Journal of investigational allergology & clinical immunology最新文献

{"title":"Association Between the Seed Storage Proteins 2S Albumin and 11S Globulin and Severe Allergic Reaction After Flaxseed Intake.","authors":"C Bueno-Díaz,&nbsp;C Biserni,&nbsp;L Martín-Pedraza,&nbsp;M de Las Heras,&nbsp;C Blanco,&nbsp;S Vázquez-Cortés,&nbsp;M Fernández-Rivas,&nbsp;E Batanero,&nbsp;J Cuesta-Herranz,&nbsp;M Villalba","doi":"10.18176/jiaci.0713","DOIUrl":"https://doi.org/10.18176/jiaci.0713","url":null,"abstract":"<p><strong>Background: </strong>Given the increased popularity of flaxseed in meals, several cases of allergy to these seeds have been reported. Little is known about the allergens implicated in hypersensitivity reactions to flaxseed. The present study aimed to identify the allergens involved in IgE-mediated reactions in 5 patients with a clinical history of severe systemic symptoms after flaxseed consumption.</p><p><strong>Methods: </strong>Proteins that were potential allergens with IgE-binding capacity were purified from flaxseed extract using chromatography and identified via MALDI-TOF mass spectrometry. Immunoassays were performed using the 5 allergic patients' sera tested individually and as a pool.</p><p><strong>Results: </strong>Immunoblotting of the flaxseed extract revealed a low-molecular-mass protein (around 13 kDa) in 4 of the 5 patients, while a protein of approximately 55 kDa was detected in 2 patients. The proteins were identified by mass spectrometry as flaxseed 2S albumin, which is included in the WHO/IUIS allergen nomenclature as Lin u 1, and 11S globulin. Inhibition assays revealed in vitro IgE-mediated cross-reactivity between Lin u 1 and peanut and cashew nut proteins, while IgE-mediated recognition of 11S globulin by patients' sera was partially inhibited by several plant-derived sources.</p><p><strong>Conclusions: </strong>Seed storage proteins from flaxseed were involved in the development of severe symptoms in the 5 patients studied and exhibited cross-reactivity with other allergenic sources. Besides the severity of flaxseed allergy in patients sensitized to 2S albumin, this is the first time that 11S globulin has been identified as a potential allergen. Taking these data into account should ensure a more accurate diagnosis.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"375-382"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38980850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Discrepant Role of Fractional Exhaled Nitric Oxide in SARS-CoV-2 Infection.","authors":"D Betancor,&nbsp;J M Olaguibel,&nbsp;J Sastre","doi":"10.18176/jiaci.0842","DOIUrl":"https://doi.org/10.18176/jiaci.0842","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"417-418"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome and Allergy: New Insights and Perspectives.","authors":"E Zubeldia-Varela,&nbsp;T C Barker-Tejeda,&nbsp;D Obeso,&nbsp;A Villaseñor,&nbsp;D Barber,&nbsp;M Pérez-Gordo","doi":"10.18176/jiaci.0852","DOIUrl":"https://doi.org/10.18176/jiaci.0852","url":null,"abstract":"<p><p>The role of the microbiome in the molecular mechanisms underlying allergy has become highly relevant in recent years. Studies are increasingly suggesting that altered composition of the microbiota, or dysbiosis, may result in local and systemic alteration of the immune response to specific allergens. In this regard, a link has been established between lung microbiota and respiratory allergy, between skin microbiota and atopic dermatitis, and between gut microbiota and food allergy. The composition of the human microbiota is dynamic and depends on host-associated factors such as diet, diseases, and lifestyle. Omics are the techniques of choice for the analysis and understanding of the microbiota. Microbiota analysis techniques have advanced considerably in recent decades, and the need for multiple approaches to explore and comprehend multifactorial diseases, including allergy, has increased. Thus, more and more studies are proposing mechanisms for intervention in the microbiota. In this review, we present the latest advances with respect to the human microbiota in the literature, focusing on the intestinal, cutaneous, and respiratory microbiota. We discuss the relationship between the microbiome and the immune system, with emphasis on allergic diseases. Finally, we discuss the main technologies for the study of the microbiome and interventions targeting the microbiota for prevention of allergy.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"327-344"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Fractional Exhaled Nitric Oxide Levels in Adult Patients With Acute Symptomatic COVID-19 Infection: Non Sequitur?","authors":"Z Z Elfessi,&nbsp;I Rubinstein","doi":"10.18176/jiaci.0834","DOIUrl":"https://doi.org/10.18176/jiaci.0834","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"415-416"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very rapid improvement of extended nitric oxide parameters, associated with clinical and functional betterment, in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) treated with Dupilumab.","authors":"G Paoletti,&nbsp;M Casini,&nbsp;L Malvezzi,&nbsp;F Pirola,&nbsp;E Russo,&nbsp;E Nappi,&nbsp;G Quintina Muci,&nbsp;C Montagna,&nbsp;M R Messina,&nbsp;S Ferri,&nbsp;F Racca,&nbsp;D Lamacchia,&nbsp;G Cataldo,&nbsp;F Puggioni,&nbsp;A De Virgilio,&nbsp;F Ferreli,&nbsp;G Mercante,&nbsp;G Spriano,&nbsp;G W Canonica,&nbsp;E Heffler","doi":"10.18176/jiaci.0851","DOIUrl":"https://doi.org/10.18176/jiaci.0851","url":null,"abstract":"<p><strong>Background and objective: </strong>Background: Dupilumab, an anti-IL-4 receptor alpha monoclonal antibody, has been recently approved for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and moderate to severe asthma, demonstrating a rapid onset of clinical effects. CRSwNP is characterized by an extended type-2 inflammatory involvement that can be assessed by extended nitric oxide analysis. Objective: In this study we investigated whether Dupilumab is associated with a rapid improvement in extended nitric oxide parameters, lung function and clinical outcomes in patients with CRSwNP.</p><p><strong>Methods: </strong>: Consecutive patients with CRSwNP and indication to be treated with Dupilumab were evaluated for extended nitric oxide analysis (exhaled, FENO; bronchial, JawNO and alveolar, CalvNO components; nasal, nNO) and lung function 15 and 30 days after treatment initiation, and for clinical outcomes (nasal polyps score, NPS; quality of life questionnaires; visual analogue scales, VAS, for main symptoms, asthma control test, ACT) after 30 days of treatment initiation.</p><p><strong>Results: </strong>33 patients were enrolled. All extended nitric oxide and lung function parameters significantly improved after 15 days of treatment remaining stable at 30 days. NPS, VAS for main CRSwNP symptoms, quality of life questionnaires and ACT significantly improved after 30 days of treatment initiation.</p><p><strong>Conclusion: </strong>Dupilumab is associated with very rapid improvement in type 2 inflammation in all airway districts and this is associated with improved lung function and clinical parameters in patients with CRSwNP.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"0"},"PeriodicalIF":7.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40345762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin G as a Milk Allergen.","authors":"M P Saura Foix,&nbsp;B Bartolomé,&nbsp;J Barrena Crespo,&nbsp;B Delavalle,&nbsp;A Izquierdo Domínguez,&nbsp;N Hernández Arauzo,&nbsp;M J Castillo Marchuet,&nbsp;M Viñas Domingo","doi":"10.18176/jiaci.0746","DOIUrl":"https://doi.org/10.18176/jiaci.0746","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"304-305"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors in Severe Anaphylaxis: Which Matters the Most, Food or Cofactors?","authors":"R Casas-Saucedo,&nbsp;C de la Cruz,&nbsp;G Araujo-Sánchez,&nbsp;S Gelis,&nbsp;T Jimenez,&nbsp;S Riggioni,&nbsp;C San Bartolomé,&nbsp;M Pascal,&nbsp;J Bartra Tomás,&nbsp;R Muñoz-Cano","doi":"10.18176/jiaci.0698","DOIUrl":"https://doi.org/10.18176/jiaci.0698","url":null,"abstract":"<p><strong>Background and objective: </strong>The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients who experience anaphylactic shock.</p><p><strong>Methods: </strong>Using lipid transfer protein (LTP) allergy as a model, we compared the characteristics of patients who developed anaphylaxis and anaphylactic shock. We recorded demographics, pollen sensitization, foods ingested up to 2 hours before onset of the reaction, and the presence of cofactors. Culprit foods were identified through a compatible clinical history and positive allergology work-up (skin prick test and/or sIgE).</p><p><strong>Results: </strong>We evaluated 150 reactions in 55 patients with anaphylaxis (134 reactions) and 12 with anaphylactic shock (16 reactions). Patients in the anaphylaxis group experienced twice as many reactions (mean [SD], 2.4 [2.5] for anaphylaxis vs 1.3 [1.5] for anaphylactic shock; P<.02). No relationship was found between any food group and severity of the reaction. The most frequent food involved in both groups of patients was the combination of several plant-derived foods (plant food mix), followed by peach and nuts. Indeed, in the reactions caused by plant food mix, the presence of a cofactor was observed more often than in other food groups. On the other hand, cofactors were not present in peach- and nut-related reactions. Exercise was the most frequent cofactor in all groups.</p><p><strong>Conclusion: </strong>In our series, the severity of the reactions was not determined by the kind of food or presence of a cofactor. Anaphylactic shock seems to be an infrequent presentation that may be associated with other individual-related factors requiring further evaluation.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"282-290"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE Antibodies to Galactose-α-1,3-galactose, an Epitope of Red Meat Allergen, Cross-react With a Novel Flounder Roe Allergen.","authors":"Y Chinuki,&nbsp;H Takahashi,&nbsp;E Morita","doi":"10.18176/jiaci.0754","DOIUrl":"https://doi.org/10.18176/jiaci.0754","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"324-326"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Fractional Exhaled Nitric Oxide During SARS-CoV-2 Infection.","authors":"D Betancor,&nbsp;M Valverde-Mongue,&nbsp;A Gomez-Lopez,&nbsp;B Barroso,&nbsp;L Ruete,&nbsp;J M Olaguibel,&nbsp;J Sastre","doi":"10.18176/jiaci.0762","DOIUrl":"https://doi.org/10.18176/jiaci.0762","url":null,"abstract":"J Investig Allergol Clin Immunol 2022; Vol. 32(4): 299-303 © 2022 Esmon Publicidad 4. Baiardini I, Paoletti G, Malipiero G, Giua C, Keber E, Canonica GW, et al. Validation of the Italian Version of the Test of Adherence to Inhalers. J Investig Allergol Clin Immunol. 2020;30(6):450-2. 5. Ortega-Martin L, Betancor D, Barroso B, Valverde-Monge M, Santillan J, Villacampa JM, et al. Where Has All The Nasal Polyposis Gone? J Investig Allergol Clin Immunol. 2021;31:500-2. 6. Rudmik L, Xu Y, Liu M, Bird C, Kukec E, Quan H. Utilization Patterns of Topical Intranasal Steroid Therapy for Chronic Rhinosinusitis: A Canadian Population-Based Analysis. JAMA Otolaryngol Head Neck Surg. 2016;142(11):1056-62. 7. Philpott C, Erskine S, Smith R, Hopkins C, Kara N, Farboud A, et al. Current use of baseline medical treatment in chronic rhinosinusitis: Data from the National Chronic Rhinosinusitis Epidemiology Study (CRES). Clin Otolaryngol. 2018;43(2):50924. 8. Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Intranasal corticosteroids and saline: Usage and adherence in chronic rhinosinusitis patients. Laryngoscope. 2020;130(4):852-6. 9. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: developing guidance for clinical trials. J Allergy Clin Immunol. 2006;118(5 Suppl):S17-61. Evaluation of Fractional Exhaled Nitric Oxide During SARS-CoV-2 Infection","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"301-303"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39859374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Geotrichosis in Chronic Granulomatous Disease.","authors":"D Palacios-Reyes,&nbsp;M A Yamazaki-Nakashimada,&nbsp;L Castaño-Jaramillo,&nbsp;C M Roman-Montes,&nbsp;M F González-Lara,&nbsp;S Scheffler-Mendoza,&nbsp;Á Costta-Michuy,&nbsp;J Bustamante,&nbsp;L Blancas-Galicia","doi":"10.18176/jiaci.0749","DOIUrl":"https://doi.org/10.18176/jiaci.0749","url":null,"abstract":"vasculitis.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"306-308"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}