Health inequalities in disease burden of dementia and early-onset dementia: findings from the Global Burden of Disease 2021 study.

IF 4 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Min Du, Lu Gram, Fude Yang, Donghua Mi, Hongguang Chen, Chao Song, Min Liu, Jue Liu
{"title":"Health inequalities in disease burden of dementia and early-onset dementia: findings from the Global Burden of Disease 2021 study.","authors":"Min Du, Lu Gram, Fude Yang, Donghua Mi, Hongguang Chen, Chao Song, Min Liu, Jue Liu","doi":"10.1186/s41256-025-00417-x","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Given the increasing aging global population and advancements in dementia action plans, the latest disparities in the dementia burden may evolve. This study aimed to analyze and compare temporal trends at regional, national, and sociodemographic levels to provide evidence for public health planning and resource prioritization.</p><p><strong>Methods: </strong>The age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years (DALYs) rate (ASDR) were derived from the Global Burden of Disease 2021 study. Estimated annual percentage changes (EAPCs) were calculated to quantify their temporal trends. Correlations between EAPC and the human resources for health (HRH) were assessed using Pearson correlation analysis.</p><p><strong>Results: </strong>Although the ASPR and ASIR remained stable or decreased globally, they both greatly increased in East Asia (ASPR: EAPC = 0.43; 95% CI 0.35, 0.51; ASIR: EAPC = 0.40; 95% CI 0.33, 0.47). For early-onset dementia, the ASPR (range of EAPC = 0.03-0.17) and ASIR (range of EAPC = 0.05-0.19) in the 45 to 59 years age group increased in North Africa and Middle East, particularly among females (ASPR: range of EAPC = 0.08-0.21; ASIR: range of EAPC = 0.09-0.2). Although the ASMR and ASDR both decreased globally and in high socio-demographic index region, they both increased greatly in South Asia (ASMR: EAPC = 0.7; 95% CI 0.66, 0.75; ASDR: EAPC = 0.40; 95% CI 0.37, 0.43). For early-onset dementia, the ASMR (range of EAPC = 0.43-0.78) and ASDR (range of EAPC = 0.19-0.33) in the 40 to 59 years age group had increased in Central Sub-Saharan Africa, particularly among females (ASMR: range of EAPC = 0.5-0.86; ASDR: range of EAPC = 0.19-0.4). Negative correlations were observed between the EAPC in ASPR, ASIR, ASMR and ASDR with various types of HRH at the national level.</p><p><strong>Conclusions: </strong>Although there has been progresses in controlling the global trends of dementia incidence, prevalence, and mortality, significant regional and national inequalities remain evident. More importantly, the early-onset dementia burden is increasing significantly among females in the African region, underscoring the critical need for healthcare systems that address dementia across the early midlife span.</p>","PeriodicalId":52405,"journal":{"name":"Global Health Research and Policy","volume":"10 1","pages":"21"},"PeriodicalIF":4.0000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087054/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Global Health Research and Policy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s41256-025-00417-x","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Given the increasing aging global population and advancements in dementia action plans, the latest disparities in the dementia burden may evolve. This study aimed to analyze and compare temporal trends at regional, national, and sociodemographic levels to provide evidence for public health planning and resource prioritization.

Methods: The age-standardized prevalence rate (ASPR), age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life years (DALYs) rate (ASDR) were derived from the Global Burden of Disease 2021 study. Estimated annual percentage changes (EAPCs) were calculated to quantify their temporal trends. Correlations between EAPC and the human resources for health (HRH) were assessed using Pearson correlation analysis.

Results: Although the ASPR and ASIR remained stable or decreased globally, they both greatly increased in East Asia (ASPR: EAPC = 0.43; 95% CI 0.35, 0.51; ASIR: EAPC = 0.40; 95% CI 0.33, 0.47). For early-onset dementia, the ASPR (range of EAPC = 0.03-0.17) and ASIR (range of EAPC = 0.05-0.19) in the 45 to 59 years age group increased in North Africa and Middle East, particularly among females (ASPR: range of EAPC = 0.08-0.21; ASIR: range of EAPC = 0.09-0.2). Although the ASMR and ASDR both decreased globally and in high socio-demographic index region, they both increased greatly in South Asia (ASMR: EAPC = 0.7; 95% CI 0.66, 0.75; ASDR: EAPC = 0.40; 95% CI 0.37, 0.43). For early-onset dementia, the ASMR (range of EAPC = 0.43-0.78) and ASDR (range of EAPC = 0.19-0.33) in the 40 to 59 years age group had increased in Central Sub-Saharan Africa, particularly among females (ASMR: range of EAPC = 0.5-0.86; ASDR: range of EAPC = 0.19-0.4). Negative correlations were observed between the EAPC in ASPR, ASIR, ASMR and ASDR with various types of HRH at the national level.

Conclusions: Although there has been progresses in controlling the global trends of dementia incidence, prevalence, and mortality, significant regional and national inequalities remain evident. More importantly, the early-onset dementia burden is increasing significantly among females in the African region, underscoring the critical need for healthcare systems that address dementia across the early midlife span.

痴呆和早发性痴呆疾病负担中的健康不平等:来自2021年全球疾病负担研究的结果。
背景:鉴于全球人口日益老龄化和痴呆症行动计划的进展,痴呆症负担的最新差异可能会发生变化。本研究旨在分析和比较区域、国家和社会人口层面的时间趋势,为公共卫生规划和资源优先排序提供证据。方法:年龄标准化患病率(ASPR)、年龄标准化发病率(ASIR)、年龄标准化死亡率(ASMR)和年龄标准化残疾调整生命年(DALYs)率(ASDR)来源于全球疾病负担2021研究。计算估计年百分比变化(EAPCs)以量化其时间趋势。采用Pearson相关分析评估EAPC与卫生人力资源(HRH)之间的相关性。结果:虽然全球范围内的ASPR和ASIR保持稳定或下降,但东亚地区的ASPR和ASIR均大幅上升(ASPR: EAPC = 0.43;95% ci 0.35, 0.51;Asir: eapc = 0.40;95% ci 0.33, 0.47)。对于早发性痴呆,北非和中东地区45 - 59岁年龄组的ASPR(范围EAPC = 0.03-0.17)和ASIR(范围EAPC = 0.05-0.19)增加,尤其是女性(ASPR:范围EAPC = 0.08-0.21;ASIR: EAPC范围= 0.09-0.2)。尽管ASMR和ASDR在全球和高社会人口指数区域均有所下降,但在南亚均大幅上升(ASMR: EAPC = 0.7;95% ci 0.66, 0.75;Asdr: eapc = 0.40;95% ci 0.37, 0.43)。对于早发性痴呆,在撒哈拉以南非洲中部,40至59岁年龄组的ASMR(范围EAPC = 0.43-0.78)和ASDR(范围EAPC = 0.19-0.33)有所增加,尤其是女性(ASMR:范围EAPC = 0.5-0.86;ASDR: EAPC范围= 0.19-0.4)。ASPR、ASIR、ASMR和ASDR的EAPC与全国不同类型的HRH呈负相关。结论:尽管在控制痴呆症发病率、患病率和死亡率的全球趋势方面取得了进展,但明显的区域和国家不平等仍然存在。更重要的是,非洲地区女性的早发性痴呆负担正在显著增加,这凸显了对解决中年早期痴呆问题的卫生保健系统的迫切需要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Global Health Research and Policy
Global Health Research and Policy Social Sciences-Health (social science)
CiteScore
12.00
自引率
1.10%
发文量
43
审稿时长
5 weeks
期刊介绍: Global Health Research and Policy, an open-access, multidisciplinary journal, publishes research on various aspects of global health, addressing topics like health equity, health systems and policy, social determinants of health, disease burden, population health, and other urgent global health issues. It serves as a forum for high-quality research focused on regional and global health improvement, emphasizing solutions for health equity.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信