Dextrose prolotherapy versus low level laser therapy in the treatment of patients with obstructive sleep apnea syndrome; a randomized controlled trial.

IF 2

Sleep & breathing = Schlaf & Atmung Pub Date : 2025-08-12 DOI:10.1007/s11325-025-03428-7

Amira A M M Attia, Mai A Haggag, Wael Said Ahmed, Aiman El-Saed, Mennatalla A M Saleh, Abdelbaset M Saleh

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Abstract

Objective: To compare the effects of Low-level laser therapy (LLLT) versus dextrose prolotherapy injection in the treatment of patients with obstructive sleep apnea (OSA).

Methods: A hospital-based randomized controlled trial was conducted among 26 OSA patients; 13 in each group. After confirmation with Polysomnography and evaluation by drug induced sleep endoscopy, the patients were randomly allocated to treatment groups. Treatment success was defined as > 50% reduction of apnea-hypopnea index (AHI) with residual AHI < 10. The outcomes were evaluated 3 months after the intervention.

Results: A total of 26 patients completed the study. The average age was 40.1 ± 7.3 years and 73.1% of the participants were males. Compared with LLLT group before intervention, prolotherapy group had higher reduction of sleep apnea measurements including total apnea, total hypopnea, and low O2 saturation but had slightly lower reduction of average O2 saturation and significant increase in minimal O2 saturation. In both groups, the levels of AHI were significantly reduced after intervention without complication (68% reduction, p = 0.001 in the prolotherapy group and 46% reduction, p = 0.001 in LLLT group). In linear models, the reduction was higher in prolotherapy group even after adjusting to baseline AHI (p = 0.011). Treatment success was much higher in the prolotherapy group than LLLT group (53.8% versus 7.7%, p = 0.030). The treatment success was significantly associated with single level obstruction (velum) and partial obstruction.

Conclusions: Both dextrose prolotherapy and LLLT were successful in reducing sleep parameters associated with OSA, with better reduction in the prolotherapy group. The promising findings need to be confirmed in larger multicenter studies before final recommendation.

Trial registration: The study was listed on www.

Clinicaltrials: gov with registration number (NCT06427161) on 23/05/2024.

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葡萄糖前驱疗法与低水平激光疗法治疗阻塞性睡眠呼吸暂停综合征的比较一项随机对照试验。

目的：比较低水平激光治疗（LLLT）与葡萄糖前驱素注射液治疗阻塞性睡眠呼吸暂停（OSA）的疗效。方法：对26例OSA患者进行医院随机对照试验；每组13人。经多导睡眠图确认及药物诱导睡眠内镜评估后，随机分为治疗组。治疗成功的定义是：呼吸暂停-低通气指数（AHI）降低50%，并伴有AHI残留。结果：共有26例患者完成了研究。平均年龄为40.1±7.3岁，男性占73.1%。与干预前的LLLT组相比，前驱治疗组睡眠呼吸暂停指标（包括总呼吸暂停、总低呼吸暂停和低氧饱和度）的降低幅度更高，但平均氧饱和度降低幅度略低，最低氧饱和度显著升高。两组患者干预后AHI水平均显著降低，无并发症（前驱治疗组降低68%，p = 0.001， LLLT组降低46%，p = 0.001）。在线性模型中，即使调整到基线AHI，前驱治疗组的降低幅度也更高（p = 0.011）。前驱治疗组治疗成功率明显高于LLLT组（53.8%比7.7%,p = 0.030）。治疗成功与单节段梗阻（膜）和部分梗阻显著相关。结论：葡萄糖前驱治疗和LLLT均能成功降低与OSA相关的睡眠参数，且前驱治疗组降低效果更好。在最终推荐之前，这些有希望的发现需要在更大规模的多中心研究中得到证实。试验注册：该研究已于2024年5月23日在www.Clinicaltrials: gov上注册，注册号（NCT06427161）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Sleep & breathing = Schlaf & Atmung

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