Journal of investigative medicine : the official publication of the American Federation for Clinical Research最新文献_第8页

Patterns and seasonality in pediatric referrals for functional somatic symptoms. 功能性躯体症状的儿科转诊模式和季节性。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-30 DOI: 10.1136/jim-2021-002252

Pepijn den Braber, Joris van Driel, Dorien Broekhuijsen, Bert Wienen, Jolita Bekhof

{"title":"Patterns and seasonality in pediatric referrals for functional somatic symptoms.","authors":"Pepijn den Braber, Joris van Driel, Dorien Broekhuijsen, Bert Wienen, Jolita Bekhof","doi":"10.1136/jim-2021-002252","DOIUrl":"https://doi.org/10.1136/jim-2021-002252","url":null,"abstract":"Functional somatic symptoms (FSS), or medically unexplained physical symptoms, are common in children and it has been suggested that the incidence is increasing. To determine the incidence and pattern of referrals for FSS to pediatricians, we performed a retrospective analysis including newly referred pediatric patients to our secondary pediatric practice in Zwolle, The Netherlands, ultimately diagnosed with FSS between 2013 and 2018. FSS was defined as functional abdominal pain, chronic fatigue, chronic musculoskeletal pain and chronic headache without an underlying medical diagnosis. In the 6-year period, 10.4% of elective referrals were related to FSS without a significant upward trend. We found clear seasonal variation with peaks in incidences in March (+31%) and November (+21%) and a nadir around August (-48%). In conclusion, FSS account for 1 in 10 non-acute pediatric referrals, without an increase in incidence in the past 6 years. The seasonal pattern is remarkable and warrants further analysis.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1545-1548"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40460846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of deep neck infections in adults and importance of clinical and laboratory findings. 成人深颈部感染的处理及临床和实验室结果的重要性。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-27 DOI: 10.1136/jim-2021-002271

Hande Arslan, Ömer Bayır, Şevket Aksoy, Kemal Keseroğlu, Cem Saka, Emel Çadallı Tatar, Güleser Saylam, Mehmet Hakan Korkmaz

{"title":"Management of deep neck infections in adults and importance of clinical and laboratory findings.","authors":"Hande Arslan, Ömer Bayır, Şevket Aksoy, Kemal Keseroğlu, Cem Saka, Emel Çadallı Tatar, Güleser Saylam, Mehmet Hakan Korkmaz","doi":"10.1136/jim-2021-002271","DOIUrl":"https://doi.org/10.1136/jim-2021-002271","url":null,"abstract":"This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38.2±14.5 years) were included in the study. Patients were divided into three groups according to the treatment strategy: group 1 received only antibiotic treatment, group 2 underwent abscess drainage with needle puncture in addition to antibiotic treatment, and group 3 underwent surgical drainage with antibiotic treatment. Laboratory outcomes, imaging methods, duration of hospital stay, treatment strategy, and clinical outcomes were analyzed.According to the laboratory results, complete blood count values did not vary among the three groups, but C reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were higher in group 3 (p<0.01). Based on receiver operating characteristic (ROC) analysis, the cut-off levels for CRP and ESR associated with the need for surgical drainage were 133 mg/L and 42.5, respectively. According to radiological imaging results, the number of involved neck spaces was significantly different among the three groups (p=0.03), and group 3 had more spaces involved when compared with groups 1 and 2 (p=0.04). Gas formation in the neck tissues was noted in 10 patients in group 3 and 5 patients in groups 1 and 2 (p=0.02). ESR and CRP levels were higher in patients who underwent surgical drainage. In patients with deep neck space infections, the involvement of two or more neck spaces and gas formation on radiological images might indicate surgical drainage as a treatment strategy.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1488-1493"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40404458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Recent findings on hyperprolactinemia and its pathological implications: a literature review. 高泌乳素血症及其病理意义的最新研究进展:文献综述。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-29 DOI: 10.1136/jim-2022-002351

Zohreh Al-Sadat Ghoreshi, Hamed Akbari, Mohsen Sharif-Zak, Nasir Arefinia, Mojtaba Abbasi-Jorjandi, Gholamreza Asadikaram

{"title":"Recent findings on hyperprolactinemia and its pathological implications: a literature review.","authors":"Zohreh Al-Sadat Ghoreshi, Hamed Akbari, Mohsen Sharif-Zak, Nasir Arefinia, Mojtaba Abbasi-Jorjandi, Gholamreza Asadikaram","doi":"10.1136/jim-2022-002351","DOIUrl":"https://doi.org/10.1136/jim-2022-002351","url":null,"abstract":"The prolactin hormone (PRL) is often secreted by lactotrophic cells of the anterior pituitary and has been shown to play a role in various biological processes, including breast feeding and reproduction. The predominant form of this hormone is the 23 kDa form and acts through its receptor (PRLR) on the cell membrane. This receptor is a member of the superfamily of hematopoietic/cytokine receptors. PRL also has a 16 kDa subunit with anti-angiogenic, proapoptotic, and anti-inflammatory effects which is produced by the proteolytic breakdown of this hormone under oxidative stress. Although the common side effects of hyperprolactinemia are exerted on the reproductive system, new studies have shown that hyperprolactinemia has a wide variety of effects, including playing a role in the development of autoimmune diseases and increasing the risk of cardiovascular disease, peripartum cardiomyopathy, and diabetes among others. The range of PRL functions is increasing with the discovery of multiple sites of PRL secretion as well as PRLR expression in various tissues. This review summarizes current knowledge of the biology of PRL and its receptor, as well as the role of PRL in human pathophysiology.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1443-1451"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40409459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Excessive proliferation and apoptosis of parathyroid cells contribute to primary hyperparathyroidism in rabbit model. 兔原发性甲状旁腺功能亢进症的发生与甲状旁腺细胞过度增殖和凋亡有关。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-08-01 Epub Date: 2022-03-22 DOI: 10.1136/jim-2021-002184

Jing-Tao Bi, Rong-Jie Bai, Hui-Li Zhan, Zhan-Hua Qian, Li-Hua Gong, Ya-Qi Liu, Zhi-Xue Zheng, Xuan Cai

{"title":"Excessive proliferation and apoptosis of parathyroid cells contribute to primary hyperparathyroidism in rabbit model.","authors":"Jing-Tao Bi, Rong-Jie Bai, Hui-Li Zhan, Zhan-Hua Qian, Li-Hua Gong, Ya-Qi Liu, Zhi-Xue Zheng, Xuan Cai","doi":"10.1136/jim-2021-002184","DOIUrl":"https://doi.org/10.1136/jim-2021-002184","url":null,"abstract":"To explore the molecular pathogenesis of primary hyperparathyroidism (PHPT), we investigated the proliferation and apoptosis of parathyroid cells in a rabbit model of diet-induced PHPT. A total of 120 adult Chinese rabbits were randomly divided into normal diet (Ca:P, 1:0.7) group (control group) or a high-phosphate diet (Ca:P, 1:7) group (experimental group). The thyroid and parathyroid complexes were harvested for 1-month interval from month 1 to month 6. The expression of proliferation markers, including proliferating cell nuclear antigen (PCNA) and cyclin-D1, and B cell lymphoma-2 (Bcl-2), were evaluated by immunohistochemistry in thyroid and parathyroid tissues. Apoptosis was quantified by DNA-fragment terminal labeling. Our results demonstrated that parathyroid cells in the experimental group started proliferating from the end of the 2nd month, the expression of PCNA, Bcl-2, and cyclin-D1 were significantly higher in the PHPT group than those of the control group (p<0.05). Furthermore, the apoptosis index (AI) was positively correlated with the glandular cell count and expression of PCNA in the 6th month in the PHPT group. Overall, our results suggested that excessive proliferation and apoptosis of parathyroid cells may contribute to the pathogenesis of PHPT through PCNA-related, Bcl-2-related, and cyclin-D1-related pathways.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1392-1398"},"PeriodicalIF":2.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40314921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Breakthrough SARS-CoV-2 infections after COVID-19 immunization. COVID-19免疫后SARS-CoV-2感染突破。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-08-01 Epub Date: 2022-06-29 DOI: 10.1136/jim-2021-002131

Joshua Hirsh, Thwe Htay, Shubhang Bhalla, Victoria Nguyen, Jorge Cervantes

引用次数: 9

Correspondence on 'COVID-19 vaccine efficacy in a rapidly changing landscape'. 关于“快速变化的形势下COVID-19疫苗有效性”的通信。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-08-01 DOI: 10.1136/jim-2022-002587

Rujittika Mungmunpuntipantip, Viroj Wiwanitkit

{"title":"Correspondence on 'COVID-19 vaccine efficacy in a rapidly changing landscape'.","authors":"Rujittika Mungmunpuntipantip, Viroj Wiwanitkit","doi":"10.1136/jim-2022-002587","DOIUrl":"https://doi.org/10.1136/jim-2022-002587","url":null,"abstract":"© American Federation for Medical Research 2022. No commercial reuse. See rights and permissions. Published by BMJ. Dear Editor, We would like to comment on the publication ‘COVID19 vaccine efficacy in a rapidly changing landscape’. A very small number of persons will still exhibit symptoms, require hospitalization, or pass away from COVID19, according to Baer and Tran’s prediction. Therefore, it is critical to identify and thoroughly characterize the impact of a specific mutation for the pathogenesis of SARCoV2. As the pandemic spreads, we should keep up our efforts to sequence and monitor SARSCoV2 evolution and modify vaccine plans as necessary. Due to the dangerous nature of COVID19 and the vast spectrum of clinical symptoms it causes, immunization is crucial for efficient illness management. The vaccine’s effectiveness is influenced by a number of variables. Since an asymptomatic COVID19 may commonly have a puzzling effect, the data that are now available may be incomplete. However, it must consider the possibility of asymptomatic COVID19 in the populations being studied. Asymptomatic infections may become symptomatic during the observation period, changing the prognosis. The history of infection, which is a key factor in predicting the clinical course of the immunological response to infection and immunization, cannot be used to rule out COVID19 silent infections. Finally, it should be noted that the type of vaccination used and the manner of delivery both affect the vaccine’s effectiveness. There are many different vaccination types available today, and the methods of delivery vary, depending on the country. Many nations still use the inactivated COVID19 vaccine, which is no longer efficacious, and heterologous mixing immunization. Low vaccine efficacy could be caused by an additional method of delivery, and this could be connected to the problem with the newly discovered COVID19 variation.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1442"},"PeriodicalIF":2.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40700947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-analysis and systematic review of the association between adverse childhood events and irritable bowel syndrome. 儿童期不良事件与肠易激综合征相关性的荟萃分析和系统综述。

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-08-01 Epub Date: 2022-01-27 DOI: 10.1136/jim-2021-002109

Shreeya Joshee, Lauren Lim, Alexis Wybrecht, Riley Berriesford, Mark Riddle

{"title":"Meta-analysis and systematic review of the association between adverse childhood events and irritable bowel syndrome.","authors":"Shreeya Joshee, Lauren Lim, Alexis Wybrecht, Riley Berriesford, Mark Riddle","doi":"10.1136/jim-2021-002109","DOIUrl":"10.1136/jim-2021-002109","url":null,"abstract":"Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction characterized by abdominal pain, bowel habits alterations, constipation, and/or diarrhea. Adverse childhood experiences (ACEs) are events such as abuse and mental illness causing childhood trauma. Studies report higher prevalence of ACEs in patients with IBS with varied effect consistency and association strength. A systematic review and meta-analysis were conducted to evaluate current literature, assess heterogeneity and research gaps in this relationship. A search across PubMed, Embase, PsycINFO, and Google Scholar with keywords ('childhood adversity' OR 'childhood trauma' OR 'adverse childhood events') AND ('irritable colon' OR 'irritable bowel syndrome') yielded 106 studies. A restricted maximum likelihood model of 15 chosen studies with 272,686 participants found the association between ACEs and IBS to be uncertain given the considerable heterogeneity (I2=93.58%, p<0.001). Objective reporting methods for ACE and IBS, study size, and study quality explained some heterogeneity. Twelve studies showed publication bias (Egger's test, p<0.001), which further weakened interpretation. Gender-stratified subanalysis of three studies found ACEs associated with IBS in females (pOR=2.20, 95% CI (1.13 to 4.29), I2=66.90%) with substantial heterogeneity, but no association in males (pOR=1.30, 95% CI (0.62 to 2.78)). This meta-analysis explores the current literature to understand the biopsychosocial perspective of IBS and ACEs' role as risk factors. However, the risk of publication and design/study quality biases substantiates the need for further research. If an association is confirmed, further mechanistic research and development of targeted psychological therapies may be warranted.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1342-1351"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39865508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer. 利用早期胃癌的监测、流行病学和最终结果数据库中的婚姻状况和其他因素建立模型。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-08-01 Epub Date: 2022-07-05 DOI: 10.1136/jim-2021-002285

Lixiang Zhang, Baichuan Zhou, Panquan Luo, Aman Xu, Wenxiu Han, Zhijian Wei

{"title":"A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer.","authors":"Lixiang Zhang, Baichuan Zhou, Panquan Luo, Aman Xu, Wenxiu Han, Zhijian Wei","doi":"10.1136/jim-2021-002285","DOIUrl":"https://doi.org/10.1136/jim-2021-002285","url":null,"abstract":"Currently, the postoperative prognosis of early stage gastric cancer (GC) is difficult to accurately predict. In particular, social factors are not frequently used in the prognostic assessment of early stage GC. Therefore, this study aimed to combine the clinical indicators and social factors to establish a predictive model for early stage GC based on a new scoring system. A total of 3647 patients with early stage GC from the Surveillance, Epidemiology, and End Results database were included in this study. A Kaplan-Meier survival analysis was used to compare differences in prognosis between different marital status, as an innovative prognostic indicator. Univariate and multivariate analyses were used to screen available prediction factors and then build a nomogram using the Cox proportional hazard regression model. The univariate analysis and multivariate analysis revealed that age at diagnosis, sex, histology, stage_T, surgery, tumor size, and marital status were independent prognostic factors of overall survival. Both the C-index and calibration curves confirmed that the nomogram had a great predictive effect on patient prognosis in training and testing sets. This nomogram based on clinical indicators and marital status can effectively help patients with early stage GC in the future.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1373-1380"},"PeriodicalIF":2.6,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/84/36/jim-2021-002285.PMC9380518.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40473262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study. 呼气流量-体积曲线下面积:国家健康与营养调查(NHANES)研究中的规范值。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-06-01 Epub Date: 2022-02-21 DOI: 10.1136/jim-2021-002057

Octavian C Ioachimescu, Kevin McCarthy, James K Stoller

{"title":"Area under the expiratory flow-volume curve: normative values in the National Health and Nutrition Survey (NHANES) study.","authors":"Octavian C Ioachimescu, Kevin McCarthy, James K Stoller","doi":"10.1136/jim-2021-002057","DOIUrl":"https://doi.org/10.1136/jim-2021-002057","url":null,"abstract":"The area under the expiratory flow-volume (AEX-FV) loop has been evaluated before as a spirometric tool for assessing respiratory functional impairment. We computed the AEX-FV curves in spirometry tests performed on 20,313 participants in the National Health and Nutrition Examination Survey (NHANES) study.We analyzed 108,939 spirometry tests performed between 2007 and 2012 (5964 children; 14,349 adults). In these tests, we computed the three areas from existing NHANES raw data on instantaneous expiratory flows measured at 0.01 s intervals.Mean best-trial measurements for AEX-FV were 3.4 in boys, 2.8 in girls, 11.8 in men and 7.7 L2/s in women. We characterized indices of central tendency and dispersion of the measurements (eg, means and fifth percentiles-lower limits of normal) by age group (children vs adults), gender, race or ethnicity group and effort grading. Simple regression equations using logarithmic transformations of the above areas and using age, gender and height as inputs provided good predictive ability for the variable AEX-FV.Regular, digital spirometry could and should make available to clinicians and researchers the area under the curves for flow versus volume graph, providing additional tools in our armamentarium to evaluate ventilatory impairments and patterns, and possibly respiratory disability.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1247-1257"},"PeriodicalIF":2.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/4f/jim-2021-002057.PMC9240334.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39639245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exosome as a target for cancer treatment. 外泌体作为癌症治疗的靶点。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-06-01 Epub Date: 2022-02-24 DOI: 10.1136/jim-2021-002194

Samira Nafar, Negar Nouri, Maedeh Alipour, Jafar Fallahi, Fateme Zare, Seyed Mohammad Bagher Tabei

{"title":"Exosome as a target for cancer treatment.","authors":"Samira Nafar, Negar Nouri, Maedeh Alipour, Jafar Fallahi, Fateme Zare, Seyed Mohammad Bagher Tabei","doi":"10.1136/jim-2021-002194","DOIUrl":"https://doi.org/10.1136/jim-2021-002194","url":null,"abstract":"Exosomes are small vesicles covered by a lipid bilayer, ranging in size from 50 nm to 90 nm, secreted by different cell types in the body under normal and pathological conditions. They are surrounded by cell-segregated membrane complexes and play a role in the pathological and physiological environments of target cells by transfer of different molecules such as microRNA (miRNA). Exosomes have been detected in many body fluids, such as in the amniotic fluid, urine, breast milk, blood, saliva, ascites, semen, and bile. They include proteins, lipids, and nucleic acids such as DNA, RNA, and miRNA, which have many functions in target cells under pathological and physiological conditions. They participate in pathological processes such as tumor growth and survival, autoimmunity, neurodegenerative disorders, infectious diseases, inflammation conditions, and others. Biomarkers in exosomes isolated from body fluids have allowed for a more precise and consistent diagnostic method than previous approaches. Exosomes can be used in a variety of intracellular functions, and with advances in molecular techniques they can be used in the treatment and diagnosis of many diseases, including cancer. These vesicles play a significant role in various stages of cancer. Tumor-derived exosomes have an important role in tumor growth, survival, and metastasis. In contrast, the use of stem cells in cancer treatment is a relatively new scientific area. We hope to address targeted use of miRNA-carrying exosomes in cancer therapy in this review paper.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1212-1218"},"PeriodicalIF":2.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39958943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10