Journal of investigative medicine : the official publication of the American Federation for Clinical Research最新文献

{"title":"Effect of the use of artificial intelligence tools on clinical education and clinical decision-making of medical students during clinical rotations: A scoping review.","authors":"Erwin Hernando Hernández Rincón, Julio Cesar Klinger Bastidas, Sofía Becerra Acevedo, Norma Constanza Robayo Florez","doi":"10.1177/10815589261460883","DOIUrl":"10.1177/10815589261460883","url":null,"abstract":"<p><p>Medical education is transforming due to new technologies such as artificial intelligence (AI). Although AI is being considered for medical education, its integration into the curriculum remains limited. Furthermore, few studies evaluate how these tools affect students' diagnostic accuracy during clinical rotations. This study aims to evaluate available evidence regarding AI tools in medical students, identifying their effects on clinical education and clinical decision-making, as well as their implications for medical practice during clinical rotations. For this purpose, a scoping review was conducted in December 2025. The literature search was performed across key databases using MeSH and DeCS terms. Studies published between 2015 and 2025 were included. After screening, 26 articles were included. Most studies suggest a positive effect of AI on students' clinical education and clinical decision-making, particularly in solving clinical cases and interpreting images. AI appears to support students in reaching performance levels closer to experienced physicians, which could influence medical care quality. Seven articles reported a neutral effect, warning that incorrect or unclear AI responses might cause confusion. In conclusion, this review suggests that AI may have a positive effect on medical students, especially those with less clinical experience, potentially bringing them on par with more experienced professionals. The need for structured AI integration into the curriculum is underscored, as it has the potential to improve academic performance and provide enriched learning environments. However, ensuring adequate training and regulation for its efficient use is key to addressing the associated ethical and legal implications in healthcare settings.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589261460883"},"PeriodicalIF":2.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary cutaneous involvement in peripheral T-cell lymphoma: Diagnostic frameworks, staging integration, and therapeutic implications.","authors":"Aura Calderon, Jose Loayza Pintado, Cristina Kochi, Jared Hensley, Andres Suarez Parraga, Everardo Cobos","doi":"10.1177/10815589261455327","DOIUrl":"https://doi.org/10.1177/10815589261455327","url":null,"abstract":"<p><p>The occurrence of secondary cutaneous manifestations in peripheral T-cell lymphoma (PTCL) is relatively infrequent and can resemble benign dermatoses, leading to diagnosis delays. We present the case of a 78-year-old female patient with a diagnosis of PTCL affecting the left parotid gland, who experienced a 2-day sudden and intensely pruritic skin eruption, which progressed from both forearms to the trunk, involving more than 50% of the total body surface area. Initially, the eruption was managed as a hypersensitivity reaction with antihistamines and corticosteroids, with temporary symptomatic relief; however, the rapid clinical progression in the context of an established diagnosis of PTCL raised suspicion of secondary cutaneous involvement. Previous pathological examinations indicated a mature T-cell phenotype (CD2⁺/CD3⁺/CD5⁺/TCRβF1⁺), partial expression of CD4, loss of CD7 in larger cells, minimal CD30 expression (10%), and a high proliferative index (Ki-67 70%). Imaging studies demonstrated persistent disease in the parotid gland and partially necrotic cervical lymph nodes, without evidence of distant metastasis. Considering significant cardiac comorbidities and CD30 expression, an anthracycline-sparing, CD30-targeted therapeutic approach was chosen. Treatment with brentuximab vedotin yielded early alleviation of pruritus and progressive resolution of lesions by the third cycle, with favorable tolerability. This case serves as a foundation for a narrative review that underscores the diagnostic challenges associated with \"allergic-appearing\" eruptions in patients with T-cell lymphoma, the importance of integrated staging utilizing TNMB (skin/blood) in conjunction with Lugano/Deauville positron emission tomography-computed tomography to assess systemic burden and therapeutic response, and biologically informed systemic therapy options aligned with comorbidities, including emerging targeted treatment strategies.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589261455327"},"PeriodicalIF":2.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to endoscopy and its effect on outcomes in acute nonvariceal and variceal upper gastrointestinal bleeding.","authors":"Emely Eid, Alan Elliott, Don C Rockey","doi":"10.1177/10815589251386727","DOIUrl":"10.1177/10815589251386727","url":null,"abstract":"<p><p>The role of early endoscopy in patients with nonvariceal upper gastrointestinal bleeding (UGIB) is controversial; in addition, the timing of endoscopy in patients with variceal hemorrhage has been poorly studied. We aimed to determine the effect of time to endoscopy on clinical outcomes in nonvariceal and variceal UGIB. We identified patients with acute UGIB admitted from the emergency room in an academic medical center. Patients were stratified by risk (low and high) and source of bleeding (variceal or nonvariceal). We examined time to endoscopy (within 3, >3-6, >6-12, and >12-24 h) and assessed the following outcomes: stigmata of bleeding, transfusions, rebleeding, surgery, mortality, ICU admission, readmission (within 42 days), weekday versus weekend admission, and length of stay (LOS). We identified 987 patients with nonvariceal UGIB and 288 patients with variceal UGIB. Clinical outcomes, including transfusions, rebleeding, surgery, mortality, ICU admission or readmission, did not vary as a function of the time to endoscopy. However, a shorter time to endoscopy was an independent predictor of identifying stigmata of bleeding (<i>p</i> < 0.001) and increases in time to endoscopy reduced the likelihood of identifying stigmata of bleeding to 66%, 35%, and 23% at 2, 6, and 12 h, respectively (<i>p</i> < 0.001). Endoscopy performed within 3 h was also associated with a significantly reduced LOS in low-risk patients with nonvariceal UGIB (<i>p</i> < 0.001). Our data indicate that although earlier endoscopy does not improve clinical outcomes, the earlier it is performed, the more likely stigmata are identified, and in certain types of patients (especially low-risk), the earlier discharge.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"515-521"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of magnesium and potassium on insulin resistance and blood sugar level among insomniac patients with diabetes mellitus-A randomized controlled trial.","authors":"Sidra Khalid, Shahid Bashir, Riffat Mehboob, Humaira Waseem, Imran Shahid, Abdullah R Alzahrani, Zergham Mazhar, Shatha Alharazy","doi":"10.1177/10815589251378179","DOIUrl":"10.1177/10815589251378179","url":null,"abstract":"<p><p>The aim of this study is to compare the effect of magnesium and potassium on insulin resistance and blood sugar levels among insomniac patients with diabetes mellitus. A randomized controlled study was conducted on 320 subjects enrolled in placebo (T1), Magnesium (T2), Potassium (T3), and Magnesium + Potassium (T4) treatment groups. Pre- and post-trial blood sugar and insulin levels were analyzed through blood. Insulin resistance was calculated by the homeostatic model assessment for insulin resistance (HOMA-IR). Analysis was performed in IBM SPSS^® version 25.0. HOMA-IR analysis showed that pretreatment mean of T4 (Magnesium + Potassium group) was 3.01 ± 0. 54, and post-treatment mean was 2.54 ± 0.29, showing a significant reduction (p = 0.001). There was a significant association among post-HOMA-IR scores of treatment groups (p = 0.001). Fasting blood sugar levels showed that all groups, except placebo, had significant differences in levels (p = 0.001). A comparison between treatment groups concluded that blood sugar levels were associated with significant differences (p = 0.001). The study suggests that magnesium alone and magnesium coupled with potassium supplementation assist insomniac diabetics more effectively to regulate insulin resistance and increased blood sugar levels.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"430-437"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing blood group diagnosis with molecular methods: A focus on clinically challenging cases.","authors":"Xiaoli Zhu, Yanfei Chen, Xi Qi, Anming Li, Junling Han, Yi Qin, Lingbao Gao","doi":"10.1177/10815589251388958","DOIUrl":"10.1177/10815589251388958","url":null,"abstract":"<p><p>Traditional serological methods often struggle with the accurate identification of rare or complex blood groups. This study addresses the challenges in diagnosing clinically difficult blood groups by employing genotyping and sequencing techniques to enhance blood supply accuracy. Two patients with challenging blood groups underwent serological testing and molecular diagnostics using fluorescent PCR typing and Sanger sequencing. Patient 1 showed a discrepancy in serological typing, indicating a B subgroup confirmed by a B/O*1 genotype and a 721C>T mutation in the ABO gene Exon 7, establishing the Bw. 03/O.01.01 genotype. Patient 2, with negative Rh antigen detection and typed as CcDEe, was diagnosed with a Rh-null phenotype due to a homozygous frameshift mutation (c.732delC) in the RHAG (Rh-Associated Glycoprotein) gene Exon 5. Integrating serological screening with genotyping and sequencing technologies is recommended for accurately identifying challenging blood groups. This three-step diagnostic process facilitates precise blood group determination, ensuring accurate blood supply management.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"489-502"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145644742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfusion defects on thallium-201 scintigraphy in cardiac amyloidosis.","authors":"Yi-Hsin Hung, An-Li Yu, Chi-Lun Ko, Yi-Chieh Chen, Mao-Yuan Su, Chia-Tung Shun, Chi-Chao Chao, Sung-Tsang Hsieh, Ping-Huei Tseng, Ming-Jen Lee, Hsueh-Wen Hsueh, Jimmy Jyh-Ming Juang, Cheng-Hsuan Tsai, Mei-Fang Cheng, Yen-Hung Lin","doi":"10.1177/10815589251384949","DOIUrl":"10.1177/10815589251384949","url":null,"abstract":"<p><p>Thallium-201 scintigraphy can detect microvascular diseases; however, the correlation between cardiac amyloidosis and thallium-201 scintigraphy findings is unknown. We aimed to investigate the influence of amyloid deposition on thallium-201 scintigraphy. We retrospectively analyzed individuals with cardiac amyloidosis at National Taiwan University Hospital, reviewing baseline characteristics, biochemistry, echocardiography, thallium-201 scintigraphy, and coronary angiography. Thirty-six participants were enrolled, of whom 32 had transthyretin amyloid cardiomyopathy. The left ventricular (LV) posterior wall thickness was 13.71 ± 2.45 mm, and the summed stress score (SSS) and summed difference score (SDS) on thallium-201 scintigraphy were 5.47 ± 6.42 and 2.16 ± 2.13, respectively. Abnormal thallium-201 scintigraphy findings were observed in 72.22% of patients. In Spearman's correlation analysis, both the SSS and summed difference score (SDS) were significantly correlated with LV posterior wall thickness (SSS: <i>r</i> = 0.43, <i>p</i> = 0.008; SDS: <i>r</i> = 0.50, <i>p</i> = 0.002). In multivariable analysis, LV posterior wall thickness remained the only significant predictor of SSS (β = 0.410, 95% CI: 0.250-1.895, <i>p</i> = 0.012). Coronary angiography was performed in eight of the patients with abnormal thallium-201 scintigraphy, none of whom had physiologically significant coronary artery lesions. Abnormal thallium-201 scintigraphy findings were common in the patients with cardiac amyloidosis, even though they did not have significant epicardial coronary lesions. Furthermore, SSS was associated with LV posterior wall thickness. These results suggest that thallium-201 scintigraphy may help identify myocardial perfusion abnormalities related to cardiac amyloidosis, particularly in patients presenting with unexplained LV hypertrophy and nonobstructive coronary arteries.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"468-477"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in hydroxyapatite-based nanosystems for targeting bone in osteoporosis: A review of current trends and future directions.","authors":"Aya Mohammed Dhiaa, Amirali Salajegheh, Ali Fawzi Al-Hussainy, Wael Waleed Mustafa, S Renuka Jyothi, Priya Priyadarshini Nayak, J Bethanney Janney, Gurjant Singh, Aashna Sinha, Hayder Naji Sameer, Rasim M Salih, Mohaned Adil, Farzaneh Yazdi","doi":"10.1177/10815589251406148","DOIUrl":"10.1177/10815589251406148","url":null,"abstract":"<p><p>Osteoporosis (OP) is a prevalent skeletal disorder characterized by low bone mass and deterioration of bone tissue, leading to increased bone fragility and a heightened risk of fractures, particularly among the elderly. This condition poses a significant global public health challenge, as osteoporotic fractures contribute substantially to morbidity, mortality, and escalating healthcare costs. Conventional treatments, such as calcium and vitamin D supplementation, often face limitations including side effects, suboptimal efficacy, and poor long-term compliance. Consequently, there is a growing impetus to explore innovative therapeutic strategies that can more effectively enhance bone regeneration and repair. Hydroxyapatite (HAp)-based bone-targeting nanosystems have emerged as a promising frontier in regenerative medicine and drug delivery for bone-related disorders, including OP. HAp, a naturally occurring mineral and a principal component of bone tissue, offers several advantages for nanosystem development: exceptional biocompatibility, chemical similarity to native bone mineral, and the capacity for controlled drug delivery to specific bone sites. These nanosystems can be engineered to optimize size, morphology, and surface functionality, enabling improved integration with bone tissue and targeted delivery of therapeutic agents. Recent advances have demonstrated that HAp-based nanosystems can facilitate personalized care, enhance drug efficacy, and reduce systemic side effects by concentrating therapeutic agents at sites of bone degeneration. Functionalization strategies, like polymer coatings, ion doping, and ligand conjugation - have expanded their potential for bone regeneration, targeted therapy, and combination treatments. This review examines the current trends, mechanisms, and future directions of HAp-based nanosystems for OP, highlighting their potential to transform clinical management and improve patient outcomes.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"407-429"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145656804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The long-term outcomes of combining pyloroplasty with gastric electrical stimulation in drug-refractory gastroparesis: A prospective single-arm trial.","authors":"Irene Sarosiek, Mohammad Bashashati, Zorisadday Gonzalez, Tamis Bright, Karina Espino, Jameson Forster, Katherine Aguirre, Jerzy Sarosiek, Jesus Diaz, Osvaldo Padilla, Brian Davis, Richard McCallum","doi":"10.1177/10815589251366904","DOIUrl":"10.1177/10815589251366904","url":null,"abstract":"<p><p>Surgical treatments for drug-refractory gastroparesis (GP) include gastric electrical stimulation (GES) and pyloric interventions. No longitudinal studies have evaluated the clinical outcomes and safety of combined GES and pyloroplasty (PP). We aimed to investigate the long-term clinical effectiveness of concurrent utilization of GES and PP in GP. Forty-nine gastroparetics (35 female; 38 diabetics [DM]) were enrolled and followed up. Baseline and follow-up total symptom scores (TSS) and individual symptom components were assessed, and a 4-hour scintigraphy gastric emptying test (GET) was performed. Hospitalization days, medication use, HbA1c level, and serious adverse events (SAE) were recorded. The median follow-up was 47 months (range 5-90). Mean TSS was significantly reduced from 18.6 to 6.2 points (<i>p</i> ≤ .001). GET mean retention of isotope-labeled meal was reduced from 74% to 47% at 2 h and from 47% to 19% at 4 h (<i>p</i> < .01). Mean HbA1c improved from 9.0 to 7.9. Annual hospitalization days were reduced from a mean of 25 to 2 (<i>p</i> < .05). The overall satisfaction rate was subjectively graded as 87% by the patients. There were no immediate complications; SAEs attributed to GES occurred in 9% of patients. Based on this study, combining GES with PP shows long-term: (a) improvement in GP symptoms and a high patient satisfaction rate; (b) acceleration and in some patients' normalization of gastric emptying; (c) a decrease in hospitalizations; and (d) an acceptable safety and SAE profile.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"449-457"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of rare and novel variants in inherited retinal disorders: Exome sequencing analysis of six Iranian families.","authors":"Jafar Aghajani, Abbas Doosti, Mojtaba Jafarinia, Mohsen Forouzanfar, Aazam Ahmadi Shadmehri","doi":"10.1177/10815589251388963","DOIUrl":"10.1177/10815589251388963","url":null,"abstract":"<p><p>Inherited retinal disorders (IRDs) are genetically heterogeneous vision disorders, including conditions such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), and congenital achromatopsia. This study aimed to identify the underlying genetic causes of IRDs in six consanguineous Iranian families. We performed whole-exome sequencing (WES) on probands from six families with IRDs. Putative pathogenic variants were validated and analyzed for segregation in family members using Sanger sequencing. We identified six homozygous, likely causative variants in five distinct IRD- associated genes. A novel frameshift variant, c.408delG (p.Val136fs), in <i>CNGB3</i> led to a definitive diagnosis of achromatopsia in one family, revising the initial clinical impression. A novel missense variant, c.G1216A (p.Glu406Lys), was identified in <i>IFT140</i> in a patient with RP. Previously reported pathogenic variants were found in <i>TULP1</i> (c.1199G>A; p.Arg400Gln) and <i>MERTK</i> (c.392G>A; p.Trp131Ter) in two families with RP. In two other families with LCA, we identified known pathogenic variants in <i>RPE65</i> (c.1088C>G; p.Pro363Arg and c.858+1delG). All variants segregated with the disease in an autosomal recessive pattern. Our findings expand the mutational spectrum of IRDs and highlight the crucial role of WES in providing precise molecular diagnoses, which can refine clinical classifications and inform genetic counseling. The identification of two novel variants underscores the importance of studying underrepresented populations, such as that of Iran, to fully characterize the genetic architecture of these disorders.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"478-488"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145491418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancement of an (in vitro/ex vivo) hybrid model framework to forecast polyviral lung disease outcomes.","authors":"Sudha Varalakshmi, Pichamuthu Vijayalakshmi, Velayutham Rajendran","doi":"10.1177/10815589251382266","DOIUrl":"10.1177/10815589251382266","url":null,"abstract":"<p><p>The advancement of an (in vitro/ex vivo) hybrid model framework for forecasting polyviral lung disease outcomes addresses the pressing need for sophisticated tools to understand the complexities of these infections. The primary objective of this study is to advance the development and application of an (in vitro/ex vivo) hybrid model framework for forecasting polyviral lung disease outcomes. This phase of data collection for lung infections, involving single and co-infecting viruses, utilizes ex vivo models (perfused lung tissue slices) and in vitro models (lung cell cultures). Before employing Local Binary Patterns for image analysis, data pre-processing, including Weighted Local Gabor Binary Pattern, is essential. Feature extraction is a critical initial step in enhancing the dataset for developing a hybrid model framework (in vitro/ex vivo) to predict polyviral lung disease outcomes. By employing VGG16 and CBRACDC algorithms, a hybrid model framework (in vitro/ex vivo) is created to forecast polyviral lung disease outcomes. Incorporating the Random Survival Forest algorithm into the hybrid model framework brings numerous benefits for polyviral lung disease prognosis. Python was utilized extensively throughout the development and analysis phases, contributing to the framework's robustness and versatility. The observed minimum cost value of 1.079 indicates the algorithm's optimal performance based on the defined objective. Future research avenues could focus on integrating advanced computational techniques, such as deep learning and artificial intelligence, to improve the predictive accuracy and scalability of hybrid models for forecasting polyviral lung disease outcomes. This could enable personalized medicine approaches and more targeted therapeutic interventions.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"438-448"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}