Journal of investigational allergology & clinical immunology最新文献

{"title":"Kounis Syndrome in a Covid-19 Patient Following Intravenous Administration of Azithromycin.","authors":"C Gogos, V Sachpekidis, V Moschovidis, I Styliadis, N G Kounis","doi":"10.18176/jiaci.0723","DOIUrl":"https://doi.org/10.18176/jiaci.0723","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"75-76"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39094155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaphylaxis to Sunflower Seed With Tolerance to Other Nuts: The Role of Lipophilic Allergens.","authors":"L González-Bravo, J Laiseca-García, F Pineda, A Rosado","doi":"10.18176/jiaci.0710","DOIUrl":"https://doi.org/10.18176/jiaci.0710","url":null,"abstract":"Sunflower (Helianthus annuus) belongs to the genus of the Asteraceae plant family (Compositae). Sunflower seeds are consumed throughout the world, and patients who are allergic to other nuts usually tolerate them. Sunflower seed allergy is rare. Very few cases of anaphylaxis after ingestion have been described [1-5], with most involving an occupational origin in exposed workers [2,4]. Several allergenic proteins have been identified in sunflower seeds [1,3,4,6] and are documented by the World Health Organization/International Union of Immunological Studies Allergen Nomenclature Sub-Committee [www. allergen.org], as follows: Hel a 1 (34 kDa, a major inhaled allergen with no specific protein family described to date); Hel a 2 (a 14.7-kDa profilin); Hel a 3 (a 9-kDa lipid transfer protein [LTP], food allergen); and Hel a 6 (a 42-kDa pectate lyase, inhaled allergen). Others, such as Hel a 2S albumin (16 kDa), a 12-kDa storage protein that appears to be the mature form of Hel a 2S albumin, and a 13-kDa LTP, have also been described as potential allergens in other publications [1,5,6]. We present a case of anaphylaxis after ingestion of sunflower seeds in a patient sensitized to other nuts, all of which he tolerated. A 35-year-old man with a personal history of atopy (egg allergy in childhood that resolved and seasonal rhinoconjunctivitis) experienced lingual and palmoplantar pruritus, generalized hives, facial angioedema, conjunctival injection, dyspnea, and intense cough 5 minutes after eating a handful of roasted sunflower seeds (previously well tolerated). He went to the emergency department (blood pressure 128/65 mmHg and baseline SatO2 of 95%) and was treated with intravenous antihistamines and corticosteroids. His condition gradually improved within the following hour. No cofactors were identified. A series of complementary tests were carried out. Commercial skin prick tests (ALK-Abelló) were performed with peanut, walnut, pistachio, almond, hazelnut, chestnut, sunflower seed, peach LTP, profilin, mustard, and mugwort. The results were positive only for sunflower seed (12 mm). Prick-prick test with hazelnut, walnut, peanut, almond, and pistachio. The results were positive only for hazelnut (9 mm) and walnut (7 mm). Sunflower seed was not tested owing to the 12-mm skin prick test result and a moderate initial reaction. ImmunoCAP (ThermoFisher) revealed the following: total Immunoglobulin E (IgE), 124 IU/mL; specific IgE against sunflower seed, 3.18 kUA/L; almond, 0.11 kUA/L; cashew, 0.06 kUA/L; hazelnut, 0.27 kUA/L; peanut, 0.14 kUA/L; walnut, 0.27 kUA/L; pistachio, 0.18 kUA/L; and rPru p 3 (peach LTP), 0.01 kUA/L. ImmunoCAP ISAC 112 (ThermoFisher) revealed the following: moderate-to-high levels of cypress allergen (Cup a 1), 10.30 ISU; group 1 timothy grass pollen allergens, 2.76 ISU; and Alternaria (Alt a 1), 4.90 ISU. The results were negative for all nut proteins included. Open oral challenges with roasted hazelnuts and walnut were negative. ","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"71-72"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39025764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Custard Apple Allergy With Glycosyltransferase as the Culprit Allergen.","authors":"A Carrón-Herrero, C Fernández-Lozano, L Peracho, E Martínez-Alonso, A Alcázar, J Martínez-Botas, B de-La-Hoz-Caballer, D González-De-Olano","doi":"10.18176/jiaci.0711","DOIUrl":"https://doi.org/10.18176/jiaci.0711","url":null,"abstract":"Allergology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain Biochemistry-Research Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain Department of Research, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain Proteomics Unit. Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain Department of Biochemistry, University Hospital Ramón y Cajal-IRYCIS, Madrid, Spain CIBER of Obesity and Nutrition Pathophysiology (CIBEROBN), Madrid, Spain Spanish Thematic Network and Co-operative Research Centres, ARADyAL, Spain Both authors have equally contributed and should be both considered as first authors","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"73-74"},"PeriodicalIF":7.2,"publicationDate":"2021-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39026180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of FOXP3 Expression and Serum Vitamin D and C Concentrations When Predicting Acquisition of Tolerance in Infants With Cow's Milk Allergy.","authors":"I Sardecka-Milewska,&nbsp;E Łoś-Rycharska,&nbsp;J Gawryjołek,&nbsp;E Toporowska-Kowalska,&nbsp;A Krogulska","doi":"10.18176/jiaci.0422","DOIUrl":"https://doi.org/10.18176/jiaci.0422","url":null,"abstract":"<p><strong>Background and objective: </strong>Treg cells and dietetic factors may play a significant role in the natural acquisition of tolerance in children with cow's milk allergy (CMA). The best marker for Treg lymphocytes is the transcription factor forkhead boxP3 (FOXP3). Objective: We examine the relationship between FOXP3 mRNA expression and serum concentrations of vitamins D and C and the development of different phenotypes of tolerance in children with CMA.</p><p><strong>Material and methods: </strong>The study group comprised 138 infants with CMA and 101 healthy infants. All children underwent oral food challenge, first with an extensively heated milk product and then with unheated products. FOXP3 mRNA expression and serum vitamin C and D concentrations were evaluated.</p><p><strong>Results: </strong>At 2 years of life, 54 children (39.1%) still had CMA, 43 (31.2%) were unheated milk-reactive and heated milk-tolerant, while 41 (29.7%) had outgrown their allergy. The mean (SD) level of FOXP3 expression in the study group was 2.07 (1.23), which was lower than the control group value of 2.98 (1.52) (P<.001). A value below 1.45 indicated allergy. The mean serum level of vitamin D in the study group was lower than in the control group (29.67 [7.09] vs 33.35 [4.13] ng/mL; P<.001). No significant differences were found in mean serum vitamin C content.</p><p><strong>Conclusions: </strong>Increased FOXP3 mRNA expression can predict faster acquisition of tolerance in infants with CMA. These children have lower serum vitamin D levels than healthy children. No relationship was found between the natural history of CMA and serum vitamin C concentration.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"182-190"},"PeriodicalIF":7.2,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0422","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40450326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concomitant Celiac Disease and Wheat Allergy: 2 Case Reports.","authors":"C Lombardi,&nbsp;E Savi,&nbsp;G Passalacqua","doi":"10.18176/jiaci.0421","DOIUrl":"https://doi.org/10.18176/jiaci.0421","url":null,"abstract":"Wheat flour (Triticum aestivum) is a major food source throughout the world. It is used in the manufacture of bread, pasta, and cereals. Wheat can cause various diseases, including IgE-mediated food allergy, wheat-dependent exercise-induced anaphylaxis, respiratory allergy (baker’s asthma), celiac disease, and nonceliac gluten sensitivity. Wheat allergy is an IgE-mediated response to any of the proteins present in wheat, including gluten. Its prevalence varies depending on age and region from 0.4% to 4% [1]. Around 65% of children outgrow this allergy by the age of 12 months. Celiac disease is an autoimmune disorder with an aberrant response to gluten proteins (present in wheat, barley, and rye) with subsequent atrophy of intestinal villi, impaired intestinal absorption, and malnutrition. The symptoms of wheat allergy can range from mild to life-threatening and include skin rash, nausea, abdominal pain, vomiting/diarrhea, respiratory symptoms, and even anaphylaxis. Onset is usually within minutes, more rarely within 1-2 hours. A tentative diagnosis can be made using skin prick testing or a specific serum IgE assay. Nonetheless, the assessment of IgE with the whole wheat extract is poorly sensitive and specific owing to crossreactivity with other allergenic molecules. Wheat proteins are classified into albumins, salt-soluble globulins, and insoluble prolamins (gliadins and glutenins). Molecular tests can identify the presence of specific IgE against individual components: glutenins, gliadin, ω-5 gliadin, α-amylase inhibitors, lipid transfer proteins, and Tri a 14 [2,3]. We report what could be the first 2 cases of concomitant celiac disease and IgE-mediated allergy to wheat proteins. The first patient was a 15-year-old girl who was diagnosed with celiac disease at the age of 6 years based on symptoms, positive antitransglutaminase IgA level (240 IU/mL, [normal value <7 IU/mL], Thermo Fisher Scientific), antiendomysial IgA (1:256), and duodenal biopsy findings. She remained on a gluten-free diet, with clinical benefits and normal immunological test results. She came to our emergency Manuscript received November 13, 2018; accepted for publication May 20, 2019.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"454-456"},"PeriodicalIF":7.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40550294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Chronic Pulmonary Aspergillosis With Isavuconazole.","authors":"D Guillen Vera,&nbsp;M Ruiz Ruigómez,&nbsp;I García Moguel,&nbsp;R Morales Ruiz,&nbsp;L Corbella,&nbsp;C Fernández Rodríguez","doi":"10.18176/jiaci.0424","DOIUrl":"https://doi.org/10.18176/jiaci.0424","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"459-460"},"PeriodicalIF":7.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40450006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of Opinion of Spanish Physicians on the Role of Eosinophils in Asthma and Other Diseases.","authors":"V Plaza,&nbsp;M Blanco,&nbsp;J Delgado,&nbsp;I Martínez,&nbsp;J M Zubeldía,&nbsp;J Molina","doi":"10.18176/jiaci.0423","DOIUrl":"https://doi.org/10.18176/jiaci.0423","url":null,"abstract":"Plaza V1, Blanco M2, Delgado J3, Martínez I4, Zubeldía JM5, Molina J6 1Director del Comité Ejecutivo de la Guía Española para el Manejo del Asma (GEMA), Servei de Pneumologia i Allèrgia, Hospital de la Santa Creu i Sant Pau, Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau), Universitat Autònoma de Barcelona, Barcelona, Spain 2Servicio de Neumología, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain 3Hospital Universitario Virgen Macarena, Sevilla, Spain 4Hospital Universitario Son Espases, Palma, Spain 5Hospital Universitario Gregorio Marañón, Madrid, Spain 6Centro de Salud Francia, Fuenlabrada, Spain","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"456-458"},"PeriodicalIF":7.2,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0423","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40541376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Asthma Phenotypes Classified by Site of Airway Involvement and Remodeling via Chest CT Scan.","authors":"S Kim,&nbsp;C H Lee,&nbsp;K N Jin,&nbsp;S H Cho,&nbsp;H R Kang","doi":"10.18176/jiaci.0265","DOIUrl":"https://doi.org/10.18176/jiaci.0265","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to establish a system that can classify severe asthma on the basis of airway remodeling patterns visualizedusing computed tomography (CT) images and to evaluate the clinical characteristics of individual image-based subtypes.</p><p><strong>Methods: </strong>Chest CT images from severe asthma patients were retrospectively evaluated to classify phenotypes by site of airway involvement and remodeling. The association between radiologic subtypes and clinical characteristics was assessed.</p><p><strong>Results: </strong>Of 91 patients with severe asthma, 74 (81.3%) exhibited abnormal radiologic findings, including bronchial wall thickening (BT), mucus plugging (MP), and bronchiectasis (BE). The severity of BT and the extent of MP were independently associated with peripheral blood eosinophil count (P=.012, r2=0.112) and sputum eosinophil count (P=.022, r2=0.090), respectively. The large-to-medium airway remodeling type, which showed diffuse BT combined with MP and BE, accounted for 44% of patients and revealed higher peripheral blood eosinophil counts than other types. In the small airway remodeling type, which accounted for 6.6% of patients, we observed a higher rate of fixed airflow obstruction, along with a predominance of males and smokers and more frequent use of controller medication than other phenotypes. In 26% of patients with severe asthma, no prominent airway remodeling was observed (near-normal type); the near-normal type required oral corticosteroids less frequently than the large-to-medium airway and small airway remodeling types.</p><p><strong>Conclusions: </strong>Depending on the site of airway involvement and remodeling pattern, 3 different structural types can be distinguished in chest CT findings from patients with severe asthma. Remodeling in large-to-medium sized airways revealed an association with systemic eosinophilic inflammation in patients with severe asthma.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"312-320"},"PeriodicalIF":7.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.18176/jiaci.0265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39985431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}