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Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair 材料表面的生物功能化策略及其对骨修复的生物效应启发
Biosurface and Biotribology Pub Date : 2024-06-03 DOI: 10.1049/bsb2.12081
Guowen Duan, Dongbiao Chang, Chengdong Zhang, Siyu Li, Xinyao Liu, Zian Wang, Long Chen, Jinsheng Li, Zhenfan Bai, Jie Weng
{"title":"Biofunctionalisation strategies of material surface and the inspired biological effects for bone repair","authors":"Guowen Duan,&nbsp;Dongbiao Chang,&nbsp;Chengdong Zhang,&nbsp;Siyu Li,&nbsp;Xinyao Liu,&nbsp;Zian Wang,&nbsp;Long Chen,&nbsp;Jinsheng Li,&nbsp;Zhenfan Bai,&nbsp;Jie Weng","doi":"10.1049/bsb2.12081","DOIUrl":"10.1049/bsb2.12081","url":null,"abstract":"<p>Due to trauma and disease, bone defects endanger the healthy life of human beings. At present, the gold standard for bone defect repair is still autologous bone transplantation and allogeneic bone transplantation. However, its insufficient source, potential disease transmission and immune rejection limit its clinical application. Therefore, the development of bone repair materials plays an important role in promoting bone repair. As the interface between material and tissue, the surface of the material plays an important role in the reaction after implantation, which determines the effectiveness of defect repair treatment. With the development of surface engineering and technology, bone repair materials have developed from biological inertia to biological activity by endowing various biological functions by controlling the composition, topological morphology and structure of the material surface etc. The inspired biofunctionalisation of material surface includes the capacities of inducing osteogenesis, promoting angiogenesis, antibacterial, immune regulation etc., as well as integration of postoperative repair and treatment. The authors review the biofunctionalisation of biomaterial surface and the inspired biological effects for bone repair, mainly including physical and chemical properties of material surface to regulate osteogenesis, and functional strategy of bone repair material surface.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141271309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles 用微型和纳米级羟基磷灰石颗粒进行表面改性,增强聚(乳酸-共聚-乙醇酸)笼状结构的生物功能
Biosurface and Biotribology Pub Date : 2024-05-23 DOI: 10.1049/bsb2.12080
Dongbiao Chang, Siyu Li, Zhenfan Bai, Jing You, Lili Cao, Qingcao Li, Huan Tan, Yan Zheng, Feilun Ye, Jie Weng
{"title":"Enhancing the biological functionality of poly (lactic-co-glycolic acid) cage-like structures through surface modification with micro- and nano-sized hydroxyapatite particles","authors":"Dongbiao Chang,&nbsp;Siyu Li,&nbsp;Zhenfan Bai,&nbsp;Jing You,&nbsp;Lili Cao,&nbsp;Qingcao Li,&nbsp;Huan Tan,&nbsp;Yan Zheng,&nbsp;Feilun Ye,&nbsp;Jie Weng","doi":"10.1049/bsb2.12080","DOIUrl":"10.1049/bsb2.12080","url":null,"abstract":"<p>Biomaterials with exceptional performance are crucial for addressing the challenges of complex bone regeneration. Compared with traditional three-dimensional scaffolds, injectable microspheres enable new strategies for the treatment of irregular bone defects. Biodegradable poly (lactic-co-glycolic acid) has found widespread applications as microcarriers of drugs, proteins, and other active macromolecules. Applied to the surface of poly (lactic-co-glycolic acid) cage-like structures (PLGA-CAS), hydroxyapatite (HA) effectively reduces inflammation while enhancing biological effects. In this study, we loaded the surface of PLGA-CAS with micro- and nano-hydroxyapatite particles, referred to as μHA/PLGA-CAS and nHA/PLGA-CAS, respectively. Subsequently, their material characteristics and biological effects were assessed. The incorporation of hydroxyapatite onto PLGA-CAS resulted in enhanced surface roughness and hydrophilicity, coupled with improved thermal stability and delayed degradation. Furthermore, μHA/PLGA-CAS induced osteogenic differentiation of osteoblast precursor cells, while nHA/PLGA-CAS improved endothelial cell adhesion and stimulated angiogenic differentiation in vitro. Collectively, these findings suggest that μHA/PLGA-CAS and nHA/PLGA-CAS, each with distinct characteristics, hold significant potential for application as microcarriers in various biomedical contexts.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microstructure development of Ti scaffold by laser powder bed fusion with chemical polishing and its mechanical properties, biocompatibility 通过激光粉末床熔融与化学抛光技术开发钛支架的微结构及其机械性能和生物相容性
Biosurface and Biotribology Pub Date : 2024-05-16 DOI: 10.1049/bsb2.12079
Changfu Lu, Jing Chen, Teng Ma, Yuxin Chen, Da Zeng, Yiliang Gan, Youwen Yang
{"title":"Microstructure development of Ti scaffold by laser powder bed fusion with chemical polishing and its mechanical properties, biocompatibility","authors":"Changfu Lu,&nbsp;Jing Chen,&nbsp;Teng Ma,&nbsp;Yuxin Chen,&nbsp;Da Zeng,&nbsp;Yiliang Gan,&nbsp;Youwen Yang","doi":"10.1049/bsb2.12079","DOIUrl":"10.1049/bsb2.12079","url":null,"abstract":"<p>Titanium (Ti) dental scaffolds are widely used in dental prosthetics due to their excellent mechanical properties and biocompatibility. However, conventional Ti scaffolds manufactured through machining often do not fit perfectly with the bone defect site. Laser powder bed fusion (LPBF) technology enables the personalised manufacturing of custom-made Ti scaffolds. A custom-made Ti scaffold was prepared using LPBF and its surface roughness was improved through chemical polishing. To enhance the surface roughness, a nitric acid mixed solution with a specific composition of HF: HNO<sub>3</sub>:C<sub>3</sub>H<sub>6</sub>O<sub>3</sub> = 2:2:3 was used. The polishing mechanism was investigated by adjusting the F/Ti ratio to control the formation and dissolution of the oxide film. As a result, the surface of the Ti scaffold after polishing exhibited a smooth and flat appearance compared to the LPBF part, with a reduced surface roughness (Ra) of 1.23 ± 0.19 μm. The custom-made Ti scaffold also demonstrated favourable mechanical properties, with a bending strength of 335.18 ± 33.62 MPa and stiffness of 2.13 ± 0.21 GPa. Furthermore, in vitro cell tests confirmed the excellent biocompatibility of the custom-made Ti scaffold. The authors present a feasible strategy for the further clinical application of custom-made Ti scaffolds, offering enhanced surface properties and addressing the limitations of conventional machining methods.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140969745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Photosynthetic co-culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury 藻类与人脐静脉内皮细胞的光合共培养系统:缓解缺氧和缺氧/复氧损伤的效果
Biosurface and Biotribology Pub Date : 2024-03-29 DOI: 10.1049/bsb2.12078
Donghu Lin, Yuanyuan Chen, Xinyu Tao, Xin Che, Shiyu Li, Shiyu Cheng, Shuxin Qu
{"title":"Photosynthetic co-culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury","authors":"Donghu Lin,&nbsp;Yuanyuan Chen,&nbsp;Xinyu Tao,&nbsp;Xin Che,&nbsp;Shiyu Li,&nbsp;Shiyu Cheng,&nbsp;Shuxin Qu","doi":"10.1049/bsb2.12078","DOIUrl":"10.1049/bsb2.12078","url":null,"abstract":"<p>It is a developed photosynthetic co-culture system to alleviate the hypoxia and hypoxia/reoxygenation (H/R)-injured human umbilical vein endothelial cells (HUVECs). The algae, <i>Chlorella vulgaris</i>, were encapsulated to slow their growth while not affecting the photosynthetic oxygen-producing capacity by Layer-by-layer (LbL) using gelatin and sodium alginate as the positive and negative charges materials, respectively. Then, the photosynthetic co-culture system of HUVECs and self-oxygenating alginate hydrogel (Algae-gel) was constructed in which the optimal ratios between algae and HUVECs were 5:1 and 20:1 for a 2D or 3D co-cultured manner, respectively. It indicated that the 3D co-cultured manner of HUVECs needed more O<sub>2</sub> by the production of algae than it did in a 2D co-cultured manner. The co-cultured Algae-gel could alleviate hypoxia and the oxidative stress injury of hypoxia and hypoxia/reoxygenation (H/R)-treated HUVECs in the proliferation, intracellular ROS and cellular migratory ability. In addition, the Algae-gel could downregulate the expression of hypoxia-inducible factors 1α (HIF-1α) and vascular endothelial growth factor (VEGF) of hypoxia and H/R-injured HUVECs due to the improvement of hypoxia and H/R injury. This photosynthetic co-culture system could offer a promising approach for repairing hypoxia and H/R-injured cells or tissue by providing safe and stable O<sub>2</sub>.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140365493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A non-antibiotic organic coating on ZA6-1 surface releasing different concentrations of sodium dodecyl sulphate/levulinic acid for orthopaedic application 一种在ZA6-1表面释放不同浓度十二烷基硫酸钠/乙酰丙酸的非抗生素有机涂层,用于骨科应用
Biosurface and Biotribology Pub Date : 2024-03-22 DOI: 10.1049/bsb2.12077
Feng Zou, Deren Zhao, Yangkai Liu, Qiqi Lu, Hulin Liu, Zilin Chen, Yaxing Fang, Xiaodong Tan, Yunjie Xiang, Xue Feng, Yongping Zhang, Xi Rao
{"title":"A non-antibiotic organic coating on ZA6-1 surface releasing different concentrations of sodium dodecyl sulphate/levulinic acid for orthopaedic application","authors":"Feng Zou,&nbsp;Deren Zhao,&nbsp;Yangkai Liu,&nbsp;Qiqi Lu,&nbsp;Hulin Liu,&nbsp;Zilin Chen,&nbsp;Yaxing Fang,&nbsp;Xiaodong Tan,&nbsp;Yunjie Xiang,&nbsp;Xue Feng,&nbsp;Yongping Zhang,&nbsp;Xi Rao","doi":"10.1049/bsb2.12077","DOIUrl":"10.1049/bsb2.12077","url":null,"abstract":"<p>Bone implantation surgery is often accompanied by bacterial infection, resulting in infectious bone non-union, pathological fracture and other serious consequences, which will aggravate the pain of patients. A non-antibiotic coating consisting of sodium dodecyl sulphate (SDS) and levulinic acid (LA) with different concentrations was prepared by the authors on the zinc–aluminium alloy (ZA6-1) using a wet chemistry treatment for orthopaedic application. The influence of SDS/LA concentrations on the surface morphology, composition and performance of the developed coating was investigated. The results showed that as-prepared coating on a zinc alloy surface could improve the substrate's corrosion resistance and increase the degradation rate from 0.82 to 19.70 μm/year upon raising the SDS/LA concentration. Furthermore, higher hydrophilicity (&lt;14°), better cell proliferation (&gt;100%) and morphology, as well as good cell adhesion and differentiation (ALP &gt;95% for 7 days) were observed on coated zinc alloys. The increased SDS/LA concentration slightly weakens the biocompatibility and enhances the antibacterial performance of coated zinc alloys due to the synergistic effect of SDS/LA. Overall, the coating comprising 6 wt.% SDS and 9 wt.% LA showed excellent antibacterial action with a high level of biocompatibility, confirming its potential application for orthopaedic implants.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140214963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drag reduction capacity of multi-scale and multi-level riblet in turbulent flow 多尺度和多层次波纹管在紊流中的减阻能力
Biosurface and Biotribology Pub Date : 2024-03-18 DOI: 10.1049/bsb2.12076
Dengke Chen, Wenhao Li, Yichen Zhao, Jinhai Liu, Xianxian Cui, Zehui Zhao, Xiaolin Liu, Huawei Chen
{"title":"Drag reduction capacity of multi-scale and multi-level riblet in turbulent flow","authors":"Dengke Chen,&nbsp;Wenhao Li,&nbsp;Yichen Zhao,&nbsp;Jinhai Liu,&nbsp;Xianxian Cui,&nbsp;Zehui Zhao,&nbsp;Xiaolin Liu,&nbsp;Huawei Chen","doi":"10.1049/bsb2.12076","DOIUrl":"https://doi.org/10.1049/bsb2.12076","url":null,"abstract":"<p>For high-speed moving objects, drag reduction has been a prolonged major challenge. To address this problem, passive and negative strategies have been proposed in the preceding decades. The integration of creatures and nature has been continuously perfected during biological evolution. Unique structure characteristics, material properties, and special functions of marine organisms can provide inexhaustible inspirations to solve this intractable problem of drag reduction. Therefore, a simple and low-cost laser ablation method was proposed. A multi-scale and multi-level riblet (MSLR) surface inspired by the denticles of the sharkskin was fabricated by controlling the density of the laser path and ablation times. The morphology and topographic features were characterised using an electron microscope and a scanning white-light interfering profilometer. Then, the drag reduction capacity of the bionic riblet surface was measured in a circulating water tunnel. Finally, the mechanism of drag reduction was analysed by the computational fluid dynamics (CFD) method. The results show that the MSLR surface has a stable drag reduction capacity with an increase in Reynold (Re) number which was contributed by high-low velocity stripes formed on the MSLR surface. This study can provide a reference for fabricating spatial riblets with efficient drag reduction at different values of Re and improving marine antifouling.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface active functional groups enhanced PET non-woven fabric for the filtering of harmful substances in smoke 用于过滤烟雾中有害物质的表面活性功能基团增强型 PET 无纺布
Biosurface and Biotribology Pub Date : 2024-02-25 DOI: 10.1049/bsb2.12075
Lu Ning, Pengfei Tang, Xiong Lu, Guangyuan Yang, Faxing Jiang, Hongping Zhang
{"title":"Surface active functional groups enhanced PET non-woven fabric for the filtering of harmful substances in smoke","authors":"Lu Ning,&nbsp;Pengfei Tang,&nbsp;Xiong Lu,&nbsp;Guangyuan Yang,&nbsp;Faxing Jiang,&nbsp;Hongping Zhang","doi":"10.1049/bsb2.12075","DOIUrl":"https://doi.org/10.1049/bsb2.12075","url":null,"abstract":"<p>Harmful components in cigarette smoke, such as nicotine, tar, and organic particulate matter, are the primary culprits behind lung diseases. While conventional filter materials based on cellulose, carbon, and molecular sieves exhibit commendable filtration capabilities, their high cost restricts their widespread applications. Based on this, the authors aim to prepare PET-based filter materials with good adsorption properties through a simple surface functionalisation strategy. The adsorption performance of the PET-based non-woven fabric was enhanced by the introduction of sodium alginate (SA). The gas adsorption experiments results reveal that SA-modified PET (SA-PET) exhibits significantly improved filtration efficiency for nicotine, tar, and total particulate matter—increasing by 27.1%, 26.2%, and 21.3%, respectively. Moreover, SA-PET exhibits more odour control ability than traditional activated carbon-based filter materials. These results prove that surface-functionalised SA-PET has better filtration performance for harmful substances in smoke and provides a new strategy for the design of high-performance filtration materials.</p>","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1049/bsb2.12075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140188528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation, properties and biomedical applications progress of 1D magnetic nanomaterials with iron 含铁一维磁性纳米材料的制备、特性和生物医学应用进展
Biosurface and Biotribology Pub Date : 2023-12-20 DOI: 10.1049/bsb2.12073
Zhongbing Huang, Juan Wang, Ximing Pu, Guangfu Yin
{"title":"Preparation, properties and biomedical applications progress of 1D magnetic nanomaterials with iron","authors":"Zhongbing Huang, Juan Wang, Ximing Pu, Guangfu Yin","doi":"10.1049/bsb2.12073","DOIUrl":"https://doi.org/10.1049/bsb2.12073","url":null,"abstract":"1D magnetic nanomaterials with iron, with the special physical properties and biological behaviour, have been found to possess the great promising applications in many fields. In this review, the components, structure, physicochemical properties, biocompatibility and in vitro and in vivo biomedical functions of magnetic nanowires (MNWs), nanorods (MNRs) with iron are summarised, especially their anisotropy shape and magnetism result in their many applications in biodetections and medical treatment fields. The potential future functions of these 1D magnetic nanomaterials compared to magnetic nanoparticles also is discussed by highlighting the possibility of integration with other metal‐compositions or bio‐compositions and with existing biotechnology as well as by pointing out their specific properties. Current limitations in the property improvement and issues related with the outcome of the MNRs in the body are also summarised in order to address the remaining challenge for the extended biomedical functions of MNRs in the clinical application field.","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138994320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving anti‐Gram‐positive‐bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non‐antibiotic lysozyme and parathyroid hormone 通过贻贝模拟多巴胺与非抗生素溶菌酶和甲状旁腺激素改善锌合金的抗革兰氏阳性菌性能和成骨作用
Biosurface and Biotribology Pub Date : 2023-12-04 DOI: 10.1049/bsb2.12072
Deren Zhao, Tianhao Chen, Jinqian Chen, Banglun Huang, Jihua Nie, Hulin Liu, Yangkai Liu, Zilin Chen, Feng Zou, Qiqi Lu, Xiaodong Tan, Yunjie Xiang, Jing Li, Yongping Zhang, Xue Feng, X. Rao
{"title":"Improving anti‐Gram‐positive‐bacterial performance and osteogenesis for zinc alloy via mussel mimetic polydopamine with non‐antibiotic lysozyme and parathyroid hormone","authors":"Deren Zhao, Tianhao Chen, Jinqian Chen, Banglun Huang, Jihua Nie, Hulin Liu, Yangkai Liu, Zilin Chen, Feng Zou, Qiqi Lu, Xiaodong Tan, Yunjie Xiang, Jing Li, Yongping Zhang, Xue Feng, X. Rao","doi":"10.1049/bsb2.12072","DOIUrl":"https://doi.org/10.1049/bsb2.12072","url":null,"abstract":"In this work, a novel coating with a non‐antibiotic agent for inhibiting Gram‐positive bacteria and promoting osteogenesis was prepared on zinc‐aluminium alloy (ZA6‐1) via mussel mimetic polydopamine (PDA) containing lysozyme (LYS) and parathyroid hormone (PTH). The results indicate that as‐deposited coatings can efficiently decrease the degradation rate of ZA6‐1 from 0.52 to 0.16 mm/year, and the addition of LYS weakens the coating resistance, while the addition of PTH enhances the coating resistance. In spite that no obvious inhibition of Escherichia coli is observed, the coated zinc alloys show good in vitro antibacterial performance against Staphylococcus aureus. Compared with ZA6‐1 zinc alloys, the increase of antibacterial efficacy reaches 86.9%–90.1%. Furthermore, the lower hydrophilicity (26.4°), higher osteoblast cell viability (>100%), good osteoblast cell morphology and better osteoblast cell differentiation (ALP = 107.7%) for PDA‐LYS/PTH coated samples support that as‐prepared coating is promising for modifying biodegradable zinc implants.","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138601967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys 钴铬钼合金表面粗糙度及其对细胞粘附的调节作用
Biosurface and Biotribology Pub Date : 2023-11-10 DOI: 10.1049/bsb2.12068
Satoshi Migita
{"title":"Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys","authors":"Satoshi Migita","doi":"10.1049/bsb2.12068","DOIUrl":"https://doi.org/10.1049/bsb2.12068","url":null,"abstract":"Abstract Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts. CCM samples with different values of surface rouges were prepared by polishing. MC3T3‐E1 mouse osteoblasts were used for cell culture experiments. Cell attachment, morphology, and the expression of actin stress fibres, vinculin, and distribution of yes‐associated protein were analysed. Our results suggest that surface roughness does not significantly affect cell attachment and proliferation on CCM, unlike on titanium. Thus implies that other properties of CCM, such as physicochemical properties, may play a more substantial role in modulating cell behaviour. This study provides important insights into the design of CCM implants, suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.","PeriodicalId":52235,"journal":{"name":"Biosurface and Biotribology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135141765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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