Journal of investigational allergology & clinical immunology最新文献

{"title":"Allergen Profile of London Plane Tree Pollen: Clinical and Molecular Pattern in Central Spain.","authors":"E Nuñez-Borque,&nbsp;D Betancor,&nbsp;S Fernández-Bravo,&nbsp;A Gómez-Cardeñosa,&nbsp;V Esteban,&nbsp;M Garrido-Arandia,&nbsp;M de Las Heras,&nbsp;C Pastor-Vargas,&nbsp;J Cuesta-Herranz","doi":"10.18176/jiaci.0702","DOIUrl":"https://doi.org/10.18176/jiaci.0702","url":null,"abstract":"<p><strong>Background and objectives: </strong>Platanus acerifolia (London plane tree) is a deciduous tree of the Platanaceae family. Sensitization to this plant varies with geography. Madrid, located in central Spain, has one of the highest London plane tree pollen concentration levels on the Iberian Peninsula. We evaluated both the clinical characteristics and the molecular sensitization pattern of patients with allergy to London plane tree pollen in the region of Madrid.</p><p><strong>Methods: </strong>Thirty-eight patients allergic to London plane tree pollen were selected according to their clinical symptoms and positive results in skin prick testing and/or specific IgE determination. Serum was collected, and allergen components were evaluated using immunodetection techniques as well as ImmunoCAP. The IgE-binding proteins detected were identified and characterized using mass spectrometry.</p><p><strong>Results: </strong>Analysis of serum samples from allergic patients revealed 9 IgE-binding bands in London plane tree pollen extract. Among these, the 45-kDa protein, which corresponded to Pla a 2, was detected in 76.3% of patients. However, the 18-kDa (Pla a 1) and 9-kDa (Pla a 3) bands were detected in 44.7% and 23.7% of sera, respectively. These results were confirmed using purified proteins. Characterization of the allergen revealed the 27-kDa protein to be glutathione-S-transferase.</p><p><strong>Conclusions: </strong>The molecular profile of patients sensitized to London plane tree pollen differs from that reported in studies from other locations. In the population we studied, the prevalence of Pla a 2 was higher than that of Pla a 1 and Pla a 3. In addition, the minor allergen previously referred to as Pla a 4 was characterized as glutathione-S-transferase.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"367-374"},"PeriodicalIF":7.2,"publicationDate":"2022-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38870907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Discrepant Role of Fractional Exhaled Nitric Oxide in SARS-CoV-2 Infection.","authors":"D Betancor,&nbsp;J M Olaguibel,&nbsp;J Sastre","doi":"10.18176/jiaci.0842","DOIUrl":"https://doi.org/10.18176/jiaci.0842","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"417-418"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome and Allergy: New Insights and Perspectives.","authors":"E Zubeldia-Varela,&nbsp;T C Barker-Tejeda,&nbsp;D Obeso,&nbsp;A Villaseñor,&nbsp;D Barber,&nbsp;M Pérez-Gordo","doi":"10.18176/jiaci.0852","DOIUrl":"https://doi.org/10.18176/jiaci.0852","url":null,"abstract":"<p><p>The role of the microbiome in the molecular mechanisms underlying allergy has become highly relevant in recent years. Studies are increasingly suggesting that altered composition of the microbiota, or dysbiosis, may result in local and systemic alteration of the immune response to specific allergens. In this regard, a link has been established between lung microbiota and respiratory allergy, between skin microbiota and atopic dermatitis, and between gut microbiota and food allergy. The composition of the human microbiota is dynamic and depends on host-associated factors such as diet, diseases, and lifestyle. Omics are the techniques of choice for the analysis and understanding of the microbiota. Microbiota analysis techniques have advanced considerably in recent decades, and the need for multiple approaches to explore and comprehend multifactorial diseases, including allergy, has increased. Thus, more and more studies are proposing mechanisms for intervention in the microbiota. In this review, we present the latest advances with respect to the human microbiota in the literature, focusing on the intestinal, cutaneous, and respiratory microbiota. We discuss the relationship between the microbiome and the immune system, with emphasis on allergic diseases. Finally, we discuss the main technologies for the study of the microbiome and interventions targeting the microbiota for prevention of allergy.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"327-344"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Fractional Exhaled Nitric Oxide Levels in Adult Patients With Acute Symptomatic COVID-19 Infection: Non Sequitur?","authors":"Z Z Elfessi,&nbsp;I Rubinstein","doi":"10.18176/jiaci.0834","DOIUrl":"https://doi.org/10.18176/jiaci.0834","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"415-416"},"PeriodicalIF":7.2,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Very rapid improvement of extended nitric oxide parameters, associated with clinical and functional betterment, in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) treated with Dupilumab.","authors":"G Paoletti,&nbsp;M Casini,&nbsp;L Malvezzi,&nbsp;F Pirola,&nbsp;E Russo,&nbsp;E Nappi,&nbsp;G Quintina Muci,&nbsp;C Montagna,&nbsp;M R Messina,&nbsp;S Ferri,&nbsp;F Racca,&nbsp;D Lamacchia,&nbsp;G Cataldo,&nbsp;F Puggioni,&nbsp;A De Virgilio,&nbsp;F Ferreli,&nbsp;G Mercante,&nbsp;G Spriano,&nbsp;G W Canonica,&nbsp;E Heffler","doi":"10.18176/jiaci.0851","DOIUrl":"https://doi.org/10.18176/jiaci.0851","url":null,"abstract":"<p><strong>Background and objective: </strong>Background: Dupilumab, an anti-IL-4 receptor alpha monoclonal antibody, has been recently approved for the treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) and moderate to severe asthma, demonstrating a rapid onset of clinical effects. CRSwNP is characterized by an extended type-2 inflammatory involvement that can be assessed by extended nitric oxide analysis. Objective: In this study we investigated whether Dupilumab is associated with a rapid improvement in extended nitric oxide parameters, lung function and clinical outcomes in patients with CRSwNP.</p><p><strong>Methods: </strong>: Consecutive patients with CRSwNP and indication to be treated with Dupilumab were evaluated for extended nitric oxide analysis (exhaled, FENO; bronchial, JawNO and alveolar, CalvNO components; nasal, nNO) and lung function 15 and 30 days after treatment initiation, and for clinical outcomes (nasal polyps score, NPS; quality of life questionnaires; visual analogue scales, VAS, for main symptoms, asthma control test, ACT) after 30 days of treatment initiation.</p><p><strong>Results: </strong>33 patients were enrolled. All extended nitric oxide and lung function parameters significantly improved after 15 days of treatment remaining stable at 30 days. NPS, VAS for main CRSwNP symptoms, quality of life questionnaires and ACT significantly improved after 30 days of treatment initiation.</p><p><strong>Conclusion: </strong>Dupilumab is associated with very rapid improvement in type 2 inflammation in all airway districts and this is associated with improved lung function and clinical parameters in patients with CRSwNP.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"0"},"PeriodicalIF":7.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40345762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoglobulin G as a Milk Allergen.","authors":"M P Saura Foix,&nbsp;B Bartolomé,&nbsp;J Barrena Crespo,&nbsp;B Delavalle,&nbsp;A Izquierdo Domínguez,&nbsp;N Hernández Arauzo,&nbsp;M J Castillo Marchuet,&nbsp;M Viñas Domingo","doi":"10.18176/jiaci.0746","DOIUrl":"https://doi.org/10.18176/jiaci.0746","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"304-305"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39392472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors in Severe Anaphylaxis: Which Matters the Most, Food or Cofactors?","authors":"R Casas-Saucedo,&nbsp;C de la Cruz,&nbsp;G Araujo-Sánchez,&nbsp;S Gelis,&nbsp;T Jimenez,&nbsp;S Riggioni,&nbsp;C San Bartolomé,&nbsp;M Pascal,&nbsp;J Bartra Tomás,&nbsp;R Muñoz-Cano","doi":"10.18176/jiaci.0698","DOIUrl":"https://doi.org/10.18176/jiaci.0698","url":null,"abstract":"<p><strong>Background and objective: </strong>The prevalence of anaphylactic shock, the most severe manifestation of anaphylaxis, remains unknown. Risk factors and biomarkers have not been fully identified. Objective: To identify risk factors in patients who experience anaphylactic shock.</p><p><strong>Methods: </strong>Using lipid transfer protein (LTP) allergy as a model, we compared the characteristics of patients who developed anaphylaxis and anaphylactic shock. We recorded demographics, pollen sensitization, foods ingested up to 2 hours before onset of the reaction, and the presence of cofactors. Culprit foods were identified through a compatible clinical history and positive allergology work-up (skin prick test and/or sIgE).</p><p><strong>Results: </strong>We evaluated 150 reactions in 55 patients with anaphylaxis (134 reactions) and 12 with anaphylactic shock (16 reactions). Patients in the anaphylaxis group experienced twice as many reactions (mean [SD], 2.4 [2.5] for anaphylaxis vs 1.3 [1.5] for anaphylactic shock; P<.02). No relationship was found between any food group and severity of the reaction. The most frequent food involved in both groups of patients was the combination of several plant-derived foods (plant food mix), followed by peach and nuts. Indeed, in the reactions caused by plant food mix, the presence of a cofactor was observed more often than in other food groups. On the other hand, cofactors were not present in peach- and nut-related reactions. Exercise was the most frequent cofactor in all groups.</p><p><strong>Conclusion: </strong>In our series, the severity of the reactions was not determined by the kind of food or presence of a cofactor. Anaphylactic shock seems to be an infrequent presentation that may be associated with other individual-related factors requiring further evaluation.</p>","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"282-290"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38956071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgE Antibodies to Galactose-α-1,3-galactose, an Epitope of Red Meat Allergen, Cross-react With a Novel Flounder Roe Allergen.","authors":"Y Chinuki,&nbsp;H Takahashi,&nbsp;E Morita","doi":"10.18176/jiaci.0754","DOIUrl":"https://doi.org/10.18176/jiaci.0754","url":null,"abstract":"","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"324-326"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39527745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Fractional Exhaled Nitric Oxide During SARS-CoV-2 Infection.","authors":"D Betancor,&nbsp;M Valverde-Mongue,&nbsp;A Gomez-Lopez,&nbsp;B Barroso,&nbsp;L Ruete,&nbsp;J M Olaguibel,&nbsp;J Sastre","doi":"10.18176/jiaci.0762","DOIUrl":"https://doi.org/10.18176/jiaci.0762","url":null,"abstract":"J Investig Allergol Clin Immunol 2022; Vol. 32(4): 299-303 © 2022 Esmon Publicidad 4. Baiardini I, Paoletti G, Malipiero G, Giua C, Keber E, Canonica GW, et al. Validation of the Italian Version of the Test of Adherence to Inhalers. J Investig Allergol Clin Immunol. 2020;30(6):450-2. 5. Ortega-Martin L, Betancor D, Barroso B, Valverde-Monge M, Santillan J, Villacampa JM, et al. Where Has All The Nasal Polyposis Gone? J Investig Allergol Clin Immunol. 2021;31:500-2. 6. Rudmik L, Xu Y, Liu M, Bird C, Kukec E, Quan H. Utilization Patterns of Topical Intranasal Steroid Therapy for Chronic Rhinosinusitis: A Canadian Population-Based Analysis. JAMA Otolaryngol Head Neck Surg. 2016;142(11):1056-62. 7. Philpott C, Erskine S, Smith R, Hopkins C, Kara N, Farboud A, et al. Current use of baseline medical treatment in chronic rhinosinusitis: Data from the National Chronic Rhinosinusitis Epidemiology Study (CRES). Clin Otolaryngol. 2018;43(2):50924. 8. Phillips KM, Hoehle LP, Caradonna DS, Gray ST, Sedaghat AR. Intranasal corticosteroids and saline: Usage and adherence in chronic rhinosinusitis patients. Laryngoscope. 2020;130(4):852-6. 9. Meltzer EO, Hamilos DL, Hadley JA, Lanza DC, Marple BF, Nicklas RA, et al. Rhinosinusitis: developing guidance for clinical trials. J Allergy Clin Immunol. 2006;118(5 Suppl):S17-61. Evaluation of Fractional Exhaled Nitric Oxide During SARS-CoV-2 Infection","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"301-303"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39859374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Geotrichosis in Chronic Granulomatous Disease.","authors":"D Palacios-Reyes,&nbsp;M A Yamazaki-Nakashimada,&nbsp;L Castaño-Jaramillo,&nbsp;C M Roman-Montes,&nbsp;M F González-Lara,&nbsp;S Scheffler-Mendoza,&nbsp;Á Costta-Michuy,&nbsp;J Bustamante,&nbsp;L Blancas-Galicia","doi":"10.18176/jiaci.0749","DOIUrl":"https://doi.org/10.18176/jiaci.0749","url":null,"abstract":"vasculitis.","PeriodicalId":520676,"journal":{"name":"Journal of investigational allergology & clinical immunology","volume":" ","pages":"306-308"},"PeriodicalIF":7.2,"publicationDate":"2022-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}