JBRA assisted reproduction最新文献

{"title":"Embryo Morphology and Euploidy Rate: A Cross-Sectional Analysis of Day-3 and Blastocyst-Stage Quality.","authors":"Giovanna Giovacchini, Paulo Victor Zattar Ribeiro, Cainã Gonçalves Rodrigues, Caroline Castrucci Ingold, Anna Luiza Braga Albuquerque, Caio Parente Barbosa, Renato de Oliveira","doi":"10.5935/1518-0557.20260065","DOIUrl":"https://doi.org/10.5935/1518-0557.20260065","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the association between embryo morphology at the cleavage stage (Day 3) and the blastocyst stage and the likelihood of euploidy.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 519 embryos from 250 patients who underwent controlled ovarian stimulation with either oral progestins or gonadotropin-releasing hormone (GnRH) antagonists, followed by intracytoplasmic sperm injection (ICSI) and preimplantation genetic testing for aneuploidy (PGT-A), between 2018 and 2023. Day-3 embryos were classified according to cell number (<8 vs. ≥8) and fragmentation grade (A, B, or C, according to the 2011 Istanbul Consensus). Blastocysts were graded using the Gardner classification and categorized as top quality (≥3BB) or non-top quality. Associations between morphology and ploidy were analyzed using the chi-square test or Fisher's exact test, as appropriate, and expressed as odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Among the 519 embryos, 140 (26.9%) were euploid and 379 (73.1%) were aneuploid. Embryos with ≥8 cells on Day 3 exhibited significantly less fragmentation (p<0.001) and were more likely to develop into top-quality blastocysts (50.1% vs. 37.7%, p=0.002). Top-quality blastocysts had nearly twice the euploidy rate of non-top-quality blastocysts (36.9% vs. 18.7%, p<0.001). No significant association was found between Day-3 cell number and euploidy (p=0.550).</p><p><strong>Conclusions: </strong>Embryos with ≥8 cells on Day 3 were more likely to develop into top-quality blastocysts and exhibited less fragmentation. Although blastocyst morphology was associated with euploidy, Day-3 parameters alone were not predictive. These findings highlight the importance of combining morphological and genetic assessments for embryo selection.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stressors and Preventive Factors Associated with Burnout in Embryologists Working in assisted reproduction: Data from a Cross-Sectional Worldwide Study.","authors":"Raquel Urteaga, Amelia Díaz","doi":"10.5935/1518-0557.20260074","DOIUrl":"https://doi.org/10.5935/1518-0557.20260074","url":null,"abstract":"<p><strong>Objectives: </strong>Recent studies of assisted reproduction (AR) teams have shown that embryologists experience the highest levels of burnout among team members. Therefore, this study aimed to identify the stressors experienced by embryologists and the preventive and mitigating strategies they consider useful.</p><p><strong>Methods: </strong>This cross-sectional study used a worldwide online survey to assess workplace stressors and preventive and mitigating strategies associated with burnout among 759 respondents. Comparisons were made among embryologists working in Europe, Latin America, North America, and the Western Pacific region.</p><p><strong>Results: </strong>More than 90% of embryologists in the four regions identified stressors inherent to the profession, as well as organizational and relational stressors. European and North American embryologists reported significantly more environmental and physical stressors than those in the Western Pacific region. Physical, organizational, and relational preventive and mitigating strategies were considered the most useful, with many endorsed by more than 90% of embryologists. Latin American embryologists considered psychological strategies significantly more appropriate and useful than did embryologists in other regions.</p><p><strong>Conclusions: </strong>This study identified the stressors that most affect embryologists worldwide and the strategies they consider useful for addressing burnout. Future interventions should incorporate these strategies to reduce or eliminate the identified stressors, improve working conditions, and positively influence the mental health of these professionals.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preimplantation genetic testing to determine polygenic disease risk: Will we know when to stop?","authors":"Daniela Paes de Almeida Ferreira Braga, Amanda Setti, Rose Marie Melamed, Edson Borges","doi":"10.5935/1518-0557.20260061","DOIUrl":"https://doi.org/10.5935/1518-0557.20260061","url":null,"abstract":"<p><p>Recent advances in genomics technologies have facilitated the introduction of new tools that broaden the scope of applications for genetic data. Preimplantation genetic testing using polygenic risk scores (PGT-P), a technique based on the fact that complex traits are influenced by multiple genes, is one such technology. Polygenic risk scoring involves the analysis of many genes in a single embryo to assess the odds of expressing diseaseand non-disease-related factors. This technique could alleviate subsequent burdens on healthcare systems, as it could lead to a population with reduced polygenic risk scores, potentially resulting in a lower incidence of genetic conditions, such as cardiovascular disease and cancer. However, following the introduction of PGT-P, numerous ethical concerns regarding its use have been raised. As such, it is crucial to gain a deeper understanding of stakeholder viewpoints regarding the technique. Worries include the validity and utility of PGT-P, limitations related to the number of embryos and available choices, and the challenges faced by prospective parents in terms of understanding and making informed decisions. Recently, published surveys have indicated that PGT-P is well accepted by both the general population and assisted reproduction patients; however, experts are concerned about the premature implementation of the technique. These findings raise the question of whether the general population is aware of the risks of technologies that could potentially manipulate the traits of future generations. To conclude, the value of PGT-P is indisputable if applied with caution, especially if relevant limits are not exceeded.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified double trigger versus recombinant hCG alone for final oocyte maturation in IVF-ICSI: Impact on oocyte and embryological outcomes.","authors":"Alvaro Ramos-Reyes, Rocio Velásquez-Falconi, Mariana Aparicio-Fabila, Elizabeth Borja-Cacho, Marcia Carmona-Maldonado, Adriana Galvan-Luna, Radamés Rivas-López","doi":"10.5935/1518-0557.20260077","DOIUrl":"https://doi.org/10.5935/1518-0557.20260077","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether a modified double trigger (recombinant hCG -36 h plus GnRH agonist -34 h) improves oocyte maturation and embryological outcomes compared with r-hCG alone in IVF-ICSI cycles, and whether effects differ by age and ovarian reserve.</p><p><strong>Methods: </strong>Retrospective single-center cohort study included 80 IVF-ICSI cycles performed between 2023 and 2025, comparing a modified double trigger (n=42) with r-hCG alone (n=38). The primary outcome was oocyte maturation rate (MII/total oocytes). Secondary outcomes included total and MII oocytes, fertilization, cleavage, blastulation, day-3 and day-5 embryo counts, and binary endpoints. Prespecified subgroup analyses were conducted by age and antral follicle count (AFC), Adjusted generalized regression models were applied for key outcomes. Spearman correlation assessed the association between maximum follicular diameter and maturation in AFC <6 and in women aged ≥41 years.</p><p><strong>Results: </strong>Baseline characteristics were comparable. Overall oocyte maturation rates were similar between groups (median 75.7% in both; p=0.691). In AFC <6, unadjusted analyses showed higher day-5 embryo yield with the modified double trigger, without independent associations in adjusted models. In women aged ≥41 years, the modified double trigger was associated with higher numbers of 2PN oocytes and day-3 embryos, and achieving ≥2 day-5 embryos occurred more frequently (33.3% vs. 0%). In adjusted analyses, double trigger remained independently associated with a higher number of MII oocytes in this subgroup.</p><p><strong>Conclusions: </strong>The modified double trigger did not improve overall oocyte maturation. Exploratory analyses suggest a potential benefit on downstream embryological outcomes in poor prognosis subgroups, supporting further prospective evaluation of trigger timing strategies.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Artificial Intelligence into Reproductive Medicine: A Predictive Algorithm for Noninvasive Live Birth Assessment.","authors":"Agnieszka Nowak, Jurij Koseniuk, Julia Gabryś-Firek, Zuzanna Chrostowska, Paulina Kuras, Bartosz Chrostowski","doi":"10.5935/1518-0557.20260073","DOIUrl":"https://doi.org/10.5935/1518-0557.20260073","url":null,"abstract":"<p><strong>Objective: </strong>To develop and evaluate a machine learning model integrating clinical, embryological, morphokinetic, and semen-related variables to estimate the probability of live birth after in vitro fertilization (IVF).</p><p><strong>Methods: </strong>This retrospective study included data from 375 IVF cycles performed between 2013 and 2022. Morphokinetic, clinical, and semen-related parameters were analyzed using four machine learning algorithms: logistic regression, support vector machine, neural network, and extreme gradient boosting (XGBoost). Model performance was assessed using the area under the receiver operating characteristic curve (AUC). The best-performing model underwent Bayesian hyperparameter optimization and synthetic data augmentation. Feature importance was evaluated to identify the variables contributing most strongly to live birth prediction.</p><p><strong>Results: </strong>Among the initial models, XGBoost demonstrated the best and most stable predictive performance, with an AUC above 0.60. Following hyperparameter optimization and data augmentation, the final XGBoost model achieved an AUC of 0.927. The most relevant predictive variables were transferred embryo class, timing of second polar body extrusion, anti-Müllerian hormone concentration, female age, and body mass index. These findings supported the development of an application designed to estimate individualized probabilities of live birth after IVF treatment.</p><p><strong>Conclusion: </strong>An artificial intelligence-based model integrating clinical, embryological, morphokinetic, and semen-related variables may provide a useful noninvasive approach to individualized live birth prediction after IVF. Prospective external validation is required to confirm its clinical applicability, assess calibration, and reduce the risk of overestimating treatment success.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Hydroxychloroquine on Frozen Embryo Transfer Outcomes in Patients with Repeated Implantation Failure: A Randomized Clinical Trial.","authors":"Malihe Afiat, Nayereh Khadem, Malihe Amirian, Sahar Ardalan Khales, Elahe Akhgari, Seyedeh Houra Mousavi Vahed, Fahimeh Alizadeh, Hamed Tabesh, Malihe Mahmoudinia","doi":"10.5935/1518-0557.20260066","DOIUrl":"https://doi.org/10.5935/1518-0557.20260066","url":null,"abstract":"<p><strong>Objective: </strong>Repeated implantation failure (RIF) poses significant challenges in assisted reproductive technology. This study investigated the effects of hydroxychloroquine, an anti-inflammatory medication, on frozen embryo transfer outcomes in patients with RIF.</p><p><strong>Methods: </strong>In this randomized, single blind study, 70 women with a history of RIF were randomly assigned to intervention and control groups. The control group received 4 mg estradiol valerate tablets starting on the third day of the menstrual cycle for four days, followed by 6 mg daily from the seventh day until the endometrial thickness reached at least 8 mm. The intervention group received 200 mg hydroxychloroquine tablets every 12 hours from the third day of the menstrual cycle, in addition to estradiol valerate. Following endometrial preparation, patients received a daily intramuscular injection of 50 mg progesterone and 400 mg of vaginal progesterone suppositories twice daily, then frozen embryo transfer was performed. The co-primary outcomes were chemical pregnancy and clinical pregnancy rates. Secondary outcomes included multiple pregnancy, miscarriage, ongoing pregnancy and live birth rates.</p><p><strong>Results: </strong>The intervention group exhibited higher rates of chemical pregnancy, clinical pregnancy, ongoing pregnancy and live birth compared to the control group; however, these differences were not statistically significant (p>0.05). Furthermore, the rate of singleton pregnancies in the intervention group was significantly higher (p=0.04).</p><p><strong>Conclusion: </strong>Although hydroxychloroquine may positively affect pregnancy outcomes, the statistical evidence in this study is not strong enough to draw definitive conclusions. Future adequately powered studies with larger cohorts are essential to confirm these clinical trends and determine its true clinical efficacy.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of Use of Follitropin Delta in Brazilian Assisted Reproduction: Results of the Multicenter PURO Real World Study.","authors":"João Antonio Dias Junior, Roberto de Azevedo Antunes, Edson Borges, Emerson Barchi Cordts, Carlos Roberto Izzo, Georges Fassolas, Luiz Fernando de Oliveira Henrique, Luciana Carvalho Delamuta, Lucas Yamakami, Renato de Oliveira Tomioka, Larissa Matsumoto, Fernanda Imperial Carneiro Liez, Maria do Carmo Borges de Souza, Marcelo Marinho de Souza, Karina Abelha Rabaço, Ana Cristina Allemand Mancebo, Amanda Setti, Daniela Braga, Caio Parente Barbosa, Renato de Oliveira, Oscar Barbosa Duarte-Filho","doi":"10.5935/1518-0557.20260052","DOIUrl":"https://doi.org/10.5935/1518-0557.20260052","url":null,"abstract":"<p><strong>Objective: </strong>To characterize prescription patterns, dosing, ovarian response, and reproductive outcomes associated with follitropin delta in routine Brazilian assisted reproduction practice.</p><p><strong>Methods: </strong>This multicenter retrospective cohort study included five private IVF centers in Brazil. A total of 2,284 women aged 18-47 years treated with follitropin delta between April 2018 and December 2023 were included. Controlled ovarian stimulation was administered as monotherapy or in combination with other gonadotropins. Starting doses were determined using an AMH/weight-based algorithm or physician discretion. Outcomes assessed included protocol distribution, follitropin delta dosing, oocyte yield, number of blastocyst, ongoing pregnancy rate, and severe OHSS incidence.</p><p><strong>Results: </strong>Protocol distribution was: algorithm-guided monotherapy, 1.9%; empirical monotherapy, 14.8%; delta plus menotropin, 75.2%; delta plus rFSH/LH, 5.0%; other combinations, 3.1%. Pituitary suppression was mainly achieved with GnRH antagonist (50.7%) or PPOS (43.4%). Final oocyte maturation was triggered with GnRH agonist (47.8%), hCG (10.9%), or dual trigger (41.3%). Among patients, 1,448 (63.4%) underwent autologous IVF/ICSI cycles, 705 (30.9%) oocyte cryopreservation, and 131 (5.7%) oocyte donation cycles. Overall, 2163 patients underwent oocyte pick-up with a mean±SD of 12.9±9.5 oocytes retrieved. Among IVF patients, 715 underwent at least one embryo transfer. Ongoing pregnancy rates across the first to fourth transfers were 50.3%, 42.4%, 24.5%, and 56.3%, respectively. Severe OHSS occurred in 0.14% of IVF patients.</p><p><strong>Conclusions: </strong>Follitropin delta was predominantly used in combination with menotropin and was associated with robust oocyte yield, favorable ongoing pregnancy rates, and low severe OHSS incidence, supporting its feasibility and safety in routine clinical practice.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of post-warming morphometric changes parameters for embryo implantation.","authors":"Daniela Braga, Amanda Souza Setti, Melissa Cavagnoli, Maite de Collado, Assumpto Iaconelli, Edson Borges","doi":"10.5935/1518-0557.20260067","DOIUrl":"https://doi.org/10.5935/1518-0557.20260067","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether post-warming blastocyst morphometric dynamics assessed by time-lapse imaging (TLI) are associated with implantation in intracytoplasmic sperm injection cycles with deferred embryo transfer.</p><p><strong>Methods: </strong>This observational cohort study included 822 vitrified-warmed high-quality blastocysts with known implantation outcomes, evaluated between January and October 2024 at a private university-affiliated in vitro fertilization centre. Post-warming morphometric parameters were recorded during a 4-hour incubation period, including initial blastocyst area, maximum blastocyst area (MXBA), initial zona pellucida thickness, minimum zona pellucida thickness (MZP), and blastocyst re-expansion. Associations with implantation were assessed using multivariable logistic regression. A composite weighted score incorporating MXBA, MZP, and blastocyst re-expansion was developed from the regression coefficients and analysed as a continuous variable. Restricted cubic spline modelling was used to assess potential non-linear associations.</p><p><strong>Results: </strong>MXBA (OR=1.078; 95% CI 1.029-1.198; p=0.048), MZP (OR=0.923; 95% CI 0.856-0.995; p=0.038), and blastocyst re-expansion (OR=1.183; 95% CI 1.010-1.386; p=0.036) were independently associated with implantation. Each one-standard-deviation increase in the composite weighted score was associated with a 21.6% increase in the odds of implantation (OR=1.216; 95% CI 1.055-1.403; p=0.007). Spline analysis showed a progressive increase in implantation probability across the score range, without strong evidence of non-linearity.</p><p><strong>Conclusion: </strong>Quantitative post-warming morphometric assessment provides clinically relevant information on blastocyst implantation potential. A composite score integrating MXBA, MZP, and blastocyst re-expansion may support embryo selection in frozen-thawed embryo transfer cycles.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing ovarian stimulation in oocyte donation: exploratory comparison of rhFSH (2:1) versus hp-hMG under PPOS protocols.","authors":"Pamela Villanueva, Silvia Ortiz, Paula Ricra, Camila Carlos, Fiorella Castillo-Velásquez, Luis Noriega- Portella, Luis Noriega-Hoces, Luis Guzmán","doi":"10.5935/1518-0557.20260068","DOIUrl":"https://doi.org/10.5935/1518-0557.20260068","url":null,"abstract":"<p><strong>Objective: </strong>To describe embryological outcomes in oocyte donors undergoing progesterone-primed ovarian stimulation (PPOS) with either recombinant human follicle-stimulating hormone (rhFSH): recombinant human luteinizing hormone (rhLH) (2:1) or highly purified human menopausal gonadotropin (hp-hMG).</p><p><strong>Methods: </strong>Young, healthy donors began PPOS on cycle day 2 and were sequentially allocated into an observational case series study. Donors receive either rhFSH:rhLH (2:1) or hp-hMG (both at 225IU/day; n=26 and n=10 donor cycles, respectively). Final oocyte maturation was triggered with triptorelin 0.2 mg. Retrieved oocytes were fertilized by ICSI, and embryos were cultured to the blastocyst stage and graded. A subset of blastocysts underwent PGT-A biopsy prior to vitrification. The oocyte retrieval team and embryologists were blinded to treatment allocation.</p><p><strong>Results: </strong>Baseline donor characteristics were similar. Donor cycles allocated to rhFSH:rhLH showed numerically higher oocyte yield, metaphase II oocytes, 2PN fertilization, and total blastocyst formation. The mean number of good-morphology blastocysts per cycle was approximately two-fold higher with rhFSH:rhLH (4.5 vs. 2.0). Following an interim descriptive review of the first ten hp-hMG cases showing suboptimal embryological outcomes, further allocation to hp-hMG was discontinued as a programmatic decision. No inferential statistical testing was performed, consistent with the exploratory case series.</p><p><strong>Conclusion: </strong>In this exploratory case series, rhFSH:rhLH within PPOS demonstrated more favorable laboratory outcomes. These results generate hypotheses and support the need for further studies to confirm the observations and determine their clinical relevance in oocyte donation programs.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149077438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality Control in Assisted Reproduction Centers.","authors":"Ana Carolina Nogueira Martinhago, Ciro Dresch Martinhago","doi":"10.5935/1518-0557.20260000","DOIUrl":"https://doi.org/10.5935/1518-0557.20260000","url":null,"abstract":"<p><p>Assisted Reproductive Technologies (ART) demand rigorous quality standards to ensure clinical safety, efficacy, and ethical responsibility. This review outlines key elements of Quality Management Systems (QMS) in ART laboratories, addressing technical, infrastructural, regulatory, and human dimensions essential to successful outcomes. Core components include standardized protocols, validation and maintenance of equipment, environmental monitoring, biosafety procedures, and robust traceability. Laboratory infrastructure must meet ISO cleanroom standards to support the microenvironment necessary for gamete and embryo viability. Biosafety in ART requires BSL-2 compliance, risk zoning, personal protective equipment, proper waste disposal, and comprehensive training, including ergonomic and psychological safety measures. Personnel qualification is essential, requiring academic credentials, continuing education, and structured competency assessments. Equipment such as incubators and cryogenic tanks must undergo regular validation, given their direct impact on embryo development. Performance indicators (KPIs), including fertilization, blastocyst formation, and cryosurvival rates, serve as benchmarks for quality improvement. Documentation and traceability systems must track all clinical and laboratory stages, supported by electronic platforms and witnessing systems. Regulatory adherence and accreditation by agencies reinforce institutional reliability and transparency. Ethical compliance remains foundational, including informed consent, embryo disposition policies, and data confidentiality. While the implementation of a comprehensive QMS involves significant investment, it yields measurable benefits: improved clinical outcomes, error reduction, enhanced patient satisfaction, and long-term sustainability. Quality management in ART is thus not only a regulatory mandate but a strategic imperative that aligns technological precision with ethical and clinical excellence.</p>","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148440753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}