The Korean journal of helicobacter and upper gastrointestinal research最新文献

Pepsinogen Assay Findings in Individuals With Gastric Atrophy and Intestinal Metaplasia. 胃萎缩和肠化生患者胃蛋白酶原测定结果。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0034

Sun-Young Lee

{"title":"Pepsinogen Assay Findings in Individuals With Gastric Atrophy and Intestinal Metaplasia.","authors":"Sun-Young Lee","doi":"10.7704/kjhugr.2026.0034","DOIUrl":"10.7704/kjhugr.2026.0034","url":null,"abstract":"Serum pepsinogen (PG) testing is widely used as a non-invasive biomarker for gastric atrophy; however, its clinical interpretation varies depending on the severity and distribution of gastritis as well as on the assay methods. Autoimmune gastritis is characterized by markedly decreased PG I levels and PG I/II ratios, along with increased gastrin levels, reflecting profound corpus atrophy. In contrast, Helicobacter pylori-associated atrophy typically shows moderate reductions in PG I levels and PG I/II ratios, with variability according to the extent of antral and corpus involvement. Accumulating evidence indicates that PG testing is more effective at identifying severe atrophy and higher Operative Link on Gastritis Assessment stages than detecting mild atrophy. Notably, cutoff values differ substantially between assay systems, with higher PG I and PG I/II cutoff values observed in GastroPanel tests than in East Asian kits interpreted with the ABC method. Overall, PG testing is useful for detecting advanced corpus atrophy and stratifying gastric cancer risk when combined with gastrin measurement, but has limited sensitivity for early-stage disease. Monitoring low PG I/II ratios and high gastrin levels may improve risk assessment, particularly in patients with corpus atrophy or persistent intestinal metaplasia after H. pylori eradication.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"275-285"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Gastric Juvenile-Type Polyposis With SMAD4 Mutation. 胃少年型息肉病伴SMAD4突变1例。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0026

Meung Chul Park, So Hyun Jeon, Chang Hun Park, Hee Kyung Kim, Su Jin Hong

{"title":"A Case of Gastric Juvenile-Type Polyposis With SMAD4 Mutation.","authors":"Meung Chul Park, So Hyun Jeon, Chang Hun Park, Hee Kyung Kim, Su Jin Hong","doi":"10.7704/kjhugr.2026.0026","DOIUrl":"10.7704/kjhugr.2026.0026","url":null,"abstract":"Juvenile polyposis syndrome (JPS) is a rare autosomal-dominant disorder characterized by the presence of multiple hamartomatous polyps in the gastrointestinal tract. JPS has been established to be attributable to SMAD4 mutations, which are frequently associated with severe gastric phenotypes and hereditary hemorrhagic telangiectasia. We report the case of a 39-year-old woman with a history of immature teratoma, who presented with persistent anemia and upper gastrointestinal bleeding. Endoscopy revealed multiple gastric polyps, including a 5-cm polyp at the cardia. She underwent repeated endoscopic mucosal resections, with the initial histopathologic findings being consistent with hyperplastic polyps. Next-generation sequencing identified a pathogenic SMAD4 mutation, confirming the diagnosis of gastric juvenile-type polyposis. This case highlights the importance of considering hereditary polyposis syndromes in patients with multiple gastric polyps and anemia, even in the absence of a family history. Early genetic testing facilitates accurate diagnosis and enables appropriate endoscopic surveillance and management, as well as screening for extra-gastrointestinal manifestations.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"330-335"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence for Endoscopic Diagnosis of Gastric Premalignant Lesions. 人工智能在胃癌前病变内镜诊断中的应用。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0035

Seung-Joo Nam

{"title":"Artificial Intelligence for Endoscopic Diagnosis of Gastric Premalignant Lesions.","authors":"Seung-Joo Nam","doi":"10.7704/kjhugr.2026.0035","DOIUrl":"10.7704/kjhugr.2026.0035","url":null,"abstract":"Gastric cancer is a leading cause of cancer-related mortality worldwide. The Correa cascade posits that intestinal-type gastric adenocarcinoma develops through a stepwise progression from chronic gastritis to atrophic gastritis, intestinal metaplasia, and dysplasia, highlighting the importance of early detection of premalignant lesions. The use of artificial intelligence (AI), particularly convolutional neural network-based deep-learning models, in upper gastrointestinal endoscopy has been expanding rapidly. This review examines the current role of such models in the endoscopic diagnosis of chronic atrophic gastritis, intestinal metaplasia, and gastric dysplasia. Data from meta-analyses indicate pooled sensitivities and specificities exceeding 90%, with performance comparable to that of expert endoscopists. The results of randomized trials suggest that AI-assisted endoscopy may improve the detection of intraepithelial neoplasia, particularly for small and subtle lesions. However, these trials are few and were conducted exclusively in China. Moreover, they largely evaluated systems of a single lineage. The one trial that prespecified centralized pathologic review found no improvement in neoplasm detection. Thus, multicenter prospective validation and real-world data are necessary before AI can be reliably used to inform routine clinical decision-making. Moreover, further integration of AI models into practice will depend on the availability of appropriate human-AI interfaces and unified multitask platforms and the resolution of hitherto unresolved legal and ethical concerns.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"286-293"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-Term Efficacy of Tegoprazan Compared With Esomeprazole in Patients With Non-Erosive Reflux Disease and Nocturnal Heartburn Symptoms: A Double-Blind, Randomized Controlled Trial. 替戈拉赞与埃索美拉唑对非糜烂性反流病和夜间胃灼热症状患者的短期疗效比较：一项双盲、随机对照试验

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0042

Jin Lee, Seong Je Kim, Yong Eun Park, Joon Hyuk Choi, Nae-Yun Heo, Seung Ha Park, Tae Oh Kim

{"title":"Short-Term Efficacy of Tegoprazan Compared With Esomeprazole in Patients With Non-Erosive Reflux Disease and Nocturnal Heartburn Symptoms: A Double-Blind, Randomized Controlled Trial.","authors":"Jin Lee, Seong Je Kim, Yong Eun Park, Joon Hyuk Choi, Nae-Yun Heo, Seung Ha Park, Tae Oh Kim","doi":"10.7704/kjhugr.2026.0042","DOIUrl":"10.7704/kjhugr.2026.0042","url":null,"abstract":"Objectives: Tegoprazan is a novel potassium-competitive acid blocker that rapidly suppresses acid secretion. This study aimed to evaluate the efficacy of tegoprazan 50 mg compared with esomeprazole 20 mg in patients with non-erosive reflux disease and nocturnal heartburn symptoms.Methods: This double-blind, randomized, active-control study was conducted to compare the efficacy of tegoprazan 50 mg and esomeprazole 20 mg in patients with non-erosive reflux disease and nocturnal heartburn symptoms. The primary endpoint was the percentage of nocturnal heartburn-free days over 2 weeks. The secondary endpoint was the percentage of patients who experienced relief from nocturnal heartburn within 24 h of the first dose. Additionally, the time to the first nocturnal heartburn-free interval was compared between the two groups.Results: Of 160 patients, 149 were included in the final analysis. The percentage of nocturnal heartburn-free days over 2 weeks was not inferior to that with esomeprazole (58.2% vs. 54.5%, p=0.001). The percentage of patients without nocturnal heartburn for 24 h was higher in the tegoprazan group, although the difference was not statistically significant. The time to the first nocturnal heartburn-free interval was shorter with tegoprazan than with esomeprazole (2.0 days vs. 2.5 days, p=0.529); however, the difference was not significant.Conclusions: Tegoprazan demonstrated non-inferiority to esomeprazole with respect to nocturnal heartburn-free days and may provide more rapid relief from nocturnal heartburn symptoms.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"307-313"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral Air Embolism Occurring During Percutaneous Endoscopic Gastrostomy. 经皮内镜胃造口术中发生脑空气栓塞。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0028

Sun Hyung Kang

{"title":"Cerebral Air Embolism Occurring During Percutaneous Endoscopic Gastrostomy.","authors":"Sun Hyung Kang","doi":"10.7704/kjhugr.2026.0028","DOIUrl":"10.7704/kjhugr.2026.0028","url":null,"abstract":"Air embolism is a rare but potentially fatal complication of gastrointestinal endoscopic procedures, primarily affecting the pulmonary circulation. Systemic air embolism, especially with cerebral involvement, is exceedingly uncommon. We report a case of cerebral air embolism that occurred during percutaneous endoscopic gastrostomy (PEG) using the pull method in a 65-year-old man with dysphagia due to progressive supranuclear palsy with frontotemporal dementia. Immediately after guidewire externalization, the patient experienced sudden respiratory arrest and hemodynamic collapse, necessitating cardiopulmonary resuscitation. Although aspiration was initially suspected, chest radiography showed no abnormalities. As spontaneous respiration did not recover, brain CT was performed, revealing multiple intracranial air densities consistent with cerebral air embolism. Transthoracic echocardiography showed no evidence of a right-to-left shunt. The patient received hyperbaric oxygen therapy; however, impaired consciousness persisted, likely due to hypoxic brain injury. This case suggests that excessive air insufflation and vascular injury during PEG may cause systemic air embolism even in the absence of an identifiable intracardiac shunt. Clinicians should consider this rare but life-threatening complication when unexplained cardiopulmonary collapse occurs during PEG.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"336-339"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 65-Year-Old Man With Abdominal Pain, Duodenal Ulceration, and Skin Lesions. 65岁男性，腹痛，十二指肠溃疡，皮肤损伤。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0032

Seung In Seo

引用次数: 0

Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System. 胃粘膜癌风险：胃炎分期评估系统的手术环节。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0027

Massimo Rugge, Marta Sbaraglia, Giulia Fiorini, Gavino Faa, Robert M Genta

{"title":"Gastric Mucosa Cancer Risk: The Operative Link on Gastritis Assessment Staging System.","authors":"Massimo Rugge, Marta Sbaraglia, Giulia Fiorini, Gavino Faa, Robert M Genta","doi":"10.7704/kjhugr.2026.0027","DOIUrl":"10.7704/kjhugr.2026.0027","url":null,"abstract":"Gastric mucosa atrophy is the cancerization field for gastric cancer development. Atrophic changes in the gastric mucosa can be assessed endoscopically and histologically. Gastric serology (e.g., pepsinogens and their ratio, and gastrin) may provide information on the functional status of the mucosa. However, outside large-scale epidemiological studies, the clinical reliability of serology at the individual patient level remains controversial. Histology-based estimates of atrophy-associated neoplastic risk require mucosal specimens from both the antral/mucus-secreting and corpus/fundus oxyntic compartments. Inspired by the clinical-biological framework of cancer staging, the Operative Link on Gastritis Assessment (OLGA) staging system classifies the severity and topography of mucosal atrophy into five stages, ranging from 0 to IV. International trials have validated the stepwise increasing risk of cancer with disease progression. Based on this evidence, OLGA stages are classified into low-risk (0-I) and high-risk (III-IV), with stage II remaining clinically controversial. The prevalence of high-risk stages varies according to patient- and population-specific risk factors. Among these, the most significant is the prevalence of Helicobacter pylori, a recognized oncogenic agent. Bacterial infection at the time of the initial endoscopy requires eradication therapy regardless of the stage of gastritis. Histological stage reliably identifies the endoscopic population at a high risk of cancer progression and shapes the schedule of endoscopy/histology-based surveillance. Serology at the index endoscopy may circumvent the inherent inconsistencies of population-based studies. This patient-specific serology could serve as an interval for non-invasive monitoring within the endoscopy/histology follow-up framework.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"265-274"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolution of Autoimmune Gastritis Research (1995-2025): A Hybrid Bibliometric-Conceptual Synthesis. 自身免疫性胃炎研究的演变（1995-2025）：混合文献计量学-概念综合。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0024

Yong Hwan Ahn

{"title":"The Evolution of Autoimmune Gastritis Research (1995-2025): A Hybrid Bibliometric-Conceptual Synthesis.","authors":"Yong Hwan Ahn","doi":"10.7704/kjhugr.2026.0024","DOIUrl":"10.7704/kjhugr.2026.0024","url":null,"abstract":"Objectives: Autoimmune gastritis (AIG) has evolved from a condition primarily recognized in the context of pernicious anemia (PA) to a clinically recognized immune-mediated gastric disease with important neoplastic implications. We investigated the structural and conceptual evolution of AIG research from 1995 to 2025 using a hybrid bibliometric-conceptual approach.Methods: Publications were retrieved from the Web of Science Core Collection. After excluding retracted records and duplicates, 1298 articles and reviews were included. Bibliometric indicators were calculated, and collaboration networks, keyword co-occurrence, temporal evolution, and reference co-citation were analyzed using Gephi, VOSviewer, and CiteSpace.Results: Annual publication output increased from 24 articles in 1995 to 86 articles in 2025, with accelerated growth after 2015. A total of 5608 authors from 45 countries contributed to the literature, with major collaborative networks centered on Europe and North America. Early research focused primarily on PA, gastric autoimmunity, and chronic gastritis. Recent studies have emphasized endoscopic recognition, biomarker-based diagnosis, gastric neuroendocrine tumors, and neoplastic risk assessment. Co-citation analysis further demonstrated a shift from immunologic and pathophysiologic investigations to clinically oriented disease recognition and surveillance-related research.Conclusions: AIG research has undergone a substantial conceptual transition over the past three decades. Contemporary research recognizes AIG as a distinct gastric disease entity that requires earlier diagnosis, risk stratification, and surveillance-oriented management.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"314-323"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Often Do Adults Acquire Helicobacter pylori? Beyond Serologic Estimates. 成人感染幽门螺杆菌的频率有多高？超出血清学估计。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2026.0045

So Young Byun, Jeong Hoon Lee

引用次数: 0

Artificial Intelligence for Esophageal Precancerous Lesions and Esophageal Cancer. 人工智能治疗食管癌前病变和食管癌。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2026-09-01 Epub Date: 2026-09-08 DOI: 10.7704/kjhugr.2025.0079

Hannah Lee, Yeong Heon Han, Jun-Won Chung, Kyoung Oh Kim, Kwang An Kwon, Jung Ho Kim

{"title":"Artificial Intelligence for Esophageal Precancerous Lesions and Esophageal Cancer.","authors":"Hannah Lee, Yeong Heon Han, Jun-Won Chung, Kyoung Oh Kim, Kwang An Kwon, Jung Ho Kim","doi":"10.7704/kjhugr.2025.0079","DOIUrl":"10.7704/kjhugr.2025.0079","url":null,"abstract":"Esophageal cancer is associated with a relatively poor prognosis. Early detection and diagnosis are important for the survival and prognosis of patients with esophageal cancer. Recently, the development of artificial intelligence (AI) and its application in clinical medicine has led to remarkable progress in various endoscopic fields, including the detection of Barrett's esophagus and esophageal cancer. Compared to human errors induced by fatigue and impairment in diagnostic precision, progression in the field of AI, including deep learning and convolutional neural networks, has resulted in improved diagnostic accuracy. Subtle microvascular changes in lesions, visual disturbances, and fatigue, as well as varying endoscopic expertise depending on the operator, are the major causes of missing rates in detecting cancerous lesions. Specifically, the rate of missed diagnoses of esophageal squamous cell carcinoma reaches 4%-17%. In contrast, deep learning-based AI assists in the diagnosis of esophageal squamous cell carcinoma, evaluation of invasion depth, microvascular classification, and delineation of the margin of the lesion. In this review article, we investigated the development of the current AI model introduced for esophageal precancerous lesions, including Barrett's and esophageal cancer.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"26 3","pages":"294-299"},"PeriodicalIF":0.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13586458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0