The Korean journal of helicobacter and upper gastrointestinal research最新文献_第5页

A Rare Complication of Endoscopic Epinephrine Injection Therapy for Duodenal Ulcer Bleeding. 内镜下注射肾上腺素治疗十二指肠溃疡出血的罕见并发症。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0071

Changwoo Oh, Tae Ho Kim

引用次数: 0

Peptic Ulcer Disease. 消化性溃疡。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0075

Seung Han Kim

引用次数: 0

Simplified Eradication of Helicobacter pylori for Patients With Penicillin-Allergy. 青霉素过敏患者幽门螺杆菌的简化根除。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0069

Dae Gon Ryu

引用次数: 0

Detection of Clarithromycin Resistance in Helicobacter pylori: Advancing Diagnostic Approaches. 幽门螺杆菌克拉霉素耐药性检测：先进的诊断方法。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2025.0014

Yong Hwan Kwon

引用次数: 0

Endoscopic Submucosal Dissection in the Treatment of Patients With Papillary Early Gastric Cancer. 内镜下粘膜剥离术治疗早期乳头状胃癌。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0065

Ju Seok Kim

引用次数: 0

Etiology and Therapeutic Strategies for Refractory Peptic Ulcers: A Comprehensive Review. 难治性消化性溃疡的病因和治疗策略：综述。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0072

Su Bee Park

引用次数: 0

Long-Term Outcomes in Patients With Non-Ampullary Duodenal Neuroendocrine Tumors. 非壶腹十二指肠神经内分泌肿瘤患者的长期预后。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2025.0008

Da-Bin Jeong, Sang-Gyun Kim, Soo-Jeong Cho

{"title":"Long-Term Outcomes in Patients With Non-Ampullary Duodenal Neuroendocrine Tumors.","authors":"Da-Bin Jeong, Sang-Gyun Kim, Soo-Jeong Cho","doi":"10.7704/kjhugr.2025.0008","DOIUrl":"10.7704/kjhugr.2025.0008","url":null,"abstract":"Objectives: Although non-ampullary duodenal neuroendocrine tumors (NADNETs) are rare neoplasms, their incidence has been increasing. In this study, we aimed to analyze the long-term outcomes of patients with NADNETs who underwent endoscopic resection (ER) or surgery.Methods: This retrospective study included 55 adults (aged 26-78 years) diagnosed with NADNETs between 2009 and 2022 at Seoul National University Hospital. We categorized the patients into 3 groups: 21 underwent ER, 28 underwent surgical resection, and 6 had no detectable residual tumors after the initial biopsy during the follow-up period. Continuous data were examined using the Mann-Whitney U or Kruskal-Wallis tests, and categorical variables were analyzed using the χ2 or Fisher's exact tests.Results: A total of 21 patients, with a mean tumor size of 9.2±5.3 mm, underwent successful ER. After ER, three patients experienced perforation (14% [3/21]); two underwent primary repair surgery, and one recovered with conservative treatment. The mean tumor size of 28 patients who underwent surgical resection was 13.9±6.7 mm. There were no cases of postoperative bleeding or perforation; however, four patients experienced ileus and required prolonged hospital stays. The median follow-up periods for patients who underwent ER, surgical resection, and removal after the initial biopsy were 42, 48, and 42.5 months, respectively. During the follow-up period, no recurrence was observed in any group.Conclusions: Recurrence-free survival in patients undergoing ER for NADNETs, with an endoscopically measured size of approximately 10 mm, was comparable to that of patients undergoing surgical resection. However, ER carried a relatively high risk of perforation due to the challenging anatomical access and thin duodenal wall.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 1","pages":"54-63"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonsteroidal Anti-Inflammatory Drug-Induced Peptic Ulcer Disease. 非甾体抗炎药引起的消化性溃疡疾病。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2025.0004

Kyoung A Ko, Dong-Kyu Lee

{"title":"Nonsteroidal Anti-Inflammatory Drug-Induced Peptic Ulcer Disease.","authors":"Kyoung A Ko, Dong-Kyu Lee","doi":"10.7704/kjhugr.2025.0004","DOIUrl":"10.7704/kjhugr.2025.0004","url":null,"abstract":"Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for their anti-inflammatory and analgesic effects; however, their prolonged use significantly contributes to peptic ulcer disease (PUD) and its complications, such as bleeding and perforation. The pathogenesis primarily involves cyclooxygenase (COX) enzyme inhibition and direct mucosal injury, leading to impaired gastrointestinal defense mechanisms. Multiple risk factors, including advanced age, a history of ulcers, and the concurrent use of anticoagulants or corticosteroids, significantly increase the risk of ulcers and related complications. Global epidemiological studies demonstrate considerable geographical variation in prevalence rates. Despite higher NSAID usage, high-income countries exhibit relatively lower rates, primarily due to well-established preventive strategies. Prevention should be based on careful risk stratification that accounts for both gastrointestinal and cardiovascular factors. Proton pump inhibitors have demonstrated superior efficacy in both prevention and treatment, while selective COX-2 inhibitors offer an alternative strategy, though they require careful cardiovascular risk assessment. The synergistic interaction between NSAID use and Helicobacter pylori infection necessitates testing and eradication, particularly in high-risk patients. NSAID discontinuation remains the primary therapeutic strategy when feasible, with studies showing significantly improved healing rates compared with continued use. Recent advances include the emergence of potassium-competitive acid blockers, which provide rapid and sustained acid suppression, offering promising alternatives for both prevention and treatment. Continued research aimed at optimizing preventive strategies and developing novel therapeutic approaches remains essential for improving clinical outcomes in NSAID-induced PUD.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 1","pages":"34-41"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patients Presenting With Reflux Symptoms - Whom to Test and Whom to Treat? 出现反流症状的患者-谁该检查，谁该治疗？

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2025.0005

Noy Lapidot Alon, Tomas Navarro Rodriguez, Ronnie Fass

{"title":"Patients Presenting With Reflux Symptoms - Whom to Test and Whom to Treat?","authors":"Noy Lapidot Alon, Tomas Navarro Rodriguez, Ronnie Fass","doi":"10.7704/kjhugr.2025.0005","DOIUrl":"10.7704/kjhugr.2025.0005","url":null,"abstract":"Gastroesophageal reflux disease (GERD) is a complex condition with diverse clinical presentations, ranging from typical heartburn and regurgitation symptoms to extraesophageal manifestations and alarm symptoms. Determining which patients should be tested first versus those who should receive empirical treatment remains a key clinical challenge. If not recently performed, initial patient testing, commonly involving upper endoscopy, is recommended for patients presenting with alarm or refractory symptoms and for those at high risk for Barrett's esophagus. Additionally, testing should be prioritized for patients with underlying comorbidities, such as scleroderma, increased body mass index, or a suspected large hiatal hernia. Older patients with atypical symptom presentations and those with extraesophageal symptoms or signs, especially in the absence of typical GERD symptoms, should also be referred for endoscopy if recent endoscopic results are not available. In contrast, patients with typical GERD symptoms in the absence of alarm features and those with extraesophageal symptoms accompanied by typical GERD symptoms could begin empirical treatment with a proton pump inhibitor (PPI) or potassium competitive acid blocker (PCAB). For individuals without alarm symptoms who do not respond to once-daily PPI therapy, escalation to twice-daily PPI therapy or switching to a PCAB, without further testing, is appropriate. Overall, an individualized approach is recommended, with patient presentation guiding the decision to test or treat first.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 1","pages":"7-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapidly Growing Gastrointestinal Stromal Tumor on the Esophagus. 食管快速生长的胃肠道间质瘤。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-03-01 Epub Date: 2025-03-07 DOI: 10.7704/kjhugr.2024.0074

Ji Hye Park, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Myung Hun Lee

{"title":"Rapidly Growing Gastrointestinal Stromal Tumor on the Esophagus.","authors":"Ji Hye Park, Sung Eun Kim, Seun Ja Park, Moo In Park, Won Moon, Jae Hyun Kim, Kyoungwon Jung, Myung Hun Lee","doi":"10.7704/kjhugr.2024.0074","DOIUrl":"10.7704/kjhugr.2024.0074","url":null,"abstract":"Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms that mainly occur in the stomach and small intestine; those arising in the esophagus are rarer. A 54-year-old woman was referred to our hospital with a one-month history of dysphagia. Esophagogastroduodenoscopy (EGD), performed approximately five months earlier, had not revealed any specific findings. However, an EGD performed in our hospital showed the presence of a round, protruding lesion (approximately 40×30 mm in size), with a normal overlying mucosal surface, 35-39 cm from the upper incisor. Chest computed tomography (CT) revealed a large esophageal mass. Enucleation was performed on the esophageal mass, and a GIST was diagnosed using immunochemical staining. Imatinib mesylate administration was initiated two months postoperatively. The patient was stable, without any evident recurrence in the 8-month postoperative follow-up EGD and chest CT examinations. Therefore, physicians should consider that patients with worsening dysphagia may have an underlying organic condition, such as an acute increase in size of an esophageal GIST, even if recent examinations were unremarkable.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 1","pages":"64-69"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0