The Korean journal of helicobacter and upper gastrointestinal research最新文献_第2页

A Migration-Informed, Risk-Based Approach to H. pylori Screening and Gastric Cancer Prevention in the U.S. 美国幽门螺杆菌筛查和胃癌预防的迁移知情、基于风险的方法

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0028

Chul S Hyun

引用次数: 0

Artificial Intelligence in Upper Gastrointestinal Diagnosis. 人工智能在上消化道诊断中的应用。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0024

Sabrina Xin Zi Quek, Khek Yu Ho

{"title":"Artificial Intelligence in Upper Gastrointestinal Diagnosis.","authors":"Sabrina Xin Zi Quek, Khek Yu Ho","doi":"10.7704/kjhugr.2025.0024","DOIUrl":"10.7704/kjhugr.2025.0024","url":null,"abstract":"Artificial intelligence (AI) has revolutionized upper gastrointestinal (GI) endoscopy by enhancing the detection, characterization, and management of GI diseases. In this review, we explore the transformative role of AI technologies, including machine learning and deep learning, in improving diagnostic accuracy and streamlining clinical workflows. AI systems such as convolutional neural networks have shown remarkable potential for identifying subtle lesions, assessing tumor margins, and reducing interobserver variability. By providing real-time decision-making support, AI minimizes unnecessary biopsies and improves patient outcomes. We also explore the applications of AI in detecting precancerous conditions such as Barrett's esophagus, atrophic gastritis, and gastric intestinal metaplasia, as well as its role in guiding therapy for early gastric cancer. Non-image-based AI tools such as Raman spectroscopy complement traditional imaging by offering molecular-level insights for real-time tissue characterization. Despite its promise, the adoption of AI in endoscopy faces challenges, including the need for robust validation, user-centric design, and targeted training for endoscopists. Concerns regarding overreliance and deskilling underscore the importance of balancing AI integration with the preservation of clinical expertise. Lastly, we examine the future of AI in upper GI diagnosis and how image-based and non-image-based AI technologies can be integrated to enable comprehensive diagnosis and personalized therapeutic planning. By addressing current limitations and fostering collaboration between clinicians and technologists, AI has the potential to redefine the standards of care for upper GI diagnosis and treatment.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"251-260"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Potential of Melatonin in Functional Dyspepsia. 褪黑素在功能性消化不良中的治疗潜力。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0037

Yeon Ji Kim

引用次数: 0

Approach to Gastric Subepithelial Lesions: From Differential Diagnosis to Histologic Confirmation. 胃上皮下病变：从鉴别诊断到组织学证实。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0038

Sang Hoon Kim

{"title":"Approach to Gastric Subepithelial Lesions: From Differential Diagnosis to Histologic Confirmation.","authors":"Sang Hoon Kim","doi":"10.7704/kjhugr.2025.0038","DOIUrl":"10.7704/kjhugr.2025.0038","url":null,"abstract":"The detection of gastric subepithelial lesions (SELs) has increased with the widespread use of endoscopic screening. While most SELs are benign, some, such as gastrointestinal stromal tumors, have malignant potential, underscoring the importance of accurate diagnosis. Histological confirmation is often challenging due to the submucosal location of these lesions, which limits the effectiveness of conventional biopsy techniques. Endoscopic ultrasonography (EUS) plays a central role in lesion characterization, providing information on the layer of origin, echogenicity, and internal features. When tissue sampling is required, techniques such as mucosal incision-assisted biopsy (MIAB) and EUS-guided fine-needle biopsy (FNB) offer complementary advantages. MIAB has demonstrated a diagnostic yield of approximately 89%, particularly for lesions <20 mm, whereas FNB provides sufficient tissue for immunohistochemical analysis. As international guidelines differ regarding indications and methods of tissue acquisition for SELs, tailored management based on EUS findings, patient-specific factors, and institutional capacity is essential for optimal diagnostic outcomes. This review aims to summarize the current understanding of gastric SELs based on evidence-based guidelines and recent studies and offer practical guidance for clinicians diagnosing these lesions in routine practice.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"209-215"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score. 人口统计学和压力测量变量可以独立预测胃食管反流病：AGES-D评分。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0030

Diego Reyes-Placencia, Ana Muñoz, Roberto Candia, Paula Rey, Javier Chahuan, Ignacio Gran, José María Remes-Troche, Daniel Cisternas, Hugo Monrroy

{"title":"Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score.","authors":"Diego Reyes-Placencia, Ana Muñoz, Roberto Candia, Paula Rey, Javier Chahuan, Ignacio Gran, José María Remes-Troche, Daniel Cisternas, Hugo Monrroy","doi":"10.7704/kjhugr.2025.0030","DOIUrl":"10.7704/kjhugr.2025.0030","url":null,"abstract":"Objective: Conclusive diagnosis of gastroesophageal reflux disease (GERD) can be challenging. When reflux monitoring is inconclusive, high-resolution esophageal manometry (HRM) may provide additional relevant information. We aimed to identify demographic and manometric parameters associated with GERD and to propose a diagnostic score.Methods: Adult patients with GERD symptoms who underwent reflux monitoring and HRM were considered for inclusion. The gold standard for GERD diagnosis was acid exposure time (AET); patients with AET>6% and AET<4% were included. Univariate and multivariate analyses were performed. A diagnostic score was developed using parameters independently associated with GERD. Generation and validation cohorts were randomly selected in a 2:1 ratio. Diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AUC ROC).Results: A total of 391 patients met the inclusion criteria; 167 had GERD (AET>6%) and 224 did not have GERD (AET<4%). In the multivariate analysis, age, male sex, and the distance between the lower esophageal sphincter and the crural diaphragm (LES-CD) were directly associated with GERD, while esophagogastric junction contractile integral (EGJ-CI) and distal contractile integral (DCI) were inversely associated with GERD (p values: 0.03, <0.01, <0.01, 0.01, and 0.01, respectively). The AUC ROC of a diagnostic score based on these parameters was 0.76 and 0.82 in the generation and validation cohorts, respectively.Conclusions: In this observational study, age, male sex, LES-CD distance, EGJ-CI, and DCI (AGES-D) were independently associated with GERD. A novel score incorporating these parameters could be useful in the assessment of inconclusive cases.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"276-283"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics Associated With Spontaneous Helicobacter pylori Clearance After Subtotal Gastrectomy in Patients With Gastric Cancer. 胃癌患者胃大部切除术后幽门螺杆菌自发清除率的相关特征。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0029

So Young Byun, Hee Sung Kim, Ji Yong Ahn, Byung Sik Kim, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung

{"title":"Characteristics Associated With Spontaneous Helicobacter pylori Clearance After Subtotal Gastrectomy in Patients With Gastric Cancer.","authors":"So Young Byun, Hee Sung Kim, Ji Yong Ahn, Byung Sik Kim, Hee Kyong Na, Jeong Hoon Lee, Kee Wook Jung, Do Hoon Kim, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung","doi":"10.7704/kjhugr.2025.0029","DOIUrl":"10.7704/kjhugr.2025.0029","url":null,"abstract":"Objective: Helicobacter pylori eradication treatment typically occurs after gastrectomy; however, the specific criteria for eradication treatment have not been reported. This study aimed to evaluate the rates and locations of spontaneous clearance, as well as the accompanying histological changes.Methods: Patients with H. pylori-positive status at the time of gastric cancer diagnosis and who underwent subtotal gastrectomy at a tertiary care center in Seoul (South Korea) were prospectively enrolled in this study. H. pylori infection status and histological features (presence of mononuclear cells, neutrophils, atrophy, and intestinal metaplasia) were evaluated pre- and postoperatively at different locations in the stomach.Results: Sixteen patients with H. pylori-positive gastric cancer underwent subtotal gastrectomy. Of these, 13 (81.3%) showed spontaneous clearance at least once during the follow-up. Half of the patients (8, 50.0%) had cleared their infections within 6 months after surgery. Histological factors, such as neutrophil and mononuclear cell counts, atrophy, and intestinal metaplasia, did not differ according to H. pylori clearance status. The spontaneous clearance rates of H. pylori were 69.2% in the cardia, 46.1% in the fundus, 38.4% in the lesser curvature of the mid-body, and 41.6% in the greater curvature of the mid-body; the differences in clearance rates were not significant (p=0.149).Conclusions: The rate of spontaneous H. pylori clearance was high in patients with gastric cancer who underwent subtotal gastrectomy. Postoperative H. pylori status should be re-evaluated to confirm the presence of infection prior to considering eradicating therapy.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"268-275"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Endoscopic Treatment Techniques for Subepithelial Lesions. 上皮下病变内镜治疗技术的最新进展。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0044

Seung Han Kim

引用次数: 0

Natural Course of Gastric Subepithelial Tumors. 胃上皮下肿瘤的自然病程。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-09-01 DOI: 10.7704/kjhugr.2025.0039

Ji Yoon Kim, Seung Joo Kang

{"title":"Natural Course of Gastric Subepithelial Tumors.","authors":"Ji Yoon Kim, Seung Joo Kang","doi":"10.7704/kjhugr.2025.0039","DOIUrl":"10.7704/kjhugr.2025.0039","url":null,"abstract":"Gastric subepithelial tumors (SETs) are being increasingly detected owing to the widespread use of endoscopy. These lesions vary in etiology, with gastrointestinal stromal tumors (GISTs), leiomyomas, and ectopic pancreas among the most common types. Because some gastric SETs, such as GISTs, have malignant potential, the development of an appropriate management plan is crucial. However, the management of gastric SETs remains challenging owing to the limited information available regarding their natural courses. In this review, currently available studies were analyzed to summarize the existing evidence on the natural history and progression of gastric SETs based on initial tumor sizes and endoscopic ultrasound (EUS) features, highlighting that most small SETs (<30 mm in size) remain stable over time. Larger initial tumor sizes and irregular tumor margins, determined during EUS, are key risk factors for tumor progression. Other factors, such as older patient age, tumor location, and certain echogenic characteristics, have also been suggested to be associated with tumor progression. Additionally, tumor doubling times provide valuable information for distinguishing aggressive tumors, with high-risk GISTs demonstrating rapid growth. Surveillance strategies should be individualized based on these factors. Regular endoscopic or EUS follow-up is generally recommended for small asymptomatic SETs, with closer monitoring of lesions exhibiting high-risk features.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 3","pages":"224-233"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12425663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibiotic Resistance of Helicobacter pylori: Current Trends in Daegu-Kyungpook. 大邱-庆北地区幽门螺杆菌耐药性现状。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.7704/kjhugr.2025.0010

Jeong Hwa Lee, Yong Hwan Kwon, Sang Un Kim, Ji Hye Park, Joon Hyun Cho, June Hwa Bae, Seong Woo Jeon

{"title":"Antibiotic Resistance of Helicobacter pylori: Current Trends in Daegu-Kyungpook.","authors":"Jeong Hwa Lee, Yong Hwan Kwon, Sang Un Kim, Ji Hye Park, Joon Hyun Cho, June Hwa Bae, Seong Woo Jeon","doi":"10.7704/kjhugr.2025.0010","DOIUrl":"10.7704/kjhugr.2025.0010","url":null,"abstract":"Objectives: Recent trends have shown reduced success rates of the standard triple therapy, underscoring the need for updated data on the antimicrobial resistance of Helicobacter pylori. This study aimed to assess the antibiotic resistance rates of H. pylori strains in the Daegu-Kyungpook region and compare them with other regions in South Korea to provide evidence for eradication therapy guidelines.Methods: Between September 2022 and February 2024, samples from 100 patients aged 20-80 years with suspected H. pylori infections were collected across five medical institutions in the Daegu-Kyungpook region. The cultured strains were subjected to antimicrobial susceptibility testing. The minimum inhibitory concentrations for antibiotics were established using agar dilution methods, with breakpoints set at >0.125 μg/mL for amoxicillin, >0.25 μg/mL for clarithromycin, >1 μg/mL for tetracycline, >1 μg/mL for levofloxacin, and >8 μg/mL for metronidazole.Results: Among the 100 samples collected, cultures were performed for 98 samples, excluding 2 that tested negative in the rapid urease test or polymerase chain reaction. Of these, 73 (74%) samples were successfully cultured, while 25 (26%) failed. Among the 73 successful cultures, resistance was observed in 20 (27%) samples for amoxicillin, 25 (34%) for clarithromycin, 34 (47%) for metronidazole, 19 (26%) for tetracycline, and 27 (37%) for levofloxacin.Conclusions: This study showed an overall increasing trend in antibiotic resistance rates, particularly in clarithromycin resistance, emphasizing the need to reconsider first-line triple therapy. This study is the first multicenter investigation of H. pylori antibiotic resistance in the Daegu-Kyungpook region, contributing valuable insights for developing region-specific treatment guidelines.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"25 2","pages":"146-151"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophilic Esophagitis: No Longer a Rarity in Asia-A Growing Concern for Clinicians. 嗜酸性粒细胞性食管炎：在亚洲不再罕见——临床医生越来越关注。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.7704/kjhugr.2025.0027

Kee Wook Jung

引用次数: 0