Global Health Research and Policy最新文献

{"title":"The spatio-temporal trends and determinants of liver cancer attributable to specific etiologies: a systematic analysis from the Global Burden of Disease Study 2021.","authors":"Jinli Liu, Tingling Xu, Yanan Wang, Fanpu Ji, Lei Zhang","doi":"10.1186/s41256-025-00416-y","DOIUrl":"10.1186/s41256-025-00416-y","url":null,"abstract":"<p><strong>Background: </strong>Although liver cancer has varied causes, its evolving epidemiology and causal drivers remain underexplored. This study quantifies the trends and drivers of liver cancer burden attributable to specific causes from 1990 to 2021.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease Study, we extracted prevalence, mortality, and disability-adjusted life years (DALYs) associated with specific causes of liver cancer. We assessed spatio-temporal trends across the sociodemographic index (SDI) and quantified the contributions of epidemiological shifts, population growth, and ageing to DALYs.</p><p><strong>Results: </strong>In 2021, liver cancer accounted for 0.74 million cases, 0.48 million deaths, and 12.89 million DALYs globally. Average annual percentage changes (AAPCs) in prevalence, mortality, and DALY rates from 1990 to 2021 were 1.17%, 1.04%, and 0.48%, respectively. HBV, HCV, and alcohol use were major contributors to DALYs, accounting for 1.92 million (36.00%), 1.53 million (28.62%), and 1.27 million (23.88%) of the increase, respectively. High-income North America and Western Europe experienced rapid growth in liver cancer prevalence from 1990 to 2021, while High-income North America and Southern Latin America had rapid growth in mortality. Global DALY increases were mainly driven by population growth (3.91 million, 73.29%) and population ageing (3.03 million, 56.86%).</p><p><strong>Conclusions: </strong>The study revealed that hepatitis B, hepatitis C, and alcohol consumption were the primary contributors to the increasing DALYs from liver cancer, with population growth and ageing as key drivers of these changes. These findings underscore the importance of considering the major factors and demographic dynamics in addressing the burden of liver cancer when formulating prevention and intervention strategies.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"22"},"PeriodicalIF":4.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12090427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health inequalities in disease burden of dementia and early-onset dementia: findings from the Global Burden of Disease 2021 study.","authors":"Min Du, Lu Gram, Fude Yang, Donghua Mi, Hongguang Chen, Chao Song, Min Liu, Jue Liu","doi":"10.1186/s41256-025-00417-x","DOIUrl":"10.1186/s41256-025-00417-x","url":null,"abstract":"<p><strong>Background: </strong>Given the increasing aging global population and advancements in dementia action plans, the latest disparities in the dementia burden may evolve. This study aimed to analyze and compare temporal trends at regional, national, and sociodemographic levels to provide evidence for public health planning and resource prioritization.</p><p><strong>Methods: </strong>The age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years (DALYs) rate (ASDR) were derived from the Global Burden of Disease 2021 study. Estimated annual percentage changes (EAPCs) were calculated to quantify their temporal trends. Correlations between EAPC and the human resources for health (HRH) were assessed using Pearson correlation analysis.</p><p><strong>Results: </strong>Although the ASPR and ASIR remained stable or decreased globally, they both greatly increased in East Asia (ASPR: EAPC = 0.43; 95% CI 0.35, 0.51; ASIR: EAPC = 0.40; 95% CI 0.33, 0.47). For early-onset dementia, the ASPR (range of EAPC = 0.03-0.17) and ASIR (range of EAPC = 0.05-0.19) in the 45 to 59 years age group increased in North Africa and Middle East, particularly among females (ASPR: range of EAPC = 0.08-0.21; ASIR: range of EAPC = 0.09-0.2). Although the ASMR and ASDR both decreased globally and in high socio-demographic index region, they both increased greatly in South Asia (ASMR: EAPC = 0.7; 95% CI 0.66, 0.75; ASDR: EAPC = 0.40; 95% CI 0.37, 0.43). For early-onset dementia, the ASMR (range of EAPC = 0.43-0.78) and ASDR (range of EAPC = 0.19-0.33) in the 40 to 59 years age group had increased in Central Sub-Saharan Africa, particularly among females (ASMR: range of EAPC = 0.5-0.86; ASDR: range of EAPC = 0.19-0.4). Negative correlations were observed between the EAPC in ASPR, ASIR, ASMR and ASDR with various types of HRH at the national level.</p><p><strong>Conclusions: </strong>Although there has been progresses in controlling the global trends of dementia incidence, prevalence, and mortality, significant regional and national inequalities remain evident. More importantly, the early-onset dementia burden is increasing significantly among females in the African region, underscoring the critical need for healthcare systems that address dementia across the early midlife span.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"21"},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of disease in the Belt and Road countries from 1990 to 2021: analysis of estimates from the Global Burden of Disease 2021.","authors":"Youyou Wu, Peishan Ning, Zhenzhen Rao, Li Li, David C Schwebel, Peixia Cheng, Yanhong Fu, Ruotong Li, Jie Li, Wanhui Wang, Guoqing Hu","doi":"10.1186/s41256-025-00403-3","DOIUrl":"https://doi.org/10.1186/s41256-025-00403-3","url":null,"abstract":"<p><strong>Background: </strong>As a newly emerging collaborative platform to boost regional growth and prosperity, the Belt and Road Initiative (BRI) has great potential to promote global health development. However, the overall health status of BRI countries remains unclear. We analyzed the health patterns and its geographical distribution in 149 BRI countries from 1990 to 2021.</p><p><strong>Methods: </strong>Using the Global Burden of Disease 2021 (GBD 2021) online database, we examined time trends, country and income variations in death rate and disability-adjusted life years (DALY) rate, and compared the trends and projected 2030 values for ten key health-related Sustainable Development Goals (SDGs) indicators among the 149 BRI countries.</p><p><strong>Results: </strong>The number of deaths and DALYs of BRI countries represented 62.9-66.0% of global deaths and 64.8-66.8% of global DALYs between 1990 and 2021, and both the overall age-standardized death rate and DALY rate continued to be higher in BRI countries than in non-BRI countries throughout the time period studied. Great variations existed across the 149 BRI countries for both level of and changes in age-standardized death rate and DALY rate. The 2030 targets for six health-related SDGs indicators will not be reached in over 70% of BRI countries according to the previous changing speed trajectory.</p><p><strong>Conclusions: </strong>Our findings demonstrate that BRI countries face a heavy burden of disease that varies across countries, although health outcomes have improved since 1990. Progress toward 2030 targets for six key health-related SDGs indicators in most BRI countries was slow. These findings support calls for more health collaborations, aid programs, and other health service to reduce health disparities across the BRI countries.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"20"},"PeriodicalIF":4.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The barriers and facilitators of herpes zoster vaccination intentions of urban residents in China: a qualitative study.","authors":"Beibei Yuan, Chao Long, Ming Wang, Elizabeth Maitland, Stephen Nicholas, Xianjing Qin, Weiying Zhao, Dawei Zhu, Ping He","doi":"10.1186/s41256-025-00413-1","DOIUrl":"https://doi.org/10.1186/s41256-025-00413-1","url":null,"abstract":"<p><strong>Background: </strong>In an aging society, herpes zoster (HZ) increases the health burden on infected patients. While quantitative studies point to a lack of willingness to accept the HZ vaccine in China, there is limited number of studies with in-depth qualitative analysis on HZ vaccination intention. This study undertakes a qualitive study method to identify the barriers and facilitators behind urban residents' HZ vaccination intention in three China cities, and contributes towards some targeted vaccination promotion suggestions to China and other LMICs with similar low coverage of HZ vaccination.</p><p><strong>Methods: </strong>We conducted 12 focus group discussions in three cities of China. In each discussion we recruited 3 to 6 participants aged 20 and older to catch the views on the HZ vaccine from residents with a wider age range. Participants were recruited by purposive sampling techniques. Guided by the health belief model, thematic analysis was used to group participants' HZ vaccine attitudes and to identify the barriers and facilitators to HZ vaccination.</p><p><strong>Results: </strong>The attitude of 59 participants participating in the focus group discussions showed a low-level acceptability of the HZ vaccine with only 27.1% (16/59) displaying a willingness to HZ vaccine uptake. The barriers to HZ vaccination included limited or incorrect conception on HZ prevalence, risk factors, susceptibility, symptoms, prevention and treatment methods, and the high cost of the HZ vaccine. Perceived vulnerability to HZ, fear of HZ pain and individuals' financial capacity were the strongest facilitators to HZ vaccination. In addition, it was found that advocacy of HZ vaccination by health professionals or government financial subsidies to HZ vaccination, could attenuate the above barriers to HZ vaccine uptake.</p><p><strong>Conclusions: </strong>Our study revealed a series of barriers and facilitators of HZ vaccination intention. We recommend HZ education and advocacy by health workers and government health officials to address the limited HZ knowledge and HZ misconceptions, and the government (or health insurance providers) to pay or subsidize the high costs of HZ vaccination to increase the HZ vaccination rate.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"19"},"PeriodicalIF":4.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-creating community initiatives on physical activity and healthy eating in a low-income neighbourhood in Quito, Ecuador.","authors":"Sergio Morales-Garzón, Elisa Chilet-Rosell, María Hernández-Enríquez, Francisco Barrera-Guarderas, Ikram Benazizi-Dahbi, Marta Puig-García, Andrés Peralta, Ana Lucía Torres-Castillo, Lucy Anne Parker","doi":"10.1186/s41256-025-00412-2","DOIUrl":"https://doi.org/10.1186/s41256-025-00412-2","url":null,"abstract":"<p><p>Promoting healthy behaviours to improve population health requires strategies that foster supportive environments and actively engage communities. Here, we detail an evidence-informed co-creation process in Ferroviaria, a low-income neighbourhood in Quito, Ecuador, led by six members of a local Women's Association. Co-creation here involved a participatory approach that integrated local epidemiological data on non-communicable disease (NCD) risk factors and employed the \"Dialogue Forum\" methodology to guide collective decision-making. Through this process, community leaders and participants prioritized initiatives based on community needs, ultimately choosing to develop a community food garden. This initiative fostered social confidence, empowerment, and cohesion, though challenges emerged, including limited participation in the evaluation phase and difficulties in sustaining actions post-implementation. We demonstrate how the \"Dialogue Forum\" can be an effective tool for inclusive decision-making in low-resource settings. For future co-creation efforts, we underscore the importance of building strong local networks and implementing strategies to prevent dominance by either community leaders or researchers within the co-creation process. Initiatives should incorporate comprehensive community-led evaluations, and it is critical for community leaders to understand the importance of developing actions that the community can independently lead and sustain without continued institutional support. When health data is used, it should be framed to emphasize contextual determinants rather than focusing solely on behavioural risk factors. This report contributes to the growing evidence on community-driven health interventions, positioning co-creation as a pathway to social change and enhanced public health outcomes.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"18"},"PeriodicalIF":4.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregate distributional cost-effectiveness analysis: a novel tool for health economic evaluation to inform resource allocation.","authors":"Shan Jiang, Boyang Li, Bonny Parkinson, Shunping Li, Yuanyuan Gu","doi":"10.1186/s41256-025-00415-z","DOIUrl":"https://doi.org/10.1186/s41256-025-00415-z","url":null,"abstract":"<p><p>Health equity is a growing concern for policymakers across the globe. Conventional cost-effectiveness analysis (CEA), commonly used in evaluating health interventions, primarily focuses on the average and aggregate health outcomes in the targeted population, neglecting the distributional impacts on health equity. This gap calls for approaches that can quantify the impact of intervention of interest on health equity to support decision-making. Distributional Cost-Effectiveness Analysis (DCEA) offers a framework to assess the distributional impacts of health interventions. Based on DCEA, aggregate DCEA (A-DCEA) was proposed as a practical and simplified alternative to DCEA. Unlike full DCEA, which requires detailed subgroup data, A-DCEA utilizes aggregated data, making it accessible and feasible for broader use. In this commentary, we discuss the rationale for A-DCEA, outline the steps for its implementation, and highlight its applicability. The purpose of this article is to introduce A-DCEA as a pragmatic and accessible tool for evaluating the equity implications of healthcare interventions. A-DCEA can inform policymakers by incorporating equity considerations into healthcare decision-making, particularly when conducting a full DCEA is impractical due to data limitation. A-DCEA provides a valuable and accessible method for evaluating the distributional impact of interventions, promoting health equity in decision-making. Its adoption can lead to more informed health policy that considers health inequities as well as the efficient use of resources.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"17"},"PeriodicalIF":4.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mpox-related stigma and healthcare-seeking behavior among men who have sex with men.","authors":"Yujie Liu, Jiechen Zhang, Yong Cai","doi":"10.1186/s41256-025-00418-w","DOIUrl":"https://doi.org/10.1186/s41256-025-00418-w","url":null,"abstract":"<p><p>The 2022 global mpox outbreak highlighted significant public health challenges, with men who have sex with men (MSM) accounting for 86.7% of confirmed cases. As a high-risk group, MSM faced not only the direct health impacts of mpox but also an additional burden of stigma and discrimination, which severely hindered their willingness to seek care and access timely medical services. This article explores mpox-related stigma and discrimination and their profound impact on healthcare-seeking behaviors among MSM, drawing on evidence from global studies. We examine how stigma affects individual decision-making and has broader public health implications by exacerbating healthcare delays during the outbreak. In response, we propose actionable strategies to mitigate stigma, including providing accurate and responsible communication, strengthening community and social support network, building capacity for frontline workers, and engaging affected individuals for effective intervention. By integrating stigma-reduction measures into pandemic preparedness and response, public health systems can better support vulnerable populations, improve healthcare access, and ensure a more effective response to future outbreaks.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"16"},"PeriodicalIF":4.0,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of health intervention coverage on reducing maternal mortality in 126 low- and middle-income countries: a Lives Saved Tool modelling study.","authors":"Xi-Ru Guo, Jue Liu, Hai-Jun Wang","doi":"10.1186/s41256-025-00414-0","DOIUrl":"10.1186/s41256-025-00414-0","url":null,"abstract":"<p><strong>Background: </strong>There is a continued and urgent need to address the stagnation of the global maternal mortality ratio (MMR), especially for low- and middle-income countries (LMICs). We aimed to assess the impact of scaling up health intervention coverage on reducing MMR under four scenarios for 126 LMICs.</p><p><strong>Methods: </strong>We conducted the modelling study to estimate MMR and additional maternal lives saved by intervention by 2030 for 126 LMICs using the Lives Saved Tool (LiST). We applied four scenarios to assess the impact of scaling up health intervention coverage with no scale-up (no change), a modest scale-up (increased by 2% per year), a substantial scale-up (increased by 5% per year), and universal coverage (coverage reached 95% by 2030). In sensitivity analysis, with the current trend, we assumed that coverage of each intervention remained unchanged from 2024, with MMR changing according to the annual percentage change (APC) of 2015-2020.</p><p><strong>Results: </strong>Among the 126 LMICs, 31.7% (40/126) countries showed an increase in MMR, and 38.1% (48/126) stalled on the reduction of MMR from 2015 to 2020. With a modest, substantial, or universal scale-up, the 2030 average MMR would be 172.1 (117.6-262.9), 139.8 (95.6-213.5) or 98.6 (67.8-149.7), not reaching the SDG Target 3.1. Additional maternal lives saved by scaling up the coverage of health interventions were mainly clustered in the African Region, the Southeast Asia Region, and the Eastern Mediterranean Region. Compared with other included interventions, uterotonics for postpartum hemorrhage, assisted vaginal delivery and cesarean delivery played more important roles in reducing maternal mortality.</p><p><strong>Conclusions: </strong>The study findings highlighted that even under a substantial scale-up of intervention coverage or scaling up to universal coverage of interventions, it would be difficult for the 126 LMICs to achieve the SDG Target 3.1 on time. Optimizing the allocation of health resources, promoting health equality, taking more decisive national, regional and global actions are urgently needed for LMICs to reduce MMR and reach the SDG Target 3.1.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"15"},"PeriodicalIF":4.0,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11963500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of a regional Mpox surveillance network in Central Africa: shared experiences in an endemic region.","authors":"Emmanuel Hasivirwe Vakaniaki, Sydney Merritt, Sylvie Linsuke, Emile Malembi, Francisca Muyembe, Lygie Lunyanga, Andrea Mayuma, Papy Kwete, Thierry Kalonji, Joule Madinga, Matthew LeBreton, Emmanuel Nakoune, Ernest Kalthan, Sevidzem Shang, Julius Nwobegahay, Odianosen Ehiakhamen, Elsa Dibongue, Jean-Médard Kankou, Bernard Erima, Denis K Byarugaba, Paige Rudin Kinzie, Franck Mebwa, Francis Baelongandi, Aimé Kayolo, Pépin Nabugobe, Dieudonné Mwamba, Jean Malekani, Beatrice Nguete, Didine Kaba, Lisa E Hensley, Jason Kindrachuk, Laurens Liesenborghs, Robert Shongo, Jean-Jacques Muyembe-Tamfum, Nicole A Hoff, Anne W Rimoin, Placide Mbala-Kingebeni","doi":"10.1186/s41256-025-00408-y","DOIUrl":"10.1186/s41256-025-00408-y","url":null,"abstract":"<p><p>To address the underreporting of mpox cases in endemic regions, a regional surveillance network, known as the Mpox Threat Reduction Network (MPX-TRN), was established between five neighboring countries in Central and West Africa in 2022. One direct outcome of the MPX-TRN has been the strengthening of regional mpox surveillance. This consortium has facilited open communication channels, detection of cross-border mpox cases, and improvements of the detection and diagnosis of mpox in Central Africa and worldwide. Importantly, the MPX-TRN provides a scalable model for addressing underreporting of diseases, such as mpox.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"14"},"PeriodicalIF":4.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a framework for estimating comorbidity burden of inpatient cancer patients based on a case study in China.","authors":"Jiamin Wang, Wenjing Zhang, Kexin Sun, Mingzhu Su, Yuqing Zhang, Jun Su, Xiaojie Sun","doi":"10.1186/s41256-025-00411-3","DOIUrl":"10.1186/s41256-025-00411-3","url":null,"abstract":"<p><p>Inpatient cancer patients often carry the dual burden of the cancer itself and comorbidities, which were recognized as one of the most urgent global public health issues to be addressed. Based on a case study conducted in a tertiary hospital in Shandong Province, this study developed a framework for the extraction of hospital information system data, identification of basic comorbidity characteristics, estimation of the comorbidity burden, and examination of the associations between comorbidity patterns and outcome measures. In the case study, demographic data, diagnostic data, medication data and cost data were extracted from the hospital information system under a stringent inclusion and exclusion process, and the diagnostic data were coded by trained coders with the 10th revision of the International Classification of Diseases (ICD-10). Comorbidities in this study was assessed using the NCI Comorbidity Index, which identifies multiple comorbidities. Rates, numbers, types and severity of comorbidity for inpatient cancer patients together form the characterization of comorbidities. All prevalent conditions in this cohort were included in the cluster analysis. Patient characteristics of each comorbidity cluster were described. Different comorbidity patterns of inpatient cancer patients were identified, and the associations between comorbidity patterns and outcome measures were examined. This framework can be adopted to guide the patient care, hospital administration and medical resource allocation, and has the potential to be applied in various healthcare settings at local, regional, national, and international levels to foster a healthcare environment that is more responsive to the complexities of cancer and its associated conditions. The application of this framework needs to be optimized to overcome a few limitations in data acquisition, data integration, treatment priorities that vary by stage, and ethics and privacy issues.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"13"},"PeriodicalIF":4.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}