{"title":"A Subepithelial Lesion of the Stomach Observed During Screening Endoscopy.","authors":"Yonghoon Choi","doi":"10.7704/kjhugr.2025.0041","DOIUrl":"10.7704/kjhugr.2025.0041","url":null,"abstract":"","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"302-304"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Effectiveness and Application Strategies of Bismuth Quadruple Therapy: Analysis of the European Helicobacter Pylori Registry (Hp-EuReg).","authors":"Hyun Ho Choi","doi":"10.7704/kjhugr.2025.0040","DOIUrl":"10.7704/kjhugr.2025.0040","url":null,"abstract":"","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"305-306"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyeong Ah Jang, Keun Young Maeng, Dong Seok Lee, Han Hee Lee, Dae Young Cheung, Tae Ho Kim
{"title":"Practical Efficacy of a 1-Week Metronidazole-Based Triple Regimen Plus Bismuth Versus a 2-Week Bismuth-Based Quadruple Regimen for Helicobacter pylori Infection With Clarithromycin-Resistance-Associated Genetic Mutations.","authors":"Kyeong Ah Jang, Keun Young Maeng, Dong Seok Lee, Han Hee Lee, Dae Young Cheung, Tae Ho Kim","doi":"10.7704/kjhugr.2025.0022","DOIUrl":"10.7704/kjhugr.2025.0022","url":null,"abstract":"<p><strong>Objective: </strong>For patients with clarithromycin-resistant Helicobacter pylori infection, a 2-week bismuth quadruple therapy (2W-PBMT) is typically recommended. However, a recent Korean guideline suggests a 1-week metronidazole-based regimen (PMA) as an alternative. This study aimed to evaluate whether a 1-week PMA plus bismuth (1W-PBMA) could achieve comparable efficacy to the conventional 2W-PBMT.</p><p><strong>Methods: </strong>This study retrospectively analyzed medical records from two academic hospitals and employed propensity score matching (PSM) to minimize confounding variables.</p><p><strong>Results: </strong>A total of 121 patients with confirmed H. pylori infection and clarithromycin resistance-related genetic mutations were identified via polymerase chain reaction. After excluding six patients with the A2142G mutation, 115 patients with the A2143G mutation were enrolled. Among them, 82 patients who received an eradication regimen were included in the final analysis. Fifty-one patients received the conventional 2W-PBMT, while 31 received the 1W-PBMA regimen. PSM resulted in 25 matched cases in each group. Before PSM, eradication rates were 70.6% (2W-PBMT) vs. 77.4% (1W-PBMA) in the intention-to-treat (ITT) analysis and 94.7% vs. 85.7% in the per-protocol (PP) analysis, with no significant differences. After PSM, ITT eradication rates were 68.0% (2W-PBMT) vs. 80.0% (1W-PBMA), while PP eradication rates were 94.4% vs. 87.0%, again showing no statistical significance. Medication adherence exceeded 85% in both groups, with comparable incidences of adverse events. However, the 2W-PBMT group had a slightly higher discontinuation rate due to intolerable side effects.</p><p><strong>Conclusions: </strong>In patients with H. pylori infection harboring the A2143G point mutation, the 1W-PBMA regimen demonstrated comparable eradication efficacy to the 2W-PBMT regimen, with potentially fewer intolerable adverse effects and improved adherence.</p>","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"261-267"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425669/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Esophageal Rupture Occurred During the Endoscopic Removal of a Lodged Denture.","authors":"Jin Ook Jang, Su Jin Kim, Min Chae Jeon","doi":"10.7704/kjhugr.2025.0035","DOIUrl":"10.7704/kjhugr.2025.0035","url":null,"abstract":"","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"299-301"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atypical Gastric Lesion Revealing Underlying Pancreatic Cancer With Direct Invasion.","authors":"Byeong Joo Jo","doi":"10.7704/kjhugr.2025.0032","DOIUrl":"10.7704/kjhugr.2025.0032","url":null,"abstract":"<p><p>Atypical gastric lesions present diagnostic challenges, particularly when they mimic benign conditions. We report the case of a 76-year-old male who underwent esophagogastroduodenoscopy (EGD) during routine screening. The EGD revealed a 1-cm ulcerative lesion in the lesser curvature of the stomach. The initial endoscopic report simply described the lesion as a \"gastric ulcer,\" and the initial biopsy indicated a tubulovillous adenoma with low-grade dysplasia. However, follow-up endoscopy demonstrated an irregular, non-healing ulcer without a clean base, raising a strong possibility of deeper infiltration. A follow-up biopsy showed atypical findings, suggestive of malignancy, and prompting further evaluation. Abdominal computed tomography (CT) revealed a mass in the pancreatic body and tail that directly invaded the gastric wall, along with extensive peritoneal metastasis. Positron emission tomography-CT confirmed hypermetabolic activity in the pancreatic lesion. The final diagnosis was a pancreatic adenocarcinoma with gastric invasion. This case highlights the importance of correlating endoscopic findings with imaging and pathology findings, especially when endoscopic morphology appears atypical and inconsistent with biopsy results. Repeat evaluations and cross-sectional imaging may prevent unnecessary procedures and allow timely identification of extrinsic malignancies that present as primary gastric lesions.</p>","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"288-291"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Step Toward Shorter, Personalized Therapy for Clarithromycin-Resistant Helicobacter pylori.","authors":"Seung Young Kim","doi":"10.7704/kjhugr.2025.0042","DOIUrl":"10.7704/kjhugr.2025.0042","url":null,"abstract":"","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"201-202"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Beom Jin Kim, Seung Joo Kang, Su Youn Nam, Chang Seok Bang, Byung-Hoon Min, Sung Eun Kim, Seung Young Kim, Hyunchul Lim, Chung Hyun Tae, Moon Won Lee, Seung Han Kim, Sang Hoon Kim, Jong Yeul Lee, Byung-Wook Kim, Jeong Seop Moon, Jong-Jae Park, Hwoon-Yong Jung
{"title":"Practice Guidelines for the Diagnosis and Treatment of Subepithelial Lesions Observed in Upper Gastrointestinal Endoscopy.","authors":"Beom Jin Kim, Seung Joo Kang, Su Youn Nam, Chang Seok Bang, Byung-Hoon Min, Sung Eun Kim, Seung Young Kim, Hyunchul Lim, Chung Hyun Tae, Moon Won Lee, Seung Han Kim, Sang Hoon Kim, Jong Yeul Lee, Byung-Wook Kim, Jeong Seop Moon, Jong-Jae Park, Hwoon-Yong Jung","doi":"10.7704/kjhugr.2025.0020","DOIUrl":"10.7704/kjhugr.2025.0020","url":null,"abstract":"<p><p>Subepithelial lesions (SELs) of the upper gastrointestinal tract are commonly detected during endoscopic examinations and encompass a broad spectrum of benign and potentially malignant tumors. Although most SELs are asymptomatic and found incidentally, accurate diagnosis remains challenging owing to their subepithelial location, necessitating advanced imaging and tissue acquisition techniques. Endoscopic ultrasonography plays a crucial role in differentiating SELs, although its diagnostic accuracy remains limited. The Korean College of Helicobacter and Upper Gastrointestinal Research has developed evidence-based practice guidelines for the diagnosis and endoscopic treatment of SELs to address the need for standardized clinical management. These guidelines were established through a systematic review of existing literature and expert consensus, resulting in 11 key recommendations for addressing diagnostic strategies, surveillance intervals, biopsy techniques, and indications for endoscopic or surgical resection.</p>","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"234-250"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Spontaneous Helicobacter pylori Clearance After Subtotal Gastrectomy: A Shift in Postoperative Strategy.","authors":"Yang Won Min","doi":"10.7704/kjhugr.2025.0047","DOIUrl":"10.7704/kjhugr.2025.0047","url":null,"abstract":"","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"203-204"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaehong Jeong, June Hwa Bae, Hyeong Ho Jo, Joong Goo Kwon, Eun Young Kim
{"title":"A Case of Black Esophagus in a Patient Presenting With Dyspnea.","authors":"Jaehong Jeong, June Hwa Bae, Hyeong Ho Jo, Joong Goo Kwon, Eun Young Kim","doi":"10.7704/kjhugr.2025.0036","DOIUrl":"10.7704/kjhugr.2025.0036","url":null,"abstract":"<p><p>Acute esophageal necrosis (AEN), also known as \"black esophagus,\" is a rare clinical condition marked by severe damage and death of the tissue lining the esophagus. During endoscopy, AEN typically presents with a blackened appearance. Risk factors for AEN include esophageal ischemia in the setting of multi-organ dysfunction, sepsis, hypoperfusion, vasculopathy, traumatic transection of the thoracic aorta, thromboembolic phenomena, gastric volvulus, diabetic ketoacidosis, alcohol intoxication, or malignancy. Here, we report a case of AEN diagnosed in a patient presenting with dyspnea and diabetic ketoacidosis who had not been diagnosed with diabetes mellitus previously.</p>","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"284-287"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dyne Ahn, Yu Kyung Cho, In Hyoung Choi, Sol Kim, Ilsoo Kim, Donghoon Kang, Jae Myung Park
{"title":"A Case of Neurofibromatosis Type 1 With Early Gastric Cancer and Multiple Small Bowel Gastrointestinal Stromal Tumors.","authors":"Dyne Ahn, Yu Kyung Cho, In Hyoung Choi, Sol Kim, Ilsoo Kim, Donghoon Kang, Jae Myung Park","doi":"10.7704/kjhugr.2025.0034","DOIUrl":"10.7704/kjhugr.2025.0034","url":null,"abstract":"<p><p>Neurofibromatosis type 1 (NF1) is a multisystem genetic disorder that primarily affects the skin and nervous system, leading to characteristic skin changes and the development of benign or malignant tumors with a broad spectrum of severity and complications. Gastrointestinal stromal tumors (GISTs) are the most common non-neurological tumors occurring in patients with NF1. The clinical, genetic, and pathological features of these tumors differ significantly from those of sporadic GISTs. Very rarely, other gastrointestinal malignancies, such as small bowel adenocarcinomas, neuroendocrine tumors, and gastric adenocarcinomas, have occurred in patients with NF1. Here, we report a case of multiple duodenal GISTs and early gastric cancer in a patient with NF1.</p>","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"292-295"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}