Zafer Sahin, Yağmur Özhan, Hande Sipahi, Sevde Nur Biltekin, Leyla Yurttaş, Barkin Berk, Şeref Demirayak
{"title":"Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation.","authors":"Zafer Sahin, Yağmur Özhan, Hande Sipahi, Sevde Nur Biltekin, Leyla Yurttaş, Barkin Berk, Şeref Demirayak","doi":"10.1515/znc-2021-0217","DOIUrl":"https://doi.org/10.1515/znc-2021-0217","url":null,"abstract":"<p><p>Novel benzofurane-pyrazolone hybrids have been synthesized for evaluating their anti-inflammatory and cytotoxic properties. 4-(2-chloroacetyl)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one were reacted with α-hydroxy aldehyde or α-hydroxy ketone derivatives to obtain nine novel pyrazolone derivatives. Structures were successfully elucidated by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR and HRMS. Enzyme inhibitory activity was measured on cyclooxygenases (COXs) as considered to address anti-inflammatory activity. Compound <b>2</b> showed the highest activity on both COX-1 and COX-2 subtypes with 12.0 μM and 8.0 μM IC<sub>50</sub>, respectively. This activity was found close to indomethacin COX-2 inhibition measured as 7.4 μM IC<sub>50</sub>. Rest of the compounds (<b>1</b>, <b>3</b>-<b>9</b>) showed 10.4-28.1 μM IC<sub>50</sub> on COX-2 and 17.0-35.6 μM IC<sub>50</sub> on COX-1 (Compound <b>1</b> has no activity on COX-1). Tested compounds (<b>1-9</b>) showed activity on NO production. Only compound was the <b>4</b>, which showed a low inhibition on IL-6 levels. Cell viability was up to 60% at 100 μM for all compounds (<b>1</b>-<b>9</b>) on RAW 264.7 and NIH3T3 cell lines, thus compounds were reported to be noncytotoxic.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"279-285"},"PeriodicalIF":2.0,"publicationDate":"2022-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39583673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"New compounds from <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp.","authors":"Mohamed Shaaban","doi":"10.1515/znc-2021-0236","DOIUrl":"https://doi.org/10.1515/znc-2021-0236","url":null,"abstract":"<p><p>Further investigation of the residual bioactive compounds produced by the soft coral <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (<b>1</b>), 9-methoxy-penicyrone B (<b>2</b>), 3-hydroxy-2,2,4-trimethyl-pentyl ester (<b>3</b>), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (<b>4</b>), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (<b>5</b>). Additional six known compounds were isolated: penicyrones A-B (<b>6</b>, <b>7</b>), 4-(2-hydroxy-3-butynoxy)benzoic acid (<b>8</b>), cyclopenol (<b>9</b>), aspermytin A (<b>10</b>), and aurantiomide A (<b>11</b>). Structures of the new compounds (<b>1-5</b>) were identified by 1D (<sup>1</sup>H & <sup>13</sup>C) and 2 D (<sup>1</sup>H-<sup>1</sup>H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"271-277"},"PeriodicalIF":2.0,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39723628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saleh S Alarfaji, Sajjad Hussain, Abdullah G Al-Sehemi, Shabbir Muhammad, Islam Ullah Khan, Faiz Rabbani, Mazhar Amjad Gilani, Hamid Ullah
{"title":"Synthesis, characterization, and computational study of copper bipyridine complex [Cu (C<sub>18</sub>H<sub>24</sub>N<sub>2</sub>) (NO<sub>3</sub>)<sub>2</sub>] to explore its functional properties.","authors":"Saleh S Alarfaji, Sajjad Hussain, Abdullah G Al-Sehemi, Shabbir Muhammad, Islam Ullah Khan, Faiz Rabbani, Mazhar Amjad Gilani, Hamid Ullah","doi":"10.1515/znc-2021-0248","DOIUrl":"https://doi.org/10.1515/znc-2021-0248","url":null,"abstract":"<p><p>In the present study, copper (II) complex of 4, 4'-di-tert-butyl-2,2'-bipyridine [Cu (C<sub>18</sub>H<sub>24</sub>N<sub>2</sub>) (NO<sub>3</sub>)<sub>2</sub>], <b>1</b> is investigated through its synthesis and characterization using elemental analysis technique, infra-red spectroscopy, and single-crystal analysis. The compound <b>1</b> crystallizes in orthorhombic space group <i>P</i>2<sub>1</sub>2<sub>1</sub>2<sub>1</sub>. The copper atom in the mononuclear complex is hexa coordinated through two nitrogen and four oxygen atoms from bipyridine ligand and nitrate ligands. The thermal analysis depicts the stability of the entitled compound up to 170 °C, and the decomposition takes place in different steps between 170 and 1000 °C. Furthermore, quantum chemical techniques are used to study optoelectronic, nonlinear optical, and therapeutic bioactivity. The values of isotropic and anisotropic linear polarizabilities of compound <b>1</b> are calculated as 41.65 × 10<sup>-24</sup> and 23.02 × 10<sup>-24</sup> esu, respectively. Likewise, the static hyperpolarizability is calculated as 47.92 × 10<sup>-36</sup> esu using M06 functional compared with <i>para</i>-nitroaniline (<i>p</i>-NA) and found several times larger than <i>p</i>-NA. Furthermore, the antiviral potential of compound <b>1</b> is studied using molecular docking technique where intermolecular interactions are checked between the entitled compound and two crucial proteins of SARS-CoV-2 (COVID-19). Our investigation indicated that compound <b>1</b> interacts more vigorously to spike protein than main protease (M<sup>Pro</sup>) due to its better binding energy of -9.60 kcal/mol compared with -9.10 kcal/mol of M<sup>Pro</sup>. Our current study anticipated that the above-entitled coordination complexes could be potential candidates for optoelectronic properties and their biological activity.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"241-251"},"PeriodicalIF":2.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39952914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Truong Nhat Van Do, Hai Xuan Nguyen, Tho Huu Le, Phu Hoang Dang, Mai Thanh Nguyen, Mai Thanh Thi Nguyen, Nhan Trung Nguyen
{"title":"A new diphenylheptanoid from the rhizomes of <i>Curcuma zedoaria</i>.","authors":"Truong Nhat Van Do, Hai Xuan Nguyen, Tho Huu Le, Phu Hoang Dang, Mai Thanh Nguyen, Mai Thanh Thi Nguyen, Nhan Trung Nguyen","doi":"10.1515/znc-2021-0096","DOIUrl":"https://doi.org/10.1515/znc-2021-0096","url":null,"abstract":"Abstract A phytochemical investigation of the rhizomes of Curcuma zedoaria was carried out, leading to the isolation of a new diphenylheptanoid, zedoaroxane A (1), together with four known compounds (2–5). Their structures were elucidated based on NMR spectroscopic data. All isolated compounds possessed α-glucosidase inhibitory activity, with the IC50 values ranging from 35.2 to 89.0 µM, more potent than that of the positive control acarbose (IC50, 214.5 µM).","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"219-223"},"PeriodicalIF":2.0,"publicationDate":"2021-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Son Ninh The, Anh Le Tuan, Thuy Dinh Thi Thu, Luyen Nguyen Dinh, Tuyen Tran Thi, Hai Pham-The
{"title":"Essential oils of <i>Uvaria boniana</i> - chemical composition, <i>in vitro</i> bioactivity, docking, and <i>in silico</i> ADMET profiling of selective major compounds.","authors":"Son Ninh The, Anh Le Tuan, Thuy Dinh Thi Thu, Luyen Nguyen Dinh, Tuyen Tran Thi, Hai Pham-The","doi":"10.1515/znc-2021-0111","DOIUrl":"https://doi.org/10.1515/znc-2021-0111","url":null,"abstract":"<p><p>Phytochemical investigation applying GC (gas chromatography)-MS (mass spectrometry)/GC-FID (flame ionization detection) on the hydro-distilled essential oils of the Vietnamese medicinal plant <i>Uvaria boniana</i> leaf and twig lead to the detection of 35 constituents (97.36%) in the leaf oil and 52 constituents (98.75%) in the twig oil. Monoterpenes, monoterpenoids, sesquiterpenes, and sesquiterpenoids were characteristic of <i>U. boniana</i> essential oils. The leaf oil was represented by major components (<i>E</i>)-caryophyllene (16.90%), bicyclogermacrene (15.95%), <i>α</i>-humulene (14.96%), and linalool (12.40%), whereas four compounds <i>α</i>-cadinol (16.16%), <i>epi</i>-<i>α</i>-muurolol (10.19%), <i>α</i>-pinene (11.01%), and <i>β</i>-pinene (8.08%) were the main ones in the twig oil. As compared with the leaf oil, the twig oil was better in antimicrobial activity. With the same MIC value of 40 mg/mL, the twig oil successfully controlled the growth of Gram (+) bacterium <i>Bacillus subtilis</i>, Gram (-) bacterium <i>Escherichia coli</i>, fungus <i>Aspergillus niger</i>, and yeast <i>Saccharomyces cerevisiae</i>. In addition, both two oil samples have induced antiinflammatory activity with the IC<sub>50</sub> values of 223.7-240.6 mg/mL in NO productive inhibition when BV2 cells had been stimulated by LPS. Docking simulations of four major compounds of <i>U. boniana</i> twig oil on eight relevant antibacterial targets revealed that <i>epi</i>-<i>α</i>-muurolol and <i>α</i>-cadinol are moderate inhibitors of <i>E. coli</i> DNA gyrase subunit B, penicillin binding protein 2X and penicillin binding protein 3 of <i>Pseudomonas aeruginosa</i> with similar free binding energies of -30.1, -29.3, and -29.3 kJ/mol, respectively. Furthermore, <i>in silico</i> ADMET studies indicated that all four docked compounds have acceptable oral absorption, low metabolism, and appropriated toxicological profile to be considered further as drug candidates.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"207-218"},"PeriodicalIF":2.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39610290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hasan Maral, Süleyman Ulupınar, Ayşegül Türk Baydır, Serhat Özbay, Konca Altınkaynak, Engin Şebin, Erdinç Şiktar, Necip Fazıl Kishalı, Yusuf Buzdağlı, Cebrail Gençoğlu, İzzet İnce
{"title":"Effect of <i>Origanum dubium, Origanum vulgare</i> subsp. <i>hirtum, and Lavandula angustifolia</i> essential oils on lipid profiles and liver biomarkers in athletes.","authors":"Hasan Maral, Süleyman Ulupınar, Ayşegül Türk Baydır, Serhat Özbay, Konca Altınkaynak, Engin Şebin, Erdinç Şiktar, Necip Fazıl Kishalı, Yusuf Buzdağlı, Cebrail Gençoğlu, İzzet İnce","doi":"10.1515/znc-2021-0142","DOIUrl":"https://doi.org/10.1515/znc-2021-0142","url":null,"abstract":"<p><p>This study aims to determine the effects of essential oils of <i>Origanum dubium</i> (DUB)<i>, Origanum vulgare</i> subsp. <i>hirtum</i> (HIR), and <i>Lavandula angustifolia</i> (LAV) on lipid profiles and liver biomarkers in athletes. Thirty-four trained athletes were randomly assigned to one of three experimental groups or the control group (CON). The concentrations of serum lipids and liver biomarkers were assessed before and after the 14-day essential oil intervention. Gas chromatography-mass spectrometry analysis showed 68.0 and 82.1% carvacrol in DUB and HIR, respectively, and 34.50% linalyl acetate and 33.68% linalool in LAV essential oils. One-way analysis of covariance (ANCOVA) indicated a significant difference (<i>p</i> = 0.001) among the groups for high-density lipoprotein cholesterol (HDL-C) when the associated preintervention values were used as a covariate. The related pairwise comparisons revealed that DUB (<i>p</i> = 0.001) and HIR (<i>p</i> = 0.024) had greater HDL-C values than CON. From the two-way ANOVA, an interaction between time (before vs. after) and the groups (DUB vs. HIR vs. LAV vs. CON) was found for HDL-C (<i>p</i> = 0.030). Findings indicated a significant increase in DUB (<i>p</i> = 0.0001) and HIR (<i>p</i> = 0.010) for HDL-C, and there was a significant decrease in DUB (<i>p</i> = 0.023) for low-density lipoprotein cholesterol. However, there was no difference in total cholesterol, triglycerides, and all liver biomarkers.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"177-187"},"PeriodicalIF":2.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39396572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of <i>Hypericum perforatum</i> oil and pomegranate seed oil in wound healing: an <i>in vitro</i> study.","authors":"Ebru Uzunhisarcıklı, Mükerrem Betül Yerer","doi":"10.1515/znc-2020-0301","DOIUrl":"https://doi.org/10.1515/znc-2020-0301","url":null,"abstract":"<p><p>This study aimed to investigate the wound-healing efficacy of <i>Hypericum perforatum</i> and pomegranate seed extract oil combined with curcumin as an anti inflammatory agent. A series of experiments were carried out to determine effective concentrations for <i>H. perforatum</i> oil, pomegranate seed extract oil, and curcumin. Ibuprofen was used as a positive control. The wound-healing effects of the applied compounds were tested according to the migration experiment model performed in HaCaT cells. A real-time cell analyzer (xCELLigence) was used to determine the cytotoxic/proliferative effects of <i>H. perforatum</i>, pomegranate seed oil, ibuprofen, and curcumin in HaCaT cells alone and their combined use at specified concentrations. After examining the noncytotoxic concentrations of <i>H. perforatum</i> oil, pomegranate seed oil, curcumin, and ibuprofen, migration experiments were performed to examine the wound healing properties. According to the results, the wound-healing efficacy of curcumin and <i>H. perforatum</i> combination was better than ibuprofen combinations. Also, according to the results, the wound-healing efficacy of curcumin and pomegranate seed oil combination was better than ibuprofen combinations. It was concluded that both oils had improved wound-healing properties in combination with curcumin or Ibuprofen.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"189-195"},"PeriodicalIF":2.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39374420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nursenem Karaca, Görkem Şener, Betül Demirci, Fatih Demirci
{"title":"Synergistic antibacterial combination of <i>Lavandula latifolia</i> Medik. essential oil with camphor.","authors":"Nursenem Karaca, Görkem Şener, Betül Demirci, Fatih Demirci","doi":"10.1515/znc-2020-0051","DOIUrl":"https://doi.org/10.1515/znc-2020-0051","url":null,"abstract":"<p><p>Combination of various compounds and essential oils for pharmaceutical formulations withdraw attention. In this present study, it was aimed to evaluate the <i>in vitro</i> potential synergistic antibacterial effect of <i>Lavandula latifolia</i> (spike lavender) essential oil with camphor by using the checkerboard method against the human pathogens; <i>Staphylococcus aureus</i> and <i>Listeria monocytogenes.</i> Pharmacopoeia quality <i>L. latifolia</i> essential oil and racemic camphor were analyzed and verified by GC-FID and GC/MS, simultaneously. <i>In vitro</i> antibacterial activity of essential oil and camphor (MIC range: 0.16-20 mg/mL) and standard antimicrobial clarithromycin (MIC range: 0.125-16 μg/mL) were carried out by broth microdilution against <i>S. aureus</i> and <i>L. monocytogenes</i> standard strains, respectively. Resulting antibacterial effects were evaluated for their fractional inhibitory concentrations (FICs) as antagonistic, additive and synergistic effects. The analytical results showed that the major component of essential oil was linalool (45.2%) and 1,8-cineole (25.6%). Antibacterial effects of essential oil were determined as MIC 1.25-5 mg/mL. As a result of the experiments, <i>L. latifolia</i> essential oil-camphor combinations were identified as \"synergistic (FIC ≤ 0.5), and additive (0.5 < FIC ≤ 1)\" in the respective combinations, suggesting further evaluation for formulations for potential antimicrobial applications in food and pharmaceuticals.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"169-173"},"PeriodicalIF":2.0,"publicationDate":"2020-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38556540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Structural elucidation and neuroprotective activities of lignans from the flower buds of <i>Magnolia biondii</i> Pamp.","authors":"Qinge Ma, Rongrui Wei, Xiaodong Zhang, Zhipei Sang, Jianghong Dong","doi":"10.1515/znc-2020-0100","DOIUrl":"https://doi.org/10.1515/znc-2020-0100","url":null,"abstract":"<p><p>Two new lignans, 3,4-(10-methoxy-phenylallyl)-9″-((10'-isopropanol-3',4'-furan)-phenylacetyl)-8″-dioxane-7″-O-<i>β</i>-d-glucopyranoside (<b>1</b>), 3,4-benzolactone-9″-((12'-isopropanol-3',4'-furan)-phenylbutenone)-8″-dioxane-7″-O-<i>β</i>-d-glucopyranoside (<b>2</b>), and nine known lignan derivatives (<b>3</b>-<b>11</b>) were isolated from the flower buds of <i>Magnolia biondii</i> Pamp. for the first time. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS data, as well as by comparison with those of the references. Compounds (<b>1</b>-<b>11</b>) were evaluated for their neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells. As a result, compounds <b>1</b>, <b>2</b>, and <b>5</b> exhibited significant neuroprotective activities with IC<sub>50</sub> values in the range of 3.08-6.12 μM.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"147-152"},"PeriodicalIF":2.0,"publicationDate":"2020-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38525316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayorinde V Ogundele, Saikat Haldar, Archana Yadav, Archana M Das
{"title":"<i>Elaeocarpus floribundus</i> Bl. seeds as a new source of bioactive compounds with promising antioxidant and antimicrobial properties.","authors":"Ayorinde V Ogundele, Saikat Haldar, Archana Yadav, Archana M Das","doi":"10.1515/znc-2020-0114","DOIUrl":"https://doi.org/10.1515/znc-2020-0114","url":null,"abstract":"<p><p>The fruits of <i>Elaeocarpus floribundus</i> Bl. (Elaeocarpaceae) are edible and are normally prescribed for treatment of diseases. The medicinal uses of the fruit create considerable quantities of seeds as wastes. In an attempt to valorise this biomass, we studied the antimicrobial and antioxidant activities of the ethanolic seed extract. The extract inhibited the growth of the tested pathogens and was also a very strong scavenger of DPPH free radicals. Consequently, the extract was phytochemically investigated and this study reports the initial isolation of five phenolic compounds from this source. The structures of the isolated compounds were elucidated by spectra analyses including HR-ESI-MS, 1D and 2D NMR experiments. The isolated compounds exhibited a wide range of antimicrobial activities against the tested pathogens. Gallic acid (<b>4</b>) showed the most activity against <i>Bacillus subtilis</i> with a minimum inhibitory concentration (MIC) value of 30 µg/mL, while the MIC values of the antimicrobial standards range between 10 and 35 µg/mL. Compound <b>4</b>, crude ethanolic extract, and the ethyl acetate fraction were more a potent free radical scavenger of DPPH compared to ascorbic acid. Hence, the seeds of <i>E. floribundus</i> could be considered as a new source of bioactive compounds for pharmaceutical and food-related industries.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"141-146"},"PeriodicalIF":2.0,"publicationDate":"2020-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/znc-2020-0114","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38488086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}