Journal of investigational allergology & clinical immunology最新文献

{"title":"Millet Seed Sensitization in a Lovebird Keeper: A Case Report.","authors":"E Bravo, I González Mahave, J P Sola, I Vidal Oribe, P Hernández Alfonso, M Peñalver-Mellado","doi":"10.18176/jiaci.0703","DOIUrl":"https://doi.org/10.18176/jiaci.0703","url":null,"abstract":"1. Kayode OS, Siew LQC, Pillai P, Haque R, Rutkowski K, Caballero MR. Mushroom allergy: Case series. J Allergy Clin Immunol Pract. 2020;8:375-9. 2. Hoff M, Trüeb RM, Ballmer-Weber BK, Vieths S, Wuethrich B. Immediate-type hypersensitivity reaction to ingestion of mycoprotein (Quorn) in a patient allergic to molds caused by acidic ribosomal protein P2. J Allergy Clin Immunol. 2003;111:1106-10. 3. Gabriel MF, González-Delgado P, Postigo I, Fernández J, Soriano V, Cueva B, et al. From respiratory sensitization to food allergy: Anaphylactic reaction after ingestion of mushrooms (Agaricus bisporus). Med Mycol Case Rep. 2015;8:14-6. 4. Betancor D, Nuñez-Borque E, Cuesta-Herranz J, Escudero C, Freundt N, Pastor-Vargas C, et al. Porin: A New Button Mushroom (Agaricus bisporus) Allergen. J Investig Allergol Clin Immunol. 2020;30:135-6. 5. Ogino R, Chinuki Y, Yokooji T, Takizawa D, Matsuo H, Morita E. Identification of peroxidase-1 and beta-glucosidase as crossreactive wheat allergens in grass pollen-related wheat allergy. Allergol Int. 2021;70:215-22. 6. Ito T, Kobayashi T, Egusa C, Maeda T, Abe N, Okubo Y, et al. A case of food allergy due to three different mushroom species. Allergol Int. 2020;69:152-3. 7. Pravettoni V, Primavesi L, Piantanida M. Shiitake mushroom (Lentinus edodes): a poorly known allergen in Western countries responsible for severe work-related asthma. Int J Occup Med Environ Health. 2014;27:871-4. Millet Seed Sensitization in a Lovebird Keeper: A Case Report","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"60-62"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Profile of Sensitization to Dermatophagoides pteronyssinus Dust Mite in Portugal.","authors":"R Limão,&nbsp;A Spínola Santos,&nbsp;L Araújo,&nbsp;J Cosme,&nbsp;F Inácio,&nbsp;E Tomaz,&nbsp;A Ferrão,&nbsp;N Santos,&nbsp;A Sokolova,&nbsp;A Môrete,&nbsp;H Falcão,&nbsp;L Cunha,&nbsp;A Ferreira,&nbsp;A Bras,&nbsp;F Ribeiro,&nbsp;C Lozoya,&nbsp;P Leiria Pinto,&nbsp;S Prates,&nbsp;J Plácido,&nbsp;A Coimbra,&nbsp;L Taborda-Barata,&nbsp;M C Pereira Santos,&nbsp;M Pereira Barbosa,&nbsp;F Pineda","doi":"10.18176/jiaci.0533","DOIUrl":"https://doi.org/10.18176/jiaci.0533","url":null,"abstract":"<p><strong>Background and objectives: </strong>To analyze component-resolved diagnosis of sensitization to Dermatophagoides pteronyssinus (Der p) in patients with respiratory allergy and the association between diagnostic findings and clinical severity in different geographical areas.</p><p><strong>Methods: </strong>The study population comprised 217 patients (mean age, 25.85 [12.7] years; 51.16% female) selected from 13 centers in Portugal (5 from the North, n=65). All had allergic rhinitis with or without asthma and positive skin prick test results to at least 1 dust mite. Specific IgE (sIgE) to Der p, Dermatophagoides farinae, Lepidoglyphus destructor, Der p 1, Der p 2, Der p 10, and Der p 23 was determined using ImmunoCAP. The Mann-Whitney test was applied for the following comparisons: rhinitis vs rhinitis and asthma; mild vs moderate-to-severe rhinitis; North vs South.</p><p><strong>Results: </strong>The prevalence of sensitization was 98.2% for Der p, and 72.4%, 89.4%, 9.7%, and 77% for Der p 1, Der p 2, Der p 10, and Der p 23, respectively. The corresponding median sIgE levels were 8.56, 17.7, 0.01, and 3.95 kUA/L. sIgE to all allergens was higher in patients with moderate-to-severe rhinitis and rhinitis with asthma (nonsignficant). Concentrations of sIgE to Der p 2 were significantly higher in the South than in the North (P=.0496).</p><p><strong>Conclusion: </strong>The most common sensitization in Portugal was to Der p. The highest prevalence and median sIgE level were observed for Der p 2. All sIgE values for molecular components were higher in more symptomatic patients (nonsignificant). Concentrations of sIgE to Der p 2 were higher in the South, probably because of the warmer temperature and/or the larger sample size.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"33-39"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0533","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38210069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Epithelial Cell Cytokines Are Associated With Early-Onset Atopic Dermatitis.","authors":"C Gamez,&nbsp;J Metcalfe,&nbsp;S L Prescott,&nbsp;D J Palmer","doi":"10.18176/jiaci.0699","DOIUrl":"https://doi.org/10.18176/jiaci.0699","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"48-50"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Localized Exanthematous Pustulosis Due to Alendronate.","authors":"S Bautista-Villanueva,&nbsp;C Galleani,&nbsp;R Barranco,&nbsp;T Bellón,&nbsp;M Blanco,&nbsp;I García-Moguel","doi":"10.18176/jiaci.0709","DOIUrl":"https://doi.org/10.18176/jiaci.0709","url":null,"abstract":"Bautista-Villanueva S1, Galleani C1, Barranco R1,2,3, Bellón T3,4, Blanco M5, García-Moguel I1 1Allergy Department, Hospital Universitario 12 de Octubre, Madrid, Spain 2RETIC ARADyAL, Instituto de Salud Carlos III, Madrid, Spain 3PIELenRed Consortium 4Drug hypersensitivity group. Hospital La Paz Institute for Health Research (IdiPaz), Madrid, Spain 5Pathology Department, Hospital Universitario 12 de Octubre, Madrid, Spain","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"69-70"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment and Outcome in Deficiency of Adenosine Deaminase 2: A Literature Review.","authors":"B Zhang,&nbsp;N Xu,&nbsp;J Chen,&nbsp;S Zhang,&nbsp;X Huang,&nbsp;M Shen,&nbsp;X Zeng","doi":"10.18176/jiaci.0748","DOIUrl":"https://doi.org/10.18176/jiaci.0748","url":null,"abstract":"<p><strong>Objectives: </strong>Deficiency of adenosine deaminase 2 (DADA2) is a rare disease with varying phenotypes and disease outcomes. We evaluated the treatment of DADA2 and explored the factors associated with disease outcome.</p><p><strong>Methods: </strong>A systemic literature review of DADA2 was conducted. Cases were included if they had documented detailed genotypes, phenotypes, treatment protocols, and outcomes. Patients were categorized as having uncontrolled and controlled disease. Factors associated with disease outcome were analyzed using logistic regression models.</p><p><strong>Results: </strong>The study population comprised 242 DADA2 patients with data on treatment protocols and responses, of whom 17 required no treatment. Tumor necrosis factor a inhibitors (TNFi) were effective in 78.6% (103/131). Hematological abnormalities and increased acute phase reactants are independently associated with the effectiveness of TNFi (OR, 0.21 [95%CI, 0.07-0.661; P=.007] and 9.62 [95%CI, 2.31-40.00; P=.002, respectively). Among the 225 patients requiring active treatment, 157 (69.8%) had controlled disease and 68 (30.2%) uncontrolled disease. Neither age of disease onset nor genotype was associated with disease outcome. Increased acute phase reactant values, constitutional symptoms, neurological symptoms, and treatment with TNFi were independently associated with disease control, while recurrent infections and severe vascular events were the main causes of mortality (10/21 and 6/21, respectively).</p><p><strong>Conclusion: </strong>In patients requiring treatment, symptoms of systemic inflammation and vasculitis and treatment with TNFi are associated with disease control. Recurrent infections and severe vascular events should be treated intensively, as they are the main causes of death. Hematological abnormalities should be monitored, as they decrease the effectiveness of TNFi.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"13-22"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Sensitization to Related Animal Proteins (Crocodile, Frog, and Chicken) Among Fish-Allergic Patients.","authors":"E Haroun-Díaz,&nbsp;N Blanca-López,&nbsp;L Martín-Pedraza,&nbsp;F J Ruano,&nbsp;M L Somoza,&nbsp;M Vázquez de la Torre,&nbsp;D Pérez-Alzate,&nbsp;P López-González,&nbsp;A Prieto-Moreno,&nbsp;B Bartolomé,&nbsp;M Blanca,&nbsp;G Canto","doi":"10.18176/jiaci.0705","DOIUrl":"https://doi.org/10.18176/jiaci.0705","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"50-52"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39410706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B Cells and COVID-19: Lessons From Patients With Agammaglobulinemia and the Study of Functional B-Cell Polymorphisms.","authors":"M Speletas,&nbsp;S Raftopoulou,&nbsp;E Farmaki,&nbsp;N Gatselis,&nbsp;G Germanidis,&nbsp;V A Mouchtouri,&nbsp;S Hatzianastasiou,&nbsp;S Georgiadou,&nbsp;G Tsinti,&nbsp;O Tsachouridou,&nbsp;M Tseroni,&nbsp;S Metallidis,&nbsp;G Dalekos,&nbsp;H Eibel,&nbsp;C Hadjichristodoulou","doi":"10.18176/jiaci.0726","DOIUrl":"https://doi.org/10.18176/jiaci.0726","url":null,"abstract":"Department of Immunology & Histocompatibility, Faculty of Medicine, University of Thessaly, Larissa, Greece First Department of Pediatrics, Ippokrateion Hospital, Medical School, Aristotle University of Thessaloniki, Greece Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Centre of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Greece First Internal Medicine Department, Infectious Diseases Division, AHEPA Hospital, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece National Public Health Organization, Athens, Greece Center for Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"53-55"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39018049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate Hypersensitivity to Mealworm and Cricket: Beyond Shrimp and House Dust Mite Cross-Reactivity.","authors":"F Mankouri,&nbsp;Y Sereme,&nbsp;M Michel,&nbsp;R Piarroux,&nbsp;L Pahus,&nbsp;P Chanez,&nbsp;J Vitte,&nbsp;M Gouitaa","doi":"10.18176/jiaci.0707","DOIUrl":"https://doi.org/10.18176/jiaci.0707","url":null,"abstract":"1. Rwawiire S, Tomkova B. Morphological, Thermal, and Mechanical Characterization of Sansevieria trifasciata Fibers. Journal of Natural Fibers. 2015;12:201-10. 2. Pamonpol K, Areerob T, Prueksakorn K. Indoor Air Quality Improvement by Simple Ventilated Practice and Sansevieria Trifasciata. Atmosphere. 2020;11:271. 3. Mahillon V, Saussez S, Michel O. High Incidence of Sensitization to Ornamental Plants in Allergic Rhinitis. Allergy. 2006;61:1138-40. 4. Laemmli UK. Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4. Nature.1970;227:680-5. 5. Goldberg A, Confino Cohen R, Waisel Y. Allergic responses to ornamental plants: High incidence in the general atopic population and especially among flower growers. J Allergy Clin Immunol. 1998;102:210-4. 6. Axelsson IG, Johansson SG, Zetterström O. A new indoor allergen from a common nonflowering plant. Allergy. 1987;42:604-11. 7. Herrera-Lasso V, Dalmau G, Gázquez V, Pineda De La Losa F, Castillo M, Garnica D, et al. Allergy to Spathiphyllum wallisii, an Indoor Allergen. J Investig Allergol Clin Immunol. 2019;29:453-4. 8. Axelsson IG. Allergy to Ficus benjamina (weeping fig) in nonatopic subjects. Allergy. 1995;50:284-5. 9. Aydin Ö, Erkekol F, Misirloigil Z, Demirel Y, Mungan D. Allergic sensitization to ornamental plants in patients with allergic rhinitis and asthma. Allergy Asthma Proc. 2014;35:9-14.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"64-66"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38974006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Hypersensitivity to Trimethoprim-Sulfamethoxazole With an Ultrarapid Desensitization Protocol in HIV Infection.","authors":"R V Villarreal-González,&nbsp;S N González-Díaz,&nbsp;A Canel Paredes,&nbsp;C E De Lira-Quezada,&nbsp;G K Rocha-Silva,&nbsp;A López Méndez","doi":"10.18176/jiaci.0708","DOIUrl":"https://doi.org/10.18176/jiaci.0708","url":null,"abstract":"Prophylaxis for opportunistic infections has been a major advance in the treatment of HIV-infected patients, significantly decreasing morbidity and mortality. Nevertheless, these improved treatment options have been accompanied by an increase in reports of hypersensitivity reactions (HSRs) to sulfonamides. The most common cutaneous manifestations of the reactions are as follows: maculopapular rash (36.6%); fixed drug eruption (22%); and type IV HSRs (urticaria) and type I HSRs (angioedema) (12.6%). Withdrawal of the drug and desensitization are both possible therapeutic approaches following confirmed diagnosis of adverse reactions to cotrimoxazole [1]. Many protocols for desensitization to trimethoprim-sulfamethoxazole in HIVinfected patients are described in the literature. These initially took several days and, more recently, a single day, although few take less than 6 hours [2]. The objective of this study was to report 3 cases of HSR to trimethoprim-sulfamethoxazole in HIV-infected patients and describe their management with a novel ultrarapid 3.25-hour, 13-step oral desensitization protocol. Written informed consent for publication was obtained from the patients. Three HIV-infected men presented clinical manifestations of drug-induced HSR after receiving treatment with trimethoprim-sulfamethoxazole. The first patient was a 30-year-old man with a complicated appendectomy and abdominal collections who had recently been diagnosed with HIV infection (CD4+ 140/μL) and syphilis. Trimethoprim-sulfamethoxazole was started owing to fever and intra-abdominal collection. After administration of the third dose, he developed disseminated dermatosis on the head, face, neck, and thorax. He was diagnosed with maculopapular rash secondary to trimethoprimsulfamethoxazole, and patch testing yielded a positive reaction (+++, vesicles covering 50% of the test site). Premedication with chlorphenamine was given prior to the protocol (3 solutions [A 1:100, B 1:10, C 1:1]), with no adverse events (Table). Raphael Piarroux is currently employed by ldbio diagnostics. The remaining authors declare that they have no conflict of interests.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"66-68"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38919267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral-like Reaction or Hypersensitivity? Erythema Multiforme Minor Reaction and Moderate Eosinophilia After the Pfizer-BioNTech BNT162b2 (mRNA-Based) SARS-CoV-2 Vaccine.","authors":"L de Las Vecillas,&nbsp;J López,&nbsp;E Morchón,&nbsp;F Rodriguez,&nbsp;M Drake,&nbsp;M Martino","doi":"10.18176/jiaci.0757","DOIUrl":"https://doi.org/10.18176/jiaci.0757","url":null,"abstract":"Department of Allergy, Marqués de Valdecilla University Hospital, Instituto de Investigación Marques de Valdecilla (IDIVAL), Santander, Spain Department of Dermatology, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain Department of Pathology, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla (IDIVAL), Santander, Spain Both can be considered as first author","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"77-78"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39472473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}