从卧枕连翘根茎中提取抗抑郁生物碱。

IF 1.8 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences Pub Date : 2022-06-24 Print Date: 2022-11-25 DOI:10.1515/znc-2021-0108

Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei

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引用次数: 0

摘要

利用硅胶、sephadex LH-20和半制备高效液相色谱等方法，首次从黄连CHCl3提取液中分离到两个新的生物碱(1和2)，分别命名为1,7-二甲氧基-2′-prenyl-1′，9-二氢吡咯-咔唑(1)和1,7-二甲氧基-4′，5′-二甲基环戊-咔唑-1′，3′-二酮(2)，以及13个已知的生物碱(3-15)。通过核磁共振、质谱、红外、紫外及相关文献对其结构进行了表征。化合物(1-15)通过测定体外单胺类神经递质再摄取的抑制作用来评估其抗抑郁活性。其中化合物1、2、4、6具有一定的抗抑郁活性。

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Antidepressant alkaloids from the rhizomes of Corydalis decumbens.

Two new alkaloids (1 and 2), named 1,7-dimethoxy-2'-prenyl-1',9-dihydropyrrolo-carbazole (1) and 1,7-dimethoxy-4',5'-dimethylcyclopenta-carbazole-1',3'-dione (2), along with thirteen known alkaloids (3-15) were isolated by means of silica gel, sephadex LH-20, and semi-preparative HPLC from the CHCl₃ extraction of Corydalis decumbens for the first time. Their structures were determined by NMR, MS, IR, UV, and related references. Compounds (1-15) were evaluated for their antidepressant activities by measuring inhibition of monoamine neurotransmitter reuptake in vitro. Among them, compounds 1, 2, 4, and 6 showed certain antidepressant activities.

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来源期刊

Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences 生物-生化与分子生物学

CiteScore

4.10

自引率

5.00%

发文量

期刊介绍： A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.