{"title":"从卧枕连翘根茎中提取抗抑郁生物碱。","authors":"Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei","doi":"10.1515/znc-2021-0108","DOIUrl":null,"url":null,"abstract":"<p><p>Two new alkaloids (<b>1</b> and <b>2</b>), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (<b>1</b>) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (<b>2</b>), along with thirteen known alkaloids (<b>3</b>-<b>15</b>) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl<sub>3</sub> extraction of <i>Corydalis decumbens</i> for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (<b>1</b>-<b>15</b>) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake <i>in vitro</i>. Among them, compounds <b>1</b>, <b>2</b>, <b>4</b>, and <b>6</b> showed certain antidepressant activities.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"501-507"},"PeriodicalIF":0.0000,"publicationDate":"2022-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antidepressant alkaloids from the rhizomes of <i>Corydalis decumbens</i>.\",\"authors\":\"Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei\",\"doi\":\"10.1515/znc-2021-0108\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Two new alkaloids (<b>1</b> and <b>2</b>), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (<b>1</b>) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (<b>2</b>), along with thirteen known alkaloids (<b>3</b>-<b>15</b>) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl<sub>3</sub> extraction of <i>Corydalis decumbens</i> for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (<b>1</b>-<b>15</b>) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake <i>in vitro</i>. Among them, compounds <b>1</b>, <b>2</b>, <b>4</b>, and <b>6</b> showed certain antidepressant activities.</p>\",\"PeriodicalId\":520830,\"journal\":{\"name\":\"Zeitschrift fur Naturforschung. C, Journal of biosciences\",\"volume\":\" \",\"pages\":\"501-507\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2022-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Naturforschung. C, Journal of biosciences\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1515/znc-2021-0108\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/11/25 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Naturforschung. C, Journal of biosciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/znc-2021-0108","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/11/25 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
Antidepressant alkaloids from the rhizomes of Corydalis decumbens.
Two new alkaloids (1 and 2), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (2), along with thirteen known alkaloids (3-15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl3 extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (1-15) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro. Among them, compounds 1, 2, 4, and 6 showed certain antidepressant activities.
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