Zeitschrift fur Naturforschung. C, Journal of biosciences最新文献

{"title":"Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines.","authors":"Tunay Karan,&nbsp;Ramazan Erenler,&nbsp;Busra Moran Bozer","doi":"10.1515/znc-2021-0298","DOIUrl":"https://doi.org/10.1515/znc-2021-0298","url":null,"abstract":"<p><p>Nanostructures have distinctive chemical and physical features owing to their surface area and nanoscale size. In this study, silver nanoparticles were synthesized using curcumin, a medicinally valuable natural product. The structure of curcumin-mediated silver nanoparticles (c-AgNPs) was identified by extensive spectroscopic techniques. The maximum absorption was observed at 430 nm in UV-Vis spectrum. The crystal structure of c-AgNPs was identified by XRD. The morphology of the structure was determined by SEM image. The particle size was found as 51.13 nm. The functional groups of curcumin and c-AgNPs were established by FTIR spectroscopy. Cytotoxic activity of c-AgNPs was carried out using A549, DLD-1, and L929 with MTT assay. c-AgNPs revealed excellent activity on DLD-1 cell lines and A549 cell lines at 1.0 mg/mL concentration with the lethal effect of 80%. However, nanoparticles did not show the considerable effect on L929. Moreover, they induced apoptosis. Consequently, c-AgNPs are a promising material for anticancer drugs candidate.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"343-350"},"PeriodicalIF":2.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical quantification of biomarker myeloperoxidase.","authors":"Javier Hoyo,&nbsp;Arnau Bassegoda,&nbsp;Tzanko Tzanov","doi":"10.1515/znc-2021-0274","DOIUrl":"https://doi.org/10.1515/znc-2021-0274","url":null,"abstract":"<p><p>Point of care testing (PoCT) devices permit precise and rapid detection of disease-related biomarkers contributing to an early disease diagnosis and administration of an appropriate treatment. The enzyme myeloperoxidase (MPO) is a relevant biomarker for infection and inflammation events assessment; however its direct electrochemical quantification is hindered by the limited accessibility to the iron atom in its active center. Herein, such hindrance of the MPO biomolecule is overcome using the redox mediator 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). The charge involved in the electrochemical reduction of the MPO-oxidized ABTS is correlated with the concentration of MPO. The use of ABTS allowed for the electrochemical assessment of a wide range of MPO concentrations (10-1000 nM) including those reported for wound infections, chronic obstructive pulmonary disease and early adverse cardiac events. The developed electroanalytical approach is rapid and inexpensive, and thus suitable for implementation in PoCT devices.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"297-302"},"PeriodicalIF":2.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39640103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation and enzyme-aided enhancement of anti-photoaging properties of <i>Camellia japonica</i> in UVA-irradiated keratinocytes.","authors":"Jung Hwan Oh,&nbsp;Gi Baeg Nam,&nbsp;Fatih Karadeniz,&nbsp;Chang-Suk Kong,&nbsp;Jaeyoung Ko","doi":"10.1515/znc-2021-0212","DOIUrl":"https://doi.org/10.1515/znc-2021-0212","url":null,"abstract":"<p><p>Exposure to ultraviolet (UV) radiation is the main reason behind extrinsic skin aging. Changes due to chronic UV exposure are called photoaging. Natural products are effective ingredients against UV-mediated skin damage. Present study investigated the anti-photoaging properties of <i>Camellia japonica</i> flowers which possess various bioactivities. To enrich the extracts of <i>C. japonica</i> flowers, pectinase and beta-glucosidase treatment was employed. Anti-photoaging effect was screened using the changes in MMP-1 and collagen levels in UVA-irradiated human HaCaT keratinocytes. The crude extract of <i>C. japonica</i> flowers (CE) was shown to decrease the UVA-induced MMP-1 secretion while attenuating the collagen levels. Pectinase and beta-glucosidase treated CE (ECE) showed increased anti-photoaging effects against UVA-induced changes in MMP-1 and collagen production. Camellenodiol (CMD), a known triterpenoid from <i>C. japonica</i>, isolated as the active ingredient of ECE and its anti-photoaging effect was screened. Results showed that CMD ameliorated the UVA-induced deterioration in collagen levels by suppressing MMP-1 production in transcriptional level. CMD treatment downregulated the phosphorylation of p38, ERK, and JNK MAPKs along their downstream effectors, c-Fos, and c-Jun. In conclusion, enzyme-assisted extraction of <i>C. japonica</i> flowers was suggested to enhance the anti-photoaging properties suggestively through high bioactive content such as CMD.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"287-296"},"PeriodicalIF":2.0,"publicationDate":"2022-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39731645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vitro</i> anticancer and antibacterial potentials of selected medicinal plants and isolation and characterization of a natural compound from <i>Withania coagulans</i>.","authors":"Bassam Oudh Aljohny,&nbsp;Yasir Anwar,&nbsp;Shahid Ali Khan","doi":"10.1515/znc-2021-0259","DOIUrl":"https://doi.org/10.1515/znc-2021-0259","url":null,"abstract":"Abstract In the current study, five different plants, Syzygium Cumini, Fagonia cretica, Acacia modesta, Withania coagulans, and Olea europaea aqueous extracts were prepared and applied against the anticancer and antibacterial activities. It was observed that O. Europaea extract shows the highest anticancer activity with cell viability of 21.5%. All the five plants extract was also used against the inhibition of Bacillus subtilis where O. Europaea extract shows a promising inhibitory activity of 3.2 cm followed by W. coagulans. Furthermore, W. coagulans was subjected to the process of column chromatography as a result a withanolide was isolated. The fast atom bombardment mass spectrometry (FAB-MS) and high resolution fast atom bombardment (HRFAB-MS) [M + 1] indicated molecular weight at m/z 453 and molecular formula C28H37O5. The UV–Vis. spectrum shows absorbance at 210 nm suggesting the presence of conjugated system, and Fourier-transform infrared spectroscopy (FTIR) was recorded to explore the functional groups. Similarly, 1D and 2D NMR spectroscopy techniques such as 1H, 13C NMR, correlation spectroscopy (COSY-45°), heteronuclear single quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC) and Nuclear Overhauser effect Spectroscopy (NOESY) techniques was carried out to determine the unknown natural product. The collective data of all these techniques established the structure of the unknown compound and recognized as a withanolide.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"263-270"},"PeriodicalIF":2.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation.","authors":"Zafer Sahin,&nbsp;Yağmur Özhan,&nbsp;Hande Sipahi,&nbsp;Sevde Nur Biltekin,&nbsp;Leyla Yurttaş,&nbsp;Barkin Berk,&nbsp;Şeref Demirayak","doi":"10.1515/znc-2021-0217","DOIUrl":"https://doi.org/10.1515/znc-2021-0217","url":null,"abstract":"<p><p>Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with α-hydroxy aldehyde or α-hydroxy ketone derivatives to obtain nine novel pyrazolone derivatives. Structures were successfully elucidated by ¹H NMR, ¹³C NMR, IR and HRMS. Enzyme inhibitory activity was measured on cyclooxygenases (COXs) as considered to address anti-inflammatory activity. Compound <b>2</b> showed the highest activity on both COX-1 and COX-2 subtypes with 12.0 μM and 8.0 μM IC₅₀, respectively. This activity was found close to indomethacin COX-2 inhibition measured as 7.4 μM IC₅₀. Rest of the compounds (<b>1</b>, <b>3</b>-<b>9</b>) showed 10.4-28.1 μM IC₅₀ on COX-2 and 17.0-35.6 μM IC₅₀ on COX-1 (Compound <b>1</b> has no activity on COX-1). Tested compounds (<b>1-9</b>) showed activity on NO production. Only compound was the <b>4</b>, which showed a low inhibition on IL-6 levels. Cell viability was up to 60% at 100 μM for all compounds (<b>1</b>-<b>9</b>) on RAW 264.7 and NIH3T3 cell lines, thus compounds were reported to be noncytotoxic.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"279-285"},"PeriodicalIF":2.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New compounds from <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp.","authors":"Mohamed Shaaban","doi":"10.1515/znc-2021-0236","DOIUrl":"https://doi.org/10.1515/znc-2021-0236","url":null,"abstract":"<p><p>Further investigation of the residual bioactive compounds produced by the soft coral <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (<b>1</b>), 9-methoxy-penicyrone B (<b>2</b>), 3-hydroxy-2,2,4-trimethyl-pentyl ester (<b>3</b>), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (<b>4</b>), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (<b>5</b>). Additional six known compounds were isolated: penicyrones A-B (<b>6</b>, <b>7</b>), 4-(2-hydroxy-3-butynoxy)benzoic acid (<b>8</b>), cyclopenol (<b>9</b>), aspermytin A (<b>10</b>), and aurantiomide A (<b>11</b>). Structures of the new compounds (<b>1-5</b>) were identified by 1D (¹H & ¹³C) and 2 D (¹H-¹H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"271-277"},"PeriodicalIF":2.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39723628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and computational study of copper bipyridine complex [Cu (C₁₈H₂₄N₂) (NO₃)₂] to explore its functional properties.","authors":"Saleh S Alarfaji,&nbsp;Sajjad Hussain,&nbsp;Abdullah G Al-Sehemi,&nbsp;Shabbir Muhammad,&nbsp;Islam Ullah Khan,&nbsp;Faiz Rabbani,&nbsp;Mazhar Amjad Gilani,&nbsp;Hamid Ullah","doi":"10.1515/znc-2021-0248","DOIUrl":"https://doi.org/10.1515/znc-2021-0248","url":null,"abstract":"<p><p>In the present study, copper (II) complex of 4, 4'-di-tert-butyl-2,2'-bipyridine [Cu (C₁₈H₂₄N₂) (NO₃)₂], <b>1</b> is investigated through its synthesis and characterization using elemental analysis technique, infra-red spectroscopy, and single-crystal analysis. The compound <b>1</b> crystallizes in orthorhombic space group <i>P</i>2₁2₁2₁. The copper atom in the mononuclear complex is hexa coordinated through two nitrogen and four oxygen atoms from bipyridine ligand and nitrate ligands. The thermal analysis depicts the stability of the entitled compound up to 170 °C, and the decomposition takes place in different steps between 170 and 1000 °C. Furthermore, quantum chemical techniques are used to study optoelectronic, nonlinear optical, and therapeutic bioactivity. The values of isotropic and anisotropic linear polarizabilities of compound <b>1</b> are calculated as 41.65 × 10^-24 and 23.02 × 10^-24 esu, respectively. Likewise, the static hyperpolarizability is calculated as 47.92 × 10^-36 esu using M06 functional compared with <i>para</i>-nitroaniline (<i>p</i>-NA) and found several times larger than <i>p</i>-NA. Furthermore, the antiviral potential of compound <b>1</b> is studied using molecular docking technique where intermolecular interactions are checked between the entitled compound and two crucial proteins of SARS-CoV-2 (COVID-19). Our investigation indicated that compound <b>1</b> interacts more vigorously to spike protein than main protease (M^Pro) due to its better binding energy of -9.60 kcal/mol compared with -9.10 kcal/mol of M^Pro. Our current study anticipated that the above-entitled coordination complexes could be potential candidates for optoelectronic properties and their biological activity.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"241-251"},"PeriodicalIF":2.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39952914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new diphenylheptanoid from the rhizomes of <i>Curcuma zedoaria</i>.","authors":"Truong Nhat Van Do,&nbsp;Hai Xuan Nguyen,&nbsp;Tho Huu Le,&nbsp;Phu Hoang Dang,&nbsp;Mai Thanh Nguyen,&nbsp;Mai Thanh Thi Nguyen,&nbsp;Nhan Trung Nguyen","doi":"10.1515/znc-2021-0096","DOIUrl":"https://doi.org/10.1515/znc-2021-0096","url":null,"abstract":"Abstract A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2–5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"219-223"},"PeriodicalIF":2.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Essential oils of <i>Uvaria boniana</i> - chemical composition, <i>in vitro</i> bioactivity, docking, and <i>in silico</i> ADMET profiling of selective major compounds.","authors":"Son Ninh The,&nbsp;Anh Le Tuan,&nbsp;Thuy Dinh Thi Thu,&nbsp;Luyen Nguyen Dinh,&nbsp;Tuyen Tran Thi,&nbsp;Hai Pham-The","doi":"10.1515/znc-2021-0111","DOIUrl":"https://doi.org/10.1515/znc-2021-0111","url":null,"abstract":"<p><p>Phytochemical investigation applying GC (gas chromatography)-MS (mass spectrometry)/GC-FID (flame ionization detection) on the hydro-distilled essential oils of the Vietnamese medicinal plant <i>Uvaria boniana</i> leaf and twig lead to the detection of 35 constituents (97.36%) in the leaf oil and 52 constituents (98.75%) in the twig oil. Monoterpenes, monoterpenoids, sesquiterpenes, and sesquiterpenoids were characteristic of <i>U. boniana</i> essential oils. The leaf oil was represented by major components (<i>E</i>)-caryophyllene (16.90%), bicyclogermacrene (15.95%), <i>α</i>-humulene (14.96%), and linalool (12.40%), whereas four compounds <i>α</i>-cadinol (16.16%), <i>epi</i>-<i>α</i>-muurolol (10.19%), <i>α</i>-pinene (11.01%), and <i>β</i>-pinene (8.08%) were the main ones in the twig oil. As compared with the leaf oil, the twig oil was better in antimicrobial activity. With the same MIC value of 40 mg/mL, the twig oil successfully controlled the growth of Gram (+) bacterium <i>Bacillus subtilis</i>, Gram (-) bacterium <i>Escherichia coli</i>, fungus <i>Aspergillus niger</i>, and yeast <i>Saccharomyces cerevisiae</i>. In addition, both two oil samples have induced antiinflammatory activity with the IC₅₀ values of 223.7-240.6 mg/mL in NO productive inhibition when BV2 cells had been stimulated by LPS. Docking simulations of four major compounds of <i>U. boniana</i> twig oil on eight relevant antibacterial targets revealed that <i>epi</i>-<i>α</i>-muurolol and <i>α</i>-cadinol are moderate inhibitors of <i>E. coli</i> DNA gyrase subunit B, penicillin binding protein 2X and penicillin binding protein 3 of <i>Pseudomonas aeruginosa</i> with similar free binding energies of -30.1, -29.3, and -29.3 kJ/mol, respectively. Furthermore, <i>in silico</i> ADMET studies indicated that all four docked compounds have acceptable oral absorption, low metabolism, and appropriated toxicological profile to be considered further as drug candidates.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"207-218"},"PeriodicalIF":2.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Origanum dubium, Origanum vulgare</i> subsp. <i>hirtum, and Lavandula angustifolia</i> essential oils on lipid profiles and liver biomarkers in athletes.","authors":"Hasan Maral,&nbsp;Süleyman Ulupınar,&nbsp;Ayşegül Türk Baydır,&nbsp;Serhat Özbay,&nbsp;Konca Altınkaynak,&nbsp;Engin Şebin,&nbsp;Erdinç Şiktar,&nbsp;Necip Fazıl Kishalı,&nbsp;Yusuf Buzdağlı,&nbsp;Cebrail Gençoğlu,&nbsp;İzzet İnce","doi":"10.1515/znc-2021-0142","DOIUrl":"https://doi.org/10.1515/znc-2021-0142","url":null,"abstract":"<p><p>This study aims to determine the effects of essential oils of <i>Origanum dubium</i> (DUB)<i>, Origanum vulgare</i> subsp. <i>hirtum</i> (HIR), and <i>Lavandula angustifolia</i> (LAV) on lipid profiles and liver biomarkers in athletes. Thirty-four trained athletes were randomly assigned to one of three experimental groups or the control group (CON). The concentrations of serum lipids and liver biomarkers were assessed before and after the 14-day essential oil intervention. Gas chromatography-mass spectrometry analysis showed 68.0 and 82.1% carvacrol in DUB and HIR, respectively, and 34.50% linalyl acetate and 33.68% linalool in LAV essential oils. One-way analysis of covariance (ANCOVA) indicated a significant difference (<i>p</i> = 0.001) among the groups for high-density lipoprotein cholesterol (HDL-C) when the associated preintervention values were used as a covariate. The related pairwise comparisons revealed that DUB (<i>p</i> = 0.001) and HIR (<i>p</i> = 0.024) had greater HDL-C values than CON. From the two-way ANOVA, an interaction between time (before vs. after) and the groups (DUB vs. HIR vs. LAV vs. CON) was found for HDL-C (<i>p</i> = 0.030). Findings indicated a significant increase in DUB (<i>p</i> = 0.0001) and HIR (<i>p</i> = 0.010) for HDL-C, and there was a significant decrease in DUB (<i>p</i> = 0.023) for low-density lipoprotein cholesterol. However, there was no difference in total cholesterol, triglycerides, and all liver biomarkers.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"177-187"},"PeriodicalIF":2.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}