Journal of investigative medicine : the official publication of the American Federation for Clinical Research最新文献

{"title":"Analysis of risk factors for uterine fibroids and construction of prediction model.","authors":"Yapei Lu, Ziqi Cheng","doi":"10.1177/10815589261451184","DOIUrl":"10.1177/10815589261451184","url":null,"abstract":"<p><p>Due to the unclear mechanism of uterine fibroids, more risk factors need to be clarified. This study explored associated factors of uterine fibroids and established a prediction model using clinical data from our institution. Logistic and Least Absolute Shrinkage and Selection Operator (LASSO) analyses were used to screen the key associated factors of uterine fibroids. The receiver operating characteristic (ROC) curve and DeLong test were used to analyze the prediction performance of indicators. XGBoost classification and random forest were used to rank the feature importance. A prediction model based on the key factors was established. Decision Curve Analysis (DCA), ROC, and nomogram analysis were used to assess the performance of the model for predicting uterine fibroids. Of the 303 patients enrolled, 201 had uterine fibroids. Logistic and LASSO regression analyses identified five core risk indicators, including age, thyroid-stimulating hormone index (TSHI), number of deliveries, abnormal menstruation, and polycystic syndrome. Both ROC and feature importance ranking analyses consistently implied the importance of age and TSHI on uterine fibroid risk. With the increase of age and TSHI, the risk of uterine fibroids was significantly increased (all <i>p</i> for trend <0.05). The combination of age and TSHI achieved favorable performance and clinical net benefit in fibroids risk prediction, and its favorable performance was also validated in the external National Health and Nutrition Examination Surveys database. Age and TSHI were the key associated factors of uterine fibroids, and their combination had promising clinical value for predicting the risk of uterine fibroids.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589261451184"},"PeriodicalIF":2.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and disparities of mortality in comorbid cardiovascular disease and osteoporosis: A 25-year nationwide study in the United States.","authors":"Jiang-Yu Tu, Tao-Ping Yi, Meng-Qin Tu","doi":"10.1177/10815589261444734","DOIUrl":"https://doi.org/10.1177/10815589261444734","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) and osteoporosis are highly prevalent age-related conditions that frequently coexist, yet their joint epidemiology and mortality burden remain poorly characterized in middle-aged and elderly adults. This retrospective cross-sectional study analyzed mortality data from the CDC WONDER database between 1999 and 2023. Cases were identified using ICD-10 codes for CVD (I00-I99) and osteoporosis (M80-M81). Age-adjusted mortality rates (AAMR) were calculated, and Joinpoint regression was applied to assess temporal trends across subgroups defined by age, sex, race/ethnicity, region, and urbanization. A total of 188,152 deaths were attributed to CVD with coexisting osteoporosis. The AAMR declined significantly from 9.28 per 100,000 in 1999 to 3.79 in 2023 (average annual percent change -3.73, <i>p</i> < 0.001). Women accounted for 88% of deaths, with consistently higher AAMR than men. Non-Hispanic Whites exhibited the highest mortality burden, while non-Hispanic Blacks had the lowest. Mortality increased markedly with age, particularly among those ≥85 years. Medium/small metropolitan and rural residents consistently demonstrated higher mortality rates compared with large metropolitan areas. Geographic variation persisted, with the Midwest and West showing the greatest burden. Mortality from comorbid CVD and osteoporosis has declined substantially over the past two decades in middle-aged and elderly adults, yet striking sex, racial, age, and geographic disparities persist. These findings underscore the need for integrated, tailored prevention and management strategies targeting high-risk populations.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"10815589261444734"},"PeriodicalIF":2.0,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147826094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential risk genotypes associated with symptoms of pesticide poisoning based on polymorphisms in the XRCC1 (<i>rs25487</i> and <i>rs1799782</i>), SOD2 (<i>rs4880</i>), PON1 (<i>rs662</i>) and GSTP1 (<i>rs1695</i>) genes, in farmers in the Cienega region.","authors":"Carlos Alfonso Flores Gutiérrez, Erandis Dheni Torres Sánchez, Emmanuel Reyes Uribe, Irán Cortes Trujillo, Gabriela Martínez Cortés, Marco Antonio Hernández Bedolla, Joel Salazar Flores","doi":"10.1177/10815589251361367","DOIUrl":"10.1177/10815589251361367","url":null,"abstract":"<p><p>The variants in the genes involved in the defense mechanisms against pesticide poisoning could be the cause to develop symptoms of poisoning with these substances. In this work, we analyzed polymorphisms in genes that defend against pesticide poisoning in 112 farmers from the Cienega region of Jalisco. We genotyped the variants <i>rs25487</i> and <i>rs1799782</i> of the <i>XRCC1</i> gene, <i>rs28360135</i> of the <i>XRCC4</i> gene, <i>rs4880</i> of the <i>SOD2</i> gene and <i>rs662</i> and <i>rs1695</i> of the PON1 and <i>GSTP1</i> genes, respectively. For <i>rs25487</i> (AA vs AG; <i>p</i> = 0.045), significance was found with heart palpitations, <i>rs1799782</i> with salivation (CC vs CT; <i>p</i> = 0.038), <i>rs4880</i> with sweating (TT+TC vs CC; <i>p</i> = 0.026; TC vs CC; <i>p</i> = 0.034) and <i>rs662</i> with cough (AA vs AG+GG; <i>p</i> = 0.001; AA vs AG; <i>p</i> = 0.006; AA vs GG; <i>p</i> = 0.027) and salivation (AG vs GG; <i>p</i> = 0.037). Furthermore, the variant <i>rs1799782</i> found significance with carbamates (<i>p</i> = 0.049) and pyrethroids (<i>p</i> = 0.015), as well as the TT versus TC+CC (<i>p</i> = 0.043) and TT versus TC (<i>p</i> = 0.034) genotypes of <i>rs4880</i> with carbamates. Finally, AA+AG versus GG (<i>p</i> = 0.039) and AG versus GG (<i>p</i> = 0.025) genotypes of the <i>rs1695</i> polymorphism were also significant with carbamates. Except for the <i>XRCC4 rs28360135</i> and <i>GSTP1 rs1695</i> variants, the rest of the polymorphisms showed significance with symptoms of acute poisoning. The presence of <i>XRCC1</i> (<i>rs1799782</i>), <i>SOD2</i> (<i>rs4880</i>) and <i>GSTP1</i> (<i>rs1695</i>) variants may be risk factors for carbamate and pyrethroid poisoning.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"309-320"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of C-reactive protein combined with platelets for the progression and prognosis of sepsis: A retrospective cohort study.","authors":"Tengfei Chen, Maoyu Ding, Yumei Yang, Qinxiang Yang, Wei Guo, Xiaolong Xu, Qingquan Liu","doi":"10.1177/10815589251375026","DOIUrl":"10.1177/10815589251375026","url":null,"abstract":"<p><p>This retrospective cohort study aimed to explore the predictive value of the C-reactive protein (CRP)/platelet count (PLT) ratio for sepsis progression and prognosis. A total of 237 sepsis patients admitted to the ICU between January 2019 and November 2024 were divided into survivor (<i>n</i> = 157) and non-survivor (<i>n</i> = 80) groups based on 28-day outcomes. Intergroup comparison, receiver operating characteristic (ROC) curve analysis, survival analysis, LASSO regression analysis, and Cox regression analysis were employed to evaluate the impact of clinical data, dynamic CRP/PLT ratios (on days 1 and 7), and change degree ((CRP/PLT day 7 - CRP/PLT day 1)/CRP/PLT day 1) on the progression and prognosis of sepsis. The non-survivor group showed significantly higher CRP/PLT ratios on day 1 (0.80 vs 0.39, <i>p</i> < 0.001), day 7 (1.40 vs 0.29, <i>p</i> < 0.001), and change degree (0.44 vs -0.31, <i>p</i> < 0.001) compared to the survivor group. Time-dependent ROC analysis revealed the CRP/PLT ratio on day 7 had the highest prognostic accuracy for short-term mortality (AUC = 0.819). After LASSO selection and multivariable adjustment, CRP/PLT ratio on day 7 > 0.51 (HR = 2.21, 95% CI: 1.17, 4.15) and change degree > -0.04 (HR = 1.89, 95% CI: 1.06, 3.38) remained significant prognostic factors for mortality. These findings suggest the CRP/PLT ratio, particularly on day 7, and the change degree can serve as effective indicators for the early assessment of mortality risk in sepsis patients, aiding clinical prognosis and treatment adjustment.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"345-356"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylation levels of the <i>LEP, LEPR</i>, and <i>ADIPOQ</i> genes and their association with metabolically healthy obesity.","authors":"Yéssika Weyman-Vela, Ada A Sandoval-Carrillo, Jose M Salas-Pacheco, Fernando Guerrero-Romero, Alma Cristina Salas-Leal, Luis E Simental-Mendía","doi":"10.1177/10815589251378182","DOIUrl":"10.1177/10815589251378182","url":null,"abstract":"<p><p>It has been reported that DNA methylation in the epigenetic profile of the genes <i>LEP</i> and <i>ADIPOQ</i> is associated with obesity. To the best of our knowledge, there are no previous reports assessing the methylation of the <i>LEP</i>, <i>LEPR</i>, and <i>ADIPOQ</i> genes in subjects with metabolically healthy obesity (MHO). Therefore, the aim of this study was to determine the association between methylation of the <i>LEP</i>, <i>LEPR</i>, and <i>ADIPOQ</i> genes with the MHO phenotype. Healthy men and women aged 20-55 years of age with a body mass index ≥30 kg/m² were enrolled in a case-control study. Exclusion criteria were pregnancy, alcohol intake, smoking, diabetes, hypertension, hepatic disease, cardiovascular disease, renal disease, thyroid disease, cancer, and/or any type of drug therapy. Individuals with MHO were allocated to the case group, while those with metabolically unhealthy obesity (MUO) were assigned to the control group. A total of 78 individuals were enrolled and allocated into the groups with MHO (n = 39) or MUO (n = 39). In the MHO group, the methylation percentage of the <i>LEP</i> gene was significantly higher than in the MUO group, while the <i>LEPR</i> and <i>ADIPOQ</i> genes did not show differences between the study groups. Finally, the methylation of the <i>LEP</i> gene (OR = 1.67; 95% confidence interval (CI): 1.29-2.16; <i>p</i> < 0.001), but not of <i>LEPR</i> (OR = 0.77; 95% CI: 0.45-1.32; <i>p</i> = 0.350) and <i>ADIPOQ</i> (OR = 1.01; 95% CI: 0.97-1.05; <i>p</i> = 0.411), presented a positive association with the MHO phenotype. In conclusion, the <i>LEP</i> gene hypermethylation is positively associated with the MHO phenotype. In addition, the <i>LEPR</i> gene overexpression was significantly associated with the MHO.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"357-363"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the nexus between myocardial microcirculation perfusion and contractile mechanics in nonobstructive hypertrophic cardiomyopathy.","authors":"Jing Nan, Lina Guan, Chao Yuan, Ya Ba, Yuming Mu","doi":"10.1177/10815589251355176","DOIUrl":"10.1177/10815589251355176","url":null,"abstract":"<p><p>This study quantitatively analyzed myocardial microcirculation perfusion in nonobstructive hypertrophic cardiomyopathy (HCM) patients and evaluated their mechanical properties. A total of 56 individuals were involved, consisting of 28 nonobstructive HCM patients and an equal number of healthy volunteers. Each participant underwent comprehensive diagnostic procedures, including two-dimensional echocardiography, contrast-enhanced myocardial ultrasound (MCE), and two-dimensional speckle tracking imaging. Nonobstructive HCM patients were further classified into two groups based on the extent of myocardial hypertrophy: hypertrophic segmental (HS) myocardium and non-hypertrophic segmental myocardium. The study's findings indicated no significant differences in essential demographic factors such as age, height, and weight between the nonobstructive HCM and control groups. However, significant disparities were observed in myocardial perfusion and mechanical properties between these groups, particularly in aspects such as myocardial thickness, tricuspid regurgitation, and left atrial volume. Notably, the myocardial global longitudinal strain (GLS) is significantly decreased in patients with nonobstructive HCM, whereas the global circumferential strain changes are not easily discernible. A notable positive correlation existed within the HS between myocardial perfusion parameters and mechanical properties. The study concluded that myocardial microcirculation perfusion and GLS are impaired in nonobstructive HCM patients, with more pronounced damage in HS, closely associated with alterations in myocardial mechanical characteristics.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"375-387"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the correlation of IL-6 with circRNA-DLGAP4 in the pathogenesis and diagnosis of rheumatoid arthritis.","authors":"Laila Mahdi, Rehab Elsayed Marzouk, Olfat G Shaker, Yasmine M Amrousy, Rania Talaat, Mona Mahrous Abdelaty, Noha O Shawky, Mai A El Kosaier, Marwa Kamel","doi":"10.1177/10815589251348916","DOIUrl":"10.1177/10815589251348916","url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) as a systemic autoimmune disease is often misdiagnosed in its early stages due to vague symptoms, delaying treatment and increasing the likelihood of severe complications including cardiovascular mortality. The main aim of this work is to evaluate the serum levels of interleukin 6 (IL-6) and circular RNA DLGAP4 (circRNA-DLGAP4) in RA patients and healthy controls, also analyzing the correlations between all biomarkers to indicate whether those can be used as predictors for early diagnoses of RA. One hundred subjects were included, they were divided into two equal groups, 50-healthy matched individuals and 50 RA patients. For all participants, a venous blood sample for serum isolation was taken and analyzed for the serum level of IL-6 and circRNA-DLGAP4 as well as laboratory tests. For all patients, full clinical investigations have been performed as well as Disease Activity Score (DAS28) and modified Larsen radiological scoring have been calculated. Results revealed that there was a significant up-regulation of the concentration level of IL-6 (p = 0.0001) and circRNA-DLGAP4 expression (p = 0.0001) in the RA group as compared to healthy controls. Moreover, altered expression of circRNA-DLGAP4 showed a slight significant difference between patients with positive deformities with p = 0.05. Serum levels of both IL-6 and circRNA-DLGAP4 increased with the severity of RA. Various correlations were detected of both IL-6 and circRNA-DLGAP4 with the associated RA parameters. It can be concluded that IL-6 and circRNA-DLGAP4 could have a potential role in RA pathogenesis and could act as possible biomarkers of RA for further studies to be applied for RA diagnostic purposes.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"364-374"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal trends and disparities in cardiovascular mortality among individuals with inflammatory bowel disease: A U.S. nationwide analysis.","authors":"Abdalhakim Shubietah, Mohammad Bdair, Anwar Zahran, Mohammed AbuBaha, Maisam Tobeh, Abubakar Nazir, Mohamed S Elgendy, Ameer Awashra, Mohammed Tareq Mutar, Jehad Zeidalkilani, Hosam I Taha, Fathi Milhem, Ahmed Emara, Suleiman Khreshi, Abdallah Hussein","doi":"10.1177/10815589251366911","DOIUrl":"10.1177/10815589251366911","url":null,"abstract":"<p><p>While the link between inflammatory bowel disease (IBD) and cardiovascular disease (CVD) is established, long-term trends in cardiovascular mortality among IBD patients remain unclear. This nationwide study analyzed U.S. mortality data from 1999-2020 using the CDC's Wide-ranging Online Data for Epidemiologic Research. We identified deaths with CVD as the underlying cause and IBD as a contributing factor, calculating age-adjusted mortality rates (AAMRs) by demographic and geographic factors. Among 11,891 CVD deaths linked to IBD, AAMRs declined significantly from 1999 to 2015 (-2.74% annually; <i>p</i> = 0.0064), then plateaued. Post-2015 increases were noted among Black individuals (+23.03%, 2017-2020; <i>p</i> = 0.0416) and men (+27.19%, 2018-2020; <i>p</i> = 0.0100). Mortality was highest among White and non-Hispanic populations, with regional variation. Forecasting models project rising mortality through 2040, especially among men and White individuals. These trends highlight persistent disparities and the need for targeted cardiovascular risk reduction in IBD populations.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"388-398"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144786441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiotensin II receptor blockers and isolated left bundle branch block: A retrospective cohort analysis.","authors":"Nada Said, Ramzi Ibrahim, Hoang Nhat Pham, George Bcharah, Mahmoud Abdelnabi, Eiad Habib, Reza Arsanjani","doi":"10.1177/10815589251366917","DOIUrl":"10.1177/10815589251366917","url":null,"abstract":"<p><p>Chronic left bundle branch block (LBBB) has been associated with adverse cardiac remodeling and the development of cardiomyopathy. This retrospective cohort study evaluated the impact of angiotensin II receptor blocker (ARB) therapy on cardiovascular outcomes in adults with isolated LBBB with no known heart failure (HF), cardiomyopathy, or ischemic heart disease. Using the TriNetX global research network, patients were stratified by ARB use and followed for up to 5 years. Propensity score matching was performed to balance characteristics. Three thousand two hundred sixty-six patients were included in each group with comparable baseline characteristics. The ARB therapy was not associated with a reduction in new-onset acute HF events (4.9% vs 4.4%; hazard ratio (HR) 1.05 (95% CI 0.84-1.32)). Similarly, there were no significant differences in rates of all-cause hospitalizations, cardiac arrest, or ventricular tachycardia. However, ARB use was associated with a significantly lower, all-cause mortality rate (8.6% vs 12.1%; HR 0.67 (95% CI 0.57-0.77)). This is the first real-world study examining ARB use in a cohort with isolated LBBB, highlighting a potential mortality benefit, despite no difference in acute HF risk. While ARBs are not effective in preventing LBBB-induced cardiomyopathy based on these findings, the observed survival advantage warrants further investigation. Prospective studies are needed to elucidate mechanisms underlying this mortality benefit and to determine whether ARBs should be considered in the management of patients with isolated LBBB.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"399-401"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and predictors of autoimmune gastritis in patients with celiac disease.","authors":"Ramazan Erdem Er, Volkan Yilmaz, Yigit Baykara, Fatih Acehan, Cagdas Kalkan, Irfan Soykan","doi":"10.1177/10815589251361891","DOIUrl":"10.1177/10815589251361891","url":null,"abstract":"<p><p>Celiac disease (CD) is an immune-mediated disease triggered by gluten in genetically susceptible individuals. Autoimmune gastritis (AIG) is an autoimmune disease of the stomach characterized by autoantibodies directed against some structures containing H⁺/K⁺-ATPase and intrinsic factor. Both diseases may lead to micronutrient malabsorption and anemia. The goals of this study were to investigate the prevalence of AIG in patients with CD and determine the possible factors that might predict presence of AIG in patients with CD. Patients diagnosed with CD were investigated and data were collected regarding patient demographics, presence of concomitant autoimmune diseases, serological markers, and micronutrient levels. Diagnosis of CD has been established according to the Marsh classification. AIG was diagnosed according to histopathologic findings. One hundred eighty-three patients with CD were enrolled. Out of 183 patients, there were 19 patients with AIG (10.4%). In multivariable regression analysis, Marsh type 2 CD (odds ratio (OR): 15.838; 95% confidence interval (CI): 4.774-52.545) and the absence of anti-endomysium IgA (OR: 0.257; 95% CI: 0.084-0.786) were identified as predictors of AIG in patients with CD. Ten point four percent of patients with CD also had AIG. Factors that might predict the presence of a concomitant AIG were the presence of Marsh type 2 CD and absence of anti-endomysium IgA in patients with CD. Therefore, we suggest that patients negative for anti-endomysium IgA antibody and who have Marsh type 2 CD should be screened for the presence of AIG.</p>","PeriodicalId":520677,"journal":{"name":"Journal of investigative medicine : the official publication of the American Federation for Clinical Research","volume":" ","pages":"321-328"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}