Zeitschrift fur Naturforschung. C, Journal of biosciences最新文献

{"title":"Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.","authors":"Özlem Özdemir,&nbsp;Lisa Marinelli,&nbsp;Ivana Cacciatore,&nbsp;Michele Ciulla,&nbsp;Bugrahan Emsen,&nbsp;Antonio Di Stefano,&nbsp;Adil Mardinoglu,&nbsp;Hasan Turkez","doi":"10.1515/znc-2020-0093","DOIUrl":"https://doi.org/10.1515/znc-2020-0093","url":null,"abstract":"<p><p>Several epidemiologic, clinical and experimental reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) could have a potential as anticancer agents. The aim of this study was the evaluation of cytotoxic potential in human glioblastoma cells of novel synthesized NSAID derivatives, obtained by linking, through a spacer, <i>α</i>-lipoic acid (ALA) to anti-inflammatory drugs, such as naproxen (AL-3, 11 and 17), flurbiprofen (AL-6, 13 and 19) and ibuprofen (AL-9, 15 and 21). The effects on the level of gene expression were also determined using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. According to our results, NSAID derivatives exhibited concentration dependent cytotoxic effects on U87-MG cell line when compared with the control group. Moreover, treatment of the most active compounds (AL-3, AL-6 and AL-9) caused upregulation of tumor suppressor gene <i>PTEN</i> and downregulation of some oncogenes such as <i>AKT1, RAF1</i> and <i>EGFR</i>. In conclusion, our results revealed that AL-3, AL-6 and AL-9 could be suitable candidates for further investigation to develop new pharmacological strategies for the prevention of cancer.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"329-335"},"PeriodicalIF":2.0,"publicationDate":"2020-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40543985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Transcriptome profiling reveals an IAA-regulated response to adventitious root formation in lotus seedling.","authors":"Cheng Libao,&nbsp;Jiang Runzhi,&nbsp;Yang Jianjun,&nbsp;Xu Xiaoyong,&nbsp;Zeng Haitao,&nbsp;Li Shuyan","doi":"10.1515/znc-2018-0133","DOIUrl":"https://doi.org/10.1515/znc-2018-0133","url":null,"abstract":"","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"409"},"PeriodicalIF":2.0,"publicationDate":"2018-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2018-0133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36483647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: A comparative proteomic analysis for adventitious root formation in lotus root (Nelumbo nucifera Gaertn).","authors":"Cheng Libao,&nbsp;Jiang Runzhi,&nbsp;Yang Mengli,&nbsp;Li Liangjun,&nbsp;Li Shuyan","doi":"10.1515/znc-2018-0134","DOIUrl":"https://doi.org/10.1515/znc-2018-0134","url":null,"abstract":"","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"411"},"PeriodicalIF":2.0,"publicationDate":"2018-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2018-0134","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36483646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental alterations in biofuel generating molecules in Zilla spinosa.","authors":"Hemmat Khattab,&nbsp;Zeinab El Marid","doi":"10.1515/znc-2016-0151","DOIUrl":"https://doi.org/10.1515/znc-2016-0151","url":null,"abstract":"<p><p>Now days, production of fuels and petrochemicals from renewable lignocellulosic biomass is an indispensable issue to meet the growing energy demand. Meanwhile, the changes in the climate and soil topography influence the growth and development as well as canopy level of the lignocellulosic biomass. In this study, Zilla spinosa Turr (Zilla) plants with similar age and size were collected from three main sectors (upstream, midstream, and downstream) of Wadi Hagul during spring (April) and summer (July) seasons. Environmental stresses evoked reduction in the energy trapping pigments concomitant with increments in chlorophyll fluorescence in summer harvested plants particularly at downstream. Furthermore, the biofuels generating compounds including carbohydrate, lignin, and lipid making the plant biomasses are greatly affected by environmental conditions. Greater amount of lignin was estimated in summer harvested Z. spinosa shoots particularly at downstream. Moreover, the total oil content which is a promising source of biodiesel was considerably decreased during summer season particularly at downstream. The physical properties of the lipids major constituent fatty acid methyl esters determine the biofuel properties and contribute in the adaptation of plants against environmental stresses. Hence, the analysis of fatty acid profile showed significant modifications under combined drought and heat stress displayed in the summer season. The maximum increase in saturated fatty acid levels including tridecanoic acid (C13:0), pentadeanoic acid (C15:0), palmitic acid (C16:0), and stearic acid (C18:0) were estimated in spring harvested Z. spinosa aerial portions particularly at midstream. In spite of the reduction in the total oil content, a marked increase in the value of unsaturated to saturated fatty acids ratio and thereby the unsaturation index were achieved during the dry summer period. Henceforth, these seasonal and spatial variations in fatty acids profiles may contribute in the acclimatization of Z. spinosa plants to soil water scarcity associated with heat stress experienced during summer. In addition, the alterations in the fatty acid profiles may match biofuel requirements. In conclusion, the most adequate growing season (spring) will be decisive for achieving high lipid productivity associated with improved biofuel quality in terms of high saturated fatty acids percentage that improves its cetane number. However, the dry summer season enhanced the accumulation of greater amount of lignin that may enhance the biodiesel quantity.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"77-91"},"PeriodicalIF":2.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2016-0151","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39976276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Binuclear manganese (III) complexes as electron donors in D1/D2/cytochrome b559 preparations isolated from spinach photosystem II membrane fragments.","authors":"S I Allakhverdiev,&nbsp;M S Karacan,&nbsp;G Somer,&nbsp;N Karacan,&nbsp;E M Khan,&nbsp;S Y Rane,&nbsp;S Padhye,&nbsp;V V Klimov,&nbsp;G Renger","doi":"10.1515/znc-1994-9-1008","DOIUrl":"https://doi.org/10.1515/znc-1994-9-1008","url":null,"abstract":"<p><p>The capability of different manganese complexes to act as PS II electron donors in D1/D2/cytochrome b559 complexes has been analyzed by measuring actinic light-induced absorption changes at 680 nm (650 nm) and 340 nm, reflecting the photoaccumulation of Pheophytin⁻ (Pheo⁻) and the reduction of NADP⁺, respectively. The data obtained revealed: a) the donor capacity of synthetic binuclear Mn (III)₂complexes containing aromatic ligands significantly exceeds that for MnCl₂ in both cases, i.e. Pheo⁻ photoaccumulation and NADP⁺ reduction; b) manganese complexes can serve as suitable electron donors for light-induced NADP⁺ reduction catalyzed by D1/D2/cytochrome b559 complexes and ferredoxin plus ferredoxin-NADP⁺ reductase under anaerobic conditions and c) the specific turnover rate of the system leading to NADP⁺ reduction is extremely small. The implications of these findings are briefly discussed.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"587-92"},"PeriodicalIF":2.0,"publicationDate":"1994-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-1994-9-1008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30995806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}