International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"Statement of Retraction: Bipolar radiofrequency ablation with four electrodes: Ex vivo liver experiments and finite element method analysis. Influence of inter-electrode distance on coagulation size and geometry.","authors":"","doi":"10.1080/02656736.2026.2617754","DOIUrl":"https://doi.org/10.1080/02656736.2026.2617754","url":null,"abstract":"","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2617754"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-intensity histotripsy based on acoustically-responsive scaffolds for tumor mechanical destruction and immune responses.","authors":"Hui Li, Qin Wang, Qiang Fu, Peng He, Zhiping Cai, Lian Lu, Zheng Liu, Ningshan Li","doi":"10.1080/02656736.2026.2674957","DOIUrl":"10.1080/02656736.2026.2674957","url":null,"abstract":"<p><strong>Background: </strong>Mechanical ablation enables precise, non-thermal tissue destruction with rapid necrosis clearance and mass-effect decompression. However, high-intensity histotripsy is limited by restricted targeting depth and high cost.</p><p><strong>Methods: </strong>We introduced an acoustically responsive scaffold (ARS)-based low-intensity histotripsy (LIH) approach for tumor mechanical disruption and evaluated its ablative efficacy and immunomodulatory potential. In total, 25 New Zealand white rabbits bearing VX2 tumors were randomly assigned to the control, ARS, LIH1 (pulse repetition frequency (PRF) = 20 Hz, pulse length (PL) = 5.37 ms + ARS), LIH2 (PRF = 20 Hz, PL = 3.36 ms + ARS), and LIH3 (PRF = 38 Hz, PL = 5.37 ms + ARS) groups (<i>n</i> = 5 each).</p><p><strong>Results: </strong>Compared with LIH2 and LIH3, LIH1 produced greater tumor damage area (31.83 ± 15.11 mm²) and damage area ratio (20.90 ± 7.07%), although differences were not statistically significant. All LIH groups exhibited significantly greater tissue damage than the ARS (0.00052 ± 0.00055 mm²; 0.0005 ± 0.00054%) and control (0.00 ± 0.00 mm²; 0.00 ± 0.00%) groups. LIH treatment significantly inhibited tumor growth (<i>p</i> < 0.05). Immunofluorescence analysis demonstrated increased CD8 and CD11c expression in tumor tissues following LIH (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>These findings indicate that LIH effectively induces mechanical tumor disruption and enhances antitumor immune responses.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2674957"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148255551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of blood-flow velocity and direction on coagulation zone symmetry induced by microwave ablation using ECO antenna.","authors":"Andrea Cafarchio, Macarena Trujillo, Marcello Iasiello, Assunta Andreozzi, Giuseppe Vanoli, Enrique Berjano","doi":"10.1080/02656736.2026.2666363","DOIUrl":"https://doi.org/10.1080/02656736.2026.2666363","url":null,"abstract":"<p><strong>Background and objective: </strong>Microwave ablation is a well-established therapy for liver tumors, but its efficacy is strongly influenced by blood perfusion. Most computational studies simplify perfusion as an isotropic sink, neglecting flow orientation. This work introduces the Antenna-Blood flow Relative Angle (ABRA) to quantify the effects of flow direction and velocity on ablation zone geometry using a commercial ECO Ceramic 14 G antenna.</p><p><strong>Methods: </strong><i>Ex vivo</i> bovine liver experiments were performed under standardized conditions and used to calibrate and validate a computational model. The antenna was reverse engineered to reproduce its electromagnetic and thermal characteristics. A local thermal non-equilibrium framework incorporating directional perfusion was implemented to simulate microwave ablation for different ABRA values and blood flow velocities.</p><p><strong>Results: </strong>Both blood flow orientation and velocity significantly affected lesion morphology. Upward-directed flow (0° ABRA) caused elongation of the coagulation zone along the flow axis, while downward-directed flow (180° ABRA) produced more compact and symmetric lesions. Increasing flow velocity amplified these effects, displacing the lesion and reducing its sphericity. Computational results showed strong agreement with experimental measurements, with mean discrepancies below 4%.</p><p><strong>Conclusions: </strong>The findings demonstrate that ABRA and perfusion velocity are key determinants of ablation zone size, shape, and symmetry. Incorporating these parameters into computational modeling and treatment planning could improve lesion predictability and completeness, supporting more personalized and effective strategies for liver tumor ablation.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2666363"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave hyperthermia enhances radiosensitivity of highly invasive non-small cell lung cancer cells via inhibiting Sonic Hedgehog signaling pathway.","authors":"Lingjie Li, Weiwei Luo, Jingjing Zhang, Shujun Xie, Jing Jia, Shenglin Ma, Yanyan Zhao","doi":"10.1080/02656736.2026.2688998","DOIUrl":"https://doi.org/10.1080/02656736.2026.2688998","url":null,"abstract":"<p><strong>Objective: </strong>Radiotherapy (RT) is the main treatment for lung cancer. However, the presence of highly invasive cell (INV) subgroups in tumors often leads to recurrence and metastasis. We hypothesize that microwave hyperthermia (HT) can significantly enhance the radiosensitivity of these INV subgroups, and further explore the molecular mechanisms involved.</p><p><strong>Methods: </strong>Cell proliferation was assessed by colony formation assay and 5-Ethynyl-2'-deoxyuridine (EdU) incorporation assay; cell migration and invasion were evaluated by wound healing and Transwell assays. Western blot (WB) analysis was used to evaluate protein expression associated with epithelial-mesenchymal transition (EMT) and DNA damage repair pathway. Flow cytometry was used to detect cell cycle distribution and apoptosis. TMT proteomics analysis was used to explore radiosensitization mechanism. The radiation sensitization effect of HT was confirmed in <i>in vivo</i> experiments.</p><p><strong>Results: </strong>Compared with RT monotherapy, RT+HT treatment significantly inhibited cell proliferation, repressed cell motility, and reversed the EMT. Moreover, a substantial reduction in proteins associated with DNA damage repair was observed. G2/M arrest and apoptosis were induced by RT+HT treatment. The proteomics analysis, WB assay and the animal experiment indicated that Sonic Hedgehog (Shh) pathway might participate the regulation of radiosensitization by HT. Furthermore, SAG (a Shh agonist) partially reversed the suppression of EMT induced by the combination of RT and HT in INV cells.</p><p><strong>Conclusion: </strong>Our findings demonstrate that HT enhances radiosensitivity of highly invasive NSCLC cells through Shh pathway-mediated EMT reversal coupled with DNA damage potentiation. This study provides a novel therapeutic strategy to overcome radioresistance in NSCLC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2688998"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on 'effects of locally applied water-filtered infrared a irradiation adjunctive to iloprost and carbon dioxide hand baths in patients with systemic sclerosis and severe Raynaud's phenomenon - a randomized controlled trial'.","authors":"Ritu Raj Singh, Sunita Sharma, Aiyesha Khatun","doi":"10.1080/02656736.2026.2697188","DOIUrl":"https://doi.org/10.1080/02656736.2026.2697188","url":null,"abstract":"","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2697188"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148400482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focused ultrasound ablation surgery combined with immune checkpoint inhibition in driver-gene wild-type NSCLC with liver metastasis: a feasibility study.","authors":"Ting Wang, Bing Ouyang, Li Chen, Jinyun Chen, Wenzhi Chen","doi":"10.1080/02656736.2026.2656313","DOIUrl":"10.1080/02656736.2026.2656313","url":null,"abstract":"<p><strong>Background: </strong>This single-arm, open-label clinical trial aimed to evaluate the preliminary safety, efficacy and feasibility of focused ultrasound ablation surgery (FUAS) sequential with immune checkpoint inhibitors (ICIs) in patients with driver-gene wild-type non-small cell lung cancer (NSCLC) and liver metastases.</p><p><strong>Materials and methods: </strong>Ten eligible patients received two cycles of FUAS sequential with ICIs. The ICIs used include Camrelizumab (7/10), Pembrolizumab (3/10) and Serplulimab used for immune rechallenge (1/10). Follow-up was conducted every 6 weeks ± 3 days, including imaging and hematological assessments. Treatment-related adverse events (AEs) were documented anytime.</p><p><strong>Results: </strong>All participants demonstrated stable tolerability and safety in this trial. Immediate post-FUAS ablation rates ranged from 73% to 80%. The median follow-up time is 84 days (IQR, 42-127 days). From baseline to week 18, continuous shrinkage of both hepatic metastatic and target lesions was observed. The DCR of the tumor has reached 80% since the 2nd follow-up (12 weeks), and it remains at 50% until the 4th follow-up (24 weeks).</p><p><strong>Conclusion: </strong>FUAS sequential with ICIs suggests preliminary safety, activity and feasibility in treating driver-gene wild-type NSCLC patients with liver metastases, further validation is needed.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2656313"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study on the structural and magnetic properties of Fe₃O₄@SiO₂ core-shell microspheres along with a safety assessment in treating chemotherapy-resistant ovarian cancer.","authors":"Huanzhi Zhang, Yao Wang, Yang Yang, Dawei Wang, Huakang Peng, Xuan Gu, Qi Wang, Hui Zhang, Jintian Tang, Xiaoping Li","doi":"10.1080/02656736.2025.2610818","DOIUrl":"10.1080/02656736.2025.2610818","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer (OC) presents a significant challenge in the medical field due to its high mortality and resistance to chemotherapy. Chemoresistance in OC diminishes treatment efficacy and contributes to poor patient outcomes. Magnetic hyperthermia (MH) has demonstrated potential for addressing the chemoresistance of ovarian cancer (OC) directly through thermal effects.</p><p><strong>Methods: </strong>The coprecipitation method was used to produce Fe₃O₄ MNPs. Using a modified Stöber approach, the core-shell Fe₃O₄@SiO₂ MNPs were produced. Transcriptome sequencing was employed to evaluate the safety of Fe₃O₄@SiO₂ nanoparticles and to investigate the underlying mechanism of magnetic hyperthermia. An animal subcutaneous xenograft model was used to investigate the safety and efficacy of magnetic fluid therapy under magnetic hyperthermia.</p><p><strong>Results: </strong>The Fe₃O₄@SiO₂ magnetic fluid was successfully synthesized and several characterization experiments confirmed its good dispersion and magnetic properties. The target temperature of 50 °C can be reached within 5 min in the magnetic induction coil, and can be maintained at the target temperature for the subsequent time. Preclinical trials (animal model) validated MH's biocompatibility and tumor suppression capacity.</p><p><strong>Conclusion: </strong>Core-shell structured Fe₃O₄@SiO₂ nanocomposites were fabricated through coprecipitation method and a modified Stöber approach, demonstrating monodisperse morphology and enhanced colloidal stability for biomedical applications. Both <i>in vitro</i> and <i>in vivo</i> experiments have confirmed that the magnetic fluid has good safety and excellent therapeutic effect under the magnetic induction coil.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2610818"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation function changes after high-intensity focused ultrasound therapy for uterine fibroids and adenomyosis: a large retrospective cohort study.","authors":"Xiaofei Zhang, Jingyi Ni, Weiwei Xu, Ruomeng Bi, Yingying Yang, Xinhua Yang, Bin Lin, Haibing Li, Aixingzi Aili, Zhen Li","doi":"10.1080/02656736.2026.2628224","DOIUrl":"10.1080/02656736.2026.2628224","url":null,"abstract":"<p><strong>Objective: </strong>High-intensity focused ultrasound (HIFU) therapy is increasingly used in the management of various solid tumors. However, limited data are available regarding the association between HIFU treatment and coagulation function.</p><p><strong>Materials and methods: </strong>A total of 1,189 patients diagnosed with uterine fibroids or adenomyosis who underwent HIFU therapy at Shanghai First Maternal and Infant Hospital between August 2015 and November 2020 were included. Paired t-tests were conducted to compare coagulation indicators measured before and after HIFU treatment. Multiple logistic regression models were used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between the risk of elevated D-dimer/fibrinogen degradation products (FDP) and HIFU treatment parameters categorized into tertiles.</p><p><strong>Results: </strong>A total of 1,148 eligible patients were included in the final analysis. After HIFU treatment, 61.8% and 55.7% of patients showed elevated D-dimer and FDP levels, respectively, and 54.6% exhibited simultaneous elevation of both on the first day after treatment. Other post-treatment coagulation indicators also demonstrated a hypercoagulable state, including prolonged prothrombin time and thrombin time, shortened activated partial thromboplastin time, and decreased platelet count. During follow-up, no patients developed thromboembolism. Several HIFU parameters were associated with increased D-dimer and FDP levels. The highest tertile of exposure energy was significantly associated with a greater risk of simultaneous elevation of both D-dimer and FDP (adjusted OR [95% CI]: 4.58 [3.17, 6.66]).</p><p><strong>Conclusion: </strong>Higher exposure energy during HIFU treatment may induce alterations in coagulation function, resulting in a transient post-treatment hypercoagulable state.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2628224"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity focused ultrasound in placenta increta: distinguishing uterine preservation from fertility preservation.","authors":"José M Palacios-Jaraquemada, Álbaro José Nieto-Calvache, Nicolás A Basanta","doi":"10.1080/02656736.2026.2708141","DOIUrl":"https://doi.org/10.1080/02656736.2026.2708141","url":null,"abstract":"","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2708141"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histotripsy for renal cell carcinoma: from animal studies to clinical application.","authors":"Ali Mutlu, Katrina L Falk, Adrienne L Kisting, Erica M Knavel Koepsel, Martin G Wagner, J Louis Hinshaw, Daniel D Shapiro, E Jason Abel, John F Swietlik, Paul F Laeseke, Timothy J Ziemlewicz, Fred T Lee, Edwarda D Golden","doi":"10.1080/02656736.2026.2685123","DOIUrl":"https://doi.org/10.1080/02656736.2026.2685123","url":null,"abstract":"<p><strong>Background/objective: </strong>Histotripsy is a novel non-thermal, noninvasive, non-ionising ablation modality that is under investigation for the treatment of renal cell carcinoma (RCC). Histotripsy utilizes a focused ultrasound transducer that creates high peak negative pressures at a focal point to cause cavitation in tissue. The rapid expansion and collapse of endogenous gas bubbles mechanically destroy targeted tissue while sparing collagen-containing critical structures such as the renal pelvis and ureter. This review aims to prepare physicians for the clinical translation of cavitation histotripsy for the treatment of RCC by introducing the basic principles, tissue effects, and results of <i>ex vivo</i> and live animal studies.</p><p><strong>Methods: </strong>This review synthesizes the current literature on cavitation histotripsy for RCC. Special emphasis is placed on the differences between histotripsy and current minimally invasive ablative modalities, the potential of histotripsy for managing kidney tumors, a comprehensive review of preclinical studies, and preliminary findings from early human clinical trials.</p><p><strong>Results: </strong>Preclinical studies have demonstrated that histotripsy can effectively ablate target tissue while sparing nearby critical structures. Histotripsy is not limited by heat-sink effects and may have a reduced risk of off-target damage due to its tissue-selective properties.</p><p><strong>Conclusion: </strong>Histotripsy is currently in clinical trials for use in treating RCC. Ongoing clinical trials, CAIN and HOPE4KIDNEY, will provide critical data on the efficacy, potential complications, and limitations of histotripsy for treating RCC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2685123"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}