International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"The comparison of fractional CO₂ laser and focused ultrasound for vulvar lichen sclerosus: a retrospective study.","authors":"Maoyu Liu, Xuerui Zhang, Linlin Xiao, Jing Liang, Dan Cheng, Yue Zhu, Shufang Chang","doi":"10.1080/02656736.2025.2507958","DOIUrl":"10.1080/02656736.2025.2507958","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the efficacy of fractional carbon dioxide laser (FxCO₂) and focused ultrasound (FUS) in treating vulvar lichen sclerosus (VLS).</p><p><strong>Methods: </strong>This single-center retrospective study included biopsy-proven VLS patients who did not respond to first-line topical corticosteroids and were treated with FxCO₂ or FUS as an alternative between January 2020 and October 2022. The efficacy was evaluated using the Cattaneo score and clinical scoring system (CSS). A subgroup analysis was conducted to compare efficacy based on VLS severity.</p><p><strong>Results: </strong>At the 3-month follow-up, the total effective rates were similar between FxCO₂ (91.18%, 31/34) and FUS (88.57%, 31/35) (<i>p</i> > 0.05). At the 6-month follow-up, the total effective rates for FxCO₂ decreased to 85.29% (29/34), while FUS remained at 88.57% (31/35) (<i>p</i> > 0.05). Recurrence rates were 14.7% (5/34) for FxCO₂ and 11.4% (4/35) for FUS (<i>p</i> > 0.05) at the 6-month follow-up. Although there was no significant difference in total CSS scores and clinician-administered sign scores between FxCO₂ and FUS at both follow-ups (<i>p</i> > 0.05), FxCO₂ suggested superior patient-administered symptom improvement at 3-month (median: FxCO₂ 3 vs. FUS 5, <i>p</i> < 0.05) and 6-month follow-ups (median: FxCO₂ 3 vs. FUS 5, <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>FxCO₂ and FUS show similar efficacy in treating VLS, with FxCO₂ suggesting a trend toward greater symptom relief. Further studies are needed to validate these preliminary observations.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2507958"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment strategies for adenomyosis before and after introducing USgHIFU in Shenzhen.","authors":"Yu Dai, Huang-Jin Luo, Yan Peng, Weichun Yang, Qiuling Shi, Ping Jin","doi":"10.1080/02656736.2025.2501244","DOIUrl":"10.1080/02656736.2025.2501244","url":null,"abstract":"<p><strong>Objective: </strong>To explore the impact of ultrasound-guided high-intensity focused ultrasound (USgHIFU) on patients with adenomyosis in Shenzhen and the changes in health economics.</p><p><strong>Design: </strong>A retrospective observational study.</p><p><strong>Setting: </strong>Hospitals.</p><p><strong>Patients: </strong>1093 patients with adenomyosis either treated with surgery or USgHIFU.</p><p><strong>Intervention(s): </strong>Surgical treatment and USgHIFU.</p><p><strong>Main outcome measure(s): </strong>Demographic information on the patients including age, education, marital status, job, fertility requirement and clinical characteristics such as fertility history, dysmenorrhea, degree of dysmenorrhea, hypermenorrhea, duration of dysmenorrhea, Numerical Rating Scale and history of cesarean section were recorded.</p><p><strong>Results: </strong>The overall trend in the number of patients with adenomyois was increasing after introduction. The average hospital stay of USgHIFU was decreasing year by year, and it was lowest among the three groups with below the total average length of hospitalization. The average cost of patients treated with USgHIFU was decreasing with the total earing for the hospital increasing. Compared to those with USgHIFU, patients selected hysterectomy are older (odds ratio [OR] = 1.17, 95% confidence interval [CI]: 1.13-1.21). However, patients undergoing hysterectomy have fewer symptoms of dysmenorrhea (OR = 0.31, 95% CI: 0.80-1.42) and tend to have lower educational levels. Patients selected adenomyomectomy tended to experience lower levels of dysmenorrhea (OR = 0.76, 95% CI: 0.60-0.93.</p><p><strong>Conclusion(s): </strong>USgHIFU reduces the cost and length of hospitalization for patients with adenomyosis and increases hospital revenue from these patients. It provides a suitable option for women with who have a strong desire to retain their uterus.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2501244"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-guided percutaneous microwave ablation for locoregional recurrence of medullary thyroid carcinoma.","authors":"Isa Cam, Almotasem Shatat, Damla Köksalan, Said Atış, Ahmet Yalnız, Özgür Çakır, Alev Selek, Mehmet Sözen, Büşra Yaprak Bayrak, Seda Öztürk, Özge Telci Çakıllı, Nuh Zafer Cantürk, Ercüment Çiftçi","doi":"10.1080/02656736.2025.2533305","DOIUrl":"https://doi.org/10.1080/02656736.2025.2533305","url":null,"abstract":"<p><strong>Objective: </strong>Medullary thyroid carcinoma (MTC) is a rare, aggressive thyroid malignancy with frequent locoregional recurrence rate at 30-50%. Reoperative neck surgery is standard but challenging and risky. Ultrasound (US)-guided microwave ablation (MWA) offers minimally invasive alternatives, though evidence in recurrent MTC remains limited. This study evaluated the efficacy and safety of percutaneous US-guided MWA for treating recurrent MTC.</p><p><strong>Methods: </strong>A retrospective review included 22 patients with biopsy-proven locoregional recurrent MTC treated by US-guided percutaneous MWA after prior total thyroidectomy. All were either poor surgical candidates or declined reoperation. Thirty-four lesions underwent single-session outpatient ablation. Tumor size, serum calcitonin and volume reduction ratio (VRR) were assessed at baseline, 1, 3, 6 and 12 months post-ablation. Imaging and biochemical responses determined treatment outcomes. Recurrence-free survival between recurrent and non-recurrent groups was compared.</p><p><strong>Results: </strong>A total of 22 patients (median age 52 years; 14% hereditary) were included and MWA was successfully performed in all. Mean tumor diameter significantly reduced from 14.3 ± 11.6 mm to 2.6 ± 3.4 mm at 12 months (<i>p</i> < .001). Median serum calcitonin decreased significantly from 1165 pg/mL to 108 pg/mL at 12 months (<i>p</i> < .001). Treated lesions showed no regrowth; however, 50% developed new metastases elsewhere, correlating with higher initial metastatic burden (<i>p</i> = .001) and higher baseline calcitonin (<i>p</i> = .037).</p><p><strong>Conclusion: </strong>US-guided MWA effectively reduces tumor volume and calcitonin levels in recurrent MTC with minimal morbidity, though close surveillance for new metastases remains essential.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2533305"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features and risk factors for pelvic metastasis after microwave ablation of hepatocellular carcinoma: a nested case-control study.","authors":"Chao-Nan Chen, Chuan Pang, Fan Xiao, Zhen Wang, Jie Yu, Hui Feng, Ping Liang","doi":"10.1080/02656736.2025.2519350","DOIUrl":"https://doi.org/10.1080/02656736.2025.2519350","url":null,"abstract":"<p><strong>Background: </strong>Pelvic metastasis (PM) from hepatocellular carcinoma (HCC) remains understudied. Clarifying its risk factors after microwave ablation (MWA) is essential for optimizing surveillance strategies and guiding personalized management.</p><p><strong>Materials and methods: </strong>This retrospective study included patients with HCC who underwent MWA between January 2006 and August 2018. The cumulative rates of extrahepatic metastasis (EHM) and PM were estimated using the Kaplan-Meier method. Risk factors for EHM and PM were identified using the Cox proportional hazards model. A nested case-control design with a ratio of 1:4 was adopted, and the risk factors for PM were identified based on the logistic proportional hazards model.</p><p><strong>Results: </strong>A total of 1646 patients were included in this study, and 95 patients (19 cases and 76 controls) were included in the final case-control analysis. The 1-, 2-, 3-, and 5-year cumulative rates of EHM were < 20.0%, whereas those of PM were < 1.0%. Sex, Barcelona Clinic Liver Cancer stage, treatment-naïve HCC, number of HCC nodules, and platelet count were associated with EHM risk. Biopsy (<i>p</i> = 0.018) and Child-Pugh class (<i>p</i> = 0.004) were identified as factors associated with an increased risk of PM in the entire cohort. In this retrospective nested case-control study, Child-Pugh class (<i>p</i> = 0.027) and the number of biopsy punctures were associated with an increased risk of PM (<i>p</i> = 0.04).</p><p><strong>Conclusion: </strong>Multiple biopsy punctures and aggressive tumor features may indicate a high risk of PM.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2519350"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of high-intensity focused ultrasound ablation for uterine fibroids with different blood flow grading based on Alder classification.","authors":"Lijun Yang, Jun Liu, Siyun Wu, Yanhua Han, Jin Bai, Qiuling Shi","doi":"10.1080/02656736.2025.2519346","DOIUrl":"10.1080/02656736.2025.2519346","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy of ultrasound-guided high-intensity focused ultrasound ablation (USgHIFU) for uterine fibroids with different blood flow grading based on Alder classification.</p><p><strong>Materials and methods: </strong>A total of 353 patients with solitary uterine fibroid who underwent USgHIFU from July 2014 to July 2019 were enrolled. The patients were classified as four groups based on blood flow grading in fibroids. The relevant factors influencing the therapeutic effect were analyzed.</p><p><strong>Results: </strong>Significant differences were observed in treatment time, irradiation time, irradiation intensity, nonperfusion volume (NPV), NPV ratio and energy efficiency factor (EEF) among the four groups (<i>p</i> < 0.05). As the level of blood flow increased, the treatment time, irradiation time, irradiation intensity and energy efficiency factor (EEF) of USgHIFU were increased, but the NPV ratio was decreased. No major complication occurred in any patient of the four groups. Overall, 318 patients completed long-term follow-up, and 55 of 318 patients underwent re-intervention (17.2%). Univariate analysis indicated that increased menstruation, uterine volume, type of fibroids, signal intensity on T2-weighted imaging, NPV ratio were factors related to reinterventin (<i>p</i> < 0.05). Multivariate analysis revealed that the type of fibroids and NPV ratio were independent risk factors for re-intervention (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Our results suggested that the difficulty of USgHIFU treatment for uterine fibroids could be evaluated using Alder classification. The fibroids with more blood flow were more difficulty to treat. However, satisfactory NPV ratio could be achieved even fibroids with abundant blood supply, and the long-term intervention rate was not increased.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2519346"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of early MRI in assessing the risk of local tumor progression following irreversible electroporation for hepatocellular carcinoma treatment.","authors":"Lorenzo Carlo Pescatori, Mathilde Dessain, Gisèle N'Kontchou, Arthur Petit, Abou Diallo, Lorraine Blaise, Marie-Pierre Rols, Clair Poignard, Jean-Charles Nault, Nathalie Ganne-Carrié, Pierre Nahon, Olivier Sutter, Olivier Seror","doi":"10.1080/02656736.2025.2505595","DOIUrl":"10.1080/02656736.2025.2505595","url":null,"abstract":"<p><strong>Background: </strong>Irreversible electroporation (IRE) in hepatocellular carcinoma (HCC) triggers apoptosis instead of thermal coagulation, resulting in specific modifications within ablation zones. Aim of this study is to evaluate the diagnostic value of MRI performed three days post-IRE (D3MRI).</p><p><strong>Methods: </strong>This single-institution retrospective study examined patients with HCC treated by IRE from 2012-2017. Criteria included no prior HCC treatment, available D3MRI and one-month MRI (M1MRI) without residual tumor and at least one follow-up MRI after 3 months. We measured the peripheral hyperemia (IREPZ) and central necrotic zone (IRECZ) in the ablation area along with the minimum thickness of IREPZ (min.Th/IREPZ) on both D3MRI and M1MRI. The duration of follow-up and instances of local tumor progression (LTP) were recorded.</p><p><strong>Results: </strong>Forty-eight patients (median age: 68 years) with 65 treated nodules (median diameter: 19 mm) were included. The median follow-up was 37 months. D3MRI median dimensions were 67 mm for IREPZ, 19 mm for IRECZ, and 5 mm for min.Th/IREPZ. LTP occurred in 25 nodules after 18 months. 52% had LTP at min.Th/IREPZ. A min.Th/IREPZ ≤ 5 mm on D3MRI indicated a 24-fold higher risk of LTP (95% CI [2.25-255.95], <i>p</i> < .01), conversely, the min.Th/IREPZ on M1MRI had no predictive value.</p><p><strong>Conclusion: </strong>D3MRI appears to be a valuable tool for assessing the true ablation margins in HCC nodules treated with IRE and for identifying potential sites of local recurrence. It may, therefore, be considered for integration into the follow-up protocol for patients undergoing IRE treatment for HCC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2505595"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the sonication energy for focused ultrasound surgery treatment of breast fibroadenomas using machine learning algorithms.","authors":"Mengdi Liang, Yuelin Liu, Yue Huang, Ge Ma, Xu Han, Shuaikang Li, Jing Hang, Hui Xie, Lin Chen, Xiaoan Liu, Shui Wang, Tiansong Xia","doi":"10.1080/02656736.2025.2497824","DOIUrl":"https://doi.org/10.1080/02656736.2025.2497824","url":null,"abstract":"<p><strong>Purpose: </strong>To establish a predictive model for the sonication energy required for focused ultrasound surgery (FUS) of breast fibroadenomas.</p><p><strong>Methods: </strong>This study retrospectively enrolled 87 patients with 154 benign breast tumors treated by FUS in our hospital. Radiomic analysis included 124 tumors from 69 patients, randomly split into a 3:1 ratio for training (96 cases) and validation (28 cases). Three machine learning algorithms were applied for feature selection. Then, all the selected features were used for the construction of the prediction model via four machine learning algorithms. Residual analysis and Intraclass Correlation Coefficient (ICC) analysis were performed to evaluate the performances of these four models. The importance of each feature is demonstrated by the Root Mean Square Error (RMSE) loss obtained through permutation importance measurement.</p><p><strong>Results: </strong>This study collected 11 clinical features and 68 ultrasound radiomics features, totaling 79 independent variables. The Bagging Tree Model, characterized by lower and stable RMSE values and high R² stability with increasing features, demonstrated superior predictive accuracy and explanatory power compared to other models. At the optimal feature count, identified by the minimum RMSE, 33 features were selected for further modeling. The bagging tree model has the highest ICC value among the four models, at 0.56, with a confidence interval of (0.23, 0.77).</p><p><strong>Conclusions: </strong>This study established an interpretable machine learning model that integrates clinical and ultrasound radiomics features to estimate the sonication energy in FUS treatment of breast fibroadenomas.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2497824"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperhydration of breast and skin cancers: effects on thermophysical tissue properties in clinical hyperthermia with water-filtered infrared-A radiation (wIRA) - an updated review.","authors":"Helmut Piazena, Peter Vaupel","doi":"10.1080/02656736.2025.2519352","DOIUrl":"https://doi.org/10.1080/02656736.2025.2519352","url":null,"abstract":"<p><strong>Background: </strong>Water contents (C_w) of soft tissues are different and influence (a) the absorption of water-filtered infrared-A radiation (wIRA) used in superficial hyperthermia, (b) key parameters of the Pennes' bioheat transfer equation, and (c) characteristics of heat exchange within and between tissues.</p><p><strong>Aim: </strong>The effect of C_w on these parameters has been quantified for normal skin, female breast and corresponding malignancies with C_w values up to ≈ 1.6 times higher.</p><p><strong>Methods: </strong>Literature data on spectral absorption and reduced scattering coefficient, density, specific heat capacity, thermal conductivity, diffusivity and effusivity of normal tissues and malignancies have been correlated with respective tissue water contents. Published <i>in vivo</i> data on wIRA-transmittance in human skin and underlying muscle have been experimentally extended to depths up to 11 mm.</p><p><strong>Results: </strong>On average, the absorption of wIRA and the thermal tissue parameters increased linearly with C_w. Mean wIRA-penetration depth reached ≈ 2.9 mm at C_w ≈ 70 wt.%. While specific heat capacities, thermal conductivities, thermal diffusivities and thermal effusivities for melanoma and breast cancer exceeded those of corresponding normal tissues, heat capacities of both malignancies differed only slightly compared to the surrounding normal tissues. Despite small C_w values, maxima of absorbance coupled with low heat capacity and thermal conductivity occurred in the subcutaneous tissues.</p><p><strong>Conclusions: </strong>These data indicate high efficacy of superficial wIRA-hyperthermia in clinical oncology when exposed to composite tissues with highly variable water and fat contents. Continuous monitoring of tissue temperature during irradiation is recommended to prevent hot spots and to ensure therapeutically relevant temperature fields.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2519352"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity focused ultrasound combined with hysteroscopic insertion of levonorgestrel-releasing intrauterine system for intrinsic adenomyosis: a retrospective observational study.","authors":"Yanjun Kang, Changmei Sang, Lei Zhao, Kun Ding, Shuping Zhao","doi":"10.1080/02656736.2025.2531028","DOIUrl":"10.1080/02656736.2025.2531028","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively analyze the safety and efficacy of high-intensity focused ultrasound (HIFU) combined with hysteroscopic insertion of Levonorgestrel-Releasing Intrauterine System the treatment of intrinsic adenomyosis.</p><p><strong>Methods: </strong>A total of 30 patients with intrinsic adenomyosis were enrolled. All patients initially underwent HIFU treatment, followed by hysteroscopic surgery to remove the remaining unabsorbed necrotic tissue and simultaneously insert the levonorgestrel-releasing intrauterine system (LNG-IUS) for long-term management of adenomyosis. The treatment results, adverse events, and 2-year follow-up data were analyzed statistically.</p><p><strong>Result: </strong>All 30 patients successfully completed the treatment without serious complications, and achieved remarkable symptom improvement. The VAS score of dysmenorrhea and MSF score of menorrhagia both decreased significantly (<i>p</i> < 0.05). Uterine volume decreased significantly after treatment (<i>p</i> < 0.05). The proportion of patients with dysmenorrhea and menorrhagia who experienced significant symptom relief was 86.7% and 93.3%, and the clinical efficacy rates were 93.3% and 96.7% respectively, with no recurrent cases. LNG-IUS was inserted during hysteroscopic surgery in 30 patients. Up to the time of submission, no significant symptom recurrence and the LNG-IUS displacement rate is 3.3%.</p><p><strong>Conclusion: </strong>Combination of HIFU and hysteroscopic insertion of Levonorgestrel-Releasing Intrauterine System is an effective and recommended therapeutic strategy for treating intrinsic adenomyosis.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2531028"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave ablation versus radiofrequency ablation for hepatocellular carcinoma: a propensity score matching and inverse probability weighting analysis.","authors":"Wenlong Yang, Xiaoyan Li, Xufang Tan","doi":"10.1080/02656736.2025.2524389","DOIUrl":"https://doi.org/10.1080/02656736.2025.2524389","url":null,"abstract":"<p><strong>Background: </strong>Radiofrequency ablation (RFA) and microwave ablation (MWA) have been proven to be safe and effective methods for treating early-stage hepatocellular carcinoma (HCC). Although researchers have compared the efficacy of MWA and RFA, the results have not been consistent. Therefore, this study utilizes a large sample size and employs propensity score matching (PSM) combined with inverse probability weighting (IPW) to further investigate the effects between the two treatments.</p><p><strong>Methods: </strong>Patients with early-stage HCC who were diagnosed and treated with MWA or RFA between 2015 and 2022 were collected. The post-treatment effects and tumor outcomes were analyzed using PSM and IPW.</p><p><strong>Results: </strong>The 1-, 2- and 3-year recurrence rates were 40.89%, 68.07% and 84.13% for MWA, and 39.13%, 62.64% and 75.71% for RFA. The overall survival rates at 1, 2 and 3 years were 70.47%, 40.98% and 21.90% for MWA, and 70.53%, 44.85% and 30.60% for RFA. Cox regression indicated that age, tumor number and post-treatment were adverse prognostic factors for recurrence-free survival, while treatment method, age, tumor number and post-treatment were adverse prognostic factors for overall survival.</p><p><strong>Conclusion: </strong>The 5-year overall survival rates for RFA and MWA remained similar. The discrepancies in the 5-year cumulative recurrence-free rate might be attributed to the small MWA cohort, possible differences in patient selection, the margin assessment procedure used and the overall short follow-up period.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2524389"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}