Sleep & breathing = Schlaf & Atmung最新文献

{"title":"Distinct EEG spectral and functional connectivity patterns in obstructive sleep apnea patients with excessive daytime sleepiness.","authors":"Menglong Dong, Mengmeng Fan, Yi Wang, Zhifeng Lin, Xianchao Zhao, Guoyan Chen, Liping Zhang, Changjun Su, Jin-Xiang Cheng","doi":"10.1007/s11325-025-03411-2","DOIUrl":"10.1007/s11325-025-03411-2","url":null,"abstract":"<p><strong>Purpose: </strong>The study investigated the differences in sleep electroencephalography characteristics between obstructive sleep apnea (OSA) patients with and without excessive daytime sleepiness (EDS), aiming to explore mechanisms underlying the development of EDS in OSA.</p><p><strong>Methods: </strong>Sixty-one adult OSA patients were divided into OSA + EDS and OSA - EDS groups based on the Epworth Sleepiness Scale (ESS). Electroencephalography (EEG) data were analyzed for power spectral density (PSD) and functional connectivity using coherence and weighted phase lag index (wPLI).</p><p><strong>Results: </strong>Compared to the OSA - EDS group, the OSA + EDS group exhibited: (1) More severe nocturnal hypoxia during non-rapid eye movement (NREM) sleep; (2) Increased gamma band PSD during NREM stages 1-2; (3) Enhanced wPLI in the delta band during NREM stage 1 and wakefulness, correlated positively with the severity of OSA.</p><p><strong>Conclusions: </strong>OSA patients with EDS show distinct neurophysiological patterns characterized by gamma hyperactivation during light sleep and compensatory delta-band synchronization during sleep-wake transition phase. Respiratory events may disrupt EEG dynamics in specific frequency bands, contributing to sleep instability and EDS. These findings highlight the importance of NREM sleep disruption and support tailored therapeutic interventions targeting cortical instability in OSA patients with persistent EDS.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"261"},"PeriodicalIF":2.0,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior cruciate ligament injury risk according to sleep quality in female college students.","authors":"Ji-Hoon Cho, Eunjae Lee, Seung-Taek Lim, Sang-Won Seo","doi":"10.1007/s11325-025-03431-y","DOIUrl":"10.1007/s11325-025-03431-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine the risk of anterior cruciate ligament (ACL) injury in female college students according to sleep quality and use this information to prevent injury.</p><p><strong>Methods: </strong>Twenty-six female university students were recruited for the present study. Participants underwent assessments for sleep quality, landing error scoring system (LESS), and electromyographic (EMG) activity for imbalances by comparing the muscle activity of the left and right rectus femoris (RF-to-RF) and biceps femoris (BF-to-BF) muscles.</p><p><strong>Results: </strong>The good sleep group exhibited significantly lower LESS scores (good sleep group: 5.13 ± 1.46, poor sleep group: 7.09 ± 1.38, p = 0.004). Additionally, the EMG activity of the RF-to-RF (good sleep group: 20.82 ± 20.29, poor sleep group: 41.74 ± 24.76, p = 0.019) and the EMG activity of the BF-to-BF (good sleep group: 27.09 ± 25.40, poor sleep group: 109.92 ± 93.43, p = 0.001) were significantly lower in the good sleep group. In all participants, a positive correlation was found between the PSQI total score and EMG activity of BF-to-BF (r = 0.446, p < 0.05), as well as the LESS score and EMG activity of BF-to-BF (r = 0.601, p < 0.01).</p><p><strong>Conclusion: </strong>This study demonstrated the relationship between sleep quality and ACL injury risk factors among female university students. We strongly recommend that these students improve their sleep quality to reduce and prevent ACL risk.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"260"},"PeriodicalIF":2.0,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of switching from continuous positive airway pressure to bilevel positive airway pressure on symptoms of continuous positive airway pressure-related aerophagia: an observational study part two of a two-part series.","authors":"Takero Fukutome","doi":"10.1007/s11325-025-03423-y","DOIUrl":"10.1007/s11325-025-03423-y","url":null,"abstract":"<p><strong>Purpose: </strong>Aerophagia occurring during continuous positive airway pressure (CPAP) (C-aerophagia) in patients with obstructive sleep apnea can impede treatment. This study aimed to evaluate the use of bilevel positive airway pressure (BiPAP) for managing C-aerophagia.</p><p><strong>Methods: </strong>Fifty-one patients newly diagnosed with C-aerophagia who switched from CPAP to auto-BiPAP were monitored. Assessment criteria included flatulence, eructation, abdominal bloating, quantitative evaluation, and onset time. BiPAP effectiveness was categorized as excellent-E (no criteria met), slight-E (partially met), or poor-E (criteria met). C-aerophagia discomfort, including residual cases on BiPAP, was rated via a visual analog scale (VAS; 0 = none, 10 = extreme). Satisfaction with BiPAP was evaluated as positive or negative.</p><p><strong>Results: </strong>BiPAP effectiveness was excellent in 80.4%, slight in 4.0%, and poor in 15.7% of the patients. The VAS scores decreased significantly with BiPAP compared with those with CPAP (p < 0.001). In the poor-E group, five patients reported positive satisfaction with BiPAP and showed reduced VAS scores. A reduction in 90th percentile expiratory positive airway pressure (EPAP) compared with the 90th-95th percentile pressure of CPAP was associated with resolved C-aerophagia, indicating that reducing expiratory pressure while maintaining airway patency is essential. However, eight patients with EPAP ≤ 6.5 cmH₂O experienced C-aerophagia, probably due to upper esophageal sphincter relaxation, indicating that alternative treatments are needed.</p><p><strong>Conclusion: </strong>BiPAP completely or partially resolved C-aerophagia symptoms in 84.3% of the patients. Among patients with residual symptoms, 62.5% (5/8) reported reduced discomfort and expressed satisfaction. Its effectiveness is likely due to lower expiratory pressure; however, in some cases, it remains challenging.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"258"},"PeriodicalIF":2.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Preliminary Integrated Metabolomics Analysis Identifies Retrograde Endocannabinoid Signaling Shift in Severe OSA Patients.","authors":"Li Han, Jinjin Liu, Juan Xu, Xiaoyan Li, Rui Chen","doi":"10.1007/s11325-025-03425-w","DOIUrl":"10.1007/s11325-025-03425-w","url":null,"abstract":"<p><strong>Purpose: </strong>The systemic influence of obstructive sleep apnea(OSA), particularly in those with severe OSA (sOSA), has frequently been disregarded. An investigation was conducted to examine the variations of reactive oxygen species (ROS) and metabolomic drifts, as well as their interrelations, in adult OSA patients.</p><p><strong>Methods: </strong>A total of 22 male patients were enrolled after undergoing polysomnography (PSG), and blood samples were obtained. Following the measurement of ROS levels in polymorphonuclear neutrophils (PMNs), plasma samples were combined and analyzed using both Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS).</p><p><strong>Results: </strong>Patients with sOSA had a higher body mass index (BMI) (p = 0.005) and more negative PSG measures compared to those with mild/moderate OSA (mOSA). Although there was no remarkable difference in neutrophil ROS between the mOSA and sOSA group, further analysis indicated sleep fragmentation was associated with ROS production(p = 0.043 for N3%, p < 0.01 for Arousal Index). Integrated metabolomics analysis revealed significant alterations in 59 metabolites from GC-MS and 27 metabolites from LC-MS in sOSA patients. These substantial changes perturbed various pathways, including the FoxO signaling pathway and its upstream PI3K-Akt signaling pathway, and so on. Notably, the retrograde endocannabinoid signaling pathway was the sole common pathway identified in both GC-MS and LC-MS data.</p><p><strong>Conclusions: </strong>This study sheds light on the systemic impact of OSA, particularly in severe cases, by uncovering extensive disturbance of metabolic pathways. The identification of retrograde endocannabinoid signaling shifts in severe OSA adults highlights its potential impact in the sleep disorder and its broader repercussions in the body.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"259"},"PeriodicalIF":2.0,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled trial comparing treatment efficacy between rapid maxillary expansion and adenotonsillectomy in pediatric obstructive sleep apnea.","authors":"Chalermthai Aksilp, Pattaralapa Pechpongsai, Pavinee Intakorn, Chaiyapol Chaweewannakorn, Supatchai Boonpratham, Yodhathai Satravaha, Niwat Anuwongnukroh, Supakit Peanchitlertkajorn","doi":"10.1007/s11325-025-03427-8","DOIUrl":"10.1007/s11325-025-03427-8","url":null,"abstract":"<p><strong>Purpose: </strong>Adenotonsillectomy (AT) is usually recommended as the first-line therapy for pediatric obstructive sleep apnea (POSA). While AT treats soft tissue obstruction, it does not address the underlying skeletal abnormalities, such as maxillary constriction. Despite growing evidence supporting RME as a treatment option for POSA, a significant research gap remains. Therefore, we conducted a randomized controlled trial to compare treatment efficacy between RME and AT.</p><p><strong>Methods: </strong>This study recruited 24 children diagnosed with POSA and presented with concurrent significant adenotonsillar hypertrophy and transverse maxillary deficiency. Participants were randomly assigned to either AT or RME for treatment. All participants underwent Type I PSG at baseline and 6 months post-treatment. Additional assessments included dental and cephalometric analyses, the pediatric sleep questionnaire (PSQ), and the OSA-18 questionnaire. Baseline and endpoint comparisons between the two treatment groups were performed.</p><p><strong>Results: </strong>The median baseline AHI for the AT and RME groups was 7.0 (5.25-9.9) and 6.85 (5.6-8.05) events/hour, respectively. There was no significant difference between treatment groups in all parameters at baseline. The comparisons between pre- and post-treatment results showed significant improvements across multiple parameters, including AHI for both AT and RME. There was no significant difference in PSG parameters (AHI, LSAT, MSAT, and REM sleep time) and cure rate between RME and AT. The post-treatment AHI for the AT and RME groups was 1.4 (0.7-1.85) and 2.3 (1.15-5.7) events/hour, respectively. However, PSQ and OSA-18 scores were significantly higher for the RME group.</p><p><strong>Conclusion: </strong>RME and AT significantly improved sleep-related respiratory parameters in patients with POSA. RME demonstrated comparable efficacy to AT in reducing AHI and improving LAST, MSAT, and REM sleep time. However, AT provided significantly better improvement in clinical symptoms and quality of life.</p><p><strong>Trial registration: </strong>The registration of this randomized controlled trial was approved on August 24th, 2023, under the registration number TCTR20230824001.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"256"},"PeriodicalIF":2.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and characterization of positional obstructive sleep apnea with peripheral arterial tonometry in a real-world Colombian cohort.","authors":"Diego I Vanegas-Cadavid, Andrés Felipe Blanco-Ruíz","doi":"10.1007/s11325-025-03429-6","DOIUrl":"10.1007/s11325-025-03429-6","url":null,"abstract":"","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"257"},"PeriodicalIF":2.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12310770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurse-managed telemonitoring in patients with sleep apnea syndrome treated with positive pressure ventilation.","authors":"Edoardo Martinotti, Francesca Zavoli, Chiara Giovannini, Alessandra Pelliccioni, Claudia Francioni, Valentina Conti","doi":"10.1007/s11325-025-03403-2","DOIUrl":"10.1007/s11325-025-03403-2","url":null,"abstract":"<p><strong>Purpose: </strong>Obstructive sleep apnea (OSA) is the commonest sleep disorder, it is characterized by episodes of complete or partial upper airway obstruction, sleep fragmentation and intermittent hypoxia (Am J Epidemiol 177:1006-14, 2013). Continuous Positive pressure ventilation (CPAP), is the gold standard treatment for Obstructive Sleep Apnoea Syndrome (OSAS). Several psycho-educational and technological interventions have been implemented to improve compliance but their impact on therapeutic adherence hasn't turned out to be substancial (Am J Respir Crit Care Med 159:1108-1114, 1999). Technological progress facilitated the use of tele-monitoring (TM) in OSAS patients (Eur Respir J 49:1601128, 2017). The use of TM, by trained nurses, improves compliance and allows for real-time adjustments to ventilatory parameters and correcting any therapeutic error. This can reduce the need for additional hospital visits and optimizes resources.</p><p><strong>Aim: </strong>To evaluate the differences in compliance, proper usage, number of visits, and overall efficacy/benefit during follow-up between two groups of OSAS patients treated with CPAP.</p><p><strong>Methods: </strong>A prospective, randomized controlled trial was conducted involving patients with OSAS treated with CPAP. Participants were randomized into two groups. Group 1 underwent standard follow-up visits at 1, 6, and 12 months. Group 2 was monitored via nurse-managed telemonitoring, which included monthly telephone contacts during the first six months, followed by contacts at 60-day intervals thereafter.</p><p><strong>Results: </strong>No significant differences were observed between Group 1 and Group 2 in terms of comfort, proper usage, and benefit from CPAP. However, Group 2 showed a reduction in hospital visits.</p><p><strong>Conclusions: </strong>OSAS patients under CPAP treatment can be effectively managed via telemonitoring, yielding results comparable to those obtained through traditional medical visits. The TM approach enables to postpone in-person visits optimizes the use of healthcare resources.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"255"},"PeriodicalIF":2.0,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of mask usage on dry eye symptoms and meibomian gland function in OSAS patients: an observational study.","authors":"Shu-Yi Wei, Zhen Wu, Yao Xu, Dan Li, Yimin Xia","doi":"10.1007/s11325-025-03405-0","DOIUrl":"10.1007/s11325-025-03405-0","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the effect of mask usage on dry eye symptoms and meibomian gland function in patients with obstructive sleep apnea syndrome (OSAS).</p><p><strong>Methods: </strong>OSAS patients who visited our hospital from January 2022 to December 2023 were selected as research subjects. All patients were treated with continuous positive airway pressure (CPAP) therapy. The polysomnography (PSG) results before and after treatment were analyzed, including the apnea-hypopnea index (AHI) and peripheral oxygen saturation (SpO₂). Dry eye conditions and ocular surface analyzer results of patients before and after treatment were evaluated. Pearson correlation was used to assess the relationship between dry eye conditions and ocular surface analyzer results in OSAS patients, and the correlations between PSG results and dry eye conditions as well as ocular surface analyzer results were also analyzed.</p><p><strong>Results: </strong>AHI levels in 31 OSAS patients were significantly decreased after treatment, while SpO₂ levels significantly increased, with a statistically significant difference (P<0.05). After treatment, the tear breakup time (BUT), palpebral (PL) scores, and Ocular Surface Disease Index (OSDI) scores of patients were significantly higher than those before treatment (P<0.05). Additionally, after treatment, the tear meniscus height of OSAS patients was significantly lower than that before treatment, and the lipid layer thickness and eye redness index were significantly higher than those before treatment, with a statistically significant difference (P<0.05). The results of Pearson correlation analysis showed that BUT was positively correlated with lipid layer thickness and eye redness improvement, while Schirmer's test (Sit) was positively correlated with tear meniscus height. PL scores were negatively correlated with tear meniscus height but positively correlated with the eye redness index (P<0.05). AHI from PSG results was negatively correlated with BUT, PL scores, and OSDI scores (P<0.05), while SpO₂ was positively correlated with BUT, PL scores, and OSDI scores but negatively correlated with Sit (P<0.05). In the PSG results, AHI was negatively correlated with lipid layer thickness and eye redness index, and positively correlated with meibomian gland opening score (P < 0.05).</p><p><strong>Conclusion: </strong>CPAP mask usage in OSAS patients may negatively impact dry eye symptoms and meibomian gland function, leading to decreased tear film stability and worsening symptoms of eye dryness.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"254"},"PeriodicalIF":2.0,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auto-adjusting positive airway pressure: the fine line between engineering and medicine.","authors":"Ludovico Messineo, David P White, Bernard Hete, Michael Knepper, Richard Berry, William H Noah","doi":"10.1007/s11325-025-03409-w","DOIUrl":"10.1007/s11325-025-03409-w","url":null,"abstract":"<p><p>Auto-adjusting positive airway pressure (APAP), unlike continuous PAP (CPAP), dynamically adjusts treatment pressure in response to events detected automatically from a derived flow signal. Introduced in the 90's, APAP quickly became a key tool in sleep clinics, initially serving as a faster alternative to manual titration for patients with obstructive sleep apnea (OSA), and later also as a long-term treatment option to expedite follow-up visits. APAP and CPAP are overall comparable in terms of adherence, efficacy and control of symptoms. However, concern remains that APAP offers less control of chronic health outcomes, such as blood pressure, kidney function and glycemic values. Other APAP-related challenges entail engineering aspects. A major issue is that APAP algorithms-which govern event detection/identification and pressure adjustments-are proprietary of and vary among manufacturers, making them poorly understood by clinicians. Furthermore, APAP algorithms do not always match-up well when compared to both manual titration or manually scored polysomnography, particularly in the presence of unintentional leak. Variability in event detection, leak compensation, and pressure adjustment algorithms among devices adds another layer of complexity to clinical decision-making. All this complicates the management of OSA patients, who could be left with substantial residual disordered breathing, high leak, and a wide pressure range.This review aims to bridge the gap between the clinical and engineering perspectives of APAP, providing an up-to-date overview of current knowledge and existing challenges that sleep clinicians should consider when managing OSA patients with PAP therapy.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"253"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of sleep quality and engraftment in patients undergoing mobilization and hematopoietic stem cell transplantation.","authors":"Nur Soyer, Mehmet Sezai Tasbakan, Filiz Vural, Ozen K Basoglu","doi":"10.1007/s11325-025-03422-z","DOIUrl":"10.1007/s11325-025-03422-z","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to evaluate the prevalence and predictors of poor sleep quality in patients undergoing stem cell mobilization and transplantation, and to investigate the relationship between sleep quality and post-transplant engraftment.</p><p><strong>Methods: </strong>This prospective, observational study comprised 107 patients with hematopoietic stem cell transplantation. Pittsburgh Sleep Quality Index [PSQI], Hospital Anxiety and Depression Scale [HADS] and World Health Organization Quality of Life-Brief Version [WHOQOL] questionnaires were administered before and after transplantation. Mann-Whitney and Student's t-tests were used to compare means. Logistic regression was used to analyze predictors of poor sleep quality after transplantation.</p><p><strong>Results: </strong>Of 107 patients [mean age 53.1 ± 13.6 years; 44.9% women], 46 [43%] had poor sleep quality before transplantation. There was a significant difference between baseline and post-transplant PSQI scores [p = 0.036]. Both the PSQI scores [5.3 ± 3.4 vs. 8.0 ± 4.2, p = 0.001] and the percentage of patients with poor sleep quality [35.7% vs. 75%, p = 0.007] increased after transplantation in allogeneic patients. The presence of engraftment, PNL and PLT engraftment time were similar in good/poor sleepers at baseline, respectively [p = 0.11, p = 0.523, p = 0.341]. There was no association between sleep quality and engraftment. The risk factors affecting poor sleep quality after transplantation were PSQI score at baseline and type of transplantation in logistic regression analysis.</p><p><strong>Conclusions: </strong>There is an increase after allogeneic transplantation in poor sleepers. The presence of engraftment and engraftment times were similar between good and poor sleepers at baseline. PSQI score at baseline and type of transplantation were risk factors for poor sleep quality after transplantation.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 4","pages":"252"},"PeriodicalIF":2.0,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144719375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}