International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"Percutaneous thermal ablation of the parathyroid glands is associated with short-term echocardiographic improvements in left ventricular structure and function in patients with end-stage renal disease and secondary hyperparathyroidism.","authors":"Jianguang Gan, Jiemei Gan, Yuanxia Jiang, Jian Li, Xuequn Yang, Zhaoyan Deng, Ling Pan","doi":"10.1080/02656736.2026.2680506","DOIUrl":"https://doi.org/10.1080/02656736.2026.2680506","url":null,"abstract":"<p><strong>Objective: </strong>To observe the effects of ultrasound-guided percutaneous thermal ablation of the parathyroid glands on the left ventricular structure and function in patients with end-stage renal disease (ESRD) and secondary hyperparathyroidism (SHPT).</p><p><strong>Methods: </strong>Retrospective cohort study (May 2019-March 2025). Patients: thermal ablation (<i>n</i> = 64) vs. medical therapy (<i>n</i> = 115). Propensity score matching (1:1, caliper 0.2) based on gender, age, baseline PTH, serum calcium, left ventricular mass index (LVMI) yielded 108 patients (54/group). Multivariable regression adjusted for residual confounding. Measurements at baseline and 6 months. Changes in LVMI, LVEF, PTH, phosphorus, serum calcium, blood pressure compared.</p><p><strong>Results: </strong>After matching, in the thermal ablation group, LVMI, PTH, serum phosphorus, serum calcium, and systolic blood pressure (SBP) at 6 months decreased compared with baseline (all <i>p</i> < 0.05). In the medical therapy group, serum calcium decreased compared with baseline (<i>p</i> < 0.05). Inter-group comparisons showed that the reductions in LVMI, PTH, serum phosphorus, serum calcium, and SBP were greater in the thermal ablation group than in the medical therapy group (all <i>p</i> < 0.05). Multivariable regression analysis showed that thermal ablation was independently associated with a greater percentage reduction in LVMI (95% CI: 7.49-24.44, <i>p</i> < 0.001). In the thermal ablation subgroup with baseline left ventricular systolic dysfunction, LVEF increased from baseline to 6 months (<i>p</i> = 0.017).</p><p><strong>Conclusion: </strong>Ultrasound-guided percutaneous thermal ablation of the parathyroid glands was associated with greater reductions in PTH, serum phosphorus, serum calcium, SBP and LVMI than medical therapy. In the pilot subgroup of patients with baseline left ventricular systolic dysfunction, LVEF showed an increase after thermal ablation.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2680506"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148379552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided versus CT-guided microwave ablation for liver metastases reduces complications with comparable tumor control.","authors":"Yezhao Li, Tianquan Cai, Zhengfeng Huang, Hongzhi Yang","doi":"10.1080/02656736.2026.2698763","DOIUrl":"https://doi.org/10.1080/02656736.2026.2698763","url":null,"abstract":"<p><strong>Objective: </strong>Microwave ablation (MWA) is a minimally invasive therapy for liver metastases. Image guidance, primarily ultrasound (US) and computed tomography (CT), is critical for precision, but their comparative safety profiles remain debated. This study aims to compare the incidence and severity of complications between US-guided and CT-guided MWA in patients with liver metastases.</p><p><strong>Methods: </strong>After propensity score matching (PSM), retrospective analysis of 120 patients (2022-2024) undergoing US-guided (<i>n</i> = 60) or CT-guided (<i>n</i> = 60) MWA at a single tertiary referral center. Complications were classified using the Clavien-Dindo system. Statistical analysis included Student's <i>t</i> test, χ² tests, and logistic regression.</p><p><strong>Results: </strong>Major complications (Clavien-Dindo ≥ III) occurred in 5% of US-guided vs. 13.3% of CT-guided cases (<i>p</i> = 0.04). US guidance correlated with fewer pneumothoraxes (0% vs. 8.3%, <i>p</i> = 0.02) and reduced radiation exposure (<i>p</i> < 0.001). There was no statistically significant difference in the 12-month local tumor progression (LTP) rate between the two groups (<i>p</i> = 0.79).</p><p><strong>Conclusion: </strong>US-guided MWA demonstrates comparable tumor control to CT guidance with fewer complications and avoids radiation exposure, supporting its preferential use for high-risk patients.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2698763"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a numerical simulation for multibipolar radiofrequency ablation.","authors":"Christina A Neizert, David Sinden, Christian Rieder, Tobias Preusser, Hanne Ballhausen, Ole Gemeinhardt, Kai S Lehmann, Franz G M Poch","doi":"10.1080/02656736.2026.2657470","DOIUrl":"10.1080/02656736.2026.2657470","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess the accuracy of a custom-developed numerical simulation of hepatic multibipolar radiofrequency ablation (mbRFA) under standardized conditions, accounting for temperature-dependent changes in tissue properties, dehydration and coagulation. The model was specifically assessed for its ability to predict vascular cooling effects induced by large vessels using an established <i>ex vivo</i> porcine liver model. A GPU-accelerated finite-difference time-domain (FDTD) simulation coupling the quasi-static Maxwell and Pennes' bioheat equations was implemented to model mbRFA.</p><p><strong>Methods: </strong><i>Ex vivo</i> mbRFA were performed using three internally cooled bipolar applicators. A saline-perfused glass tube was employed to simulate a standardized blood flow and positioned at five predefined distances from the ablation center in 2.5 mm increments. Simulated and experimental ablations were compared using area-, surface- and classification-based metrics on a standardized two-dimensional (2D) cross section to evaluate the model's predictive accuracy.</p><p><strong>Results: </strong>The numerical simulation reliably predicted the ablation shape for mbRFA while effectively accounting for vascular cooling effects. Conformity between simulated and real ablation areas was 96% across all experimental settings. The average similarity between the <i>ex vivo</i> ablations and the simulation were 0.92 (Dice coefficient) and 0.85 (Jaccard coefficient), respectively. Compared to the reference area, the simulation overestimated the ablation zone by 4% (false-positive regions) and underestimated it by 10% (false-negative regions).</p><p><strong>Conclusion: </strong>Overall, the numerical model demonstrated good spatial agreement with the experimental ablations, confirming its suitability for quantitative prediction of ablation geometry.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2657470"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute kidney injury after cytoreductive surgery and HIPEC: incidence and timing in a 10-year single-center cohort.","authors":"Michał Kazanowski, Paweł Lesiak, Jędrzej Wierzbicki, Bartosz Kapturkiewicz, Paweł Maciejewski, Marcin Pawłowski, Krzysztof Szewczyk, Tomasz Jastrzębski, Marek Bębenek","doi":"10.1080/02656736.2026.2699378","DOIUrl":"10.1080/02656736.2026.2699378","url":null,"abstract":"<p><strong>Introduction: </strong>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is used for selected peritoneal malignancies but carries substantial perioperative physiological stress. Acute kidney injury (AKI) is clinically relevant, yet data on its incidence and postoperative timing remain heterogeneous.</p><p><strong>Methods: </strong>We performed a retrospective single-center cohort study of consecutive adults undergoing CRS-HIPEC between 2014 and 2024. AKI was defined using KDIGO serum creatinine criteria assessed from postoperative day (POD) 1 to POD 5. Baseline, oncologic and treatment related variables were compared according to AKI status. Exploratory multivariable logistic regression assessed associations between routinely available variables and postoperative AKI. Secondary outcomes included length of stay and exploratory overall survival.</p><p><strong>Results: </strong>Among 308 cases, AKI occurred in 70 cases (22.7%). Stage 1 AKI occurred in 45 cases (14.6%), stage 2 in 18 cases (5.8%) and stage 3 in 7 cases (2.3%). Renal replacement therapy was required in 2 cases (0.6%). Peak serum creatinine occurred on POD 1 to POD 2 in 64.3% of cases, while 35.7% peaked on POD 3 to POD 5. Median length of stay was 7.5 days [IQR 6.5 to 9.6] in the AKI group and 7.4 days [IQR 6.5 to 8.8] in the non-AKI group (<i>p</i> = 0.0998). In exploratory multivariable analysis, no included variable was significantly associated with AKI; PCI showed a non-significant association (OR 1.04 per point, <i>p</i> = 0.11).</p><p><strong>Conclusions: </strong>AKI was frequent after CRS-HIPEC, and more than one third of cases peaked beyond the first 48 h. These findings support postoperative renal surveillance through POD 5.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2699378"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful pregnancy via assisted reproductive technology following combined high-intensity focused ultrasound, ethanol injection, and GnRH agonist therapy for refractory uterine fibroids: a case report.","authors":"Qi Wan, Qingling Wang, Xue Jiao Wang, Xiaoli Wang","doi":"10.1080/02656736.2026.2653775","DOIUrl":"10.1080/02656736.2026.2653775","url":null,"abstract":"<p><strong>Background: </strong>Refractory and recurrent uterine fibroids present complex therapeutic challenges, particularly in patients who desire fertility preservation. Clinical management must balance multiple competing risks: preserving reproductive potential, preventing oestrogen-stimulated regrowth during assisted reproduction, and avoiding complications from repeated surgical interventions.</p><p><strong>Materials and methods: </strong>We report a challenging case of a woman with multiple recurrent refractory uterine fibroids and associated infertility. The patient underwent two prior open myomectomies followed by four sessions of high-intensity focused ultrasonography. Due to inadequate response, subsequent combination therapy included ultrasound-guided absolute ethanol injection into the residual perfused fibroid tissue and three months of gonadotropin-releasing hormone agonist administration. Pregnancy was ultimately achieved through <i>in vitro</i> fertilization embryo transfer.</p><p><strong>Results: </strong>Following the combined treatment approach, the patient successfully conceived and delivered a healthy newborn.</p><p><strong>Conclusion: </strong>This case suggests that for patients with difficult-to-treat, recurrent uterine fibroids, a multimodal strategy combining serial high-intensity focused ultrasound procedures with adjuvant gonadotropin-releasing hormone agonist therapy may facilitate favorable reproductive outcomes. Although the evidence continues to evolve, this successful live birth offers clinical support for the use of this integrated approach in selected cases.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2653775"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic ultrasound in ophthalmology: a comprehensive review.","authors":"Ying Zhang, Luhui Yi, Lingdong Kong, Sinan Zhou, Min He, Jingchen Liu, Yezhou Liu, Sheng Fang","doi":"10.1080/02656736.2026.2658736","DOIUrl":"10.1080/02656736.2026.2658736","url":null,"abstract":"<p><strong>Background: </strong>Therapeutic ultrasound has emerged as a promising noninvasive or minimally invasive modality in ophthalmology, offering novel solutions across a range of ocular disorders. This review summarizes the current advances in both the underlying biophysical mechanisms and their translation into clinical and experimental applications.</p><p><strong>Methods: </strong>This review synthesizes and analyzes the current literature, focusing on the core mechanisms of therapeutic ultrasound and its present and emerging applications in ophthalmic care.</p><p><strong>Results: </strong>The key biophysical mechanisms of therapeutic ultrasound include thermal effects, acoustic streaming, and cavitation. Established clinical procedures based on these mechanisms, such as phacoemulsification for cataract surgery and ultrasound cycloplasty (UCP) for glaucoma, have demonstrated clinical efficacy and safety. Meanwhile, emerging applications show substantial potential in preclinical and early clinical studies, including the treatment of meibomian gland dysfunction (MGD), HIFU-based corneal reshaping, photo-mediated ultrasound therapy (PUT) for retinal neovascular diseases, and ultrasound-based retinal prostheses (U-RP) for vision restoration.</p><p><strong>Conclusion: </strong>Despite these advances, challenges such as treatment protocol standardization, device miniaturization, and the need for large-scale clinical validation remain. Looking forward, integration with wearable technologies, artificial intelligence, and personalized theranostics is expected to further enhance the precision and scope of therapeutic ultrasound, positioning it as a transformative tool in the future landscape of ophthalmic care.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2658736"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of deep hyperthermia on hematological parameters and tumor markers in cancer patients: a retrospective cohort study.","authors":"Quan-Yao Li, Yi-Chao Wang, Wen-Chao Qiu, Ming-Jun Lan, Xuan Zhou, Xi Li, Jun Shi, Dan Lin","doi":"10.1080/02656736.2026.2653783","DOIUrl":"10.1080/02656736.2026.2653783","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effects of deep hyperthermia on hematological parameters and tumor markers in patients with malignant tumors and to evaluate its potential adjuvant therapeutic value in improving hematopoietic and immune function.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 182 tumor patients who underwent deep hyperthermia at Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine. A detailed deep hyperthermia treatment protocol, including tumor localization, temperature monitoring, treatment parameters and quality assurance, was strictly implemented. Hematological parameters and tumor markers were monitored dynamically during treatment. The Friedman test and a linear mixed-effects model were used for comparison and trend prediction.</p><p><strong>Results: </strong>After deep hyperthermia treatment, the Neutrophil, White blood cell count, Red blood cell count, Lymphocyte, Hemoglobin, and Platelet count were significantly increased over time (<i>p</i> < 0.01). At Day 56, hemoglobin increased by 12.21% and lymphocytes increased by 27.48% compared to baseline. The levels of CA153, CA724, CA242, CA50 and SCCA decreased significantly (<i>p</i> < 0.01). In contrast, there was no significant change in CEA, CA125 and CA199 (<i>p</i> > 0.05). A linear mixed-effects model predicted continued improvement in hematological parameters until Day 70.</p><p><strong>Conclusion: </strong>Deep hyperthermia is associated with significantly improves hematological parameters and reduces specific tumor markers in cancer patients, with a favorable safety profile. It suggests potential benefits in enhancing immune function, correcting anemia, and reducing bleeding risk, and can serve as an effective adjuvant therapy for malignant tumors.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2653783"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effect of combined hyperthermia and radiotherapy mediated by AQP5 reduction in pancreatic cancer.","authors":"Jaewan Jeon, Hyosun Jang, Geumju Park, Hyeon Jeong Hwang, Mi Hwa Lee, Minji Kang, Seung Bum Lee, Wonyi Jang, Wanyeon Kim, Hye Young Kim, Bo-Hyun Jung, Yong-Kyu Chung, Junghwan Lee, HyeSook Youn, Sunmi Jo, BuHyun Youn","doi":"10.1080/02656736.2026.2644451","DOIUrl":"10.1080/02656736.2026.2644451","url":null,"abstract":"<p><strong>Objective: </strong>Pancreatic ductal adenocarcinoma (PDAC), a clinically aggressive stage IV cancer, exhibits poor prognosis and limited therapeutic efficacy due to numerous somatic mutations. In this study, we aimed to elucidate the molecular mechanisms underlying enhanced radiosensitivity in PDAC when hyperthermia was combined with radiotherapy, with a focus on the role of aquaporin 5 (AQP5).</p><p><strong>Materials and methods: </strong>Hyperthermia (41 °C-44 °C for 30 min) and radiotherapy (3 Gy) were applied individually or in combination to pancreatic cancer cell lines. AQP5 expression was analyzed by quantitative reverse transcription PCR. Oxidative stress and signaling pathways (ERK, p38 MAPK, and AKT) were evaluated to identify potential underlying mechanisms. To investigate the clinical significance of AQP5, its expression was evaluated by immunohistochemistry in pancreatic cancer tissues across different stages of disease progression.</p><p><strong>Results: </strong>Combination treatment significantly reduced AQP5 expression in pancreatic cancer cells compared to monotherapies. This reduction was associated with increased oxidative stress, enhanced apoptosis, and inhibition of ERK/p38 MAPK/AKT signaling pathways. Immunohistochemical analysis revealed elevated AQP5 expression in human PDAC tissues compared to adjacent normal tissues, supporting its clinical relevance.</p><p><strong>Conclusions: </strong>Our findings demonstrate that AQP5 plays a key role in mediating resistance to radiotherapy in PDAC. Its downregulation through combined hyperthermia and radiotherapy enhances radiosensitivity by promoting oxidative stress and blocking survival pathways. AQP5 may serve as a promising molecular target to improve the therapeutic efficacy of combined treatment strategies in pancreatic cancer.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2644451"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Methodological considerations regarding propensity score matching and interpretation of oncologic outcomes in ultrasound-guided versus CT-guided microwave ablation for liver metastases'.","authors":"Deep Shikha, Sunita Sharma","doi":"10.1080/02656736.2026.2723463","DOIUrl":"https://doi.org/10.1080/02656736.2026.2723463","url":null,"abstract":"","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2723463"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of genetic and morphological evaluation (GAME) score for outcomes after thermal ablation in patients with colorectal liver metastases.","authors":"Yaqing Kong, Xiaoning Yue, Xiaojing Cao, Fan Tang, Xiang Zhou","doi":"10.1080/02656736.2026.2710713","DOIUrl":"https://doi.org/10.1080/02656736.2026.2710713","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the predictive value of the genetic and morphological evaluation (GAME) score for the prognosis of patients with colorectal liver metastases (CRLM) receiving thermal ablation (TA) and compare it with the Fong score.</p><p><strong>Materials and methods: </strong>We conducted a retrospective analysis of CRLM patients who underwent TA between January 2016 and December 2021 at two tertiary medical centers in China. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier curves and log-rank testing. Prognostic variables associated with early recurrence (ER) and OS were identified through univariate and multivariate Cox regression, and nomograms were developed based on significant factors.</p><p><strong>Results: </strong>Both the GAME and Fong scores effectively predicted RFS and OS in patients with CRLM undergoing TA treatment, though the GAME score showed superior discriminatory ability. Cox regression identified the largest liver metastasis diameter (HR: 0.45, 95% CI: 0.29-0.69; <i>p</i> < 0.001) and GAME group (HR: 1.88, 95% CI: 1.13-3.12; <i>p</i> = 0.015) as independent prognostic factors for ER. The largest liver metastasis diameter (HR: 0.49, 95% CI: 0.31-0.78; <i>p</i> = 0.003), image-guidance technique (HR: 2.10, 95% CI: 1.04-4.27; <i>p</i> = 0.039) and GAME group (HR: 1.88, 95% CI: 1.12-3.16; <i>p</i> = 0.017) were independent prognostic factors for OS. Based on these findings, nomograms with good discrimination and calibration were constructed.</p><p><strong>Conclusion: </strong>The GAME score, which outperforms the Fong score in predicting the prognosis of patients with CRLM who meet the stringent eligibility criteria of this study and undergo TA, should be considered a preoperative prognostic tool.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2710713"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}