{"title":"New compounds from <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp.","authors":"Mohamed Shaaban","doi":"10.1515/znc-2021-0236","DOIUrl":null,"url":null,"abstract":"<p><p>Further investigation of the residual bioactive compounds produced by the soft coral <i>Sarcophyton glaucom</i>-derived <i>Penicillium</i> sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (<b>1</b>), 9-methoxy-penicyrone B (<b>2</b>), 3-hydroxy-2,2,4-trimethyl-pentyl ester (<b>3</b>), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (<b>4</b>), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (<b>5</b>). Additional six known compounds were isolated: penicyrones A-B (<b>6</b>, <b>7</b>), 4-(2-hydroxy-3-butynoxy)benzoic acid (<b>8</b>), cyclopenol (<b>9</b>), aspermytin A (<b>10</b>), and aurantiomide A (<b>11</b>). Structures of the new compounds (<b>1-5</b>) were identified by 1D (<sup>1</sup>H & <sup>13</sup>C) and 2 D (<sup>1</sup>H-<sup>1</sup>H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.</p>","PeriodicalId":49344,"journal":{"name":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2021-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift Fur Naturforschung Section C-A Journal of Biosciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/znc-2021-0236","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/7/26 0:00:00","PubModel":"Print","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 1
Abstract
Further investigation of the residual bioactive compounds produced by the soft coral Sarcophyton glaucom-derived Penicillium sp. MMA afforded five new compounds assigned as 9-methoxy-penicyrone A (1), 9-methoxy-penicyrone B (2), 3-hydroxy-2,2,4-trimethyl-pentyl ester (3), 3-hydroxy-1-isopropyl-2,2-dimethyl-propyl ester (4), and 3-isobutyryloxy-2,2,4-trimethyl-pentyl linoleate (5). Additional six known compounds were isolated: penicyrones A-B (6, 7), 4-(2-hydroxy-3-butynoxy)benzoic acid (8), cyclopenol (9), aspermytin A (10), and aurantiomide A (11). Structures of the new compounds (1-5) were identified by 1D (1H & 13C) and 2 D (1H-1H COSY, HMBC and NOESY) NMR and HRESI-MS spectroscopic data. Biologically, the antimicrobial activities of the obtained compounds were studied as well.
期刊介绍：
A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) is an international scientific journal and a community resource for the emerging field of natural and natural-like products. The journal publishes original research on the isolation (including structure elucidation), bio-chemical synthesis and bioactivities of natural products, their biochemistry, pharmacology, biotechnology, and their biological activity and innovative developed computational methods for predicting the structure and/or function of natural products. A Journal of Biosciences: Zeitschrift für Naturforschung C (ZNC) welcomes research papers in fields on the chemistry-biology boundary which address scientific ideas and approaches to generate and understand natural compounds on a molecular level and/or use them to stimulate and manipulate biological processes.
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