Zeitschrift fur Naturforschung. C, Journal of biosciences最新文献

Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil. Lepisanthes rubiginosa化学成分及抗胆碱酯酶活性研究Leenh。精油。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-09-19 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0105

Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Abu-Baker M Abdel-Aal

{"title":"Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil.","authors":"Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Abu-Baker M Abdel-Aal","doi":"10.1515/znc-2022-0105","DOIUrl":"https://doi.org/10.1515/znc-2022-0105","url":null,"abstract":"Essential oils obtained from medicinal plants show high therapeutic potential against several types of pathologies, including Alzheimer's disease. The purpose of this work was to study the chemical composition and anticholinesterase inhibitory activity of the essential oil obtained from Lepisanthes rubiginosa leaves collected from Malaysia. Twenty-four components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.5% of the essential oil. The identified major components include α-cadinol (40.0%), safrole (12.6%), α-amorphene (9.5%), (E)-isosafrole (5.0%), δ-cadinene (4.2%), and t-muurolol (4.1%). Anticholinesterase activity was assessed using Ellman method, and the essential oil demonstrated a moderate inhibitory activity against acetylcholinesterase (I%: 75.2%) and butyrylcholinesterase (I%: 70.2%) at conconcetration of 1000 μg/mL. The current study is the first to report chemical composition and anticholinesterase activity of the essential oil obtained from L. rubiginosa, which may have implications on the characterization, pharmaceutical, and therapeutic applications of Lepisanthes genus essential oils.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"525-529"},"PeriodicalIF":2.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40361510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies.

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-07-20 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0075

Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı, Gülhan Turan

引用次数: 0

Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues. 甲基乙二醛和高糖抑制VEGFR2特定酪氨酸残基的磷酸化。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-29 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0033

Fabian Betting, Günther Schlunck, Hansjürgen T Agostini, Gottfried Martin

{"title":"Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues.","authors":"Fabian Betting, Günther Schlunck, Hansjürgen T Agostini, Gottfried Martin","doi":"10.1515/znc-2022-0033","DOIUrl":"https://doi.org/10.1515/znc-2022-0033","url":null,"abstract":"Diabetes is characterized by hyperglycemia and a significant risk of vascular complications. Vascular endothelial growth factor (VEGF) and its main receptor VEGFR2 (KDR), which is highly expressed in vascular endothelial cells, are essential mediators of vascular maintenance and angiogenesis. During glycolysis after high calorie food intake, methylglyoxal (MGO) is formed and MGO blood levels are elevated in diabetes. MGO reacts with arginine residues to generate MG-H1 or with lysine residues to carboxyethyl lysine which are common components of advanced glycation end-products. Therefore, the question arises whether hyperglycemic conditions affect VEGF signaling via a ligand-independent direct modification of signaling components. As a first step, the effect of MGO on VEGFR2 activation was investigated in cultured endothelial cells from human umbilical vein by determination of VEGFR2 phosphorylation at selected tyrosine residues by ELISA and immunoblotting using phospho-specific antibodies. Phosphorylation of VEGFR2-Y996, VEGFR2-Y1054, or VEGFR2-Y1175 reached a maximum 5 min after stimulation of endothelial cells with VEGF. Phosphorylation was significantly inhibited by 100 µM MGO and to a lesser extent by high glucose treatment. 2,3-Pentanedione and glyoxal were investigated for comparison. In summary, VEGFR2 phosphorylation is sensitive to MGO or high glucose concentrations which may be relevant in the pathophysiology of microvascular disease in diabetes.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"493-500"},"PeriodicalIF":2.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom. 1,2,3-三唑类化合物的合成及构效关系研究。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-29 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0010

Jenifer Frouche de Souza, Marcos Vinicius da Silva Santana, Ana Cláudia Rodrigues da Silva, Marcio Roberto Henriques Donza, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Eladio Flores Sanchez, Helena Carla Castro, André Lopes Fuly

{"title":"Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom.","authors":"Jenifer Frouche de Souza, Marcos Vinicius da Silva Santana, Ana Cláudia Rodrigues da Silva, Marcio Roberto Henriques Donza, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Eladio Flores Sanchez, Helena Carla Castro, André Lopes Fuly","doi":"10.1515/znc-2022-0010","DOIUrl":"https://doi.org/10.1515/znc-2022-0010","url":null,"abstract":"Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent in vitro (coagulant, hemolytic, and proteolytic) and in vivo (hemorrhagic, edematogenic, and lethal) activities of Bothrops jararaca venom. The derivatives were synthesized, and had their molecular structures fully characterized by CHN element analysis, Fourier-transform infrared spectroscopy and Nuclear magnetic resonance. The derivatives were incubated with the B. jararaca venom (incubation protocol) or administered before (prevention protocol) or after (treatment protocol) the injection of B. jararaca venom into the animals. Briefly, the derivatives were able to inhibit the main toxic effects triggered by B. jararaca venom, though with varying efficacies, and they were devoid of toxicity through in vivo, in silico or in vitro analyses. However, it seemed that the derivatives AM006 or AM010 inhibited more efficiently hemorrhage or lethality, respectively. The derivatives were nontoxic. Therefore, the 1,2,3-triazole derivatives may be useful as an adjuvant to more efficiently treat the local toxic effects caused by B. jararaca envenoming.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"459-471"},"PeriodicalIF":2.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant alkaloids from the rhizomes of Corydalis decumbens. 从卧枕连翘根茎中提取抗抑郁生物碱。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-24 Print Date: 2022-11-25 DOI: 10.1515/znc-2021-0108

Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei

引用次数: 0

Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae). 来自小果苣苔的次生代谢物。和佩尔。（蚕豆科）。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-02-23 Print Date: 2022-05-25 DOI: 10.1515/znc-2021-0239

William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack

{"title":"Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae).","authors":"William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack","doi":"10.1515/znc-2021-0239","DOIUrl":"https://doi.org/10.1515/znc-2021-0239","url":null,"abstract":"The chemical investigation of the ethanol/water (7:3) extract of the roots of Detarium microcarpum (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (1) and one new ceramide derivative, microcarpamide (2), along with eight known secondary metabolites (3-10) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (3), microcarposide (4), rhinocerotinoic acid (5), 1,7-dihydroxy-6-methylxanthone (6), ursolic acid (7), 3β,23-dihydroxylup-20(29)-en-28-oic acid (8), alphitolic acid (9), and stigmasterol glucoside (10). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds 3 and 4 are known, their crystalline structures are reported here for the first time. These compounds were evaluated in vitro for their antisalmonella activity. The results obtained showed that, microcarpamide (2), microcarposide (4), and rhinocerotinoic acid (5) were moderately active against three salmonella strains: Salmonella typhi, Salmonella enteritidis and Salmonella typhimirium, with minimum inhibition concentration values of 76.7 and 153.5 μM.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"253-261"},"PeriodicalIF":2.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines. 用姜黄素合成和表征纳米银:对多种细胞系的细胞毒性、凋亡和坏死作用。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-02-23 Print Date: 2022-07-26 DOI: 10.1515/znc-2021-0298

Tunay Karan, Ramazan Erenler, Busra Moran Bozer

{"title":"Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines.","authors":"Tunay Karan, Ramazan Erenler, Busra Moran Bozer","doi":"10.1515/znc-2021-0298","DOIUrl":"https://doi.org/10.1515/znc-2021-0298","url":null,"abstract":"Nanostructures have distinctive chemical and physical features owing to their surface area and nanoscale size. In this study, silver nanoparticles were synthesized using curcumin, a medicinally valuable natural product. The structure of curcumin-mediated silver nanoparticles (c-AgNPs) was identified by extensive spectroscopic techniques. The maximum absorption was observed at 430 nm in UV-Vis spectrum. The crystal structure of c-AgNPs was identified by XRD. The morphology of the structure was determined by SEM image. The particle size was found as 51.13 nm. The functional groups of curcumin and c-AgNPs were established by FTIR spectroscopy. Cytotoxic activity of c-AgNPs was carried out using A549, DLD-1, and L929 with MTT assay. c-AgNPs revealed excellent activity on DLD-1 cell lines and A549 cell lines at 1.0 mg/mL concentration with the lethal effect of 80%. However, nanoparticles did not show the considerable effect on L929. Moreover, they induced apoptosis. Consequently, c-AgNPs are a promising material for anticancer drugs candidate.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"343-350"},"PeriodicalIF":2.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Electrochemical quantification of biomarker myeloperoxidase. 生物标志物髓过氧化物酶的电化学定量分析。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-02-22 Print Date: 2022-07-26 DOI: 10.1515/znc-2021-0274

Javier Hoyo, Arnau Bassegoda, Tzanko Tzanov

引用次数: 1

Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes. uva照射下山茶角质形成细胞抗光老化特性的评价及酶辅助增强。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-01-20 Print Date: 2022-07-26 DOI: 10.1515/znc-2021-0212

Jung Hwan Oh, Gi Baeg Nam, Fatih Karadeniz, Chang-Suk Kong, Jaeyoung Ko

{"title":"Evaluation and enzyme-aided enhancement of anti-photoaging properties of Camellia japonica in UVA-irradiated keratinocytes.","authors":"Jung Hwan Oh, Gi Baeg Nam, Fatih Karadeniz, Chang-Suk Kong, Jaeyoung Ko","doi":"10.1515/znc-2021-0212","DOIUrl":"https://doi.org/10.1515/znc-2021-0212","url":null,"abstract":"Exposure to ultraviolet (UV) radiation is the main reason behind extrinsic skin aging. Changes due to chronic UV exposure are called photoaging. Natural products are effective ingredients against UV-mediated skin damage. Present study investigated the anti-photoaging properties of Camellia japonica flowers which possess various bioactivities. To enrich the extracts of C. japonica flowers, pectinase and beta-glucosidase treatment was employed. Anti-photoaging effect was screened using the changes in MMP-1 and collagen levels in UVA-irradiated human HaCaT keratinocytes. The crude extract of C. japonica flowers (CE) was shown to decrease the UVA-induced MMP-1 secretion while attenuating the collagen levels. Pectinase and beta-glucosidase treated CE (ECE) showed increased anti-photoaging effects against UVA-induced changes in MMP-1 and collagen production. Camellenodiol (CMD), a known triterpenoid from C. japonica, isolated as the active ingredient of ECE and its anti-photoaging effect was screened. Results showed that CMD ameliorated the UVA-induced deterioration in collagen levels by suppressing MMP-1 production in transcriptional level. CMD treatment downregulated the phosphorylation of p38, ERK, and JNK MAPKs along their downstream effectors, c-Fos, and c-Jun. In conclusion, enzyme-assisted extraction of C. japonica flowers was suggested to enhance the anti-photoaging properties suggestively through high bioactive content such as CMD.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"287-296"},"PeriodicalIF":2.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39731645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans. 部分药用植物的体外抑癌抑菌活性及其一种天然化合物的分离与表征。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-01-14 Print Date: 2022-07-26 DOI: 10.1515/znc-2021-0259

Bassam Oudh Aljohny, Yasir Anwar, Shahid Ali Khan

{"title":"In vitro anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from Withania coagulans.","authors":"Bassam Oudh Aljohny, Yasir Anwar, Shahid Ali Khan","doi":"10.1515/znc-2021-0259","DOIUrl":"https://doi.org/10.1515/znc-2021-0259","url":null,"abstract":"Abstract In the current study, five different plants, Syzygium Cumini, Fagonia cretica, Acacia modesta, Withania coagulans, and Olea europaea aqueous extracts were prepared and applied against the anticancer and antibacterial activities. It was observed that O. Europaea extract shows the highest anticancer activity with cell viability of 21.5%. All the five plants extract was also used against the inhibition of Bacillus subtilis where O. Europaea extract shows a promising inhibitory activity of 3.2 cm followed by W. coagulans. Furthermore, W. coagulans was subjected to the process of column chromatography as a result a withanolide was isolated. The fast atom bombardment mass spectrometry (FAB-MS) and high resolution fast atom bombardment (HRFAB-MS) [M + 1] indicated molecular weight at m/z 453 and molecular formula C28H37O5. The UV–Vis. spectrum shows absorbance at 210 nm suggesting the presence of conjugated system, and Fourier-transform infrared spectroscopy (FTIR) was recorded to explore the functional groups. Similarly, 1D and 2D NMR spectroscopy techniques such as 1H, 13C NMR, correlation spectroscopy (COSY-45°), heteronuclear single quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC) and Nuclear Overhauser effect Spectroscopy (NOESY) techniques was carried out to determine the unknown natural product. The collective data of all these techniques established the structure of the unknown compound and recognized as a withanolide.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"263-270"},"PeriodicalIF":2.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0