Sleep & breathing = Schlaf & Atmung最新文献

{"title":"Association of cerebrospinal fluid FGF21 with sleep quality in Chinese adults.","authors":"Lingling Chen, Siyuan Li, Xiyi Chen, Yu-Hsin Chen, Xingguang Luo, Weiming Hu, Yimin Kang, Li Chen, Fan Wang, Xiaokun Li, Yanlong Liu, Caixia Tong","doi":"10.1007/s11325-025-03443-8","DOIUrl":"10.1007/s11325-025-03443-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine whether FGF21 levels in cerebrospinal fluid (CSF) and plasma are associated with sleep quality, as measured by the Pittsburgh Sleep Quality Index (PSQI) scores, and to assess the correlation between FGF21 levels and sleep disorder severity.</p><p><strong>Methods: </strong>We recruited 90 Chinese adult males undergoing anterior cruciate ligament reconstruction surgery, gathering sociodemographic and clinical characteristics. Sleep quality was assessed using the PSQI, and CSF samples were obtained for FGF21 analysis.</p><p><strong>Results: </strong>Spearman's correlation analysis showed that CSF FGF21 levels were positively correlated with PSQI global scores (r = 0.51, p < 0.001), as well as with specific components, including sleep quality (r = 0.32, p < 0.01), sleep latency (r = 0.46, p < 0.001), sleep disturbances (r = 0.53, p < 0.001), and daytime dysfunction (r = 0.55, p < 0.001). CSF FGF21 levels also positively correlated with APOA1 levels. However, plasma FGF21 levels showed no correlation with these sleep parameters. Elevated CSF FGF21 levels were associated with higher PSQI scores and increased prevalence of prolonged sleep latency, sleep disturbances, and daytime dysfunction. The association between CSF FGF21 levels and sleep disorders remained significant after adjusting for age, BMI, education, living situation, marital status, and biochemical markers.</p><p><strong>Conclusions: </strong>This study identifies a novel positive association between CSF FGF21 levels, rather than plasma FGF21, and sleep quality, as assessed by PSQI scores, particularly in subcategories including low sleep quality, prolonged sleep latency, severe sleep disturbances, and marked daytime dysfunction in healthy adults.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"279"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive PCO₂ monitoring during polysomnography: transcutaneous versus end-tidal measurement.","authors":"Hannah Park, Jin Yoo, Ji Su Kim, Do-Yang Park, Bumhee Park, Hyun Jun Kim","doi":"10.1007/s11325-025-03455-4","DOIUrl":"https://doi.org/10.1007/s11325-025-03455-4","url":null,"abstract":"<p><strong>Purpose: </strong>The objectives of this study were to monitor transcutaneous and end-tidal partial pressures of CO₂ simultaneously during polysomnography, determine the advantages and disadvantages of each method, and identify relevant factors that can affect the results.</p><p><strong>Methods: </strong>This cross-sectional study enrolled 55 adults who underwent polysomnography at the Ajou University Hospital Sleep Center between February 2021 and September 2022. They were volunteers who spontaneously breathed room air. Polysomnography reports, including those of CO₂ monitoring, of all participants were reviewed and analyzed by sleep experts. Generalized Estimation Evaluation, Bon Ferroni Post Hoc and multivariable regression analysis were used for statistical analysis.</p><p><strong>Results: </strong>Throughout all sleep stages, the mean, highest, and lowest values of end-tidal and transcutaneous partial pressure of CO₂ showed significant differences. The mean transcutaneous partial pressure was higher than the mean end-tidal partial pressure by 2.53 mmHg. The apnea index, apnea-hypopnea index, and height were significant factors affecting the difference between the mean transcutaneous and end-tidal partial pressure of CO₂. As the obstructive sleep apnea grade increased, the mean end-tidal CO₂ partial pressure value decreased. Two patients had hypoventilation; one met the criteria based on the transcutaneous partial pressure of CO₂ and the other met those based on the end-tidal partial pressure of CO₂.</p><p><strong>Conclusion: </strong>During diagnostic sleep studies, the application of both transcutaneous and end-tidal measurements is suggested for stable and accurate monitoring of partial pressure of CO₂ and complementary analysis.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"281"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of carbonic anhydrase activity is associated with amelioration of obstructive sleep apnea.","authors":"Ali M Komai, Saliha Musovic, Kaj Stenlöf, Ludger Grote, Ding Zou, Jan Hedner","doi":"10.1007/s11325-025-03430-z","DOIUrl":"10.1007/s11325-025-03430-z","url":null,"abstract":"<p><strong>Background: </strong>The carbonic anhydrase (CA) enzyme plays an important role in the equilibration of carbon dioxide and bicarbonate (HCO₃) under the production of H⁺ ions. Emerging evidence suggest that CA activity may play a fundamental regulatory role on respiratory control mechanisms in obstructive sleep apnea (OSA). Clinical trials suggest that CA inhibitors significantly reduce OSA.</p><p><strong>Methods: </strong>Data from three separate cohorts of healthy volunteers and patients with OSA were used to quantify CA activity in whole blood and cerebrospinal fluid (CSF). The influence of the CA inhibitory drugs acetazolamide and sulthiame, on CA activity in-vitro/in-vivo, was assessed. The association between CA-inhibitor plasma concentration and HCO₃, as well as the influence of HCO₃ on the apnea-hypopnea severity was determined.</p><p><strong>Results: </strong>Stability of CA activity in stored blood was high. CA activity in whole blood contained five times higher activity compared with CSF. The CA-inhibitory drugs dose-dependently reduced CA activity in-vitro/in-vivo. The CA inhibitor sulthiame reduced venous HCO₃ concentration (P = 0.022). The reduction of HCO₃ was linked to improvement of OSA (P = 0.040).</p><p><strong>Conclusions: </strong>CA-inhibitory drugs reduced CA activity in whole blood suggesting a therapeutic role of CA inhibition in OSA. The findings also suggest that an activated CA system may constitute a pathophysiological mechanism in some forms of OSA.</p><p><strong>Clinical trial registration: </strong>N/A.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"278"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of armodafinil in moderate to severe obstructive sleep apnea patients with excessive daytime sleepiness after suboptimal usage of continuous positive airway pressure treatment: a prospective study.","authors":"Jinjuta Ngeyvijit, Tayard Desudchit, Nattapot Dadphan, Pantaree Aswanetmanee, Dittapol Muntham, Naricha Chirakalwasan","doi":"10.1007/s11325-025-03448-3","DOIUrl":"https://doi.org/10.1007/s11325-025-03448-3","url":null,"abstract":"<p><strong>Purpose: </strong>Armodafinil has been approved for treating excessive daytime sleepiness (EDS) in OSA patients who still experience EDS after adequately treated with CPAP. However, the effectiveness of armodafinil administration in OSA patients with suboptimal CPAP usage and persistent EDS remains unexplored.</p><p><strong>Method: </strong>A 12-week prospective cohort study enrolled 33 moderate to severe OSA patients with suboptimal CPAP usage (2- < 4 h/night) who experienced EDS and were naïve to armodafinil. Patients received daily 150 mg of armodafinil and continued using CPAP. Efficacy and adverse events were evaluated.</p><p><strong>Results: </strong>A total of 30 patients with mean age of 45.10 ± 10.74 years and Epworth sleepiness scale (ESS) of 13.93 ± 3.16 completed the study; however, one participant completed only the 8-week follow-up. After 12 weeks, ESS was significantly decreased by 5.03 ± 4.22 (p < 0.001). Clinical global impression (CGI) rated by investigators and by participants was significantly decreased by 1.79 ± 0.72 (p < 0.001) and 1.93 ± 0.75 (p < 0.001); respectively. Pittsburgh sleep quality index (PSQI) was significantly decreased by 5.27 ± 2.93 (p < 0.001). The OSLER error index did not significantly improved (p = 0.61); however, a trend toward improvement was observed in patients with baseline psychomotor vigilance impairment (p = 0.17). While CPAP adherence showed no statistically significant change, there was a trend toward improvement from 2.99 ± 0.63 h/night at baseline to 3.47 ± 1.38 h/night (p = 0.09). No serious side effects were observed.</p><p><strong>Conclusion: </strong>In moderate to severe OSA patients with suboptimal CPAP usage who still experience EDS, administering armodafinil over 12 weeks period significantly improved EDS and sleep quality subjectively without compromising CPAP adherence. Armodafinil demonstrated excellent tolerability with self-limiting side effects.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"280"},"PeriodicalIF":2.0,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Failure to complete diagnostic testing in patients with suspected obstructive sleep apnoea and inconclusive home sleep apnoea test.","authors":"Marcus Jin Hui Sim, Yvonne Poh, Hang Siang Wong, Yingjuan Mok","doi":"10.1007/s11325-025-03445-6","DOIUrl":"10.1007/s11325-025-03445-6","url":null,"abstract":"<p><strong>Purpose: </strong>Home sleep apnoea test (HSAT) is an effective diagnostic test for obstructive sleep apnoea (OSA). However, a proportion of patients who undergo HSAT may obtain an inconclusive result and require further diagnostic testing. Our objective is to evaluate the proportion of patients who have an inconclusive HSAT and complete diagnostic testing with an in-laboratory polysomnogram.</p><p><strong>Methods: </strong>Patients who had HSAT performed for suspected OSA and obtained an inconclusive test (technically inadequate study or low pAHI less than 5) were included. Rates of completion of diagnostic testing, factors associated with completion of diagnostic testing and rates of OSA in patients who completed diagnostic testing were evaluated.</p><p><strong>Results: </strong>139 patients (106 male and 33 female, age 38 ± 27, body mass index 25.6 ± 7.9 kg/m²) with inconclusive HSAT were included. Only 35 patients (25.2%) completed diagnostic testing after the inconclusive HSAT. Multivariate analysis showed male gender, individuals at elevated risk of moderate to severe OSA and those who were previously counseled about the need for repeat testing had significantly higher odds of completing diagnostic testing. 20 out of 35 patients (57%) who completed diagnostic testing had moderate to severe OSA.</p><p><strong>Conclusion: </strong>A considerable percentage of patients with an inconclusive HSAT failed to complete diagnostic testing, which puts them at risk of missing out on a diagnosis of OSA and potential treatment. Physicians should be aware of this limitation when choosing a diagnostic test for suspected OSA.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"277"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive outcomes in chronic obstructive pulmonary disease (COPD)/OSA overlap syndrome compared to obstructive sleep apnea (OSA) alone: a systematic review.","authors":"Ahmad M Alharbi, Nawal Alotaibi, Ömer Faruk Uysal, Roby D Rakhit, Simon E Brill, John R Hurst, Swapna Mandal","doi":"10.1007/s11325-025-03426-9","DOIUrl":"10.1007/s11325-025-03426-9","url":null,"abstract":"<p><strong>Background: </strong>Obstructive Sleep Apnoea (OSA) and Chronic Obstructive Pulmonary Disease (COPD) are both independently associated with cognitive impairment. COPD/OSA overlap syndrome could potentially result in greater cognitive impairment that is more than additive. This systematic review evaluates attention, memory, executive function and global cognition in OSA alone compared to COPD/OSA overlap syndrome.</p><p><strong>Methods: </strong>Systematic searches in MEDLINE, EMBASE, PsycINFO, CINAHL, and CENTRAL identified studies assessing cognitive function in adults with OSA and/or COPD/OSA overlap syndrome. Inclusion criteria required validated diagnostic and cognitive assessment tools. Twelve studies, including 7,424 participants, were reviewed: 10 involving OSA alone and 2 involving overlap syndrome. A narrative synthesis was performed due to methodological heterogeneity. Registration number is: CRD42024557577.</p><p><strong>Results: </strong>OSA alone was primarily associated with mild to moderate cognitive impairment, with attention and executive function most affected, with nocturnal hypoxemia and sleep fragmentation thought to be underlying causative factors. Memory and global cognition were relatively preserved. In contrast, COPD/OSA overlap syndrome was associated with more severe impairments, particularly in memory and global cognition. Overlap patients had significantly lower cognitive scores and a higher prevalence of mild cognitive impairment compared to OSA alone.</p><p><strong>Conclusions: </strong>Whilst OSA alone is associated with mild to moderate cognitive impairments, COPD/OSA overlap syndrome associates with more pronounced impairments, particularly in memory and global cognition. Nocturnal hypoxemia and systemic inflammation may be important mechanisms. Early cognitive screening and targeted interventions could support clinicians in mitigating these risks.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"275"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based approaches for sleep-related breathing events identification using EEG and ECG signals.","authors":"Nguyen Thi Hoang Trang, Tran Thanh Duy Linh, Do Quoc Vu, Bui Thi Hong Loan, Nguyen Nhu Vinh, Tran Ngoc Dang","doi":"10.1007/s11325-025-03442-9","DOIUrl":"10.1007/s11325-025-03442-9","url":null,"abstract":"<p><strong>Purposes: </strong>Sleep apnea or hypopnea is a sleep-related breathing disorder characterized by insufficient ventilation during sleep. Sleep apnea is classified into two major forms: obstructive sleep apnea (OSA) and central sleep apnea (CSA). The conventional diagnosis with Polysomnography (PSG) is time-consuming, uncomfortable, and costly in the clinical setting. To address these issues, wearable devices and AI techniques have been developed, utilizing single or multi-modal physiological signals. This study aims to deploy a multi-modal approach by analyzing both EEG and ECG signals derived from home sleep testing devices for OSA/CSA/hypopnea identification. A robust ensemble learning model is proposed to compare with the performance of the deep learning model in event classification.</p><p><strong>Methods: </strong>EEG and ECG signals from 201 PSG were collected. Non-linear features extracted by wavelet transform methods and machine learning were used to develop a classification algorithm. ECG spectrograms and the deep learning model were also deployed to compare with traditional method. Two classification strategies including 3-class (OSA-hypopnea-normal, OSA-CSA-normal) and 2-class (OSA-hypopnea, OSA-CSA) were also examined.</p><p><strong>Results: </strong>The highest classification performance was achieved using the combined signal-based model with 98.8% accuracy, 99.1% sensitivity, and 98.5% specificity for classifying OSA and CSA. When compared with the deep learning model, the classification accuracy of the combined signal-based machine learning model was significantly higher in almost all classification strategies.</p><p><strong>Conclusion: </strong>The findings highlight the effectiveness of combining non-linear features from ECG and EEG signals for classifying various sleep-related breathing events. A proposed machine learning model provides significantly precise classification compared to a deep learning approach, offering improved reliability in-home sleep setting.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"276"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12402030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144987063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of electromyographic activity during REM sleep in Chinese narcolepsy patients and healthy controls: a comparative study.","authors":"Dhirendra Paudel, Shengpeng Liang, Shixu Du, Qianqian Xin, Yan Xu, Dan Zhou, Bin Zhang","doi":"10.1007/s11325-025-03450-9","DOIUrl":"10.1007/s11325-025-03450-9","url":null,"abstract":"<p><strong>Study objectives: </strong>This study aimed to assess and quantify rapid eye movement (REM) sleep electromyographic (EMG) activity in narcolepsy patients.</p><p><strong>Methods: </strong>The study involved 95 participants, including 25 with narcolepsy type 1 (NT1), 36 with narcolepsy type 2 (NT2), and 34 healthy controls (HC). We visually analyzed phasic, tonic, and \"any\" muscle activity for the submentalis (SM) and phasic for the anterior tibialis (AT) by both 3-s REM mini-epochs (3sRME) and 30-s REM epochs (30sRE) methods. Group metrics of EMG activity indices in 3sRME and positive REM sleep without atonia (RWA) indices in 30sRE (AASM rules) were analyzed. Receiver operating characteristic (ROC) curves determined the best cutoff thresholds for narcolepsy.</p><p><strong>Results: </strong>All median SM and AT EMG activity indices in 3sRME were significantly higher in NT1 and NT2 compared to HC (P < 0.05). In the 30sRE method, positive RWA with phasic SM, total SM, and combined SM + AT indices were significantly higher only in NT1 versus HC in all analyses. The 3sRME phasic AT index had the highest area under the curve (AUC) of 0.884 (cutoff > 1.74%) for narcolepsy, 0.920 (cutoff > 2.03%) for NT1, and 0.859 (cutoff > 1.74%) for NT2. In the 30sRE method, the positive RWA with combined SM + AT index had the highest AUC of 0.691 (cutoff > 4.37%) for narcolepsy.</p><p><strong>Conclusions: </strong>The study demonstrated increased levels of REM sleep EMG activity in narcoleptic patients compared to HC, with more pronounced abnormalities in NT1 than NT2, suggesting its potential as an alternative biomarker for narcolepsy.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"274"},"PeriodicalIF":2.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The reliability and validity of the Korean version of the sleep health index using self-report measures and wearable-derived sleep metrics.","authors":"Ah-Yeon Kim, Chul-Hyun Cho, Sooyeon Suh","doi":"10.1007/s11325-025-03439-4","DOIUrl":"10.1007/s11325-025-03439-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to validate the Korean version of the Sleep Health Index (K-SHI) using both self-report measures and objective sleep indices from wearable devices.</p><p><strong>Methods: </strong>A total of 204 adults (mean age 30.35 ± 9.76 years, 64.71% female) were recruited and categorized into insomnia and good sleeper groups. Participants completed the K-SHI, the Insomnia Severity Index (ISI) and the Pittsburgh Sleep Quality Index (PSQI). Objective sleep indices were collected using a wearable device (Fitbit Inspire 3) for 4 weeks. Confirmatory factor analysis (CFA), and analyses for internal consistency, test-retest reliability, and convergent validity, and group comparisons were conducted.</p><p><strong>Results: </strong>CFA supported a three-factor model (x² = 78.51(df = 52, p < .01), CFI = 0.963, TLI = 0.952, RMSEA = 0.050, SRMR = 0.049). The K-SHI showed adequate internal consistency (Cronbach's α = 0.766) and test-retest reliability (r = .871, p < .001). The K-SHI total score was significantly associated with ISI (r = - .545, p < .001) and PSQI (r = - .564, p < .001). When correlated with the wearable device, the K-SHI sleep duration subindex was significantly associated with mean total sleep time (r = .170, p < .05), mean sleep onset (r = - .147, p < .05), and total sleep time standard deviation (r = - .168, p < .05). Additionally, the K-SHI total score was associated with mean wake time (r = .160, p < .05) and total sleep time standard deviation (r = - .171, p < .05). The K-SHI total score significantly differentiated the insomnia and good sleeper groups, with notable differences in K-SHI sleep duration and sleep quality subindices, but no significant difference in the K-SHI disordered sleep subindex.</p><p><strong>Conclusions: </strong>These results demonstrate the validity and reliability of the K-SHI, incorporating both subjective self-report measures and objective sleep data from wearable devices.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"273"},"PeriodicalIF":2.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dextrose prolotherapy versus low level laser therapy in the treatment of patients with obstructive sleep apnea syndrome; a randomized controlled trial.","authors":"Amira A M M Attia, Mai A Haggag, Wael Said Ahmed, Aiman El-Saed, Mennatalla A M Saleh, Abdelbaset M Saleh","doi":"10.1007/s11325-025-03428-7","DOIUrl":"10.1007/s11325-025-03428-7","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of Low-level laser therapy (LLLT) versus dextrose prolotherapy injection in the treatment of patients with obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>A hospital-based randomized controlled trial was conducted among 26 OSA patients; 13 in each group. After confirmation with Polysomnography and evaluation by drug induced sleep endoscopy, the patients were randomly allocated to treatment groups. Treatment success was defined as > 50% reduction of apnea-hypopnea index (AHI) with residual AHI < 10. The outcomes were evaluated 3 months after the intervention.</p><p><strong>Results: </strong>A total of 26 patients completed the study. The average age was 40.1 ± 7.3 years and 73.1% of the participants were males. Compared with LLLT group before intervention, prolotherapy group had higher reduction of sleep apnea measurements including total apnea, total hypopnea, and low O2 saturation but had slightly lower reduction of average O2 saturation and significant increase in minimal O2 saturation. In both groups, the levels of AHI were significantly reduced after intervention without complication (68% reduction, p = 0.001 in the prolotherapy group and 46% reduction, p = 0.001 in LLLT group). In linear models, the reduction was higher in prolotherapy group even after adjusting to baseline AHI (p = 0.011). Treatment success was much higher in the prolotherapy group than LLLT group (53.8% versus 7.7%, p = 0.030). The treatment success was significantly associated with single level obstruction (velum) and partial obstruction.</p><p><strong>Conclusions: </strong>Both dextrose prolotherapy and LLLT were successful in reducing sleep parameters associated with OSA, with better reduction in the prolotherapy group. The promising findings need to be confirmed in larger multicenter studies before final recommendation.</p><p><strong>Trial registration: </strong>The study was listed on www.</p><p><strong>Clinicaltrials: </strong>gov with registration number (NCT06427161) on 23/05/2024.</p>","PeriodicalId":520777,"journal":{"name":"Sleep & breathing = Schlaf & Atmung","volume":"29 5","pages":"272"},"PeriodicalIF":2.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144824837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}