Caterina Antonaglia, Gloria Maria Citton, Matteo Siciliano, Barbara Ruaro, Francesco Salton, Marco Confalonieri
{"title":"Obstructive Sleep Apnea Syndrome in women: gender in sleep respiratory medicine is a first step towards personalized medicine.","authors":"Caterina Antonaglia, Gloria Maria Citton, Matteo Siciliano, Barbara Ruaro, Francesco Salton, Marco Confalonieri","doi":"10.1007/s11325-025-03420-1","DOIUrl":"10.1007/s11325-025-03420-1","url":null,"abstract":"<p><p>Obstructive sleep apnea syndrome is the most common sleep disordered breathing. In recent years, literature has focused on the anatomical and functional factors in the pathophysiology of patients to better understand their clinical and polysomnographic features, aiming for personalized treatment. Studies suggest that sleep-disorders breathing in women are underestimated and associated with cardiovascular and metabolic disorders. Women tend to experience more mood disorders and behavioral symptoms, leading to a reduced quality of life. The sleep and respiratory pathophysiology in women are complex and varies with age and hormonal status. This review summarizes recent knowledge on this topic, emphasizing the pathophysiological mechanisms to explain the typical clinical and polysomnographic patterns observed in females. In sleep respiratory medicine, gender- specific approaches are now essential for personalized patient care.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"250"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of obstructive sleep apnea syndrome in sarcoidosis patients: a clinical and polysomnographic analysis.","authors":"Nigar Aliyeva, Aytan İsmayilova, Buket Çalişkaner Öztürk, Günay Can, Ersan Atahan","doi":"10.1007/s11325-025-03375-3","DOIUrl":"10.1007/s11325-025-03375-3","url":null,"abstract":"<p><strong>Background: </strong>While some studies suggest an elevated risk of obstructive sleep apnea (OSA) in sarcoidosis, comprehensive research remains limited. This study aims to assess the prevalence of OSA among sarcoidosis patients, compare its occurrence with the general population, and evaluate the clinical and polysomnographic features of sarcoidosis patients diagnosed with OSA.</p><p><strong>Methods: </strong>This prospective observational study identified 150 out of 290 sarcoidosis-diagnosed patients with OSA symptoms. Of these, 52 underwent polysomnography (PSG), and 45 patients with an Apnea-Hypopnea Index (AHI) ≥ 5 events/hour were included. The control group consisted of 48 OSA patients without lung disease history who had previously undergone PSG. Demographic, anthropometric, clinical, and polysomnographic parameters were compared between groups. Respiratory function test results and pulmonary involvement were also analyzed for sarcoidosis patients.</p><p><strong>Results: </strong>Ninety-three patients (45 sarcoidosis, 48 controls) were included. Sarcoidosis patients had a mean age of 50.7 ± 9.5 years, with 68.8% female and 55.5% obese. Pulmonary involvement was observed in 20%, and 62.5% of actively treated patients received corticosteroids. The median AHI and ODI values for sarcoidosis patients were 17.9 and 13.5, respectively. Supine apnea count was significantly higher in sarcoidosis patients (p = 0.003). N3 sleep stage proportion was significantly lower in severe OSA (p = 0.006). Pulmonary involvement increased with OSA severity: 2.2% in mild, 6.6% in moderate, and 11.1% in severe cases.</p><p><strong>Conclusion: </strong>OSA is a common comorbidity in sarcoidosis; warranting further investigation to optimize management in this population.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"251"},"PeriodicalIF":2.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Obesity hypoventilation syndrome and risk of road traffic accidents.","authors":"Gulfem Ozduygu, Esen Kiyan, Aylin Pihtili, Felemez Arslan, Zuleyha Bingol, Gulfer Okumus","doi":"10.1007/s11325-025-03378-0","DOIUrl":"10.1007/s11325-025-03378-0","url":null,"abstract":"<p><strong>Purpose: </strong>The relationship between obesity hypoventilation syndrome (OHS) and traffic accidents has not been previously studied. We aimed to determine the frequency of traffic accidents and the associated risk factors among people with OHS and compare with obstructive sleep apnoea (OSA) individuals.</p><p><strong>Methods: </strong>We screened patients diagnosed with OSA and/or OHS in our sleep laboratory between 2015 and 2023. Patients who had a driver's license, had been driving for at least five years, at least three days a week, and drove more than 5000 km/year and had not received positive airway pressure treatment prior to their diagnosis were included. Polysomnographic data, the Epworth Sleepiness Scale (ESS), the Berlin Sleep Questionnaire were collected from the records. The Fatigue Assessment Scale (FAS) and inattention scores before the diagnosis, driving information and accident numbers from the three years before the diagnosis to the phone call were evaluated.</p><p><strong>Results: </strong>A total of 121 patients (OHS/OSA: 43/78, F/M: 5/116, age: 46.9 ± 9.7 years, body mass index [BMI]: 32.5 ± 5.7 kg/m²) were included. ESS, FAS, apnoea-hypopnea index (AHI), oxygen desaturation index (ODI) and percentage of total sleep time with SpO<sub>2</sub> less than 90% were significantly greater in OHS patients (p = 0.012, p = 0.028, p = 0.003, p = 0.002 and p = 0.021, respectively). The frequency of accidents was greater in OHS patients than in OSA patients (46.5% vs. 26.9%, p = 0.029). In the multivariate analysis, only BMI was an independent factor (OR: 1.185, 95% CI: 1.005-1.396, p = 0.044).</p><p><strong>Conclusion: </strong>Traffic accidents were more common in OHS patients than in OSA patients, with obesity as the primary independent risk factor.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"247"},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is vaping e-cigarettes associated with sleep duration in US young adults? evidence from the 2022 BRFSS.","authors":"Wei Li, Ebbie Kalan, Rime Jebai, Anthony J Kondracki, Olatokunbo Osibogun","doi":"10.1007/s11325-025-03389-x","DOIUrl":"10.1007/s11325-025-03389-x","url":null,"abstract":"<p><strong>Background: </strong>The increasing use of e-cigarettes and the decline in sleep duration among young people are growing public health concerns. While cigarette smoking has been linked to shorter sleep duration, less is known about the effects of e-cigarettes. This study explores the association between exclusive e-cigarette use and sleep duration among US young adults aged 18-24 who only use e-cigarettes.</p><p><strong>Methods: </strong>We analyzed data from 26,943 young adults in the 2022 Behavioral Risk Factor Surveillance System survey. Sleep duration was categorized as short (< 7 h/24 hours), normal (7-9 h), or long (> 9 h). We excluded participants using any tobacco/nicotine products other than e-cigarettes and restricted the sample to 4,553 young adults with complete data. Logistic regression models assessed e-cigarette use status (i.e., current use, past use, and non-use) in relation to sleep duration, adjusting for demographics, current substance use, lifestyle factors, and health conditions.</p><p><strong>Results: </strong>Overall, 31.9% of young adults experienced short sleep duration, 63.2% reported normal sleep, and 4.9% had long sleep. Current e-cigarette users had a higher prevalence of short sleep duration (44.6%) than past users (33.0%) and non-users (27.4%; p-value < 0.001). Weighted analyses indicated that current e-cigarette use was significantly associated with short sleep duration (adjusted OR = 1.82; 95%CI: 1.30-2.54), but no significant associations were found with long sleep duration (all p-values > 0.05).</p><p><strong>Conclusions: </strong>Current exclusive e-cigarette use is associated with short sleep duration among US young adults. Efforts to reduce e-cigarette use in this population may contribute to improved sleep health.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"248"},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12376356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicholas R Lenze, Dania Alazawi, Meghan Dailey, Christopher Brown, Paul T Hoff, Cathy A Goldstein
{"title":"Evaluating changes in hypoglossal nerve stimulator use over time and long-term adherence.","authors":"Nicholas R Lenze, Dania Alazawi, Meghan Dailey, Christopher Brown, Paul T Hoff, Cathy A Goldstein","doi":"10.1007/s11325-025-03415-y","DOIUrl":"10.1007/s11325-025-03415-y","url":null,"abstract":"<p><strong>Purpose: </strong>Evaluate patient phenotypes and longitudinal patterns of hypoglossal nerve stimulator (HGNS) use and identify predictors of long-term HGNS adherence.</p><p><strong>Methods: </strong>Patients who underwent HGNS implantation for obstructive sleep apnea (OSA) from 2017 to 2023 and had available data through 9 months post-device activation were included. Adherence rate was defined as percentage of patients using the device for at least 4 h for 70% of nights. Repeated measures ANOVA and Cochran's Q tests were used to analyze changes in HGNS use over time. A k-means clustering analysis was used to identify HGNS user subgroups with shared characteristics and associations with HGNS use.</p><p><strong>Results: </strong>A total of 59 patients were included, with a mean (SD) age of 62.7 (11.2) years, mean (SD) body mass index of 28.5 kg/m2 (3.2), and an average pre-operative apnea-hypopnea index (AHI) of 38.7 events/hour; the majority were male (78%) and White (98.3%). Patients used their HGNS devices on average for 81.1% of nights (SD 23.5%) and 362 min/night (SD 115), with 0.96 (SD 1.4) pauses/night at 9 months post-activation. The mean percentage of nights and the time/night used decreased significantly over the first 9 months (p < 0.001 for both), while pauses/night increased (p = 0.008). The estimated adherence rate was 52.5% at 9 months. The cluster analysis revealed subgroups with shared characteristics; however, clusters were not associated with HGNS use.</p><p><strong>Conclusions: </strong>HGNS use appears to decrease over the first nine months after activation. Additional research is warranted to investigate drivers of HGNS use decrement. Given lack of a standardized definition for adherence, future studies should report more granular HGNS use metrics to facilitate comparison across studies.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"249"},"PeriodicalIF":2.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Real-world status of continuous positive airway pressure (CPAP) persistence in patients with sleep apnea syndrome (SAS): a retrospective longitudinal study of administrative claims data in Japan.","authors":"Hiroyuki Takahashi, Shiori Yoshida, Akihiro Nakajima, Ruriko Koto, Hideaki Nakayama","doi":"10.1007/s11325-025-03417-w","DOIUrl":"10.1007/s11325-025-03417-w","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the real-world status of continuous positive airway pressure (CPAP) persistence in patients with sleep apnea syndrome (SAS) using administrative claims data in Japan.</p><p><strong>Methods: </strong>We designed a retrospective longitudinal study using administrative claims and medical check-up data collected from April 2014 to February 2022. We identified patients newly starting CPAP therapy as their first-line SAS treatment, and assessed patient characteristics, CPAP persistence rates, predictors of CPAP discontinuation, and second-line therapy options.</p><p><strong>Results: </strong>The analysis population (n = 13,007) was 76.2% male, and the mean age (± standard deviation) was 64.0 ± 15.0 years. CPAP persistence rates were 90.1% at 90 days, 77.1% at one year, 70.3% at two years, and 66.5% at three years. More discontinuation was noted in patients aged 18 to 44 (adjusted hazard ratio [95% confidence interval]: 1.27 [1.13-1.42]) and ≥ 65 (65-74 years, 1.18 [1.07-1.30]; ≥75 years, 1.59 [1.43-1.76]) than in those aged 45 to 64. Comorbidities of dementia (1.47 [1.25-1.73]), insomnia (1.26 [1.16-1.36]), and restless legs syndrome (RLS, 1.60 [1.16-2.23]) were also associated with more discontinuation. Testing with a Type 3 portable monitor (1.31 [1.21-1.42]), or no record of sleep testing before therapy (1.21 [1.09-1.36]), tended to be associated with more discontinuation than polysomnography. CPAP therapy starting in 2020 (0.72 [0.63-0.82]) and 2021 (0.63 [0.46-0.85]) resulted in better persistence than that starting in 2016. Only 6.1% of patients received second-line therapy after CPAP discontinuation.</p><p><strong>Conclusions: </strong>CPAP therapy was continued for at least a year by about 80% of patients. Because second-line therapies are rarely implemented, efforts are needed to ensure CPAP persistence by considering the factors that influence it. It is also crucial to raise awareness of alternative therapies.</p><p><strong>Registration number: </strong>NA.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"245"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Declining spirometry values associated with development of sleep disordered breathing in old age.","authors":"Donald L Bliwise, Cosmo Fowler","doi":"10.1007/s11325-025-03416-x","DOIUrl":"10.1007/s11325-025-03416-x","url":null,"abstract":"","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"246"},"PeriodicalIF":2.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Using short video-based educational intervention to enhance initial acceptance to continuous positive pressure therapy in Thai obstructive sleep apnea patients in a tertiary care: a randomized controlled trial.","authors":"Jindapa Srikajon, Chawanont Pimolsri, Chatchawan Rattanabannakit, Wattanachai Chotinaiwattarakul","doi":"10.1007/s11325-025-03419-8","DOIUrl":"10.1007/s11325-025-03419-8","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) is a prevalent condition associated with decreased quality of life and increased risk of cardiovascular complications. Continuous positive airway pressure (CPAP) therapy is the gold standard treatment, particularly in moderate to severe OSA. Its effectiveness depends on patient adherence, with compliance rates ranging from 46 to 83%. Various strategies, including education, cognitive behavioral therapy, and supportive care, aim to improve CPAP adherence. This study evaluated the effectiveness of a low-cost, time-efficient video-based educational intervention to enhance CPAP compliance.</p><p><strong>Methods: </strong>Patients diagnosed with moderate to severe OSA or mild OSA who fulfilled the indication for CPAP therapy in Siriraj Hospital between December 1st, 2022, and May 31st, 2023, age ≥ 18 years, were randomized into the three-minute video intervention group, based on Albert Bandura's social cognitive theory, and usual care group using a simple random sampling method. Demographics, Epworth Sleepiness Scale scores (ESS), polysomnographic data, and CPAP usage were recorded.</p><p><strong>Results: </strong>Of the 132 subjects in this study, the majority were male, with an average age of 50 and comparable body mass index (BMI) and baseline ESS in both groups. We found a significantly higher percentage meeting the Centers for Medicare & Medicaid Services (CMS) criteria for adherence in the video education group (68.2%, vs. 50%; p = 0.034) compared to the usual care group. Moreover, in our post-hoc analysis, higher education years and lower BMI were associated with better CPAP adherence.</p><p><strong>Conclusion: </strong>Our data demonstrated a promising result of using a short-formed video education intervention to enhance CPAP usage in OSA patients. Longer-term studies with a larger population would provide more reliable outcomes. This trial was retrospectively registered with Thaiclinicaltrials.org. The trial registration number (TRN) was TCTR20240619006, and the registration date is 18 June 2024.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"244"},"PeriodicalIF":2.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judy Easow, Tulasiram Bommasamudram, Madhavi Munnilari, Ragini Adhikari, Ben J Edwards, Kirtana Raghurama Nayak, K Vaishali, Aishwarya Ravindrakumar, Chloe Gallagher, Samuel A Pullinger
{"title":"Implications of sleep loss or sleep deprivation on muscle strength: a systematic review.","authors":"Judy Easow, Tulasiram Bommasamudram, Madhavi Munnilari, Ragini Adhikari, Ben J Edwards, Kirtana Raghurama Nayak, K Vaishali, Aishwarya Ravindrakumar, Chloe Gallagher, Samuel A Pullinger","doi":"10.1007/s11325-025-03413-0","DOIUrl":"10.1007/s11325-025-03413-0","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this review was to evaluate the current evidence regarding the impact of sleep deprivation (SD) on strength performance.</p><p><strong>Methods: </strong>An English-language literature search revealed 514 articles through primary database searches, and 563 via organization searches/citation searching. The inclusion criteria were met by thirteen articles which were included in the review. The inclusion criteria set were healthy male and/or female adult participants, a sleep loss condition (e.g. SD or partial sleep deprivation), strength measures (e.g. back strength or leg strength or grip strength), and a peer-reviewed academic paper counterbalanced and/or or randomised in design.</p><p><strong>Results: </strong>The systematic review identified a total of 13 studies that met the inclusion criteria. Some studies reported a negative impact of SD on strength performance, while others showed no significant differences following a night of SD. Both acute and chronic SD were found to result in some measures of muscle strength, power output, and muscular endurance to be significantly reduced. Additionally, impaired neuromuscular function and increased fatigue were commonly observed in sleep-deprived individuals.</p><p><strong>Conclusion: </strong>The findings of this systematic review highlight the detrimental effects of SD on strength performance. Individuals involved in strength-based activities should prioritize adequate sleep to optimize their physical performance. Further research is needed to explore the underlying mechanisms linking SD and strength impairment, as well as to investigate potential interventions to mitigate these effects. Sleep hygiene education and interventions targeting sleep duration and quality should be implemented to promote optimal strength and performance outcomes. Future research should focus on understanding the mechanisms behind these effects and developing effective interventions to mitigate the adverse consequences of SD on muscle function.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"242"},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karin Jeppesen, Asbjørn Kørvel-Hanquist, Donna Lykke Wolff, Sofie Ronja Petersen, Preben Homøe, Eva Kirkegaard Kiær, Poul Jørgen Jennum, Helene Skjøt-Arkil
{"title":"Patterns and stability of long-term adherence in continuous positive airway pressure therapy for obstructive sleep apnea: a cohort study.","authors":"Karin Jeppesen, Asbjørn Kørvel-Hanquist, Donna Lykke Wolff, Sofie Ronja Petersen, Preben Homøe, Eva Kirkegaard Kiær, Poul Jørgen Jennum, Helene Skjøt-Arkil","doi":"10.1007/s11325-025-03418-9","DOIUrl":"10.1007/s11325-025-03418-9","url":null,"abstract":"<p><strong>Purpose: </strong>• Despite being the gold standard for treating obstructive sleep apnea (OSA), continuous positive airway pressure (CPAP) therapy faces a persistent challenge: patient adherence. This study aimed to investigate long-term adherence and stabilisation patterns after initiating CPAP therapy.</p><p><strong>Methods: </strong>• We conducted a multicenter cohort study using tele-monitored CPAP data from adult patients treated for at least 24 months at two Danish sleep clinics. These data were combined with local hospital administrative data and national registry data.</p><p><strong>Results: </strong>• The study included data from 1,907 OSA patients who had initiated CPAP. The median age was 55 years (SD 12.5), and 26% were females. After long-term CPAP therapy, 45% of the OSA patients had achieved high adherence to CPAP, while 39% were CPAP non-adherent, and 16% of the patients were in the low-adherent group. The probability of high adherence after two years was 79% if the patient achieved high adherence within the first month. All groups showed stability within the first three months after CPAP initiation, particularly for the CPAP non-adherent patients and the patients with high adherence.</p><p><strong>Conclusion: </strong>• We found that less than half of the OSA patients achieved high adherence to CPAP therapy 24 months after CPAP initiation. Patients who achieved high adherence within the first month were more likely to maintain it.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"243"},"PeriodicalIF":2.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}