International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"The efficacy of hyperthermia-based multimodal therapy is dependent on gatekeeper protein, BID.","authors":"Sarah Helmueller, Xinxin Song, Dong-Hyun Kim, Yong J Lee","doi":"10.1080/02656736.2025.2544017","DOIUrl":"10.1080/02656736.2025.2544017","url":null,"abstract":"<p><strong>Objectives: </strong>The combination of ferroptotic agent artesunate (ART) and apoptotic agent rhTRAIL (recombinant human tumor necrosis factor-related apoptosis-inducing ligand) has been shown to synergistically enhance apoptosis in various cancer cell lines via crosstalk between the endoplasmic reticulum (ER) stress response, the rhTRAIL-induced extrinsic cell death receptor pathway, and the intrinsic BID-Bax-mitochondrial-dependent-apoptosis pathway. This synergistic interaction has been demonstrated to be effective in multiple types of cancer cell lines, making artesunate combined with rhTRAIL a promising second-line therapy for colon cancer patients after cytoreductive surgery and chemotherapeutic treatments. To further enhance the second-line therapy's tumoricidal effect, a multimodal therapy was developed by combining artesunate, rhTRAIL, and hyperthermic conditions where samples were treated at 42 °C for 1 h.</p><p><strong>Methods: </strong>The effects of this therapy were tested in human colon carcinoma HCT116 and pancreatic adenocarcinoma BxPC-3 cell models. The cytotoxic and synergistic effects were analyzed using fluorescence microscopy, cell survival assays, and protein analysis through Western blotting.</p><p><strong>Results: </strong>Our findings demonstrated a significant enhancement of apoptosis when artesunate and rhTRAIL treatments were combined with heat exposure. The synergistic and apoptotic effect of the agents was effectively abrogated in BID-deficient and BID mutant-type cells as well as Bax-deficient cells, but not Bak-deficient cells.</p><p><strong>Conclusions: </strong>The results suggest that BID acts as a key gatekeeper molecule of apoptosis during hyperthermia-based multimodal treatment. These findings raise important questions about the underlying mechanisms of heat-induced apoptosis and its involvement in orchestrating various cellular stress pathways.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2544017"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144819026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the sonication energy for focused ultrasound surgery treatment of breast fibroadenomas using machine learning algorithms.","authors":"Mengdi Liang, Yuelin Liu, Yue Huang, Ge Ma, Xu Han, Shuaikang Li, Jing Hang, Hui Xie, Lin Chen, Xiaoan Liu, Shui Wang, Tiansong Xia","doi":"10.1080/02656736.2025.2497824","DOIUrl":"https://doi.org/10.1080/02656736.2025.2497824","url":null,"abstract":"<p><strong>Purpose: </strong>To establish a predictive model for the sonication energy required for focused ultrasound surgery (FUS) of breast fibroadenomas.</p><p><strong>Methods: </strong>This study retrospectively enrolled 87 patients with 154 benign breast tumors treated by FUS in our hospital. Radiomic analysis included 124 tumors from 69 patients, randomly split into a 3:1 ratio for training (96 cases) and validation (28 cases). Three machine learning algorithms were applied for feature selection. Then, all the selected features were used for the construction of the prediction model via four machine learning algorithms. Residual analysis and Intraclass Correlation Coefficient (ICC) analysis were performed to evaluate the performances of these four models. The importance of each feature is demonstrated by the Root Mean Square Error (RMSE) loss obtained through permutation importance measurement.</p><p><strong>Results: </strong>This study collected 11 clinical features and 68 ultrasound radiomics features, totaling 79 independent variables. The Bagging Tree Model, characterized by lower and stable RMSE values and high R² stability with increasing features, demonstrated superior predictive accuracy and explanatory power compared to other models. At the optimal feature count, identified by the minimum RMSE, 33 features were selected for further modeling. The bagging tree model has the highest ICC value among the four models, at 0.56, with a confidence interval of (0.23, 0.77).</p><p><strong>Conclusions: </strong>This study established an interpretable machine learning model that integrates clinical and ultrasound radiomics features to estimate the sonication energy in FUS treatment of breast fibroadenomas.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2497824"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperhydration of breast and skin cancers: effects on thermophysical tissue properties in clinical hyperthermia with water-filtered infrared-A radiation (wIRA) - an updated review.","authors":"Helmut Piazena, Peter Vaupel","doi":"10.1080/02656736.2025.2519352","DOIUrl":"https://doi.org/10.1080/02656736.2025.2519352","url":null,"abstract":"<p><strong>Background: </strong>Water contents (C_w) of soft tissues are different and influence (a) the absorption of water-filtered infrared-A radiation (wIRA) used in superficial hyperthermia, (b) key parameters of the Pennes' bioheat transfer equation, and (c) characteristics of heat exchange within and between tissues.</p><p><strong>Aim: </strong>The effect of C_w on these parameters has been quantified for normal skin, female breast and corresponding malignancies with C_w values up to ≈ 1.6 times higher.</p><p><strong>Methods: </strong>Literature data on spectral absorption and reduced scattering coefficient, density, specific heat capacity, thermal conductivity, diffusivity and effusivity of normal tissues and malignancies have been correlated with respective tissue water contents. Published <i>in vivo</i> data on wIRA-transmittance in human skin and underlying muscle have been experimentally extended to depths up to 11 mm.</p><p><strong>Results: </strong>On average, the absorption of wIRA and the thermal tissue parameters increased linearly with C_w. Mean wIRA-penetration depth reached ≈ 2.9 mm at C_w ≈ 70 wt.%. While specific heat capacities, thermal conductivities, thermal diffusivities and thermal effusivities for melanoma and breast cancer exceeded those of corresponding normal tissues, heat capacities of both malignancies differed only slightly compared to the surrounding normal tissues. Despite small C_w values, maxima of absorbance coupled with low heat capacity and thermal conductivity occurred in the subcutaneous tissues.</p><p><strong>Conclusions: </strong>These data indicate high efficacy of superficial wIRA-hyperthermia in clinical oncology when exposed to composite tissues with highly variable water and fat contents. Continuous monitoring of tissue temperature during irradiation is recommended to prevent hot spots and to ensure therapeutically relevant temperature fields.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2519352"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity focused ultrasound combined with hysteroscopic insertion of levonorgestrel-releasing intrauterine system for intrinsic adenomyosis: a retrospective observational study.","authors":"Yanjun Kang, Changmei Sang, Lei Zhao, Kun Ding, Shuping Zhao","doi":"10.1080/02656736.2025.2531028","DOIUrl":"10.1080/02656736.2025.2531028","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively analyze the safety and efficacy of high-intensity focused ultrasound (HIFU) combined with hysteroscopic insertion of Levonorgestrel-Releasing Intrauterine System the treatment of intrinsic adenomyosis.</p><p><strong>Methods: </strong>A total of 30 patients with intrinsic adenomyosis were enrolled. All patients initially underwent HIFU treatment, followed by hysteroscopic surgery to remove the remaining unabsorbed necrotic tissue and simultaneously insert the levonorgestrel-releasing intrauterine system (LNG-IUS) for long-term management of adenomyosis. The treatment results, adverse events, and 2-year follow-up data were analyzed statistically.</p><p><strong>Result: </strong>All 30 patients successfully completed the treatment without serious complications, and achieved remarkable symptom improvement. The VAS score of dysmenorrhea and MSF score of menorrhagia both decreased significantly (<i>p</i> < 0.05). Uterine volume decreased significantly after treatment (<i>p</i> < 0.05). The proportion of patients with dysmenorrhea and menorrhagia who experienced significant symptom relief was 86.7% and 93.3%, and the clinical efficacy rates were 93.3% and 96.7% respectively, with no recurrent cases. LNG-IUS was inserted during hysteroscopic surgery in 30 patients. Up to the time of submission, no significant symptom recurrence and the LNG-IUS displacement rate is 3.3%.</p><p><strong>Conclusion: </strong>Combination of HIFU and hysteroscopic insertion of Levonorgestrel-Releasing Intrauterine System is an effective and recommended therapeutic strategy for treating intrinsic adenomyosis.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2531028"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No-touch ablation for hepatocellular carcinoma: a narrative review.","authors":"Yongzhi Tang, Hedan Chen, Tongjing Xing, Yonghui Lu, Yan Chen, Hui Shao","doi":"10.1080/02656736.2025.2549810","DOIUrl":"https://doi.org/10.1080/02656736.2025.2549810","url":null,"abstract":"<p><strong>Purpose: </strong>Hepatocellular carcinoma is one of the major causes of tumor-related death worldwide. Surgical resection, as the main radical treatment method, is only applicable to certain liver cancer patients considering factors such as liver reserve function, tumor location, and quantity.</p><p><strong>Methods: </strong>Ablation therapy serves as a useful supplement to surgical resection. However, due to the heat sink effect and local tumor recurrence, operators are cautious about ablation.</p><p><strong>Results: </strong>The no-touch ablation technology can provide sufficient ablation boundaries. Since it does not directly puncturing the tumor, it also avoids the risk of tumor needle tract implantation, thereby reducing local tumor recurrence.</p><p><strong>Conclusion: </strong>This technology has been used in hepatic tumor treatment for many years, and many global studies have reported its safety and reliable efficacy.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2549810"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145077159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryoablation combined with programmed cell death protein 1 (PD-1) inhibitors regulates myeloid-derived suppressor cells (MDSCs) through the JAK2-STAT3-S100A8/A9 axis in mice with Lewis lung carcinoma.","authors":"Jiao Li, Xiaoyu Zhao, Man Qi, Xuxin Chen, Wei Chen, Shuo Zhang, Zhouli Tan, Chunyang Zhang, Zhihai Han","doi":"10.1080/02656736.2025.2525444","DOIUrl":"https://doi.org/10.1080/02656736.2025.2525444","url":null,"abstract":"<p><strong>Background: </strong>Cryoablation (Cryo) can enhance the efficacy of tumor immunotherapy, and the synergistic effect of Cryo with immune checkpoint inhibitors has been demonstrated in some tumor models. Because myeloid-derived suppressor cells (MDSCs) accumulate in lung cancer patients and promote tumor progression, lung cancer can be treated by targeting MDSCs. At present, the effect and mechanism of action of combination Cryo + programmed cell death protein 1(PD-1) inhibitors on MDSCs in cancer patients are unclear.</p><p><strong>Methods: </strong>A mouse model of Lewis lung carcinoma (LLC) with bilateral tumor-bearing was established and mice were treated with Cryo, PD-1 inhibitor, or Cryo + PD-1 inhibitor (combination therapy). Subsequently, the growth trend of right-side (distant) tumors was determined. The expression of apoptosis-related proteins was detected by western blot assay, and flow cytometry was used to analyze the percentages of MDSCs and CD8⁺ T cells. QRT-PCR and western blot were used to detect the levels of effector molecules related to the immunosuppressive function of MDSCs and signaling pathways.</p><p><strong>Results: </strong>Cryo + PD-1 inhibitor significantly inhibited the growth of right-side untreated tumors and promoted tumor cell apoptosis in LLC mice. Combined therapy reduced the proportion of MDSCs in the tumor microenvironment and peripheral blood of tumor-bearing mice, promoted MDSCs maturation, and increased the proportion of CD8 ⁺ T cells. The combination therapy also decreased the level of effector molecules related to the immunosuppressive function of MDSCs and down-regulated the JAK2-STAT3-S100A8/A9 axis in MDSCs.</p><p><strong>Conclusions: </strong>Cryo + PD-1 inhibitor treatment can significantly delay tumor growth in mice and inhibit the proliferation and function of MDSCs through the JAK2-STAT3-S100A8/A9 axis, thereby improving the immunosuppressive tumor microenvironment.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2525444"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of thermal ablation for T1N0M0 papillary thyroid cancer in pediatric and adolescent patients - a preliminary multicenter retrospective study.","authors":"Zhenlong Zhao, Shurong Wang, Shengnan Huo, Jinke Li, Lu Zhou, Lihong Liu, Songsong Wu, Zhibin Cong, Ying Wei, Jie Wu, Shiliang Cao, Na Yu, Yan Li, Ming'an Yu","doi":"10.1080/02656736.2025.2539182","DOIUrl":"10.1080/02656736.2025.2539182","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the efficacy and safety of thermal ablation (TA) for T1N0M0 PTC in pediatric and adolescent patients who refused surgery.</p><p><strong>Materials and methods: </strong>This was a retrospective multicenter study of 25 pediatric and adolescent patients (19 females) who underwent TA for T1N0M0 between August 2015 and November 2023. The median age of the patients was 18 years (range, 10-18 years), and the median follow-up time was 27 months (range, 12-60 months). Ablation zone disappearance, tumor progression, and complications were assessed.</p><p><strong>Results: </strong>The technical success rate was 100%. The median time for ablation zone absorption was 12 months in the T1a group and 18 months in the T1b group (log-rank <i>p</i> = 0.027). The tumor progression rate was 4.0%, with one case of lymph node metastasis at the 24-month follow up. The 1-, 3- and 5-year progression free survival rates were 100%, 93.8%, and 93.8%, respectively. No major complications were encountered. Mild thyroid function abnormality was observed in two patients at the 1-month follow up, both of whom recovered without treatment.</p><p><strong>Conclusions: </strong>This multicenter study provideds evidence that TA is an effective and safe treatment option in selected pediatric and adolescent patients with T1N0M0 PTC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2539182"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144736556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncovering the time-temperature thresholds of <i>in vitro</i> mitochondrial bioenergetics dysfunction under hyperthermic stress.","authors":"Natasha F Mezzacappo, Natalia M Inada, José D Vollet-Filho, Michael L Denton, Vladislav V Yakovlev, Vanderlei S Bagnato","doi":"10.1080/02656736.2025.2560017","DOIUrl":"https://doi.org/10.1080/02656736.2025.2560017","url":null,"abstract":"<p><p>Mitochondrial respiration is particularly vulnerable to temperature fluctuations, yet time-dependent effects of hyperthermia on mitochondria remain largely unexplored. In this study, we evaluated the thermal sensitivity of mitochondria isolated from mouse liver using high-resolution respirometry (HRR) to assess the combined effects of temperature elevation and exposure time. Our results demonstrated that isolated mitochondria experienced progressive dysfunction of the electron transport chain (ETC) and the phosphorylation system as both temperature and incubation time increased. Notably, even moderate thermal stress led to significant impairments, and damage became irreversible when exceeding 40% at a minimum temperature of 43 °C. A mathematical analysis of the time-temperature relationship further supported these findings, highlighting a threshold beyond which mitochondrial function cannot recover. These results emphasize the importance of accounting for the degree of heat exposure and its duration when evaluating thermal effects on mitochondrial bioenergetics. This study provides valuable insights into mitochondrial resilience's <i>in vitro</i> thermal limits.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2560017"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145116027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy outcomes and influencing factors following high-intensity focused ultrasound treatment for adenomyosis: a single-center retrospective study.","authors":"Xiaogang Zhu, Qiuling Shi, Min Xue","doi":"10.1080/02656736.2025.2567477","DOIUrl":"https://doi.org/10.1080/02656736.2025.2567477","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate pregnancy outcomes and influencing factors in adenomyosis patients undergoing high-intensity focused ultrasound (HIFU) treatment with fertility requirements.</p><p><strong>Materials and methods: </strong>From April 2012 to December 2022, 223 patients with adenomyosis desiring fertility underwent HIFU at the Third Xiangya Hospital. Patients were followed up at 1, 3, 6, and 12 months post-HIFU treatment in the first year, and subsequently every 6 months. Data on pregnancy and pregnancy outcomes were recorded.</p><p><strong>Results: </strong>All patients completed HIFU treatment in a single session. During the average follow-up period of 39.0 ± 19.3 months (range: 7-91 months), 103 patients achieved a total of 109 pregnancies, resulting in an overall pregnancy rate of 48.9% (109/223). Among these, 82 pregnancies occurred through natural conception and 27 through assisted reproductive technology. Among 45 infertile patients, 23 (51.1%) conceived after HIFU treatment. Among the 57 patients with a history of adverse pregnancy outcomes, 27 achieved successful pregnancies post-treatment, with 15 live births. The incidence of complications during pregnancy and delivery was 23.8% (15/63). Body mass index (BMI) and ablation rate significantly influenced post-HIFU pregnancy outcomes. Higher BMI values and excessive ablation rates were associated with lower pregnancy rates. Advanced age was significantly associated with a higher risk of adverse pregnancy outcomes.</p><p><strong>Conclusion: </strong>HIFU treatment is associated with improved pregnancy outcomes in patients with adenomyosis complicated by infertility or a history of adverse pregnancy outcomes. Higher BMI values and excessive ablation rates may reduce postoperative pregnancy rates, while advanced age increases the risk of adverse pregnancy outcomes.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2567477"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of sonographic feature-based prediction models for ultrasound-guided HIFU ablation of uterine fibroids.","authors":"Danling Zhang, Songsong Wu, Guisheng Ding, Sheng Chen","doi":"10.1080/02656736.2025.2563302","DOIUrl":"https://doi.org/10.1080/02656736.2025.2563302","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a nomogram for predicting the efficacy of high-intensity focused ultrasound (HIFU) ablation in patients with uterine fibroids.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 153 patients (39.84 ± 6.37 years old, 224 fibroids) who underwent HIFU. Patients were randomly divided into training group (<i>n</i> = 162) and validation group (<i>n</i> = 62) in a 7:3 ratio. Pre-HIFU ultrasonic features of fibroids were observed. An effective treatment was defined as an ablation rate of ≥70%. In the training group, Lasso regression was used to identify independent predictive factors, and a nomogram model was developed. Internal validation was conducted using the Bootstrap method, and model discrimination was evaluated with ROC curves. Model accuracy was assessed using calibration curves, and clinical benefits were analyzed using decision curve analysis (DCA).</p><p><strong>Results: </strong>The Lasso regression model identified uterine fibroid type, peripheral blood flow grading, fibroid location, and maximum fibroid diameter as potential predictive factors. The nomogram showed good predictive performance with AUCs of 0.819 (95% CI 0.789-0.822) in the training set and 0.900 (95% CI 0.840-0.901) in the validation set. Its sensitivity and specificity were 0.750/0.732 in the training set and 0.759/0.818 in the validation set, respectively. The calibration curve showed good agreement between observed and predicted outcomes, and DCA confirmed the clinical utility and broad applicability of the nomogram model.</p><p><strong>Conclusion: </strong>The prediction model comprising ultrasonic characteristics of uterine fibroids had good performance in patients undergoing HIFU ablation and hence can improve clinical decision-making.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2563302"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}