William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack
{"title":"Secondary metabolites from <i>Detarium microcarpum</i> Guill. and Perr. (Fabaceae).","authors":"William Fouatio Feudjou, Arnaud Michel Mbock, Valerie Tedjon Sielinou, Hugue Fouotsa, Steven Collins Njonté Wouamba, Racéline Kamkumo Gounoue, Marcel Freeze, Hans-Georg Stammler, Jean Jules Kezeutas Bankeu, Mkounga Pierre, Bruno Ndjakou Lenta, Alembert Tiabou Tchinda, Norbert Sewald, Augustin Ephrem Nkengfack","doi":"10.1515/znc-2021-0239","DOIUrl":null,"url":null,"abstract":"<p><p>The chemical investigation of the ethanol/water (7:3) extract of the roots of <i>Detarium microcarpum</i> (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (<b>1</b>) and one new ceramide derivative, microcarpamide (<b>2</b>), along with eight known secondary metabolites (<b>3-10</b>) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (<b>3</b>), microcarposide (<b>4</b>), rhinocerotinoic acid (<b>5</b>), 1,7-dihydroxy-6-methylxanthone (<b>6</b>), ursolic acid (<b>7</b>), 3<i>β</i>,23-dihydroxylup-20(29)-en-28-oic acid (<b>8</b>), alphitolic acid (<b>9</b>), and stigmasterol glucoside (<b>10</b>). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds <b>3</b> and <b>4</b> are known, their crystalline structures are reported here for the first time. These compounds were evaluated <i>in vitro</i> for their antisalmonella activity. The results obtained showed that, microcarpamide (<b>2</b>), microcarposide (<b>4</b>), and rhinocerotinoic acid (<b>5</b>) were moderately active against three salmonella strains: <i>Salmonella typhi</i>, <i>Salmonella enteritidis</i> and <i>Salmonella typhimirium</i>, with minimum inhibition concentration values of 76.7 and 153.5 μM.</p>","PeriodicalId":520830,"journal":{"name":"Zeitschrift fur Naturforschung. C, Journal of biosciences","volume":" ","pages":"253-261"},"PeriodicalIF":0.0000,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Naturforschung. C, Journal of biosciences","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1515/znc-2021-0239","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/5/25 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 2
Abstract
The chemical investigation of the ethanol/water (7:3) extract of the roots of Detarium microcarpum (Fabaceae) led to the isolation of one new labdane diterpenoid, microcarpin (1) and one new ceramide derivative, microcarpamide (2), along with eight known secondary metabolites (3-10) including, 5-(carboxymethyl)-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydronaphthalene-1-carboxylic acid (3), microcarposide (4), rhinocerotinoic acid (5), 1,7-dihydroxy-6-methylxanthone (6), ursolic acid (7), 3β,23-dihydroxylup-20(29)-en-28-oic acid (8), alphitolic acid (9), and stigmasterol glucoside (10). The structures of these compounds were elucidated based on their spectroscopic data. Although compounds 3 and 4 are known, their crystalline structures are reported here for the first time. These compounds were evaluated in vitro for their antisalmonella activity. The results obtained showed that, microcarpamide (2), microcarposide (4), and rhinocerotinoic acid (5) were moderately active against three salmonella strains: Salmonella typhi, Salmonella enteritidis and Salmonella typhimirium, with minimum inhibition concentration values of 76.7 and 153.5 μM.
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