Zeitschrift fur Naturforschung. C, Journal of biosciences最新文献_第4页

Role of Hypericum perforatum oil and pomegranate seed oil in wound healing: an in vitro study. 贯叶连翘油和石榴籽油在伤口愈合中的作用:体外研究。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2021-09-01 Print Date: 2022-05-25 DOI: 10.1515/znc-2020-0301

Ebru Uzunhisarcıklı, Mükerrem Betül Yerer

{"title":"Role of Hypericum perforatum oil and pomegranate seed oil in wound healing: an in vitro study.","authors":"Ebru Uzunhisarcıklı, Mükerrem Betül Yerer","doi":"10.1515/znc-2020-0301","DOIUrl":"https://doi.org/10.1515/znc-2020-0301","url":null,"abstract":"This study aimed to investigate the wound-healing efficacy of Hypericum perforatum and pomegranate seed extract oil combined with curcumin as an anti inflammatory agent. A series of experiments were carried out to determine effective concentrations for H. perforatum oil, pomegranate seed extract oil, and curcumin. Ibuprofen was used as a positive control. The wound-healing effects of the applied compounds were tested according to the migration experiment model performed in HaCaT cells. A real-time cell analyzer (xCELLigence) was used to determine the cytotoxic/proliferative effects of H. perforatum, pomegranate seed oil, ibuprofen, and curcumin in HaCaT cells alone and their combined use at specified concentrations. After examining the noncytotoxic concentrations of H. perforatum oil, pomegranate seed oil, curcumin, and ibuprofen, migration experiments were performed to examine the wound healing properties. According to the results, the wound-healing efficacy of curcumin and H. perforatum combination was better than ibuprofen combinations. Also, according to the results, the wound-healing efficacy of curcumin and pomegranate seed oil combination was better than ibuprofen combinations. It was concluded that both oils had improved wound-healing properties in combination with curcumin or Ibuprofen.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"189-195"},"PeriodicalIF":2.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39374420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor. 薰衣草的协同抗菌组合。樟脑精油。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-11-02 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0051

Nursenem Karaca, Görkem Şener, Betül Demirci, Fatih Demirci

{"title":"Synergistic antibacterial combination of Lavandula latifolia Medik. essential oil with camphor.","authors":"Nursenem Karaca, Görkem Şener, Betül Demirci, Fatih Demirci","doi":"10.1515/znc-2020-0051","DOIUrl":"https://doi.org/10.1515/znc-2020-0051","url":null,"abstract":"Combination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the in vitro potential synergistic antibacterial effect of Lavandula latifolia (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; Staphylococcus aureus and Listeria monocytogenes. Pharmacopoeia quality L. latifolia essential oil and racemic camphor were analyzed and verified by GC-FID and GC/MS, simultaneously. In vitro antibacterial activity of essential oil and camphor (MIC range: 0.16-20 mg/mL) and standard antimicrobial clarithromycin (MIC range: 0.125-16 μg/mL) were carried out by broth microdilution against S. aureus and L. monocytogenes standard strains, respectively. Resulting antibacterial effects were evaluated for their fractional inhibitory concentrations (FICs) as antagonistic, additive and synergistic effects. The analytical results showed that the major component of essential oil was linalool (45.2%) and 1,8-cineole (25.6%). Antibacterial effects of essential oil were determined as MIC 1.25-5 mg/mL. As a result of the experiments, L. latifolia essential oil-camphor combinations were identified as \"synergistic (FIC ≤ 0.5), and additive (0.5 < FIC ≤ 1)\" in the respective combinations, suggesting further evaluation for formulations for potential antimicrobial applications in food and pharmaceuticals.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"169-173"},"PeriodicalIF":2.0,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Structural elucidation and neuroprotective activities of lignans from the flower buds of Magnolia biondii Pamp. 白玉兰花蕾中木脂素的结构解析及其神经保护作用。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-10-26 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0100

Qinge Ma, Rongrui Wei, Xiaodong Zhang, Zhipei Sang, Jianghong Dong

引用次数: 5

Elaeocarpus floribundus Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties. 作为一种具有抗氧化和抗菌特性的生物活性化合物的新来源。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-10-15 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0114

Ayorinde V Ogundele, Saikat Haldar, Archana Yadav, Archana M Das

{"title":"Elaeocarpus floribundus Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties.","authors":"Ayorinde V Ogundele, Saikat Haldar, Archana Yadav, Archana M Das","doi":"10.1515/znc-2020-0114","DOIUrl":"https://doi.org/10.1515/znc-2020-0114","url":null,"abstract":"The fruits of Elaeocarpus floribundus Bl. (Elaeocarpaceae) are edible and are normally prescribed for treatment of diseases. The medicinal uses of the fruit create considerable quantities of seeds as wastes. In an attempt to valorise this biomass, we studied the antimicrobial and antioxidant activities of the ethanolic seed extract. The extract inhibited the growth of the tested pathogens and was also a very strong scavenger of DPPH free radicals. Consequently, the extract was phytochemically investigated and this study reports the initial isolation of five phenolic compounds from this source. The structures of the isolated compounds were elucidated by spectra analyses including HR-ESI-MS, 1D and 2D NMR experiments. The isolated compounds exhibited a wide range of antimicrobial activities against the tested pathogens. Gallic acid (4) showed the most activity against Bacillus subtilis with a minimum inhibitory concentration (MIC) value of 30 µg/mL, while the MIC values of the antimicrobial standards range between 10 and 35 µg/mL. Compound 4, crude ethanolic extract, and the ethyl acetate fraction were more a potent free radical scavenger of DPPH compared to ascorbic acid. Hence, the seeds of E. floribundus could be considered as a new source of bioactive compounds for pharmaceutical and food-related industries.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"141-146"},"PeriodicalIF":2.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38488086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Root essential oil of Chrysopogon zizanioides relaxes rat isolated thoracic aorta - an ex vivo approach. 金沙根精油对离体大鼠胸主动脉的放松作用。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-10-14 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0143

Lekha Sivakumar, David Raj Chellappan, Venkatraman Sriramavaratharajan, Ramar Murugan

{"title":"Root essential oil of Chrysopogon zizanioides relaxes rat isolated thoracic aorta - an ex vivo approach.","authors":"Lekha Sivakumar, David Raj Chellappan, Venkatraman Sriramavaratharajan, Ramar Murugan","doi":"10.1515/znc-2020-0143","DOIUrl":"https://doi.org/10.1515/znc-2020-0143","url":null,"abstract":"Root of Chrysopogon zizanioides (L.) Roberty has been used in Siddha system of medicine to treat hypertension. The present study was therefore to investigate the vasorelaxation effect of root essential oil of C. zizanioides using rat isolated thoracic aortic rings. Chemical characterization of root essential oil was carried out using Gas Chromatography-Flame Ionization Detector (GC-FID) and Gas Chromatography-Mass Spectrometry (GC-MS). Essential oil nanoemulsion (EONE) was prepared and characterized. Vasorelaxant effect of EONE in endothelium-intact aortic rings precontracted with phenylephrine (PE) (1 µM) or KCl (80 mM) was investigated. Role of Ca2+, nitric oxide and K+ channels in precontracted aortic rings were investigated to elucidate the mechanism of action of the essential oil. Further, the role of muscarinic and prostacyclin receptors in EONE induced relaxation was studied. The EONE significantly induced relaxation (Emax 77.1 ± 4.87%) in PE precontracted aortic rings. The nitric oxide synthase, and cyclooxygenase inhibitors and potassium channel blockers have not significantly inhibited the vasorelaxation induced by EONE. However, EONE induced relaxation in precontracted endothelium-intact aortic rings was significantly inhibited by muscarinic receptor and calcium channel. The root essential oil of C. zizanioides possesses vasorelaxant effect through muscarinic pathway as well as acts as calcium channel blocker.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"161-168"},"PeriodicalIF":2.0,"publicationDate":"2020-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0143","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38578274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Potential insecticidal activity of aminonaphthoquinone Mannich bases derived from lawsone and their copper (II) complex derivatives. 由lawsone及其铜(II)络合衍生物衍生的氨基萘醌曼尼希碱的潜在杀虫活性。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-10-12 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0115

Andréia P Matos, André L F Sarria, Ana C Volante, Antônio R Bernardo, Gracielle O S Cunha, João B Fernandes, Paulo C Vieira, Maria Fátima das G F da Silva

引用次数: 1

Distillation time effecting on the composition of Origanum floribundum essential oils and their antioxidant and antimicrobial activities. 蒸馏时间对花牛挥发油成分及抗氧化、抗菌活性的影响。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-10-01 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0102

Lamia Kerbouche, Mohamed Hazzit, Aoumeur Baaliouamer, Soraya Akretche

{"title":"Distillation time effecting on the composition of Origanum floribundum essential oils and their antioxidant and antimicrobial activities.","authors":"Lamia Kerbouche, Mohamed Hazzit, Aoumeur Baaliouamer, Soraya Akretche","doi":"10.1515/znc-2020-0102","DOIUrl":"https://doi.org/10.1515/znc-2020-0102","url":null,"abstract":"The essential oils (EOs) of Origanum floribundum Munby, an aromatic and medicinal plant endemic in Algeria, were extracted by different hydrodistillation times (30 min, 1, 2 and 3 h) and analyzed by GC and GC-MS. The chromatographic analysis showed that thymol (32.7-45.0%), p-cymene (16.8-23.1%) and γ-terpinene (21.6-28.7%) were the most prominent components of the oils. The antioxidant ability was measured using the reductive potential, thiobarbituric acid reactive substances (TBARS) assay and the inhibition of free radicals DPPH● and ABTS●+. Antibacterial activity was assessed by the disc diffusion method against three bacteria (Escherichia coli, Staphylococcus aureus and Bacillus subtilis) and one fungus (Candida albicans). Minimal inhibitory concentrations (MICs) were determined using a microdilution method. Thymol is one of the compounds of EOs, which are widely reported as very biologically active. Although the oil isolated for 30 min was the less-thymol rich, it was the most active with all the antioxidant tests. In the most cases, the antimicrobial activity showed the best results with oils isolated for 30 min and 3 h (MIC = 0.25-1.75 μL/mL). These results suggest that it might be possible to isolate the EO from this plant for a minimum distillation time to obtain oil that can give maximum biological activities.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"153-160"},"PeriodicalIF":2.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0102","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38442586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design and synthesis of novel n-butyphthalide derivatives as promising botanical fungicides. 新型植物性杀菌剂正丁酞衍生物的设计与合成。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-09-28 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0192

Zhongfu Luo, Yu Deng, Bilan Luo, Yong Li, Qing Lan, Judi Fan, Wei Xue, Lei Tang, Lingling Fan

引用次数: 4

Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway. 苦参皂苷IVa通过MAPK途径抑制RAW264.7细胞系炎症反应。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-09-28 Print Date: 2021-03-26 DOI: 10.1515/znc-2019-0107

Guangren Xu, Hongyu Lei, Qiaoling Yuan, Huiyu Chen, Jianming Su

{"title":"Inhibition of chikusetsusaponin IVa on inflammatory responses in RAW264.7 cell line via MAPK pathway.","authors":"Guangren Xu, Hongyu Lei, Qiaoling Yuan, Huiyu Chen, Jianming Su","doi":"10.1515/znc-2019-0107","DOIUrl":"https://doi.org/10.1515/znc-2019-0107","url":null,"abstract":"Chikusetsusaponin IVa (CHS-IVa), a saponin from herb Panacis japonicas, possesses extensive biological activities. However, the roles and underlying mechanisms of CHS-IVa on inflammation have not been fully clarified in the setting of murine macrophages. In this study, we found that CHS-IVa effectively reduced the expression of inflammatory mediators, including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-10 (IL-10), interleukin-1β (IL-1β), cyclooxygenase (COX-2), inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated murine macrophage-like RAW264.7 cells. Meanwhile, CHS-IVa could also evidently bate the contents of nitric oxide (NO) and prostaglandin E2 (PGE2) in cell culture supernatants. Furthermore, the anti-inflammatory activity of CHS-IVa may be via diminishing the phosphorylation of extracellular regulated protein kinases (ERK), p38, and c-Jun N-terminal kinase (JNK). Collectively, these findings will help to understand of the anti-inflammatory effects and mechanisms of P. japonicas deeply, and suggest a validated therapeutic use as an anti-inflammatory medication.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"103-110"},"PeriodicalIF":2.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2019-0107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38429313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells. Cotinus coggygria Scop。在MCF7乳腺癌细胞中诱导细胞周期阻滞、细胞凋亡、基因毒性效应、热力学和表观遗传事件。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2020-09-25 Print Date: 2021-03-26 DOI: 10.1515/znc-2020-0087

Zlatina I Gospodinova, Istvan Zupkó, Noémi Bózsity, Vasilissa I Manova, Mariyana S Georgieva, Svetla J Todinova, Stefka G Taneva, Imre Ocsovszki, Maria E Krasteva

{"title":"Cotinus coggygria Scop. induces cell cycle arrest, apoptosis, genotoxic effects, thermodynamic and epigenetic events in MCF7 breast cancer cells.","authors":"Zlatina I Gospodinova, Istvan Zupkó, Noémi Bózsity, Vasilissa I Manova, Mariyana S Georgieva, Svetla J Todinova, Stefka G Taneva, Imre Ocsovszki, Maria E Krasteva","doi":"10.1515/znc-2020-0087","DOIUrl":"https://doi.org/10.1515/znc-2020-0087","url":null,"abstract":"Current plant-derived anticancer therapeutics aim to reach higher effectiveness, to potentiate chemosensitivity and minimize the toxic side effects compared to conventional chemotherapy. Cotinus coggygria Scop. is a herb with high pharmacological potential, widely applied in traditional phytotherapy. Our previous study revealed that leaf aqueous ethanolic extract from C. coggygria exerts in vitro anticancer activity on human breast, ovarian and cervical cancer cell lines. The objective of the present research was to investigate possible molecular mechanisms and targets of the antitumor activity of the extract in breast cancer MCF7 cells through analysis of cell cycle and apoptosis, clonogenic ability assessment, evaluation of the extract genotoxic capacity, characterization of cells thermodynamic properties, and analysis on the expression of genes involved in cellular epigenetic processes. The obtained results indicated that in MCF7 cells C. coggygria extract causes S phase cell cycle arrest and triggers apoptosis, reduces colony formation, induces DNA damage, affects cellular thermodynamic parameters, and tends to inhibit the relative expression of DNMT1, DNMT3a, MBD3, and p300. Further studies on the targeted molecules and the extract anti-breast cancer potential on animal experimental model system, need to be performed in the future.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"129-140"},"PeriodicalIF":2.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38418374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10