International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"Factors influencing the volume reduction rate of ultrasound-guided high-intensity focused ultrasound for breast fibroadenoma.","authors":"Xiuying Wu, Feibao Pan, Yao Xiao, Maoshan Chen, Heng Yin, Dewu Mu, Lei Yang, Hongwei Yang, Wenzhi Chen, Cai Zhang","doi":"10.1080/02656736.2025.2610775","DOIUrl":"10.1080/02656736.2025.2610775","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the factors influencing the volume reduction rate (VRR) at 12 months after ultrasound (US)-guided high-intensity focused ultrasound (HIFU) for breast fibroadenoma (FA).</p><p><strong>Materials and methods: </strong>A retrospective analysis of 104 patients with 302 FAs who underwent US-guided HIFU from January 2021 to May 2023 was conducted. All patients received US assessment and contrast-enhanced US (CEUS) evaluation, and treatment information was recorded. VRR ≥ 80% was set as the dependent variable, while nineteen baseline- and treatment-related factors were considered as the independent variables. A logistic regression model was constructed to predict 12-month VRR.</p><p><strong>Results: </strong>All patients successfully underwent one-session HIFU. Significant differences were observed in volume, distance from the superficial margin of FA to skin, distance from the deep margin of FA to chest wall, mean power, energy efficacy factor, type of near-field acoustic pathway, and appearance of hyperechoic changes. Multivariate analysis revealed that type of near-field acoustic pathway, distance from the deep margin of FA to chest wall, and appearance of hyperechoic changes were independent predictors of the 12-month VRR after HIFU. The area under Receiver Operating Characteristic curve was 0.688.</p><p><strong>Conclusions: </strong>The type of near-field acoustic pathway, distance from the deep margin of FA to chest wall, and appearance of hyperechoic changes could serve as predictors of 12-month VRR following HIFU treatment for FA.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2610775"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival and morbidity in elderly patients treated with cytoreductive surgery and HIPEC for colorectal peritoneal metastases: a population-based study.","authors":"Tamara Yousef Yacoub, Peter Matthiessen, Wilhelm Graf, Peter Cashin, Gabriella Jansson Palmer, Elinor Bexe Lindskog, Ingvar Syk, Lana Ghanipour","doi":"10.1080/02656736.2026.2620731","DOIUrl":"10.1080/02656736.2026.2620731","url":null,"abstract":"<p><strong>Objective: </strong>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) has improved outcomes in colorectal cancer (CRC) patients with peritoneal metastases (PM), yet evidence regarding perioperative risk and long-term survival in those 75 years or older remains uncertain. The aim of this study was to evaluate whether age ≥75 years impacts on overall survival (OS) and postoperative in-hospital morbidity, according to Clavien-Dindo classification (CD), compared with patients aged <75 years.</p><p><strong>Method: </strong>This population-based study collected data from the National Swedish HIPEC Registry, including patients with colorectal PM operated with CRS-HIPEC. Patients were stratified by age (≤74 vs ≥75) with OS as primary outcome. Secondary outcomes were in-hospital mortality, postoperative morbidity and disease free survival (DFS). Potential variables assessed for association with OS were Complete Cytoreduction Score (CCS), Peritoneal Carcinomatosis Index (PCI) score, p/ypN stage of the primary tumor, postoperative morbidity and age.</p><p><strong>Results: </strong>A total of 592 patients were operated between 2004 and 2021, of which 553 were ≤74 years and 39 were ≥75 years. OS did not differ between age groups (<i>p</i> = .951). Factors affecting OS negatively were high CCS (<i>p</i> = .004), PCI ≥21 (<i>p</i> = .009) and p/ypN2 (<i>p</i> = .041). No difference was observed in DFS (<i>p</i> = .525). The rate of CD grade III-IV was 27% in patients ≤74 years and 21% in patients ≥75 years (<i>p</i> = .495). The in-hospital mortality rate was 1.3% in patients ≤74 and none in patients ≥75 years. Reoperation rates were similar between groups.</p><p><strong>Conclusion: </strong>These results indicate that age above 74 should not automatically exclude patients from undergoing CRS-HIPEC. Careful selection ensures favorable survival without an increase in postoperative morbidity.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2620731"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal sensitivity of nuclear pore complexes as a potential early driver of heat-induced cell death.","authors":"Natalia Samsonova, Andrey Samsonov","doi":"10.1080/02656736.2026.2654989","DOIUrl":"10.1080/02656736.2026.2654989","url":null,"abstract":"<p><strong>Objective: </strong>To examine cellular responses to mild hyperthermia at nominally sublethal temperatures (∼40-45 °C), where irreversible injury and cell death occur only after several minutes of exposure, and to identify a plausible early mechanism underlying heat-induced cell death.</p><p><strong>Method: </strong>Experimental observations were made in mammalian cells exposed to 40-45 °C for several minutes or briefly to 50 °C for 1-2 s. Nuclear-cytoplasmic compartmentalization, cell morphology, adhesion, proliferation, and apoptosis were assessed to characterize the sequence of cellular changes following thermal exposure.</p><p><strong>Results: </strong>Cells exposed to 40-45 °C for several minutes lost nuclear-cytoplasmic compartmentalization before overt morphological signs of cell death. Normally excluded cytoplasmic proteins entered the nucleus, whereas nuclear proteins redistributed into the cytoplasm. Brief heating to 50 °C for 1-2 s produced the same nuclear permeability phenotype in all exposed cells. Nuclear envelope leakage behaved as an all-or-nothing event: cells that retained nuclear compartmentalization survived and continued proliferating, whereas cells with leaky nuclei rapidly rounded up, lost adhesion, and detached within 1-2 h. Detached cells never re-adhered and consistently underwent apoptosis within 15-17 h, as detected by YO-PRO-1 staining.</p><p><strong>Conclusion: </strong>These observations indicate that loss of nuclear compartmentalization is an early, irreversible event in heat-induced cell death. Because nuclear pore complex (NPC)-mediated selective macromolecular transport is indispensable for cell survival, irreversible NPC damage appears to severely limit cellular recovery. Irreversible impairment of NPC selectivity is therefore proposed as the most parsimonious explanation for observed heat-induced nuclear leakiness.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2654989"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized risk-stratified management after HIFU treatment for placenta increta: a fertility preservation strategy.","authors":"Yun Long, Yan Peng, Zhen Yuan, Cuili Wen, Yu Dai, Hui' Xia, Xue Liu, Miao Liu, Lei Zhang, Pin Jing","doi":"10.1080/02656736.2026.2643511","DOIUrl":"10.1080/02656736.2026.2643511","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy, safety, and fertility preservation outcomes of high-intensity focused ultrasound (HIFU) ablation for postpartum placenta increta.</p><p><strong>Materials and methods: </strong>This prospective single-center study included 38 patients with postpartum placenta increta treated with ultrasound-guided HIFU from November 2019 to July 2025. Evaluation metrics comprised ablation rate, natural expulsion rate, additional interventions required, β-hCG changes, menstrual recovery, and adverse events.</p><p><strong>Results: </strong>Of 38 enrolled patients, 27 were allocated to conservative management and 11 to planned curettage. After excluding 4 patients who elected curettage by personal preference, 34 patients were included in the stratified outcome analysis: 15 (44.1%) achieved spontaneous placental expulsion, while 19 (55.9%) required active intervention (curettage or hysteroscopy). No significant differences in baseline characteristics were observed between the two groups. Serum β-hCG levels and menstrual cycles returned to normal in all patients during follow-up. Among 10 patients who sought subsequent pregnancy, 9 (90%) achieved successful delivery. Treatment-related adverse events were minimal, including treatment-site pain (20.6%) and other minor events (5.9%); no serious complications were recorded. The mean hospital stay was 6.35 days, which was marginally shorter in the spontaneous expulsion group (<i>p</i> = 0.050).</p><p><strong>Conclusion: </strong>HIFU is a viable option within a shared decision-making framework for fertility-preserving management of placenta accreta spectrum (PAS) disorder. In conservatively managed cases, HIFU achieved spontaneous placental expulsion in 44.1% of patients; however, 55.9% ultimately required additional intervention, underscoring the need for close coordination with curettage or hysteroscopy. Larger prospective multicenter studies are warranted to establish optimal patient selection criteria and to validate long-term reproductive outcomes.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2643511"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of high-intensity focused ultrasound ablation on lesion stiffness and symptoms of adenomyosis.","authors":"Xuan Shen, Wenzhi Chen, Qiuling Shi, Dan Zi, Xiaoyu Ren, Xin Tian","doi":"10.1080/02656736.2026.2642927","DOIUrl":"10.1080/02656736.2026.2642927","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the relationship between lesion stiffness and symptoms of patients and to evaluate the effectiveness of high-intensity focused ultrasound ablation (HIFUa) against lesion stiffness and symptoms of patients with adenomyosis.</p><p><strong>Methods: </strong>A total of 124 patients with adenomyosis treated with HIFUa were included. Baseline characteristics and adenomyotic lesion stiffness were collected to identify factors associated with stiffness. Data on the changes of uterine lesion stiffness (<i>E</i> value), the menstrual volume score (PBAC), and the dysmenorrhea numeric rating scale (NRS) score before and 1, 3, and 6 months after HIFUa treatment in 42 patients were collected to explore the effects of HIFUa on stiffness and symptom changes.</p><p><strong>Results: </strong>Before HIFUa, adenomyotic lesion stiffness was significantly greater than that of the normal myometrium. Adenomyotic lesion stiffness was significantly positively correlated with moderate to severe dysmenorrhea (<i>r</i> = 0.731), however, there was no significant linear correlation with hypermenorrhea (<i>r</i> = 0.153). Compared with that at pretreatment, stiffness at 3 and 6 months significantly decreased (that is, the elasticity increased) (<i>p</i> < 0.01). The NRS and PBAC scores at 1, 3, and 6 months were significantly lower than those at before HIFUa (<i>p</i> < 0.01), and the decrease in the NRS score was related to the decrease in stiffness.</p><p><strong>Conclusion: </strong>For adenomyosis patients with moderate to severe dysmenorrhea, lesion stiffness has been proven to be an objective reflection of dysmenorrhea severity. Lesion stiffness can be used as an imaging index to evaluate dysmenorrhea severity. Dysmenorrhea relief after HIFUa is related to decreased lesion stiffness.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2642927"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory pre-clinical study of the combination of hyperthermia and checkpoint inhibitors.","authors":"Pernille B Elming, Patricia S Nielsen, Jan Alsner, Michael R Horsman","doi":"10.1080/02656736.2026.2692414","DOIUrl":"10.1080/02656736.2026.2692414","url":null,"abstract":"<p><strong>Background and purpose: </strong>This was a pre-clinical study designed to investigate the potential of combining hyperthermia with checkpoint inhibitors.</p><p><strong>Material and methods: </strong>C3H mammary carcinomas, grown in the right rear foot of CDF1 mice, were treated when tumors reached 200 mm³. Hyperthermia (39.5-42.5 °C for 30-120 min) was applied following immersion of the tumor bearing leg into a circulating water bath. The checkpoint inhibitors were anti-CTLA-4/PD-1/PD-L1 antibodies injected intraperitoneally (4 x 10 mg/kg). Tumor growth was monitored daily and the treatment endpoint was TGT5 (time for tumors to regrow to 5 times treatment volume).</p><p><strong>Results: </strong>None of the antibodies alone affected TGT5 when compared to controls. However, while neither the anti-PD-1 nor anti-PD-L1 antibodies influenced heat response, an enhanced effect was found with the anti-CTLA-4 antibody. This was most apparent when tumors were heated once at 42.5 °C for 1-hour on day 0 and the antibody administered on days 1, 4, 8 and 11 or 1, 2, 3 and 4 after heating. However, the responses were heterogenous with some animals treated with heat and anti-CTLA-4 showing an increase in TGT5 compared to heat alone, while others showed no change. Mechanistic studies of tumor blood perfusion and infiltrating lymphocytes in tissue sections showed a substantial decrease reaching a nadir 1-3 days after heating, with recovery by 7-10 days.</p><p><strong>Conclusions: </strong>Under specific conditions, there appeared to be an enhanced anti-tumor effect with the hyperthermia-checkpoint inhibitor combination, but these effects were often sporadic. Mechanisms for the interaction between heat and the anti-CTLA-4 antibody remain unclear.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2692414"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zero echo time imaging-based skull density ratio for high-intensity focused ultrasound.","authors":"R Kälvälä, R Blanco Sequeiros, J Frantzén, T Sainio","doi":"10.1080/02656736.2026.2706720","DOIUrl":"https://doi.org/10.1080/02656736.2026.2706720","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether skull density ratio (SDR) estimates required for high-intensity focused ultrasound (HIFU) treatment of tremor can be accurately derived from zero echo time (ZTE) magnetic resonance images (MRI) by comparing them with measurements from computed tomography (CT) scans using an intensity profile-based approach.</p><p><strong>Materials and methods: </strong>Fifty-seven patients with essential tremor (<i>n</i> = 44), Parkinson's disease (PD) tremor (<i>n</i> = 10), both (<i>n</i> = 1) or uncategorized tremor-dominant disease (<i>n</i> = 2), underwent ZTE imaging before a neuro-HIFU treatment. Skull attenuation estimates, i.e. skull density ratios, were calculated from ZTE and CT images using the developed in-house SDR calculation pipeline and compared with the vendor-provided benchmark SDR values. To statistically evaluate the linear relationships between the datasets, Pearson correlation coefficients (<i>r</i>) and their corresponding <i>p</i>-values were calculated. A novel ZTE-based SDR inclusion threshold was derived.</p><p><strong>Results: </strong>A statistically significant positive correlation (<i>r</i> = 0.96, <math><mrow><mi>p</mi><mo><</mo></mrow></math> 0.0001) was detected between the CT-derived SDRs and the benchmark values, indicating that the in-house pipeline achieved high accuracy. Statistically significant positive correlation (<i>r</i> = 0.80, <math><mrow><mi>p</mi><mo><</mo></mrow></math> 0.0001) between the benchmark SDR values and the ZTE-derived SDR values was detected. A novel ZTE-based inclusion threshold of 0.51-0.53 was suggested.</p><p><strong>Conclusions: </strong>To our knowledge, this research was the first to take an intensity-profile-based approach when comparing high-resolution ZTE images and CT scans for skull density ratio calculation. The findings of this study support the possibility of the zero echo time sequence being validated for clinical use.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2706720"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148868884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of early postoperative human chorionic gonadotropin change direction after high-intensity focused ultrasound on ultrasound-guided dilation and curettage outcomes in cesarean scar pregnancy: a retrospective study.","authors":"Yan Yin, Fan Yang, Xiuli Zhang, Ruiqian Liu, Yang Liu","doi":"10.1080/02656736.2026.2719928","DOIUrl":"https://doi.org/10.1080/02656736.2026.2719928","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether the changing direction of serum β-subunit of human chorionic gonadotropin (β-hCG) after high-intensity focused ultrasound (HIFU) and before ultrasound-guided dilation and curettage (USg-D&C) influences procedural safety and outcome in caesarean scar pregnancy (CSP).</p><p><strong>Methods: </strong>This retrospective study was conducted at Deyang People's Hospital, Deyang, China. A total of 210 patients with cesarean scar pregnancy (CSP) were enrolled and divided into two groups based on the direction of serum β-hCG change after HIFU: the hCG declining group (<i>n</i> = 75) and the hCG rising group (<i>n</i> = 135). Baseline features, sonication parameters, blood loss, use of adjuvant haemostasis, re-intervention rate and time to β-hCG normalisation were compared.</p><p><strong>Results: </strong>No significant differences were found in baseline data or HIFU parameters between groups. β-hCG on post-curettage day 1 remained higher in the rising group (<i>p</i> < 0.05), yet the percentage drop from post-HIFU value was similar in two groups (<i>p</i> > 0.05). Median intra-curettage blood loss (10 vs 20 mL), adjuvant haemostatic procedures (4.0% vs 6.7%) and re-intervention (6.7% vs 7.4%) also showed no differences (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>In this cohort, a post-HIFU rise or fall in β-hCG was not associated with differences in USg-D&C procedure, blood loss or re-intervention. These findings do not establish equivalence, but suggest that short-term β-hCG direction alone may not be a reliable predictor of procedural outcomes.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2719928"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148993594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The superiority of one-day dietary preparation over three-day dietary preparation for high-intensity focused ultrasound treatment: a retrospective study.","authors":"Lifei Wang, Jie Zhang, Yang Liu, Xianxi Liu, Yan Yin, Yiwen Zhang","doi":"10.1080/02656736.2026.2653779","DOIUrl":"10.1080/02656736.2026.2653779","url":null,"abstract":"<p><strong>Objective: </strong>To compare dietary preparation durations and evaluate optimal diet types before high-intensity focused ultrasound (HIFU) treatment.</p><p><strong>Materials and methods: </strong>Five hundred patients with uterine fibroids or adenomyosis undergoing HIFU were enrolled. Initially, 300 patients were randomized to 3-day, 2-day, or 1-day dietary preparation (<i>n</i> = 100 each) to compare enema frequency, intestinal gas volume, comfort scores, and compliance. Subsequently, the 1-day group (Group A, clear liquid diet) was compared with 200 additional patients assigned to Group B (semiliquid diet) or Group C (low-residue diet) regarding intestinal cleansing efficacy, comfort scores, serum electrolyte changes, and physical recovery.</p><p><strong>Results: </strong>No significant differences were observed in enema frequency or intestinal gas volume among the three duration groups (<i>p</i> > 0.05); however, the 1-day group demonstrated superior comfort scores (<i>p</i> < 0.05). Within 1-day preparation, the low-residue diet group exhibited higher comfort scores, reduced intestinal gas volume, and better compliance compared to clear liquid and semiliquid diets (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>One-day dietary preparation is superior to three-day preparation for bowel cleansing before HIFU. Low-residue diet effectively meets clinical bowel cleansing requirements while achieving high patient acceptability. We recommend one-day low-residue diet as the preferred bowel preparation protocol for patients undergoing HIFU treatment.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2653779"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of ultrasound-guided thermal ablation for T1N0M0 papillary thyroid carcinoma in adolescent patients.","authors":"Ran Yi, Qiuya Yang, Shuo Wang, Taohua Gou, Lei Cai, Lin Yan, Yan Zhang, Yukun Luo","doi":"10.1080/02656736.2026.2705282","DOIUrl":"https://doi.org/10.1080/02656736.2026.2705282","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of ultrasound-guided thermal ablation (TA)for the treatment of T1N0M0 papillary thyroid carcinoma (PTC) in adolescent patients.</p><p><strong>Methods: </strong>This retrospective study enrolled adolescent patients with solitary T1N0M0 PTC who underwent TA between January 2015 and January 2025. Patients were stratified into T1a and T1b subgroups based on maximum tumor diameter. The primary outcomes were tumor progression rate and progression-free survival (PFS); secondary outcomes included ablation zone volume dynamics, volume reduction rate, complications, thyroid function, and patient-reported satisfaction.</p><p><strong>Results: </strong>A total of 82 patients were included (56 in T1a group, 26 in T1b group), with a technical success rate of 100%. The overall median follow-up duration was 36 months (interquartile range [IQR]: 24-60 months). Ablation zone volumes progressively decreased and eventually vanished in all cases. The median time to complete disappearance of the ablation zone was significantly longer in the T1b group than in the T1a group (18 months vs. 12 months, <i>p</i> = 0.014). The overall tumor progression rate was 2.4% (2/82), with no significant difference between subgroups (<i>p</i> = 0.579). Progression-free survival (PFS) rates were comparable between T1a and T1b groups (96.5% vs. 94.0%, <i>p</i> = 0.550). No major complications occurred.</p><p><strong>Conclusion: </strong>Ultrasound-guided TA is a safe and effective treatment modality for both T1a and T1b subgroups of adolescent patients with solitary T1N0M0 PTC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2705282"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}