Journal of investigational allergology & clinical immunology最新文献

{"title":"Factors Affecting the Success of Step-up Therapy in Patients With Moderate-Severe Asthma: A Real-Life Study.","authors":"J Delgado,&nbsp;E Martinez-Moragón,&nbsp;T Fernández-Sánchez","doi":"10.18176/jiaci.0470","DOIUrl":"https://doi.org/10.18176/jiaci.0470","url":null,"abstract":"<p><strong>Introduction and objective: </strong>Introduction: Clinical practice guidelines recommend regular adjustment of treatment to achieve control of asthma. A step-up approach based on the degree of disease control should be followed. Objective: To perform a real-life analysis of the factors that affect the success or failure of this therapeutic strategy and of the criteria applied by clinicians when applying a step-up approach in a representative sample of patients diagnosed with moderate-severe asthma.</p><p><strong>Material and methods: </strong>We performed a multicenter retrospective cohort study involving 226 Spanish specialist physicians (98 allergologists, 127 pulmonologists, and 1 family physician). We included 1254 patients (787 women) diagnosed with moderate-severe asthma who underwent step-up therapy during 2016.</p><p><strong>Results: </strong>Step-up was successful in 44% of cases. The factors associated with success were presence of <2 comorbid conditions, lower grade of severity and therapy step before modification, absence of exacerbations during the previous year, fewer daytime/nighttime symptoms, and limitation in activities, as well as type of inhaled corticosteroid/ long-acting β₂-agonist combination after modification, lower body mass index, and higher fractional exhaled nitric oxide. An early increase in the maintenance dose once a lack of control was detected (≤3 months, >3 to ≤6 months, >6 to ≤12 months) was more likely to be successful.</p><p><strong>Conclusion: </strong>The factors that determine whether or not this therapeutic strategy manages to control asthma are time since onset of clinical impairment, previous grade of severity, number of comorbid conditions, previous exacerbations, and frequency of symptoms.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"145-150"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37454206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19.","authors":"J M Rodrigo-Muñoz,&nbsp;B Sastre,&nbsp;J A Cañas,&nbsp;M Gil-Martínez,&nbsp;N Redondo,&nbsp;V Del Pozo","doi":"10.18176/jiaci.0624","DOIUrl":"https://doi.org/10.18176/jiaci.0624","url":null,"abstract":"<p><p>Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health and disease status. Classically, eosinophils have been considered important immune cells in the pathogenesis of inflammatory processes (eg, parasitic helminth infections) and allergic or pulmonary diseases (eg, asthma) and are always associated with a type 2 immune response. Furthermore, in recent years, eosinophils have been linked to the immune response by conferring host protection against fungi, bacteria, and viruses, which they recognize through several molecules, such as toll-like receptors and the retinoic acid-inducible gene 1-like receptor. The immune protection provided by eosinophils is exerted through multiple mechanisms and properties. Eosinophils contain numerous cytoplasmatic granules that release cationic proteins, cytokines, chemokines, and other molecules, all of which contribute to their functioning. In addition to the competence of eosinophils as effector cells, their capabilities as antigen-presenting cells enable them to act in multiple situations, thus promoting diverse aspects of the immune response. This review summarizes various aspects of eosinophil biology, with emphasis on the mechanisms used and roles played by eosinophils in host defence against viral infections and response to vaccines. The review focuses on respiratory viruses, such as the new coronavirus, SARS-CoV-2.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"94-107"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0624","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38051327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pilot Experience Using Drug Provocation Testing for the Study of Hypersensitivity to Chemotherapy and Biological Agents.","authors":"J Martí-Garrido,&nbsp;P Vázquez-Revuelta,&nbsp;R Lleonart-Bellfill,&nbsp;K Molina-Mata,&nbsp;C Muñoz-Sánchez,&nbsp;R Madrigal-Burgaleta","doi":"10.18176/jiaci.0552","DOIUrl":"https://doi.org/10.18176/jiaci.0552","url":null,"abstract":"Martí-Garrido J1,2, Vázquez-Revuelta P1,2, Lleonart-Bellfill R1,2, Molina-Mata K1,3, Muñoz-Sánchez C1,4, Madrigal-Burgaleta R1,5 1Drug Desensitisation Centre, Catalan Institute of Oncology, Barcelona, Spain 2Allergy Service, Internal Medicine Department, Bellvitge University Hospital, Barcelona, Spain 3Medical Oncology Service, Catalan Institute of Oncology, Barcelona, Spain 4Pharmacy Service, Catalan Institute of Oncology, Barcelona, Spain 5Allergy and Severe Asthma Service, St Bartholomew’s Hospital, Barts Health NHS Trust, London, UK","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"166-168"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0552","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38079168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and Allergy: Allergists' Workload During the Pandemic.","authors":"I Fernández-de-Alba,&nbsp;C Brigido,&nbsp;I García-Gutierrez,&nbsp;D Antolín-Amérigo,&nbsp;S Sánchez-García","doi":"10.18176/jiaci.0632","DOIUrl":"https://doi.org/10.18176/jiaci.0632","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"187-190"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0632","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38116021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between IgE-Mediated Sensitization to Staphylococcus aureus Enterotoxin B, Asthma Severity, and Atopy.","authors":"P Barranco,&nbsp;P Palao,&nbsp;I Ruiz,&nbsp;J Domínguez-Ortega,&nbsp;G Vilà-Nadal,&nbsp;B Pola,&nbsp;S Quirce","doi":"10.18176/jiaci.0573","DOIUrl":"https://doi.org/10.18176/jiaci.0573","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"170-173"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0573","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38177330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ARADyAL: The Spanish Multidisciplinary Research Network for Allergic Diseases.","authors":"M J Torres,&nbsp;J Agundez,&nbsp;D Barber,&nbsp;J Bartra,&nbsp;I Davila,&nbsp;M M Escribese,&nbsp;M Fernandez-Rivas,&nbsp;M Ferrer,&nbsp;E Perez-Inestrosa,&nbsp;M Villalba,&nbsp;C Mayorga","doi":"10.18176/jiaci.0629","DOIUrl":"https://doi.org/10.18176/jiaci.0629","url":null,"abstract":"<p><p>Thematic cooperative health research networks (RETICS) are organizational structures promoted by the Instituto de Salud Carlos III of the Spanish Ministry of Science with the objective of carrying out cooperative research projects addressing challenges of general interest for society as a whole in the field of health care. The RETICS of Asthma, Adverse Drug Reactions, and Allergy (ARADyAL) received funding in 2016 for a 5-year program (2017-2021). ARADyAL integrates basic and clinical research in the areas of allergy, immunology, genetics, nanomedicine, pharmacology, and chemistry, with special interest in research on new biomarkers and the design and evaluation of new interventions for allergic patients with severe phenotypes. The consortium comprises 28 groups across Spain, including 171 clinical and basic researchers, 17 clinical groups that cover more than 10 000 000 patients of all ages from urban and rural areas and 11 basic groups active mostly at universities and research institutes. ARADyAL has proposed a research program organized into 3 different areas focusing on precision medicine, as follows: Program 1, Mechanisms and prediction of adverse drug reactions and allergic diseases; Program 2, Toward a precise diagnosis of allergic diseases; and Program 3, Predicting interventions in allergic diseases. There is also 1 common program dedicated to training. The network has a Steering Committee and an External Advisory Scientific Committee, which advise the global network coordinator, who has recognized expertise in the field. ARADyAL is a unique meeting point for clinicians and basic scientists who are already working in allergy.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"108-119"},"PeriodicalIF":7.2,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0629","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38179869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Environmental Pollen Concentration a Risk Factor for SARS-CoV-2 Infection?","authors":"A J Moral de Gregorio,&nbsp;R Guzmán Rodríguez,&nbsp;C J Senent Sánchez,&nbsp;J A Lemus Calderón,&nbsp;A Valero Santiago","doi":"10.18176/jiaci.0743","DOIUrl":"https://doi.org/10.18176/jiaci.0743","url":null,"abstract":"To the Editor: Since the new betacoronavirus SARS-CoV-2 [1] emerged in Wuhan, People's Republic of China, in late 2019 and the World Health Organization declared COVID-19 a pandemic on March 11, 2020, the number of cases increased progressively, reaching 153 632 235 million infected and 3 215 270 million dead as at April 30, 2021 [2]. In this context, various publications have linked the SARS-CoV-2 infection rate to the pollen concentration in a specific area, the most recent being that of Damialis et al [3], who reported data on 31 countries around the world. This theory is supported by studies indicating that pollens, regardless of their allergenic potential, possess the ability to suppress antiviral immunity by weakening the immune system’s response to respiratory viruses [4]. At cellular level, the eosinophil, especially in eosinopenia, has been reported to be a relevant factor in COVID-19, although further studies are needed to confirm and clarify its role in this emerging disease [5]. Other articles have also appeared. Hoogeveen et al [6] concluded that pollen is an inverse predictor of respiratory infections, including COVID-19. In our opinion, the statement made by Damialis et al [3] at a global level does not bear any relation to what we have observed in Spain, since, as COVID-19 occurs in waves, a period of pollination may coincide at some point with a certain increase in cases. Therefore, we believe that chance plays a greater role in this relationship than increased pollen concentrations in the environment. In addition, Damialis et al only assess 1 month of pollination, thus potentially inviting bias. Data from a whole year would make for a more interesting assessment. For this reason, we proposed a retrospective longitudinal study to interpret the relationship between daily cases of SARS-CoV-2 infection and the total daily pollen concentration in Spain. To this end, we collected the total daily pollen concentration and the daily incidence of COVID-19 cases in 14 Spanish cities (Madrid, Barcelona, Valencia, Sevilla, La Coruña, Oviedo, Burgos, San Sebastian, Logroño, Zaragoza, Pamplona, Murcia, Toledo, and Cáceres) from March 1, 2020 to February 28, 2021. We chose these cities to ensure a heterogeneous sample of the Spanish population; the dates chosen cover the first year of the pandemic in Spain. Pollen data were collected from the website www.polenes. com of the Aerobiology Network of the Spanish Society of Allergology and Clinical Immunology (SEAIC); the data on infections per city per day were obtained from the website of the Spanish Ministry of Health, Consumption, and Social Welfare. Once these data were available, a Spearman correlation was performed to determine whether there was a significant relationship between total pollen concentrations and cases of SARS-CoV-2 infection. Comparison of the daily cases of COVID-19 with the daily pollen concentration in the cities analyzed yielded a negative correlation coefficient, thus rul","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"79-80"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allergic Rhinitis Due to the Ornamental Plant Sansevieria trifasciata.","authors":"A Nin-Valencia,&nbsp;M Tomás-Pérez,&nbsp;B Bartolomé Zavala","doi":"10.18176/jiaci.0704","DOIUrl":"https://doi.org/10.18176/jiaci.0704","url":null,"abstract":"1. Habiyaremye C, Matanguihan JB, D'Alpoim Guedes J, Ganjyal GM, Whiteman MR, Kidwell KK, et al. Proso Millet (Panicum miliaceum L.) and Its Potential for Cultivation in the Pacific Northwest, U.S.: A Review. Front Plant Sci. 2017;7:1961. 2. Verma V, Patel S. Nutritional security and value-added products from finger millets (ragi). J. Appl. Chem. 2012;1:485-9. 3. Changmei S, Dorothy J. Millet-the frugal grain. Int J Sci Res. Rev. 2014;3:75-90. 4. Parker JL, Yunginger JW, Swedlund HA. Anaphylaxis after ingestion of millet seeds. J. Allergy Clin. Immunol. 1981;67(1):78-80. 5. Bohle B, Hirt W, Nachbargauer P, Ebner H, Ebner C. Allergy to millet: another risk for atopic bird keepers. Allergy 2003;58(4):325-8. 6. Rombold S, Ollert M, Sbornik M, Rakoski J, Darsow U, Ring J. Immediate-Type respiratory allergy to millet-containing seed mixture of bird food. WAO Journal. 2008;1(8):135-7. 7. Kalinova J, Moudry J. Content and quality of protein in proso millet (Panicum miliaceum L.) varieties. Plant Foods Hum Nutr. 2006;61(1):45-9. 8. Parameswaran KP, Thayumanavan B. Isolation and characterization of a 20 kD prolamin from kodo millet (Paspalum scrobiculatum): Homology with other millets and cereals. Plant Foods for Human Nutrition. 1997;50:359-73. 9. Parameswaran KP, Thayumanavan B. Homologies between prolamins of different minor millets. Plant Foods Hum Nutr. 1995;48(2):119-26. 10. Hemmer W, Sesztak-Greinecker G, Wöhrl S, Wantke F. Food allergy to millet and cross-reactivity with rice, corn and other cereals Allergol Int. 2017;66:490-2.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"62-64"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ascites as a Rare Presentation of Eosinophilic Enteritis in a Pollinic Patient.","authors":"M P López-Sáez,&nbsp;K Magdalena Bethencourt,&nbsp;M Muñoz Tornero,&nbsp;M Alajarin Cervera,&nbsp;E Serrano Santos,&nbsp;I Sánchez-Guerrero Villajos,&nbsp;J D López Sánchez","doi":"10.18176/jiaci.0697","DOIUrl":"https://doi.org/10.18176/jiaci.0697","url":null,"abstract":"López-Sáez MP1, Magdalena Bethencourt K1, Muñoz Tornero M2, Alajarin Cervera M2, Serrano Santos E1,3, Sánchez-Guerrero Villajos I1, López Sánchez JD1 1Allergy Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain 2Gastroenterology Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain 3Biochemical Department, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"56-58"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Ribosomal Proteins as Cross-Reactive Allergens in a Case of Mushroom Allergy.","authors":"R Ogino,&nbsp;Y Chinuki,&nbsp;R Tobita,&nbsp;E Morita","doi":"10.18176/jiaci.0700","DOIUrl":"https://doi.org/10.18176/jiaci.0700","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"58-60"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}