Zeitschrift fur Naturforschung. C, Journal of biosciences最新文献_第2页

Elucidating the biodegradation potential of Nudix hydrolase from Bacillus paranthracis via different approaches. 不同途径对副芽孢杆菌Nudix水解酶的生物降解潜力的研究。

IF 2.1

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2026-04-07 DOI: 10.1515/znc-2025-0301

Muhammad Naveed, Nimra Hanif, Minahil Zahid, Muhammad Asjad Haseeb, Maida Salah Ud Din, Muhammad Nouman Majeed, Ayaz Ali Khan, Manal F Elkhadragy, Ashwag Shami, Hayam A Alwabsi

{"title":"Elucidating the biodegradation potential of Nudix hydrolase from Bacillus paranthracis via different approaches.","authors":"Muhammad Naveed, Nimra Hanif, Minahil Zahid, Muhammad Asjad Haseeb, Maida Salah Ud Din, Muhammad Nouman Majeed, Ayaz Ali Khan, Manal F Elkhadragy, Ashwag Shami, Hayam A Alwabsi","doi":"10.1515/znc-2025-0301","DOIUrl":"10.1515/znc-2025-0301","url":null,"abstract":"The Nudix hydrolase from Bacillus paranthracis MBBL1 was investigated using in silico approaches. Polyfluoroalkyl substances (PFAS) are persistent environmental contaminants associated with serious health and ecological risks because of their stable chemical nature and strong resistance to breakdown. The enzyme sequence was retrieved from NCBI (Accession No. MFQ6175622.1), and its secondary structure revealed 33 alpha-helices, 50 beta-strands, and 66 coil regions, suggesting a balanced structural conformation. Tertiary structure prediction using AlphaFold3 achieved a high-confidence model with 94.5 % residues in the most favored regions of the Ramachandran plot and an ERRAT quality score of 96.99 %, validating its stereochemical reliability. Physicochemical profiling indicated a molecular weight of 17 kDa, a theoretical pI of 4.86, and a GRAVY index of -0.245, confirming its hydrophilic and slightly acidic nature. Two active-sites were predicted by PrankWeb, with Pocket 1 showing a high binding score of 6.46. Molecular docking against twelve PFAS derivatives showed favorable binding affinities ranging from -6.4 to -9.5 kcal/mol. Perfluorodecanoic acid demonstrated the strongest interaction (-9.5 kcal/mol), followed by H-PFOS (-9.0 kcal/mol) and perfluorooctanesulfonic acid (-8.8 kcal/mol). Interaction analysis identified key residues such as ALA22, THR40, ASP42, and ASN133 forming multiple hydrogen, halogen, and electrostatic bonds. These findings suggest that Nudix hydrolase may have structural and functional attributes relevant to PFAS biodegradation. Acknowledging the computational nature of this study, experimental validation will be required to confirm biodegradation activity.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of zinc oxide nanoparticles by the aerial part of Artemisia roxburghiana extract and assessment of their biological activities. 刺蒺藜提取物气相部分氧化锌纳米颗粒的合成、表征及生物活性评价。

IF 2.1

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2026-03-13 DOI: 10.1515/znc-2025-0159

Ruchika Sharma, Ghazala Shaheen, Indra Rautela, Sheetal Tyagi, Rakesh Kumar Bachheti, Archana Bachheti, Limenew Abate Worku

{"title":"Synthesis and characterization of zinc oxide nanoparticles by the aerial part of Artemisia roxburghiana extract and assessment of their biological activities.","authors":"Ruchika Sharma, Ghazala Shaheen, Indra Rautela, Sheetal Tyagi, Rakesh Kumar Bachheti, Archana Bachheti, Limenew Abate Worku","doi":"10.1515/znc-2025-0159","DOIUrl":"https://doi.org/10.1515/znc-2025-0159","url":null,"abstract":"The zinc oxide nanoparticle (ZnONPs) used in this study were synthesized using Artemisia roxburghiana extract (aerial part). The absorption peak at 353 nm in UV spectroscopy indicates the production of zinc oxide nanoparticles. The synthesis of ZnONPs using extracts of the aerial part of A. roxburghiana is also supported by FTIR peaks around 622 cm-1. DLS analysis showed the synthesis of A-ZnONPs (zinc oxide nanoparticle synthesized by extracts of aerial part A. roxburghiana) with a particle size of 6-10 nm. XRD pattern's detection of a hexagonal crystal structure of A-ZnONPs. HRTEM image confirming the preparation of irregularly shaped A-ZnONPs. The preparation, capping, and stabilization of A-ZnONPs are facilitated by bioactive compounds in the plant's aerial parts. This gives a plant with high total phenol content (TPC) of 93.4 ± 0.53 μg GAE/mg and total flavonoid content (TFC) of 23.22 ± 0.23 μg CE/mg, both of which are responsible for antioxidant activities. A-ZnONPs exhibited more significant antioxidant activity (IC50 = 147.4 μg/mL) and antibacterial activity against Salmonella abony, Escherichia coli, Bacillus subtilis, and Staphylococcus aureus. A-ZnONPs exhibited improved inhibition as their concentration increased. A maximum inhibition zone of 23 mm is observed for E. coli, suggesting that it has antibacterial and antioxidant properties to combat illnesses.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147477679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical and antibacterial studies of the ethanolic stem barks extract of Anthocleista vogelii planch, and the in silico study of its secondary metabolites on two bacteria strains Staphylococcus aureus and Salmonella typhi. 花青树茎皮乙醇提取物的植物化学和抗菌研究及其对金黄色葡萄球菌和伤寒沙门氏菌次生代谢产物的计算机模拟研究

IF 2.1

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2026-03-12 DOI: 10.1515/znc-2025-0229

Tengu Awazi, Judith Caroline Ngo Nyobe, Baruch Ateba Amana, Clemencia Iwo, Maraf Mbah Bake, Hans Merlin Tsahnang Fofack, Pierre Roger Koliye, Haydar Mohammad-Salim, Jesus Vicente de Julian-Ortiz, Pierre Mkounga

{"title":"Phytochemical and antibacterial studies of the ethanolic stem barks extract of Anthocleista vogelii planch, and the in silico study of its secondary metabolites on two bacteria strains Staphylococcus aureus and Salmonella typhi.","authors":"Tengu Awazi, Judith Caroline Ngo Nyobe, Baruch Ateba Amana, Clemencia Iwo, Maraf Mbah Bake, Hans Merlin Tsahnang Fofack, Pierre Roger Koliye, Haydar Mohammad-Salim, Jesus Vicente de Julian-Ortiz, Pierre Mkounga","doi":"10.1515/znc-2025-0229","DOIUrl":"https://doi.org/10.1515/znc-2025-0229","url":null,"abstract":"This study investigates the phytochemical composition, antibacterial efficacy, and molecular interactions of Anthocleista vogelii stem barks extracts. Phytochemical screening revealed the presence of flavonoids, alkaloids, triterpenes, phenols, saponins, and other bioactive compounds in 95 % ethanol and hydro-ethanol extracts, while coumarins, steroids, and anthraquinones were absent in aqueous extracts. The 95 % ethanol extract demonstrated significant antibacterial activity against Esherichia coli (MIC: 64 μg/mL) and Klebsiella pneumoniae (MIC: 8 μg/mL), with moderate effects against Staphylococcus aureus, A. baumannii, and Salmonella Spp. (MIC: 512 μg/mL). Bactericidal activity (MBC/MIC ≤ 4) paralleled ciprofloxacin, particularly against Gram-positive pathogens. LC-MS analysis identified nine bioactive flavone derivatives, including fabiatrin, kaempferitrin, quercitrin, and naringin. Molecular docking revealed these compounds exhibited superior binding affinities (-6.6 to -11.7 kcal mol-1) to S. aureus and Salmonella typhi targets compared to ciprofloxacin (-3.6 to -5.4 kcal mol-1), forming hydrogen bonds and π-interactions critical for inhibition. ADMET predictions indicated poor gastrointestinal absorption and AMES toxicity risks but favorable plasma protein binding and cardiac safety. Frontier Molecular Orbital (FMO) analysis highlighted quercetin's high reactivity (ΔEgap: 3.70 eV) and naringin's stability. These findings position A. vogelii as a rich source of antimicrobial phytochemicals, though further optimization is needed to address pharmacokinetic limitations.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae). 夹竹桃叶次生代谢物的抗疟原虫和细胞毒活性。

IF 2.1

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2026-02-26 DOI: 10.1515/znc-2025-0209

Aurore M Bella, Guy R Ebede, Gaetan B N Bayiha, Christelle Tsaffo, Lauve R Y Tchokouaha, Rabia Farooq, Fabrice F Boyom, Muhammad I Choudhary, Josephine N Mbing, Joseph T Ndongo, Christian G Bochet, Hartmut Laatsch

{"title":"Antiplasmodial and cytotoxic activities of secondary metabolites from the leaves of Pleiocarpa bicarpellata Stapf (Apocynaceae).","authors":"Aurore M Bella, Guy R Ebede, Gaetan B N Bayiha, Christelle Tsaffo, Lauve R Y Tchokouaha, Rabia Farooq, Fabrice F Boyom, Muhammad I Choudhary, Josephine N Mbing, Joseph T Ndongo, Christian G Bochet, Hartmut Laatsch","doi":"10.1515/znc-2025-0209","DOIUrl":"https://doi.org/10.1515/znc-2025-0209","url":null,"abstract":"Phytochemical studies of the leaves of Pleiocarpa bicarpellata led to the isolation of a new indole C-glycoside, Bicarpellatoside A (1), along with eight known compounds (2-9), including three indoles, two indolines, an iridoid monoterpenoid, a triterpenoid, and a phenolic acid. The structures of all isolated compounds were elucidated using NMR, MS, and IR spectroscopic data, in comparison with the literature. Compounds 1, 3, and 9 are reported in this genus for the first time. In vitro antiplasmodial activity tests were conducted against both chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) strains of Plasmodium falciparum, using the crude extract and isolated compounds 1-4. The crude extract exhibited promising activity, with IC50 values of 4.07 ± 0.78 μg/mL (Dd2) and 4.32 ± 0.42 μg/mL (3D7). Bicarpellatoside A (1) showed good activity, with IC50 values of 2.24 ± 0.05 µM and 2.74 ± 0.05 µM against Dd2 and 3D7 strains of P. falciparum, respectively. Compound 4 showed moderate activity (IC50 of 40.93 ± 3.39 µM and 48.13 ± 5.63 µM on Dd2 and 3D7 strains of P. falciparum, respectively, with a high selectivity index of 34.48, indicating potential for further development. Overall, these findings highlight and confirm the antiplasmodial potential of compounds from P. bicarpellata.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147329162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil. Lepisanthes rubiginosa化学成分及抗胆碱酯酶活性研究Leenh。精油。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-09-19 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0105

Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Abu-Baker M Abdel-Aal

{"title":"Chemical composition and anticholinesterase activity of Lepisanthes rubiginosa (Roxb.) Leenh. essential oil.","authors":"Wan Mohd Nuzul Hakimi Wan Salleh, Nurunajah Ab Ghani, Abu-Baker M Abdel-Aal","doi":"10.1515/znc-2022-0105","DOIUrl":"https://doi.org/10.1515/znc-2022-0105","url":null,"abstract":"Essential oils obtained from medicinal plants show high therapeutic potential against several types of pathologies, including Alzheimer's disease. The purpose of this work was to study the chemical composition and anticholinesterase inhibitory activity of the essential oil obtained from Lepisanthes rubiginosa leaves collected from Malaysia. Twenty-four components were identified using gas chromatography-flame ionization detection (GC-FID) and gas chromatography/mass spectrometry (GC-MS), which represent 99.5% of the essential oil. The identified major components include α-cadinol (40.0%), safrole (12.6%), α-amorphene (9.5%), (E)-isosafrole (5.0%), δ-cadinene (4.2%), and t-muurolol (4.1%). Anticholinesterase activity was assessed using Ellman method, and the essential oil demonstrated a moderate inhibitory activity against acetylcholinesterase (I%: 75.2%) and butyrylcholinesterase (I%: 70.2%) at conconcetration of 1000 μg/mL. The current study is the first to report chemical composition and anticholinesterase activity of the essential oil obtained from L. rubiginosa, which may have implications on the characterization, pharmaceutical, and therapeutic applications of Lepisanthes genus essential oils.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"525-529"},"PeriodicalIF":2.0,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40361510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis of new derivatives containing pyridine, investigation of MAO inhibitory activities and molecular docking studies.

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-07-20 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0075

Derya Osmaniye, Begüm Nurpelin Sağlık, Serkan Levent, Yusuf Özkay, Zafer Asım Kaplancıklı, Gülhan Turan

引用次数: 0

Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues. 甲基乙二醛和高糖抑制VEGFR2特定酪氨酸残基的磷酸化。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-29 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0033

Fabian Betting, Günther Schlunck, Hansjürgen T Agostini, Gottfried Martin

{"title":"Methylglyoxal and high glucose inhibit VEGFR2 phosphorylation at specific tyrosine residues.","authors":"Fabian Betting, Günther Schlunck, Hansjürgen T Agostini, Gottfried Martin","doi":"10.1515/znc-2022-0033","DOIUrl":"https://doi.org/10.1515/znc-2022-0033","url":null,"abstract":"Diabetes is characterized by hyperglycemia and a significant risk of vascular complications. Vascular endothelial growth factor (VEGF) and its main receptor VEGFR2 (KDR), which is highly expressed in vascular endothelial cells, are essential mediators of vascular maintenance and angiogenesis. During glycolysis after high calorie food intake, methylglyoxal (MGO) is formed and MGO blood levels are elevated in diabetes. MGO reacts with arginine residues to generate MG-H1 or with lysine residues to carboxyethyl lysine which are common components of advanced glycation end-products. Therefore, the question arises whether hyperglycemic conditions affect VEGF signaling via a ligand-independent direct modification of signaling components. As a first step, the effect of MGO on VEGFR2 activation was investigated in cultured endothelial cells from human umbilical vein by determination of VEGFR2 phosphorylation at selected tyrosine residues by ELISA and immunoblotting using phospho-specific antibodies. Phosphorylation of VEGFR2-Y996, VEGFR2-Y1054, or VEGFR2-Y1175 reached a maximum 5 min after stimulation of endothelial cells with VEGF. Phosphorylation was significantly inhibited by 100 µM MGO and to a lesser extent by high glucose treatment. 2,3-Pentanedione and glyoxal were investigated for comparison. In summary, VEGFR2 phosphorylation is sensitive to MGO or high glucose concentrations which may be relevant in the pathophysiology of microvascular disease in diabetes.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"493-500"},"PeriodicalIF":2.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40408453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom. 1,2,3-三唑类化合物的合成及构效关系研究。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-29 Print Date: 2022-11-25 DOI: 10.1515/znc-2022-0010

Jenifer Frouche de Souza, Marcos Vinicius da Silva Santana, Ana Cláudia Rodrigues da Silva, Marcio Roberto Henriques Donza, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Eladio Flores Sanchez, Helena Carla Castro, André Lopes Fuly

{"title":"Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom.","authors":"Jenifer Frouche de Souza, Marcos Vinicius da Silva Santana, Ana Cláudia Rodrigues da Silva, Marcio Roberto Henriques Donza, Vitor Francisco Ferreira, Sabrina Baptista Ferreira, Eladio Flores Sanchez, Helena Carla Castro, André Lopes Fuly","doi":"10.1515/znc-2022-0010","DOIUrl":"https://doi.org/10.1515/znc-2022-0010","url":null,"abstract":"Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent in vitro (coagulant, hemolytic, and proteolytic) and in vivo (hemorrhagic, edematogenic, and lethal) activities of Bothrops jararaca venom. The derivatives were synthesized, and had their molecular structures fully characterized by CHN element analysis, Fourier-transform infrared spectroscopy and Nuclear magnetic resonance. The derivatives were incubated with the B. jararaca venom (incubation protocol) or administered before (prevention protocol) or after (treatment protocol) the injection of B. jararaca venom into the animals. Briefly, the derivatives were able to inhibit the main toxic effects triggered by B. jararaca venom, though with varying efficacies, and they were devoid of toxicity through in vivo, in silico or in vitro analyses. However, it seemed that the derivatives AM006 or AM010 inhibited more efficiently hemorrhage or lethality, respectively. The derivatives were nontoxic. Therefore, the 1,2,3-triazole derivatives may be useful as an adjuvant to more efficiently treat the local toxic effects caused by B. jararaca envenoming.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"459-471"},"PeriodicalIF":2.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antidepressant alkaloids from the rhizomes of Corydalis decumbens. 从卧枕连翘根茎中提取抗抑郁生物碱。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-06-24 Print Date: 2022-11-25 DOI: 10.1515/znc-2021-0108

Qin-Ge Ma, Ye Tang, Mao-Hua He, Rong-Rui Wei

引用次数: 0

Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae). 来自小果苣苔的次生代谢物。和佩尔。（蚕豆科）。

IF 2

Zeitschrift fur Naturforschung. C, Journal of biosciences Pub Date : 2022-02-23 Print Date: 2022-05-25 DOI: 10.1515/znc-2021-0239

William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack

{"title":"Secondary metabolites from Detarium microcarpum Guill. and Perr. (Fabaceae).","authors":"William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack","doi":"10.1515/znc-2021-0239","DOIUrl":"https://doi.org/10.1515/znc-2021-0239","url":null,"abstract":"The chemical investigation of the ethanol/water (7:3) extract of the roots of Detarium microcarpum (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (1) and one new ceramide derivative, microcarpamide (2), along with eight known secondary metabolites (3-10) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (3), microcarposide (4), rhinocerotinoic acid (5), 1,7-dihydroxy-6-methylxanthone (6), ursolic acid (7), 3β,23-dihydroxylup-20(29)-en-28-oic acid (8), alphitolic acid (9), and stigmasterol glucoside (10). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds 3 and 4 are known, their crystalline structures are reported here for the first time. These compounds were evaluated in vitro for their antisalmonella activity. The results obtained showed that, microcarpamide (2), microcarposide (4), and rhinocerotinoic acid (5) were moderately active against three salmonella strains: Salmonella typhi, Salmonella enteritidis and Salmonella typhimirium, with minimum inhibition concentration values of 76.7 and 153.5 μM.","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"253-261"},"PeriodicalIF":2.0,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39960196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2