Journal of investigative medicine : the official publication of the American Federation for Clinical Research最新文献_第7页

Demographic variations and temporal trends in the United States nephrology fellowship match: An analysis of the National Resident Matching Program from 2010 to 2024. EXPRESS：美国肾脏病奖学金匹配的人口变化和时间趋势：2010年至2024年国家居民匹配计划的分析。

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2025-05-30 DOI: 10.1177/10815589251348912

Aman Goyal, Samuel L Flesner, Mah I Kan Changez, Viraj Shah, Gauranga Mahalwar, Andrei Brateanu

{"title":"Demographic variations and temporal trends in the United States nephrology fellowship match: An analysis of the National Resident Matching Program from 2010 to 2024.","authors":"Aman Goyal, Samuel L Flesner, Mah I Kan Changez, Viraj Shah, Gauranga Mahalwar, Andrei Brateanu","doi":"10.1177/10815589251348912","DOIUrl":"10.1177/10815589251348912","url":null,"abstract":"Each year, the National Resident Matching Program (NRMP) releases match outcomes data, highlighting trends, match rates, and competitiveness for each specialty. However, research on the demographics, temporal trends, and disparities among Nephrology applicants remains limited. This retrospective study analyzed data from the NRMP for Nephrology fellowships from 2016 to 2024, including applicant demographics and match outcomes. Chi-square tests were used to assess differences and temporal trends were evaluated with Mann-Kendall tests, and statistical significance was set at p < 0.05. Although the total number of training programs (p < 0.001) and fellowship positions (p < 0.001) increased from 2010 to 2024, the percentage of filled positions significantly declined from 94.1% in 2010 to 65.8% in 2024 (p = 0.047). Females were less likely to apply for Nephrology compared to other fellowships (p = 0.002) and had a lower match rate (p< 0.001). White applicants were less likely to apply for Nephrology than for other fellowships (p < 0.001). US MD graduates had a significantly higher match rate than non-US MD graduates over the study period (p < 0.001). In conclusion, despite the annual increase in Nephrology training positions, declining applicant numbers have reduced fellowship competitiveness. Males, Asians, and non-US international medical graduates comprised the majority of trainees. Addressing pay, job opportunities, and gender disparities is crucial to sustaining the future Nephrology workforce in the United States.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251348912"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstructive sleep apnea, preserved ratio impaired spirometry (PRISm), and all-cause mortality: a community-based prospective study. EXPRESS：阻塞性睡眠呼吸暂停、保留比例肺功能受损（PRISm）和全因死亡率：一项基于社区的前瞻性研究。

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2025-05-30 DOI: 10.1177/10815589251348913

Yuhan Wang, Mengcan Wang, Beini Zhou, Wuriliga Yue, Ke Hu

{"title":"Obstructive sleep apnea, preserved ratio impaired spirometry (PRISm), and all-cause mortality: a community-based prospective study.","authors":"Yuhan Wang, Mengcan Wang, Beini Zhou, Wuriliga Yue, Ke Hu","doi":"10.1177/10815589251348913","DOIUrl":"10.1177/10815589251348913","url":null,"abstract":"The association between obstructive sleep apnea (OSA) and preserved ratio impaired spirometry (PRISm) has not been well studied. This prospective cohort study enrolled 3408 adults aged 20-79 years without airflow obstruction. The median follow-up time was 11.8 years. Probable OSA (pOSA) was defined based on symptoms (snore, snort/stop breathing, sleepy) and was divided into a normal lung function group (FEV1 ≥ 80% predicted) and a PRISm group (FEV1 < 80% predicted) according to spirometry. Multivariable regression was used to analyze the association between pOSA and PRISm, and Cox regression and Kaplan-Meier analysis were used to assess the effects of pOSA alone, PRISm alone, and both on the risk of mortality. All analyses used survey weights. At baseline, 28.5% of participants presented with pOSA, and 11.4% had PRISm. Multivariable analysis showed an independent association between pOSA and PRISm (adjusted OR = 1.40, 95% CI 1.01-1.94, p = 0.04). Individuals with comorbid pOSA and PRISm had the highest risk of death (adjusted HR = 2.34, 95% CI 1.55-3.55) compared with individuals with PRISm alone (adjusted HR = 1.78, 95% CI 1.3-2.44), while individuals with pOSA alone were not significantly associated with death (adjusted p = 0.893). Kaplan-Meier analysis confirmed significant survival differences between the groups (p < 0.0001). Our results show that individuals with suspected OSA are associated with a higher prevalence of PRISm and individuals with comorbid OSA and PRISm have a higher risk of all-cause death. Although the limitations of the observational study do not allow us to determine causality, it emphasizes that the association between OSA and PRISm deserves further in-depth study.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251348913"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of CRP-to-prealbumin and CRP-to-albumin ratios and other laboratory-derived indices on clinical outcomes in the oldest-old patients in a geriatric ward: A retrospective observational study. 一项回顾性观察研究：c反应蛋白(CRP)/白蛋白前期和CRP/白蛋白比率及其他实验室衍生指标对老年病房老年患者临床结局的影响。

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2025-05-25 DOI: 10.1177/10815589251346967

Zeynep Iclal Turgut, Orhan Cicek, Ilyas Akkar, Merve Yilmaz Kars, Mustafa Hakan Dogan, Ayse Dikmeer, Muhammet Cemal Kizilarslanoglu

{"title":"The effects of CRP-to-prealbumin and CRP-to-albumin ratios and other laboratory-derived indices on clinical outcomes in the oldest-old patients in a geriatric ward: A retrospective observational study.","authors":"Zeynep Iclal Turgut, Orhan Cicek, Ilyas Akkar, Merve Yilmaz Kars, Mustafa Hakan Dogan, Ayse Dikmeer, Muhammet Cemal Kizilarslanoglu","doi":"10.1177/10815589251346967","DOIUrl":"10.1177/10815589251346967","url":null,"abstract":"This study explores the prognostic value of several inflammation-based indices-C-reactive protein (CRP)-to-albumin ratio (CAR), CRP-to-prealbumin ratio (CPR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and mean platelet volume-to-lymphocyte ratio (MPVLR)-in hospitalized patients aged 80 years and older. A total of 133 patients were retrospectively analyzed. The in-hospital mortality rate was 11.3%, and the median length of hospital stay was 15 days. Patients who died were significantly older and had higher CAR, CPR, NLR, and MPVLR levels compared to survivors (p < 0.05 for all). In multivariate Cox regression analysis, CAR (HR = 1.671, p = 0.021), NLR (HR = 1.175, p = 0.006), and MPVLR (HR = 1.169, p = 0.007) emerged as independent predictors of in-hospital mortality. Receiver operating characteristic curve analysis demonstrated moderate discriminative ability for these indices: NLR (area under the curve (AUC) = 0.777, cutoff >3.12, p < 0.001), CAR (AUC = 0.721, cutoff >0.99, p < 0.001), MPVLR (AUC = 0.689, cutoff >9.82, p = 0.006), and CPR (AUC = 0.676, cutoff >187.8, p = 0.009). These findings suggest that inflammatory indices-particularly NLR, CAR, and MPVLR-may serve as accessible and clinically relevant prognostic tools in very old-hospitalized patients.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251346967"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging the gut and the heart-Exploring pathophysiology, risk factors, and therapeutic implications of cardiovascular disease in inflammatory bowel disease. 心血管疾病在炎症性肠病中的病理生理和危险因素：综述。

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2025-05-25 DOI: 10.1177/10815589251346966

Diana Othon-Martínez, Sylvia Valeria Peña-Muñoz, Margarita Riojas-Barrett, Genesis Vidales-López, Josué Moisés Sánchez Guzmán, Lukasz Kwapisz

{"title":"Bridging the gut and the heart-Exploring pathophysiology, risk factors, and therapeutic implications of cardiovascular disease in inflammatory bowel disease.","authors":"Diana Othon-Martínez, Sylvia Valeria Peña-Muñoz, Margarita Riojas-Barrett, Genesis Vidales-López, Josué Moisés Sánchez Guzmán, Lukasz Kwapisz","doi":"10.1177/10815589251346966","DOIUrl":"10.1177/10815589251346966","url":null,"abstract":"Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic systemic immune dysregulated disorder affecting the gastrointestinal tract that often has extraintestinal manifestations. Limited data exist on the cardiovascular (CV) implications of IBD, but a higher prevalence of CV disease (CVD) has been observed compared to the general population, resulting in increased mortality risk. This review examines the pathophysiology and risk factors linking IBD to CVD, highlighting several key mechanisms: The \"lipid paradox\" in active IBD, arterial stiffness and endothelial dysfunction, proinflammatory cytokine activity, gut microbiota dysbiosis, and drug-induced myocardiopathy. The main findings include information about IBD patients exhibiting a higher incidence of CVD compared to the general population, independent of traditional risk factors. Chronic inflammation, altered lipid profiles, and gut microbiome imbalances play a significant role in heightened CV risk. Routine CV risk assessment should be considered during clinical assessment, to integrate into IBD management. Anti-inflammatory therapies may reduce CVD risk, while careful consideration is needed for drugs with potential CV side effects. Further research is required to understand the complex interplay between IBD and CVD, particularly regarding the impact of novel therapies and lifestyle interventions on long-term CV outcomes in IBD patients.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589251346966"},"PeriodicalIF":0.0,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Efficacy and safety of endovascular therapy versus surgical clipping for patients with unruptured middle cerebral artery bifurcation aneurysms. 纠正:血管内治疗与手术夹持治疗未破裂的大脑中动脉分叉动脉瘤的疗效和安全性。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-12-01 DOI: 10.1136/jim-2021-002230corr1

引用次数: 0

Construction and validation of an autophagy-related long non-coding RNA signature to predict the prognosis of kidney renal papillary cell carcinoma. 自噬相关长链非编码RNA标记预测肾乳头状细胞癌预后的构建和验证。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-20 DOI: 10.1136/jim-2022-002379

Zhen Kang, Junfeng Yang

{"title":"Construction and validation of an autophagy-related long non-coding RNA signature to predict the prognosis of kidney renal papillary cell carcinoma.","authors":"Zhen Kang, Junfeng Yang","doi":"10.1136/jim-2022-002379","DOIUrl":"https://doi.org/10.1136/jim-2022-002379","url":null,"abstract":"To identify the autophagy-related long non-coding RNAs (ARlncRNAs) associated with the prognosis of kidney renal papillary cell carcinoma (KIRP), thereby establishing a clinical prognostic model. The gene expression matrix and clinical survival information of patients with KIRP were downloaded from The Cancer Genome Atlas database, and were divided into the training and testing groups. ARlncRNAs associated with the KIRP prognosis were analyzed by univariate, Least Absolute Shrinkage and Selection Operator (LASSO(, and multivariate Cox regression to construct a signature. We combined clinical factors associated with the prognosis with ARlncRNAs to establish a prognostic model of patients with KIRP. A nomogram was established to predict 1-year, 3-year, and 5-year survival of patients with KIRP. Besides, we built the lncRNA-messenger RNA co-expression network and used Kyoto Encyclopedia of Genes and Genomes and Gene Set Enrichment Analysis to detect the biological functions of ARlncRNAs. LEF1-AS1, CU634019.6, C2orf48, AC027228.2, and AC107464.3 were identified. A prognosis-related ARlncRNAs signature was constructed in the training group and validated in the testing group. Patients with KIRP with a low risk score had significantly longer survival time than those with a high risk score. The risk score significantly affected the prognosis of patients, thereby being used for modeling. The area under the receiver operating characteristic curve values of 1-year, 3-year, and 5-year overall survival were 0.80, 0.78, and 0.84 in the training group, respectively. The signature had high concordance index and good accuracy in predicting the prognosis, which were confirmed by the nomogram. The prognosis-related ARlncRNAs signature we identified had a more accurate prediction for the prognosis of patients with KIRP.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1536-1544"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40086934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial. 比较每日两次艾塞那肽与胰岛素对2型糖尿病患者肾功能的影响:一项随机对照试验的二次分析。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-20 DOI: 10.1136/jim-2021-002237

Jie Zhang, Tong-Zhang Xian, Ming-Xiao Wu, Chen Li, Weihao Wang, Fuli Man, Xianbo Zhang, Xiaoxia Wang, Qi Pan, Lixin Guo

{"title":"Comparing the effects of twice-daily exenatide and insulin on renal function in patients with type 2 diabetes mellitus: secondary analysis of a randomized controlled trial.","authors":"Jie Zhang, Tong-Zhang Xian, Ming-Xiao Wu, Chen Li, Weihao Wang, Fuli Man, Xianbo Zhang, Xiaoxia Wang, Qi Pan, Lixin Guo","doi":"10.1136/jim-2021-002237","DOIUrl":"https://doi.org/10.1136/jim-2021-002237","url":null,"abstract":"This is a secondary analysis of a randomized controlled trial (RCT) on the effects of the glucagon-like peptide-1 receptor agonists exenatide and insulin aspartate 30 injection on carotid intima-media thickness. Here, we report the renal outcomes of the intervention in patients with type 2 diabetes mellitus (T2DM). Data from the RCT study was used to evaluate the effect of exenatide or insulin given for 52 weeks on estimated glomerular filtration rate (eGFR) in patients with T2DM. The primary end point was the change in the eGFR from baseline between the exenatide and insulin groups in normal versus overweight patients and patients with obesity. The secondary end point was the correlation between change in eGFR and oxidative stress, glycemic control, and dyslipidemia. There was a significant difference in eGFR between the insulin and exenatide groups at 52 weeks (p=0.0135). Within the insulin group, the eGFR remained below baseline at 52 weeks in all patients, and there was an increase in body weight in the normal group compared with the overweight patients and patients with obesity. The opposite was observed in the exenatide group. A decrease in body weight was prominent in the exenatide group at 52 weeks (p<0.05), the eGFR was below baseline in overweight patients and patients with obesity and significantly above baseline in the normal group (p<0.05). The eGFR was positively correlated to 8-oxo-7,8-dihydroguanosine in the insulin group (p<0.05) but not the exenatide group. It can be concluded that compared with insulin, exenatide may improve renal function in overweight patients and patients with obesity more than in normal-weight patients with T2DM, but a further RCT is needed to confirm this effect.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1529-1535"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40086935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-risk human papillomavirus infection in pregnant women: a descriptive analysis of cohorts from two centers. 高危人乳头瘤病毒感染孕妇:来自两个中心队列的描述性分析。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-06-21 DOI: 10.1136/jim-2022-002442

Jing Liu, Yuhong Li, Di Bo, Jiandong Wang, Yudong Wang

{"title":"High-risk human papillomavirus infection in pregnant women: a descriptive analysis of cohorts from two centers.","authors":"Jing Liu, Yuhong Li, Di Bo, Jiandong Wang, Yudong Wang","doi":"10.1136/jim-2022-002442","DOIUrl":"https://doi.org/10.1136/jim-2022-002442","url":null,"abstract":"The aim was to descriptively analyze the clinical characteristics, cytopathology, and outcomes of pregnant patients with high-risk human papillomavirus (HPV) infection. Clinical data of 151,516 female patients with high-risk HPV infection were retrospectively collected. Baseline data, cervical cytology results, histopathology, HPV types, delivery mode, and follow-up outcomes were recorded for descriptive analysis. A total of 157 patients were identified as positive for high-risk HPV. There were 32 (24.2%), 6 (4.5%), and 107 (81.1%) cases of HPV-16, HPV-18, and other types, respectively. Additionally, 12 patients showed combined infection with HPV-18 or HPV-16 and other types. Cytopathological examinations showed that the most common type was low-grade squamous intraepithelial lesion (LSIL; 104 cases, 78.8%), followed by high-grade squamous intraepithelial lesion (HSIL; 17 cases, 12.8%), atypical squamous cells of undetermined significance (10 cases, 9.6%), and cervical cancer (1 case, 0.7%). Thirty-seven patients underwent colposcopic biopsy, of whom 9 (24.3%) showed normal results, while 12 (32.4%) and 13 (35.1%) patients had LSIL and HSIL, respectively. χ2 tests demonstrated that different delivery modes did not show significant difference in patients' cervical cytopathology (p>0.05). However, therapeutic methods were statistically different among patients with different cytopathological types (p<0.05). Cervical alterations in pregnancy mostly go along with high-risk HPV infection. High-risk HPV infection in pregnancy with abnormal cervical cytology should be followed closely during the pregnancy and postpartum period.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1494-1500"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40150626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Review of existing evidence demonstrates that methotrexate does not cause liver fibrosis. 对现有证据的回顾表明甲氨蝶呤不会引起肝纤维化。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-08-24 DOI: 10.1136/jim-2021-002206

Hira Imad Cheema, Dirk Haselow, Jonathan Ankin Dranoff

{"title":"Review of existing evidence demonstrates that methotrexate does not cause liver fibrosis.","authors":"Hira Imad Cheema, Dirk Haselow, Jonathan Ankin Dranoff","doi":"10.1136/jim-2021-002206","DOIUrl":"https://doi.org/10.1136/jim-2021-002206","url":null,"abstract":"It has long been believed that methotrexate in therapeutic doses causes progressive liver injury resulting in advanced fibrosis and cirrhosis. Historically, this was a common indication for serial liver biopsy. However, new evidence suggests that methotrexate may not be a direct cause of liver injury; rather the injury and fibrosis attributed to methotrexate may be mediated by other mechanisms, specifically non-alcoholic fatty liver disease. The recent widespread use of non-invasive assessment of liver fibrosis has provided new evidence supporting this hypothesis. Thus, we conducted a meta-analysis and systematic review to determine whether methotrexate is indeed a direct cause of liver injury. For the meta-analysis portion, a comprehensive literature search was performed to identify manuscripts relevant to the topic. Of the 138 studies examined, 20 met our inclusion criteria. However, only 3 studies had sufficient homogeneity to allow aggregation. Thus, the remainder of the study was dedicated to a critical review of all studies relevant to the topic with particular attention to populations examined, risk factors, and assessment of injury and/or fibrosis. Meta-analysis did not show a statistically significant association between methotrexate dose and liver fibrosis. Individual studies reported fibrosis related to confounding factors such as diabetes, obesity, pre-existing chronic liver disease but not methotrexate exposure. In conclusion, existing evidence demonstrates that advanced liver fibrosis and cirrhosis previously attributed to methotrexate are in fact caused by metabolic liver disease or other chronic liver diseases, but not by methotrexate itself. This observation should direct the care of patients treated with long-term methotrexate.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1452-1460"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40416357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C. 在LDL-C控制的胸痛患者中，MHR和NHR与冠状动脉疾病相关，而LHR与冠状动脉疾病无关。

IF 2.6

Journal of investigative medicine : the official publication of the American Federation for Clinical Research Pub Date : 2022-10-01 Epub Date: 2022-07-11 DOI: 10.1136/jim-2021-002314

Mengping Liu, Xiaojun Liu, Zhen Wei, Rui Hua, Yuzhi Huang, Xiang Hao, Zuyi Yuan, Juan Zhou

{"title":"MHR and NHR but not LHR were associated with coronary artery disease in patients with chest pain with controlled LDL-C.","authors":"Mengping Liu, Xiaojun Liu, Zhen Wei, Rui Hua, Yuzhi Huang, Xiang Hao, Zuyi Yuan, Juan Zhou","doi":"10.1136/jim-2021-002314","DOIUrl":"https://doi.org/10.1136/jim-2021-002314","url":null,"abstract":"Several leukocyte to high-density lipoprotein cholesterol (HDL-C) ratios, including monocyte to HDL-C ratio (MHR), neutrophil to HDL-C ratio (NHR) and lymphocyte to HDL-C ratio (LHR), have been proposed as novel inflammatory indicators. We performed a cross-sectional study to investigate the relationships between these leukocyte to HDL-C ratios and coronary artery disease (CAD) in patients with chest pain with controlled low-density lipoprotein cholesterol (LDL-C). A total of 3482 patients with chest pain with LDL-C <1.8 mmol/L were enrolled. We evaluated the relationships between MHR, NHR, LHR and HDL-C and the occurrence of CAD as well as severe stenosis. We found that in patients with chest pain, higher MHR (adjusted OR=2.83, 95% CI 1.61 to 4.99, p<0.001) and NHR (adjusted OR=1.08, 95% CI 1.04 to 1.13, p<0.001), as well as lower HDL-C (adjusted OR=0.53, 95% CI 0.36 to 0.78, p=0.001), but not higher LHR (adjusted OR=1.06, 95% CI 0.94 to 1.20, p=0.341), had a stronger association with the occurrence of CAD. Moreover, unlike LHR (adjusted OR=1.02, 95% CI 0.93 to 1.13, p=0.654), higher MHR (adjusted OR=2.10, 95% CI 1.43 to 3.07, p<0.001) and NHR (adjusted OR=1.06, 95% CI 1.04 to 1.09, p<0.001) and lower HDL-C (adjusted OR=0.38, 95% CI 0.26 to 0.56, p<0.001) were risk factors for severe stenosis. A receiver operating characteristic curve analysis exhibited comparable abilities between MHR and NHR in predicting the presence and severity of CAD. In conclusion, even though patients with chest pain have achieved LDL-C <1.8 mmol/L, the inflammatory indicators MHR and NHR maintained their predictive abilities and remained associated with the occurrence and severity of CAD.","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"1501-1507"},"PeriodicalIF":2.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40607322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3