, suggesting the need to reassess the role of TB in suicide theories.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101025"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental health in adults aged 50+ since the COVID-19 pandemic: Are we (all) back to ‘normal’? evidence from England","authors":"Darío Moreno-Agostino ,&nbsp;Giorgio Di Gessa","doi":"10.1016/j.jadr.2025.101012","DOIUrl":"10.1016/j.jadr.2025.101012","url":null,"abstract":"<div><h3>Objectives</h3><div>To understand how population mental health levels and inequalities in these are in the post-lockdown world compared to before the pandemic in adults aged 50 and older.</div></div><div><h3>Methods</h3><div>We used data from three Waves (2016–2017, <em>n</em> = 7191; 2018–2019, <em>n</em> = 7286; and 2021–2023, <em>n</em> = 6249) of the English Longitudinal Study of Ageing. Using linear and modified Poisson regression models, we investigated whether prevalence of high depressive symptomatology, anxiety, and loneliness, and quality-of-life levels changed across time points overall and by gender, living situation, and wealth quintiles. Models were adjusted for age group, gender, education, and long-standing illnesses.</div></div><div><h3>Results</h3><div>No significant differences were found between 2016–2017 and 2018–2019. However, compared to 2018–2019, prevalence of high depressive symptoms (RR_2021–2023 = 1.23[95 %CI 1.12;1.34], <em>p</em> &lt; 0.001), loneliness (RR_2021–2023 = 1.32[1.22;1.42], <em>p</em> &lt; 0.001) and quality-of-life levels (B_2021–2023 = -1.84 [-2.21;-1.48], <em>p</em> &lt; 0.001) were worse by 2021–2023. Pre-existing inequalities by gender, living arrangements, and wealth were not significantly different after the pandemic, except for depression, where gaps were significantly smaller by gender (RR_{2021–2023*women} = 0.72[0.59;0.89], <em>p</em> = 0.002) and, to a smaller extent, living situation (RR_{2021–2023*not_alone}=1.22[1.02;1.47], <em>p</em> = 0.026).</div></div><div><h3>Conclusion</h3><div>Population mental health levels in the population aged 50 and older seem to have declined after the pandemic, and inequalities within the population persist.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101012"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146039595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-dependent alterations in circulating mitochondrial DNA copy number and common deletion in bipolar disorder","authors":"Yuki Kageyama ,&nbsp;Shohei Okura ,&nbsp;Yasuhiko Deguchi ,&nbsp;Kenji Kuroda ,&nbsp;Koki Inoue","doi":"10.1016/j.jadr.2026.101031","DOIUrl":"10.1016/j.jadr.2026.101031","url":null,"abstract":"<div><h3>Background</h3><div>Mitochondrial dysfunction has been increasingly implicated in the pathophysiology of bipolar disorder (BD), and circulating mitochondrial DNA (mtDNA) has emerged as a potential biomarker. However, the biological significance of distinct circulating forms, structural abnormalities, and their association with inflammatory cytokines remains unclear. This study aimed to (1) quantify plasma mtDNA and extracellular vesicle-associated mtDNA (EV mtDNA), examine their correlations, and assess associations with interleukin-6 (IL-6), and (2) evaluate state-dependent alterations in the 4977-bp common deletion.</div></div><div><h3>Methods</h3><div>Twenty-one paired plasma samples were collected longitudinally from BD patients during depressive (dBD) and remitted (rBD) states. Plasma and EV mtDNA copy numbers and the 4977-bp common deletion were quantified using multiplex qPCR. Plasma IL-6 levels were measured by ELISA. Data were normalized using median normalization.</div></div><div><h3>Results</h3><div>Plasma and EV mtDNA copy numbers were significantly reduced in dBD compared with rBD (P_FDR &lt; 0.01 for both). In contrast, <em>ND4/ND1</em> ratio was significantly lower in dBD in both plasma and EV fractions (P_FDR &lt; 0.001 for both). Plasma and EV mtDNA levels were strongly correlated in both states, with EV mtDNA comprising ∼30% of total circulating mtDNA. Plasma IL-6 levels were decreased in dBD (P_FDR &lt; 0.01) but showed no significant correlations with mtDNA measures.</div></div><div><h3>Conclusion</h3><div>Depressive states in BD are associated with reduced circulating mtDNA copy number and increased common deletion compared with remission. Combined assessment of mtDNA abundance and integrity across extracellular compartments may represent a novel biomarker strategy for state-dependent mitochondrial dysfunction in BD.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101031"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and the patient experience with vortioxetine vs other standard-of-care antidepressants in major depressive disorder: Real-world insights from an observational, prospective, decentralized study using the PatientsLikeMe platform","authors":"Jeoffrey Bispham ,&nbsp;Christopher Blair ,&nbsp;Sagar V. Parikh ,&nbsp;Roger S. McIntyre ,&nbsp;Mark Opler ,&nbsp;Erlyn Macarayan ,&nbsp;Mary C. Burke ,&nbsp;Alina Karim ,&nbsp;Michael Martin ,&nbsp;Priscilla Driscoll Shempp ,&nbsp;Ian Robinson ,&nbsp;Maggie McCue","doi":"10.1016/j.jadr.2025.101019","DOIUrl":"10.1016/j.jadr.2025.101019","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder (MDD) remains a clinical challenge, showing low remission rates with standard-of-care (SOC) antidepressants (ADs). This study evaluated real-world treatment experience with vortioxetine vs SOC ADs through the online peer community PatientsLikeMe (PLM).</div></div><div><h3>Methods</h3><div>This observational, prospective, patient-centric, decentralized study recruited adults with MDD using the PLM platform. In this 2-part study, qualitative surveys informed study flow. The quantitative study enrolled participants who started or switched SOC AD monotherapy or vortioxetine within 180 days and had baseline Patient Health Questionnaire-9 scores ≥5. Primary endpoint was proportion with Patient Global Impression of Improvement (PGI-I) score &lt;2 at week 12 (W12). Secondary endpoints included MDD severity, MDD symptoms, and quality of life (QoL).</div></div><div><h3>Results</h3><div>Qualitative survey responses refined the quantitative study design. Quantitative study enrolled 352 receiving SOC and 151 receiving vortioxetine. At W12, proportions with PGI-I scores &lt;2 were similar (vortioxetine vs SOC: 4.5% vs 1.8%; <em>P</em> = 0.830). Mean PGI-I scores were similar at W12 (vortioxetine vs SOC: 3.5 vs 3.6; <em>P</em> = 0.831) and lower with vortioxetine at W24 (vortioxetine vs SOC: 3.0 vs 3.4; <em>P</em> &lt; 0.001). Remission rates at W24 were higher with vortioxetine (11.4%) vs SOC (2.5%; <em>P</em> &lt; 0.001). Feelings of anhedonia were significantly less frequent with vortioxetine (<em>P</em> = 0.005).</div></div><div><h3>Limitations</h3><div>Self-reported data may introduce recall bias. PLM users may have higher health literacy than the general population.</div></div><div><h3>Conclusions</h3><div>Although primary endpoint was not met, long-term vortioxetine was associated with improved global impression, QoL and life satisfaction, and a higher rate of remission, which can guide clinical decisions and empower patients.</div></div>","PeriodicalId":52768,"journal":{"name":"Journal of Affective Disorders Reports","volume":"24 ","pages":"Article 101019"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146190161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}