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Journal of investigational allergology & clinical immunology最新文献

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Hypersensitivity to the Moderna COVID-19 Vaccine Caused by Tromethamine: PEG Is Not Always the Culprit Excipient. 由三聚氰胺引起的现代COVID-19疫苗过敏:聚乙二醇并不总是罪魁祸首。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-12-20 DOI: 10.18176/jiaci.0773
T Azenha Rama, R Moço Coutinho, D Mota, A Moreira, J Cernadas
{"title":"Hypersensitivity to the Moderna COVID-19 Vaccine Caused by Tromethamine: PEG Is Not Always the Culprit Excipient.","authors":"T Azenha Rama, R Moço Coutinho, D Mota, A Moreira, J Cernadas","doi":"10.18176/jiaci.0773","DOIUrl":"https://doi.org/10.18176/jiaci.0773","url":null,"abstract":"Serviço de Imunoalergologia, Centro Hospitalar Universitário de São João, Porto, Portugal Serviço de Imunologia Básica e Clínica, Departamento de Patologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal EPIUnit, Institute of Public Health, University of Porto, Portugal & Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal Unidade de Imunoalergologia, Hospital Lusíadas, Porto","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"414-415"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39738417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Positive Basophil Activation Test Result in a Patient With Anaphylaxis to Cotrimoxazole. 复方新诺明过敏反应患者的嗜碱性粒细胞激活试验阳性。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2022-01-14 DOI: 10.18176/jiaci.0778
M P Berges Gimeno, L Bernal Rubio, E Roldán, C G Rita
{"title":"Positive Basophil Activation Test Result in a Patient With Anaphylaxis to Cotrimoxazole.","authors":"M P Berges Gimeno, L Bernal Rubio, E Roldán, C G Rita","doi":"10.18176/jiaci.0778","DOIUrl":"https://doi.org/10.18176/jiaci.0778","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"410-412"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39822131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Allopurinol-Induced DRESS and Neosensitization to Thalidomide: Complex Management and Diagnosis in a Patient With Multiple Myeloma. 别嘌呤醇诱导的DRESS和对沙利度胺的新敏化:多发性骨髓瘤患者的复杂管理和诊断。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2022-01-14 DOI: 10.18176/jiaci.0776
F Vílchez-Sánchez, J M Busto Leis, E Sendagorta, E Ramírez, A Fiandor, T Bellón, T De Soto Álvarez, H Sánchez Ocando, R Heredia Revuelto, R Cabañas
{"title":"Allopurinol-Induced DRESS and Neosensitization to Thalidomide: Complex Management and Diagnosis in a Patient With Multiple Myeloma.","authors":"F Vílchez-Sánchez, J M Busto Leis, E Sendagorta, E Ramírez, A Fiandor, T Bellón, T De Soto Álvarez, H Sánchez Ocando, R Heredia Revuelto, R Cabañas","doi":"10.18176/jiaci.0776","DOIUrl":"https://doi.org/10.18176/jiaci.0776","url":null,"abstract":"1Institute for Health Research (IdiPAZ), Madrid, Spain. 2Allergy Department, La Paz University Hospital, Madrid, Spain. 3Dermatology Department, La Paz University Hospital, Madrid, Spain. 4PIELenRed Consortium. 5Pharmacology Department La Paz University Hospital, Madrid, Spain. 6Drug Hypersensitivity Laboratory, IdiPAZ, Madrid, Spain. 7Hematology Department, La Paz University Hospital, Madrid, Spain. 8Centro de Investigación en Red de Enfermedades Raras (CIBERER, U754).","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"406-407"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39822133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Tolerance to SARS CoV-2 Vaccines Containing Polyethylene Glycol in Patients Allergic to Polysorbate 80. 聚山梨酯80过敏患者对含聚乙二醇的SARS CoV-2疫苗的耐受性
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-12-15 DOI: 10.18176/jiaci.0772
I Vidal Oribe, M Venturini Díaz, P Hernández Alfonso, M D Del Pozo Gil, I González Mahave, T Lobera Labairu
{"title":"Tolerance to SARS CoV-2 Vaccines Containing Polyethylene Glycol in Patients Allergic to Polysorbate 80.","authors":"I Vidal Oribe, M Venturini Díaz, P Hernández Alfonso, M D Del Pozo Gil, I González Mahave, T Lobera Labairu","doi":"10.18176/jiaci.0772","DOIUrl":"https://doi.org/10.18176/jiaci.0772","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"403-405"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39726823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
The Lights and the Shadows of Controlled Sting Challenge With Hymenoptera. 膜翅目昆虫控制刺击的光与影。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2022-06-22 DOI: 10.18176/jiaci.0838
B Ruiz-León, M Martínez San Ireneo, F de la Roca, L Arenas, T Alfaya Arias, C Cordobés, L Marqués, A Vega, C Moreno-Aguilar
{"title":"The Lights and the Shadows of Controlled Sting Challenge With Hymenoptera.","authors":"B Ruiz-León,&nbsp;M Martínez San Ireneo,&nbsp;F de la Roca,&nbsp;L Arenas,&nbsp;T Alfaya Arias,&nbsp;C Cordobés,&nbsp;L Marqués,&nbsp;A Vega,&nbsp;C Moreno-Aguilar","doi":"10.18176/jiaci.0838","DOIUrl":"https://doi.org/10.18176/jiaci.0838","url":null,"abstract":"<p><p>Hymenoptera venom immunotherapy (VIT) is effective for protecting individuals with systemic allergic reactions caused by Hymenoptera stings. The need for a tool that shows the degree of protection afforded by VIT and the lack of useful biomarkers have made the sting challenge test (SCT) the gold standard for this disorder, although its use has both lights and shadows. SCT with Hymenoptera involves causing a real sting in a patient diagnosed with allergy to the venom of the stinging insect and who is undergoing treatment with specific immunotherapy. In Spain, SCT is included in the list of services offered by some hospitals and forms part of their daily clinical practice. This review aims to analyze the strengths and weaknesses of this test and to describe the standardized procedure and necessary resources, based on the experience of a group of Spanish experts and a review of the literature.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"357-366"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40239556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Remifentanil-Induced Symmetric Drug-Related Intertriginous and Flexural Exanthema: A Diagnostic Challenge in an Intensive Care Patient. 瑞芬太尼诱导的对称药物相关的三角间性和弯曲性皮疹:重症监护患者的诊断挑战。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-11-15 DOI: 10.18176/jiaci.0764
J F Martins, I Alen Coutinho, M Castro, J Carvalho, C Faria, E Sousa, P Martins
{"title":"Remifentanil-Induced Symmetric Drug-Related Intertriginous and Flexural Exanthema: A Diagnostic Challenge in an Intensive Care Patient.","authors":"J F Martins,&nbsp;I Alen Coutinho,&nbsp;M Castro,&nbsp;J Carvalho,&nbsp;C Faria,&nbsp;E Sousa,&nbsp;P Martins","doi":"10.18176/jiaci.0764","DOIUrl":"https://doi.org/10.18176/jiaci.0764","url":null,"abstract":"Intensive Medicine Departement, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Allergy and Clinical Immunology Departement, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Anesthesiology Departement, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Pathological Anatomy Departement, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal Faculty of Medicine, University of Coimbra, Coimbra, Portugal *Both authors contributed equally to this work","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"399-401"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39625891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Anaphylaxis After Mango Fruit Intake: Identification of New Allergens. 芒果水果摄入后的过敏反应:新过敏原的鉴定。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-11-16 DOI: 10.18176/jiaci.0766
L Ortega-Martín, B Sastre, J M Rodrigo-Muñoz, J A Cañas, M Valverde-Monge, V Del Pozo
{"title":"Anaphylaxis After Mango Fruit Intake: Identification of New Allergens.","authors":"L Ortega-Martín,&nbsp;B Sastre,&nbsp;J M Rodrigo-Muñoz,&nbsp;J A Cañas,&nbsp;M Valverde-Monge,&nbsp;V Del Pozo","doi":"10.18176/jiaci.0766","DOIUrl":"https://doi.org/10.18176/jiaci.0766","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"401-403"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39717204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Allergenicity of Grass Pollen From Polluted and Nonpolluted Areas Measured Using the Skin Prick Test and Basophil Activation Test. 用皮肤点刺试验和嗜碱性粒细胞活化试验测定污染地区和非污染地区草花粉的致敏性。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2022-01-14 DOI: 10.18176/jiaci.0775
T Alfaya Arias, F Feo Brito, M L Somoza Álvarez, M Amo-Salas, J A Lucas, J Gutiérrez Mañero, J M Urra Ardanaz
{"title":"Allergenicity of Grass Pollen From Polluted and Nonpolluted Areas Measured Using the Skin Prick Test and Basophil Activation Test.","authors":"T Alfaya Arias,&nbsp;F Feo Brito,&nbsp;M L Somoza Álvarez,&nbsp;M Amo-Salas,&nbsp;J A Lucas,&nbsp;J Gutiérrez Mañero,&nbsp;J M Urra Ardanaz","doi":"10.18176/jiaci.0775","DOIUrl":"https://doi.org/10.18176/jiaci.0775","url":null,"abstract":"1Allergy Department. Hospital General Universitario de Ciudad Real, Spain 2Allergy Department. Hospital Universitario Fundación Alcorcón, Madrid, Spain 3Faculty of Medicine. Universidad de Castilla-La Mancha (UCLM), Spain 4Allergy Department. Hospital Universitario Infanta Leonor, Madrid, Spain 5Faculty of Medicine. Mathematics department. Universidad de Castilla La Mancha (UCLM), Spain. 6Plant Physiology, Pharmaceutical and Health Sciences Department, Faculty of Pharmacy, Universidad San Pablo-CEU, Spain 7Immunology Department, Hospital General Universitario de Ciudad Real. Spain","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"393-395"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39822134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association Between the Seed Storage Proteins 2S Albumin and 11S Globulin and Severe Allergic Reaction After Flaxseed Intake. 种子贮藏蛋白2S白蛋白和11S球蛋白与摄入亚麻籽后严重过敏反应的关系
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-06-04 DOI: 10.18176/jiaci.0713
C Bueno-Díaz, C Biserni, L Martín-Pedraza, M de Las Heras, C Blanco, S Vázquez-Cortés, M Fernández-Rivas, E Batanero, J Cuesta-Herranz, M Villalba
{"title":"Association Between the Seed Storage Proteins 2S Albumin and 11S Globulin and Severe Allergic Reaction After Flaxseed Intake.","authors":"C Bueno-Díaz,&nbsp;C Biserni,&nbsp;L Martín-Pedraza,&nbsp;M de Las Heras,&nbsp;C Blanco,&nbsp;S Vázquez-Cortés,&nbsp;M Fernández-Rivas,&nbsp;E Batanero,&nbsp;J Cuesta-Herranz,&nbsp;M Villalba","doi":"10.18176/jiaci.0713","DOIUrl":"https://doi.org/10.18176/jiaci.0713","url":null,"abstract":"<p><strong>Background: </strong>Given the increased popularity of flaxseed in meals, several cases of allergy to these seeds have been reported. Little is known about the allergens implicated in hypersensitivity reactions to flaxseed. The present study aimed to identify the allergens involved in IgE-mediated reactions in 5 patients with a clinical history of severe systemic symptoms after flaxseed consumption.</p><p><strong>Methods: </strong>Proteins that were potential allergens with IgE-binding capacity were purified from flaxseed extract using chromatography and identified via MALDI-TOF mass spectrometry. Immunoassays were performed using the 5 allergic patients' sera tested individually and as a pool.</p><p><strong>Results: </strong>Immunoblotting of the flaxseed extract revealed a low-molecular-mass protein (around 13 kDa) in 4 of the 5 patients, while a protein of approximately 55 kDa was detected in 2 patients. The proteins were identified by mass spectrometry as flaxseed 2S albumin, which is included in the WHO/IUIS allergen nomenclature as Lin u 1, and 11S globulin. Inhibition assays revealed in vitro IgE-mediated cross-reactivity between Lin u 1 and peanut and cashew nut proteins, while IgE-mediated recognition of 11S globulin by patients' sera was partially inhibited by several plant-derived sources.</p><p><strong>Conclusions: </strong>Seed storage proteins from flaxseed were involved in the development of severe symptoms in the 5 patients studied and exhibited cross-reactivity with other allergenic sources. Besides the severity of flaxseed allergy in patients sensitized to 2S albumin, this is the first time that 11S globulin has been identified as a potential allergen. Taking these data into account should ensure a more accurate diagnosis.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"375-382"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38980850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Patients With Atopic Dermatitis Sensitized to Pet Dander Mount IgE and T-Cell Responses to Mammalian Cystatins, Including the Human Self-Protein. 对宠物皮屑Mount IgE敏感的特应性皮炎患者和对哺乳动物胱抑素(包括人类自身蛋白)的t细胞反应。
IF 7.2
Journal of investigational allergology & clinical immunology Pub Date : 2022-10-11 Epub Date: 2021-09-07 DOI: 10.18176/jiaci.0737
L M Roesner, K Swiontek, D Lentz, G Begemann, P Kienlin, F Hentges, M Ollert, T Werfel, C Hilger
{"title":"Patients With Atopic Dermatitis Sensitized to Pet Dander Mount IgE and T-Cell Responses to Mammalian Cystatins, Including the Human Self-Protein.","authors":"L M Roesner,&nbsp;K Swiontek,&nbsp;D Lentz,&nbsp;G Begemann,&nbsp;P Kienlin,&nbsp;F Hentges,&nbsp;M Ollert,&nbsp;T Werfel,&nbsp;C Hilger","doi":"10.18176/jiaci.0737","DOIUrl":"https://doi.org/10.18176/jiaci.0737","url":null,"abstract":"<p><strong>Background: </strong>Immediate and delayed-type hypersensitivity reactions to pet-borne allergens are common in atopic diseases. In atopic dermatitis (AD), controversy surrounds the contribution to the disease of cross-reactivity to self-proteins. Human cystatin A and the cat allergen Fel d 3 belong to the cystatins, an evolutionary conserved protein family. The objective of the present study was to assess crossreactivity between mammalian cystatins and to analyze T-cell responses to cystatin in AD patients sensitized to pet dander.</p><p><strong>Methods: </strong>cDNA coding for dog cystatin was cloned from dog skin. Sera from 245 patients with IgE-mediated sensitization to cat and dog dander were tested for IgE binding to recombinantly expressed feline, canine, and human cystatin. Of these, 141 were also diagnosed with AD.</p><p><strong>Results: </strong>Cystatin-specific IgE was detected in 36 patients (14.7%), of whom 19 were considerably affected by AD. Within the AD patients, 9 had measurable IgE against all 3 cystatins. Cystatin-sensitized AD patients did not differ from non-cystatin-sensitized patients in terms of disease severity, age, or total IgE levels. T-cell cytokine measurements showed elevated IL-4 levels after stimulation with feline and human cystatin.</p><p><strong>Conclusions: </strong>The humoral response suggests that in addition to Fel d 3, the homologous protein from dog might play a role in allergy. Furthermore, human cystatin appears to be capable of driving a type 2 immune response in sensitized AD patients and may therefore be considered a so-called autoallergen, as proposed for other evolutionary conserved proteins.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"383-392"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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