Journal of fungi (Basel, Switzerland)最新文献_第6页

Genetic Diversity, Population Structure and Mating Type Distribution of Setosphaeria turcica on Corn in Midwestern China. 中国中西部地区玉米绒球菌的遗传多样性、群体结构和配种分布。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-04 DOI: 10.3390/jof8111165

Linkai Cui, Linxi Zhao, Bin Wang, Zanping Han, Yanhong Hu

{"title":"Genetic Diversity, Population Structure and Mating Type Distribution of Setosphaeria turcica on Corn in Midwestern China.","authors":"Linkai Cui, Linxi Zhao, Bin Wang, Zanping Han, Yanhong Hu","doi":"10.3390/jof8111165","DOIUrl":"https://doi.org/10.3390/jof8111165","url":null,"abstract":"Setosphaeria turcica is the causal agent of northern corn leaf blight (NCLB), which is a destructive foliar disease of corn around the world. To date, limited information is available on the genetic diversity, population structure, and mating type distribution of the pathogen in the mid-west of China. In this study, based on single nucleotide polymorphism (SNP) markers and mating type-specific primers, we characterized 117 S. turcica isolates collected from Henan, Hebei, Shanxi, and Shaanxi provinces in China. Based on the developed 33 SNP markers, all isolates can be categorized into two genetic groups. Each group consisted of isolates from all four provinces. The Nei's gene diversity of four populations ranged from 0.328 to 0.419 with a mean of 0.391. The analysis of fixation index (Fst) and gene flow (Nm) suggested that low genetic differentiation and high gene flow existed among four geographic populations. The analysis of molecular variance (AMOVA) demonstrated that the principal molecular variance existed within populations (98%) rather than among populations (2%). The analysis of mating type loci revealed that two mating types (MAT1-1 and MAT1-2) were basically in equilibrium in all four populations. These findings advance our understanding of the genetic diversity, population structure and mating type distribution of S. turcica on corn in the mid-west of China and will aid in developing efficient strategies to control NCLB.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40464318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clonostachys rosea Promotes Root Growth in Tomato by Secreting Auxin Produced through the Tryptamine Pathway. 通过分泌色胺途径产生的生长素促进番茄根系生长。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-04 DOI: 10.3390/jof8111166

Zhengyuan Han, Hossein Ghanizadeh, Haotian Zhang, Xinmao Li, Tiantian Li, Qi Wang, Jiayin Liu, Aoxue Wang

{"title":"Clonostachys rosea Promotes Root Growth in Tomato by Secreting Auxin Produced through the Tryptamine Pathway.","authors":"Zhengyuan Han, Hossein Ghanizadeh, Haotian Zhang, Xinmao Li, Tiantian Li, Qi Wang, Jiayin Liu, Aoxue Wang","doi":"10.3390/jof8111166","DOIUrl":"https://doi.org/10.3390/jof8111166","url":null,"abstract":"Clonostachys rosea (Link) Schroers is a filamentous fungus that has been widely used for biological control, biological fermentation, biodegradation and bioenergy. In this research, we investigated the impact of this fungus on root growth in tomato and the underlying mechanisms. The results showed that C. rosea can promote root growth in tomato, and tryptophan enhances its growth-promoting impacts. The results also showed that tryptophan increases the abundance of metabolites in C. rosea, with auxin (IAA) and auxin-related metabolites representing a majority of the highly abundant metabolites in the presence of tryptophan. It was noted that C. rosea could metabolize tryptophan into tryptamine (TRA) and indole-3-acetaldehyde (IAAId), and these two compounds are used by C. rosea to produce IAA through the tryptamine (TAM) pathway, which is one of the major pathways in tryptophan-dependent IAA biosynthesis. The IAA produced is used by C. rosea to promote root growth in tomato. To the best of our knowledge, this is the first report on IAA biosynthesis by C. rosea through the TAM pathway. More research is needed to understand the molecular mechanisms underlying IAA biosynthesis in C. rosea, as well as to examine the ability of this fungus to boost plant development in the field.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40455208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Antiproliferative Fatty Acids Isolated from the Polypore Fungus Onnia tomentosa. 从多孔真菌毛毡Onnia tomtosa中分离的抗增殖脂肪酸。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-03 DOI: 10.3390/jof8111163

Hooi Xian Lee, Wai Ming Li, Jatinder Khatra, Zhicheng Xia, Oleg Sannikov, Yun Ling, Haoxuan Zhu, Chow H Lee

{"title":"Antiproliferative Fatty Acids Isolated from the Polypore Fungus Onnia tomentosa.","authors":"Hooi Xian Lee, Wai Ming Li, Jatinder Khatra, Zhicheng Xia, Oleg Sannikov, Yun Ling, Haoxuan Zhu, Chow H Lee","doi":"10.3390/jof8111163","DOIUrl":"https://doi.org/10.3390/jof8111163","url":null,"abstract":"Onnia tomentosa is a widespread root rot pathogen frequently found in coniferous forests in North America. In this study, the potential medicinal properties of this wild polypore mushroom collected from north-central British Columbia, Canada, were investigated. The ethanol extract from O. tomentosa was found to exhibit strong antiproliferative activity. Liquid-liquid extraction and bioactivity-guided fractionation, together with HPLC-MS/MS and 1D/2D NMR analyses of the ethanol extract of O. tomentosa, led to the identification of eight known linoleic oxygenated fatty acids (1.1-1.4 and 2-5), together with linoleic (6) and oleic acids (7). The autoxidation of linoleic acid upon isolation from a natural source and compound 5 as an autoxidation product of linoleic acid are reported here for the first time. GC-FID analysis of O. tomentosa, Fomitopsis officinalis, Echinodontium tinctorium, and Albatrellus flettii revealed linoleic, oleic, palmitic, and stearic acids as the major fatty acids. This study further showed that fatty acids were the major antiproliferative constituents in the ethanol extract from O. tomentosa. Linoleic acid and oleic acid had IC50 values of 50.3 and 90.4 µM against human cervical cancer cells (HeLa), respectively. The results from this study have implications regarding the future exploration of O. tomentosa as a possible edible and/or medicinal mushroom. It is also recommended that necessary caution be taken when isolating unstable fatty acids from natural sources and in interpreting the results.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40464316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phylogenomic and Evolutionary Analyses Reveal Diversifications of SET-Domain Proteins in Fungi. 系统基因组学和进化分析揭示真菌中set结构域蛋白的多样性。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-02 DOI: 10.3390/jof8111159

Guoqing Ding, Liqiu Shang, Wenliang Zhou, Siyi Lu, Zong Zhou, Xinyi Huang, Juan Li

{"title":"Phylogenomic and Evolutionary Analyses Reveal Diversifications of SET-Domain Proteins in Fungi.","authors":"Guoqing Ding, Liqiu Shang, Wenliang Zhou, Siyi Lu, Zong Zhou, Xinyi Huang, Juan Li","doi":"10.3390/jof8111159","DOIUrl":"https://doi.org/10.3390/jof8111159","url":null,"abstract":"In recent years, many publications have established histone lysine methylation as a central epigenetic modification in the regulation of chromatin and transcription. The histone lysine methyltransferases contain a conserved SET domain and are widely distributed in various organisms. However, a comprehensive study on the origin and diversification of the SET-domain-containing genes in fungi has not been conducted. In this study, a total of 3816 SET-domain-containing genes, which were identified and characterized using HmmSearch from 229 whole genomes sequenced fungal species, were used to ascertain their evolution and diversification in fungi. Using the CLANS program, all the SET-domain-containing genes were grouped into three main clusters, and each cluster contains several groups. Domain organization analysis showed that genes belonging to the same group have similar sequence structures. In contrast, different groups process domain organizations or locations differently, suggesting the SET-domain-containing genes belonging to different groups may have obtained distinctive regulatory mechanisms during their evolution. These genes that conduct the histone methylations (such as H3K4me, H3K9me, H3K27me, H4K20me, H3K36me) are mainly grouped into Cluster 1 while the other genes grouped into Clusters 2 and 3 are still functionally undetermined. Our results also showed that numerous gene duplication and loss events have happened during the evolution of those fungal SET-domain-containing proteins. Our results provide novel insights into the roles of SET-domain genes in fungal evolution and pave a fundamental path to further understanding the epigenetic basis of gene regulation in fungi.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9692433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40464313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trichocladium solani sp. nov.-A New Pathogen on Potato Tubers Causing Yellow Rot. 马铃薯块茎上引起黄腐病的新病原菌——茄尼毛霉。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-02 DOI: 10.3390/jof8111160

Arseniy Belosokhov, Maria Yarmeeva, Lyudmila Kokaeva, Elena Chudinova, Svyatoslav Mislavskiy, Sergey Elansky

引用次数: 1

Fluconazole Failure in the Treatment of Coccidioidal Meningitis. 氟康唑治疗球虫性脑膜炎的失败。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-01 DOI: 10.3390/jof8111157

Simran Gupta, Neil M Ampel, Molly Klanderman, Marie F Grill, Janis E Blair

{"title":"Fluconazole Failure in the Treatment of Coccidioidal Meningitis.","authors":"Simran Gupta, Neil M Ampel, Molly Klanderman, Marie F Grill, Janis E Blair","doi":"10.3390/jof8111157","DOIUrl":"https://doi.org/10.3390/jof8111157","url":null,"abstract":"Introduction: Coccidioidal meningitis (CM) is the most lethal form of disseminated coccidioidomycosis. Current guidelines recommend fluconazole as initial therapy but there has been a paucity of data regarding failure of fluconazole and optimal fluconazole dosage in the treatment of CM. We conducted this study to understand risk factors for fluconazole failure.Methods: We conducted a single-center retrospective chart review of patients diagnosed with coccidioidal meningitis between 1 January 1988 and 15 May 2021. Relevant demographic and clinical variables were collected, along with outcomes including treatment failure and death at any point. Univariate tests were conducted using the chi-squared goodness of fit test and analysis of variance.Results: Among 71 patients who began treatment for CM with fluconazole, 22 (31%) developed worsening meningitis at a median time of 206 days. Longer time from symptom onset to diagnosis of CM was a risk factor for fluconazole failure. Although the absolute failure rate of fluconazole starting dose of 400 mg daily was higher than that of 800 mg daily, the differences did not achieve statistical significance (p = 0.39).Conclusion: Fluconazole failure is not uncommon in the treatment of CM. A dose of 800 mg daily was not superior to a dose of 400 mg daily. All patients on fluconazole for CM require close monitoring.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9697806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Phylogeny and Systematics of the Genus Tolypocladium (Ophiocordycipitaceae, Hypocreales). 水蛭属的系统发育和系统分类学(蛇虫草科，蛇尾目)。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-11-01 DOI: 10.3390/jof8111158

Quan-Ying Dong, Yao Wang, Zhi-Qin Wang, Yan-Fang Liu, Hong Yu

引用次数: 2

Three New Trichoderma Species in Harzianum Clade Associated with the Contaminated Substrates of Edible Fungi. Harzianum分支中的三个新木霉属与食用菌污染基质有关。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-31 DOI: 10.3390/jof8111154

Zi-Jian Cao, Wen-Tao Qin, Juan Zhao, Yu Liu, Shou-Xian Wang, Su-Yue Zheng

{"title":"Three New Trichoderma Species in Harzianum Clade Associated with the Contaminated Substrates of Edible Fungi.","authors":"Zi-Jian Cao, Wen-Tao Qin, Juan Zhao, Yu Liu, Shou-Xian Wang, Su-Yue Zheng","doi":"10.3390/jof8111154","DOIUrl":"https://doi.org/10.3390/jof8111154","url":null,"abstract":"Trichoderma is known worldwide as biocontrol agents of plant diseases, producers of enzymes and antibiotics, and competitive contaminants of edible fungi. In this investigation of contaminated substrates of edible fungi from North China, 39 strains belonging to 10 Trichoderma species isolated from four kinds of edible fungi were obtained, and three novel species belonging to the Harzianum clade were isolated from the contaminated substrates of Auricularia heimuer and Pholiota adipose. They were recognized based on integrated studies of phenotypic features, culture characteristics, and molecular analyses of RNA polymerase II subunit B and translation elongation factor 1-α genes. Trichoderma auriculariae was strongly supported as a separate lineage and differed from T. vermifimicola due to its larger conidia. Trichoderma miyunense was closely related to T. ganodermatigerum but differed due to its smaller conidia and higher optimum mycelial growth temperature. As a separate lineage, T. pholiotae was distinct from T. guizhouense and T. pseudoasiaticum due to its higher optimum mycelial growth temperature and larger conidia. This study extends the understanding of Trichoderma spp. contaminating substrates of edible fungi and updates knowledge of species diversity in the group.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

GPI-Anchored Protein Homolog IcFBR1 Functions Directly in Morphological Development of Isaria cicadae. gpi锚定蛋白同源物IcFBR1在蝉蝉形态发育中的直接作用

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-31 DOI: 10.3390/jof8111152

Dong Li, Yunpeng Gai, Junlong Meng, Jingyu Liu, Weiming Cai, Fu-Cheng Lin, Hongkai Wang

{"title":"GPI-Anchored Protein Homolog IcFBR1 Functions Directly in Morphological Development of Isaria cicadae.","authors":"Dong Li, Yunpeng Gai, Junlong Meng, Jingyu Liu, Weiming Cai, Fu-Cheng Lin, Hongkai Wang","doi":"10.3390/jof8111152","DOIUrl":"https://doi.org/10.3390/jof8111152","url":null,"abstract":"Isaria cicadae is a famous edible and medicinal fungus in China and Asia. The molecular basis of morphogenesis and synnemal formation needs to be understood in more detail because this is the main source of biomass production in I. cicadae. In the present study, a fruiting body formation-related gene with a glycosylphosphatidylinositol (GPI) anchoring protein (GPI-Ap) gene homolog IcFBR1 was identified by screening random insertion mutants. Targeted deletion of IcFBR1 resulted in abnormal formation of synnemata, impairing aerial hyphae growth and sporulation. The IcFBR1 mutants were defective in the utilization of carbon sources with reduced polysaccharide contents and the regulation of amylase and protease activities. Transcriptome analysis of ΔIcfbr1 showed that IcFBR1 deletion influenced 49 gene ontology terms, including 23 biological processes, 9 molecular functions, and 14 cellular components. IcFBR1 is therefore necessary for regulating synnemal development, secondary metabolism, and nutrient utilization in this important edible and medicinal fungus. This is the first report illustrating that the function of IcFBR1 is associated with the synnemata in I. cicadae.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary Cryptococcosis. 肺隐球菌病。

IF 4.7

Journal of fungi (Basel, Switzerland) Pub Date : 2022-10-31 DOI: 10.3390/jof8111156

Annaleise R Howard-Jones, Rebecca Sparks, David Pham, Catriona Halliday, Justin Beardsley, Sharon C-A Chen

{"title":"Pulmonary Cryptococcosis.","authors":"Annaleise R Howard-Jones, Rebecca Sparks, David Pham, Catriona Halliday, Justin Beardsley, Sharon C-A Chen","doi":"10.3390/jof8111156","DOIUrl":"https://doi.org/10.3390/jof8111156","url":null,"abstract":"Pulmonary cryptococcosis describes an invasive lung mycosis caused by Cryptococcus neoformans or Cryptococcus gattii complex. It is often a high-consequence disease in both immunocompromised and immunocompetent populations, and may be misdiagnosed as pulmonary malignancy, leading to a delay in therapy. Epidemiology follows that of cryptococcal meningoencephalitis, with C. gattii infection more common in certain geographic regions. Diagnostic tools include histopathology, microscopy and culture, and the detection of cryptococcal polysaccharide antigen or Cryptococcus-derived nucleic acids. All patients with lung cryptococcosis should have a lumbar puncture and cerebral imaging to exclude central nervous system disease. Radiology is key, both as an adjunct to laboratory testing and as the initial means of detection in asymptomatic patients or those with non-specific symptoms. Pulmonary cryptococcomas (single or multiple) may also be associated with disseminated disease and/or cryptococcal meningitis, requiring prolonged treatment regimens. Optimal management for severe disease requires extended induction (amphotericin B and flucytosine) and consolidation therapy (fluconazole) with close clinical monitoring. Susceptibility testing is of value for epidemiology and in regions where relatively high minimum inhibitory concentrations to azoles (particularly fluconazole) have been noted. Novel diagnostic tools and therapeutic agents promise to improve the detection and treatment of cryptococcosis, particularly in low-income settings where the disease burden is high.","PeriodicalId":520671,"journal":{"name":"Journal of fungi (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9696922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7