The Korean journal of helicobacter and upper gastrointestinal research最新文献_第5页

Underwater Endoscopic Resection for the Rare Periampullary Tumor. 罕见壶腹周围肿瘤的水下内镜切除术。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0084

Soo Bin Synn, Jin Ook Jang, Woo Jin Kim, Cheol Min Lee, Dae Gon Ryu, Cheol Woong Choi, Su Bum Park, Su Jin Kim

{"title":"Underwater Endoscopic Resection for the Rare Periampullary Tumor.","authors":"Soo Bin Synn, Jin Ook Jang, Woo Jin Kim, Cheol Min Lee, Dae Gon Ryu, Cheol Woong Choi, Su Bum Park, Su Jin Kim","doi":"10.7704/kjhugr.2025.0084","DOIUrl":"10.7704/kjhugr.2025.0084","url":null,"abstract":"Composite gangliocytoma/neuroma and neuroendocrine tumors (CoGNETs) are extremely rare periampullary neoplasms composed of neuroendocrine epithelial, Schwannian spindle, and ganglion cells. Although endoscopic papillectomy or surgery have been used to treat ampullary CoGNETs, underwater endoscopic mucosal resection (UEMR) for periampullary lesions has not been previously described. In this study, we present a case of a 53-year-old man referred to our hospital with an incidentally detected subepithelial tumor in the second portion of the duodenum. Endoscopic ultrasound revealed a 13×10-mm homogeneous, hypoechoic, and well-demarcated submucosal mass. UEMR was performed under conscious sedation without submucosal injection, achieving safe en bloc resection within 12 min. Histopathology revealed a 2.0×1.5×1.2-cm lesion composed of mixed neuroendocrine epithelial, Schwannian spindle, and ganglion cells. Immunohistochemical staining was positive for chromogranin A, synaptophysin, CD56, neuron-specific enolase, and S-100, confirming CoGNET with a Ki-67 index of <1% and no lymphovascular or perineural invasion. Follow-up endoscopy 3 months later revealed only a post-resection scar without residual or recurrent tumors. This appears to be the first reported case of periampullary CoGNET successfully treated with UEMR. Therefore, UEMR might represent a safe and effective therapeutic option for selected periampullary subepithelial tumors.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 1","pages":"95-99"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural History of Gastric Subepithelial Lesions Measuring 1 to 2 cm. 胃上皮下病变1 - 2厘米。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0057

Younghee Choe, Byung-Wook Kim, Soo-Young Na, Joon Sung Kim

{"title":"Natural History of Gastric Subepithelial Lesions Measuring 1 to 2 cm.","authors":"Younghee Choe, Byung-Wook Kim, Soo-Young Na, Joon Sung Kim","doi":"10.7704/kjhugr.2025.0057","DOIUrl":"10.7704/kjhugr.2025.0057","url":null,"abstract":"Objectives: Management strategies for subepithelial lesions (SELs) measuring 1-2 cm remain undefined in most guidelines due to limited data. We aimed to establish a practical clinical approach by analyzing the long-term outcomes of SELs in this size range.Methods: We retrospectively reviewed cases of gastric SELs measuring 1-2 cm between 2011 and 2023. We reviewed esophagogastroduodenoscopy and endoscopic ultrasound images, alongside data from abdominal computed tomography, biopsy results, and long-term follow-up records.Results: Gastric SELs were initially identified in 648 patients. Of these, 88 patients (mean age, 57.1±10.6 years; 60% women) had lesions measuring 1-2 cm and underwent further evaluation or surveillance. The mean lesion size determined by endoscopy was 13.7±3.3 mm. Among the 52 patients with histological confirmation, 24 (46%) were diagnosed with gastrointestinal stromal tumors (GISTs), whereas the remainder had benign lesions. Most gastric SELs were located in the fundus and upper body. Pathological analysis indicated that the majority of GISTs were low-risk. Three GISTs were stratified as moderate-to-high risk; notably, one measured 0.9 cm upon pathological examination. The median surveillance period for the 28 patients without histological confirmation was 55 months (range, 43-115 months). Two of these patients underwent endoscopic or wedge resection due to tumor enlargement; both lesions were histologically confirmed as low-risk.Conclusions: Approximately half of the gastric SELs measuring 1-2 cm were GISTs, representing an intermediate- to high-risk tumors. Given that GISTs in the upper stomach were associated with elevated risk even when smaller than 2 cm, we recommend strict short-term surveillance for such lesions.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 1","pages":"79-84"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Submucosal Dissection for Early Gastric Cancer: Current Standard Indication and Management. 内镜下粘膜剥离术治疗早期胃癌：目前的标准指征和处理。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0087

Moon Won Lee

{"title":"Endoscopic Submucosal Dissection for Early Gastric Cancer: Current Standard Indication and Management.","authors":"Moon Won Lee","doi":"10.7704/kjhugr.2025.0087","DOIUrl":"10.7704/kjhugr.2025.0087","url":null,"abstract":"Endoscopic submucosal dissection (ESD) has been established as the standard treatment for early gastric cancer, enabling en bloc resection regardless of lesion size and offering high curability with organ preservation. The indications for ESD have expanded with the accumulation of long-term data, and recent guidelines from Korea, Japan, and Western countries share similar criteria, although subtle differences regarding the undifferentiated-type histology remain. Despite its efficacy, ESD remains technically demanding, particularly for lesions with severe fibrosis or those located at difficult anatomical sites. Furthermore, as the population ages, perioperative management with antithrombotic agents has become a critical safety issue. This review provides a comprehensive overview of the current indications and clinical outcomes of ESD based on large-scale global data. It also offers practical strategies for overcoming technical difficulties and managing adverse events, with a specific focus on updated guidelines for antithrombotic agents and perforation management.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction Between Metabolic Diseases, GLP-1 Receptor Agonists, and Helicobacter pylori Infection: An Updated Evidence Summary. 代谢性疾病、GLP-1受体激动剂和幽门螺杆菌感染之间的相互作用：最新证据摘要

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0088

Ju Yup Lee

引用次数: 0

Antimicrobial Peptides: Potential Therapeutic Substitute for Antibiotics in Helicobacter pylori Infection. 抗菌肽：幽门螺杆菌感染抗生素的潜在治疗替代品。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2026.0005

Seokin Kang

引用次数: 0

Efficacy of Helicobacter pylori Eradication for Gastric Cancer Prevention in Older Adults. 根除幽门螺杆菌预防老年人胃癌的疗效。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0073

Jin Lee

引用次数: 0

Gastric Plexiform Fibromyxoma Presenting With Gastrointestinal Hemorrhage. 胃丛状纤维黏液瘤表现为胃肠道出血。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.7704/kjhugr.2025.0070

Si Hyung Lee

引用次数: 0

Helicobacter pylori Positivity by 16S rRNA Gene PCR in Fecal Samples From Patients With Gastroduodenal Symptoms: A Retrospective Observational Study. 胃十二指肠症状患者粪便样本中幽门螺杆菌16S rRNA基因PCR阳性：回顾性观察研究

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0067

Dayaneth Jácome-Montero, Jhoan Guamán-Angulo, Angélica Tigre-León, Favian Bayas-Morejón, Sebastián Guerrero-Luzuriaga, Byron Herrera-Chávez

{"title":"Helicobacter pylori Positivity by 16S rRNA Gene PCR in Fecal Samples From Patients With Gastroduodenal Symptoms: A Retrospective Observational Study.","authors":"Dayaneth Jácome-Montero, Jhoan Guamán-Angulo, Angélica Tigre-León, Favian Bayas-Morejón, Sebastián Guerrero-Luzuriaga, Byron Herrera-Chávez","doi":"10.7704/kjhugr.2025.0067","DOIUrl":"10.7704/kjhugr.2025.0067","url":null,"abstract":"Objectives: Helicobacter pylori is recognized as one of the most virulent microorganisms within the genus Helicobacter owing to its genomic characteristics. It has been associated with diseases, such as peptic ulcers and gastric cancer. This study aimed to evaluate Helicobacter pylori positivity in fecal samples using 16S rRNA gene polymerase chain reaction (PCR) in fecal samples.Methods: Fecal samples from patients with gastroduodenal symptoms were analyzed. Stool antigen test (SAT) was performed to identify H. pylori-positive cases. Subsequently, a pre-enrichment step was performed to increase the bacterial DNA yield and improve the molecular detection efficiency. Finally, PCR amplification, targeting a specific region of the H. pylori 16S rRNA gene, was performed to confirm the presence of the pathogen.Results: A 70% PCR positivity rate was observed among SAT-positive samples amplified for the 16S rRNA gene.Conclusions: The positivity rate for H. pylori (70%) was confirmed by PCR, indicating that molecular testing of fecal samples is an effective non-invasive tool for detecting infection.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 1","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Helicobacter pylori Management in Older Adults: Current Perspectives From Japan. 老年人幽门螺杆菌的管理：来自日本的最新观点。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-03-05 DOI: 10.7704/kjhugr.2025.0091

Hideki Mori, Hidekazu Suzuki

{"title":"Helicobacter pylori Management in Older Adults: Current Perspectives From Japan.","authors":"Hideki Mori, Hidekazu Suzuki","doi":"10.7704/kjhugr.2025.0091","DOIUrl":"10.7704/kjhugr.2025.0091","url":null,"abstract":"Helicobacter pylori infection-although its overall prevalence has declined over time-remains a major cause of peptic ulcer disease and gastric cancer, particularly among older adults in aging societies such as Japan. While eradication therapy is known to reduce the gastric cancer risk, its use in older adults is often complicated by comorbidities, polypharmacy, altered drug metabolism, and limited life expectancy. This review summarizes current perspectives on the management of H. pylori infection in older patients, based on Japanese clinical practice and recent evidence. Older individuals frequently have long-standing infections accompanied by advanced gastric atrophy and intestinal metaplasia, which may adversely affect diagnostic accuracy and therapeutic outcomes. Diagnostic evaluation is further complicated by severe mucosal atrophy and the frequent use of acid-suppressive medications, requiring careful interpretation of test results and, in some cases, correlation with endoscopic findings. In Japan, vonoprazan-based eradication regimens have become the standard of care because of their high efficacy and pharmacological stability regardless of CYP2C19 genotype. Available data indicate that eradication therapy is generally safe and well tolerated in older patients, with adverse event rates comparable to those observed in younger populations. Eradication therapy is highly recommended for disease-specific indications (e.g., peptic ulcer) and for primary prevention of gastric cancer. Overall, older age alone should not be considered a contraindication to eradication therapy; rather, treatment decisions should be based on a comprehensive assessment of comorbidities, concomitant medications, the patient's functional status, and the patient's preferences.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 1","pages":"42-49"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes of Tegoprazan Versus Proton Pump Inhibitors in Patients Receiving Antiplatelet Therapy After Percutaneous Coronary Intervention: A Retrospective, Observational Study. 替戈拉赞与质子泵抑制剂在经皮冠状动脉介入治疗后接受抗血小板治疗的患者中的临床结果：一项回顾性观察研究。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.7704/kjhugr.2025.0065

Jin Lee, Jongha Park, Jino Park, Yong Eun Park, Joon Hyuk Choi, Nae-Yun Heo, Seung Ha Park, Tae Oh Kim

{"title":"Clinical Outcomes of Tegoprazan Versus Proton Pump Inhibitors in Patients Receiving Antiplatelet Therapy After Percutaneous Coronary Intervention: A Retrospective, Observational Study.","authors":"Jin Lee, Jongha Park, Jino Park, Yong Eun Park, Joon Hyuk Choi, Nae-Yun Heo, Seung Ha Park, Tae Oh Kim","doi":"10.7704/kjhugr.2025.0065","DOIUrl":"10.7704/kjhugr.2025.0065","url":null,"abstract":"Objectives: Tegoprazan is an alternative to proton pump inhibitors (PPIs). This study evaluated the occurrence of upper gastrointestinal (GI) and cardiovascular (CV) complications in patients with ischemic heart disease undergoing antiplatelet therapy after percutaneous coronary intervention (PCI) who were treated with tegoprazan or PPIs.Methods: Data from 604 patients who received antiplatelet therapy with tegoprazan or PPIs for >6 months after PCI between March 2019 and November 2023 were retrospectively analyzed. The primary GI endpoints were symptomatic gastroduodenal ulcers and upper GI bleeding, while the primary CV endpoints comprised major adverse cardiac events (MACEs), nonfatal myocardial infarction (MI), target vessel revascularization, and death from CV-related causes.Results: Among the 604 patients, 265 received tegoprazan and 339 received PPIs. During a mean follow-up of 17 months, seven patients experienced a GI event (0.4% with tegoprazan vs. 1.8% with PPIs; p=0.112) and 12 experienced MACEs (1.1% with tegoprazan vs. 2.7% with PPIs; p=0.183). Subgroup analysis indicated that target vessel revascularization occurred in six patients, with event rates of 0.8% (n=2) for tegoprazan and 1.2% (n=4) for PPIs (p=0.598). Tegoprazan was associated with similar rates of nonfatal MI (0.8% vs. 2.4%; p=0.125) and death from CV-related causes (0.4% vs. 0%; p=0.258) as PPIs.Conclusions: There were no significant differences in GI- or CV-related complications between patients treated with tegoprazan and those treated with PPIs.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":" ","pages":"73-78"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12997061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146005001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0