International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"A preliminary comparative study of microwave ablation for cervical lymph node metastases originating from papillary thyroid carcinoma vs. non-papillary thyroid carcinoma.","authors":"Yu-Tong Liu, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-An Yu","doi":"10.1080/02656736.2025.2553205","DOIUrl":"https://doi.org/10.1080/02656736.2025.2553205","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate the feasibility, efficacy, and safety of microwave ablation (MWA) for cervical lymph node metastasis (CLNM) originating from papillary thyroid carcinoma (PTC) versus non-papillary thyroid carcinoma (non-PTC).</p><p><strong>Methods: </strong>In this retrospective study, 262 patients with CLNM treated by MWA between July 2016 and May 2024 were included. Comparative study based on propensity score matching (PSM) between the PTC and non-PTC groups was carried out.</p><p><strong>Results: </strong>After PSM, 30 cases (median age, 54.5 years [IQR 48-65.3]; 26 women) in the PTC group and 10 cases (median age, 56.5 years [IQR 49.5-66]; 7 women) in the non-PTC group were followed for a median of 22.5 months [IQR 12-36] and 8 months [IQR 6-22.5] (<i>p</i> = 0.072), respectively. Statistical analysis revealed significant differences between the PTC and non-PTC groups in disease progression (13.3% vs. 50%, <i>p</i> = 0.029), distant metastasis (0% vs. 30%, <i>p</i> = 0.012), disease progression-free survival (68% vs. 45%, log-rank <i>p</i> = 0.003), and tumor disappearance progression-free survival (99.9% vs. 20%, log-rank <i>p</i> = 0.019). The only complication observed was transient hoarseness, with no significant difference in complication rates between the two groups (6.7% vs. 0%, <i>p</i> > 0.99). Significant reductions in MD and volume were observed between pre- and post-MWA at 1, 3, 6, 9, and 12 months (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>MWA is a safe and effective treatment option for patients with CLNM from PTC. However, for CLNM from non-PTC, more aggressive monitoring and additional therapies after MWA may be necessary.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2553205"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous treatment of pulmonary ground-glass opacity nodules with microwave ablation and coaxial puncture biopsy.","authors":"Yibing Li, Mingyuan Hou, Zhenhua Du, Lei Su, Zerui Wang, Fangzhou Jiang, Zhilong Wang, Yining Liang, Taiyang Zuo","doi":"10.1080/02656736.2025.2520879","DOIUrl":"https://doi.org/10.1080/02656736.2025.2520879","url":null,"abstract":"<p><strong>Objective: </strong>To explore the feasibility of microwave ablation combined with coaxial biopsy in the simultaneous treatment of malignant-prone pulmonary ground-glass opacity (GGO) nodules, the advantages and disadvantages of different sequences, and differences in curative efficacy.</p><p><strong>Methods: </strong>We retrospectively analyzed 45 patients (46 lesions) who received microwave ablation combined with coaxial puncture biopsy for pulmonary GGO nodules, with 24 patients (25 lesions) in Group A having biopsies taken after microwave ablation and 21 patients (21 lesions) in Group B having biopsies taken before microwave ablation. By comparing the clinical data, technical success rate, complications, and positive pathological diagnosis rate of the two groups, the advantages and disadvantages of different sequences of puncture biopsy and microwave ablation treatment and their respective efficacies were discussed.</p><p><strong>Results: </strong>The pathological positive diagnosis rates of the two groups were 64.00% and 80.95%, respectively. The pneumothorax rates were 36.00% (9/25) and 33.33% (7/21), respectively, and there were no statistical differences between the two groups (<i>p</i> > 0.05). The incidence rates of intrapulmonary oozing blood in the two groups were 4.00% (3/25) and 28.57% (9/21), respectively, with a statistically significant difference between the two groups (<i>p</i> < 0.05). The rates of complete ablation of the pulmonary nodules at the recent follow-up were 84.00% (21/25) and 71.43% (15/21) in both groups, respectively.</p><p><strong>Conclusion: </strong>Microwave ablation combined with coaxial biopsy is safe, feasible, and effective for treating malignant-prone pulmonary GGO nodules. Sequencing of ablations and biopies has advantages and disadvantages in the diagnosis and treatment of pulmonary GGO.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2520879"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Method for fabricating tissue-mimicking materials with designated dielectric and thermal properties for radiofrequency ablation.","authors":"Fangyu Liu, Tianqi Liu, Jiahao Ye, Feng Zhou, Xueran Ma, Xuegang Xin","doi":"10.1080/02656736.2025.2555683","DOIUrl":"10.1080/02656736.2025.2555683","url":null,"abstract":"<p><strong>Purpose: </strong>This study presents a novel method for fabricating polyacrylamide-based tissue-mimicking materials with designated dielectric and thermal properties, designed to address the existing gap in tools that can accurately assess heat generation, transfer, and distribution during radiofrequency ablation procedures.</p><p><strong>Methods: </strong>The dielectric and thermal properties of the materials were tuned by varying the concentrations of ethylene glycol, aluminum oxide, and sodium chloride. A total of 27 samples were fabricated, and their properties were measured at four RFA-relevant temperatures (45 °C, 60 °C, 75 °C, and 90 °C). Regression models were developed to quantitatively predict these properties based on the component concentrations. To validate the models, four additional samples were fabricated to mimic the dielectric and thermal properties of liver tissue at each of the four temperatures. Short-term stability was assessed by storing these validation samples at 4 °C for two weeks and repeating the measurements.</p><p><strong>Results: </strong>The regression models achieved coefficients of determination (<i>R</i>²) above 0.87, 0.99, and 0.91 for electrical conductivity, thermal conductivity, and volumetric heat capacity, respectively. Validation experiments showed that measured properties deviated from reference liver tissue values by less than 6%, surpassing previous studies in accuracy. After two weeks of storage, relative errors remained below 10%, confirming short-term stability.</p><p><strong>Conclusion: </strong>This study demonstrates an effective method for fabricating tissue-mimicking phantoms with designated dielectric and thermal properties, contributing to the advancement of phantoms for radiofrequency ablation research.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2555683"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical morphology and elasticity following treatment of cervical squamous intraepithelial lesions with focused ultrasound <i>vs</i>. loop electrosurgical excision procedure: a prospective non-randomized controlled study.","authors":"Yulu Yang, Wenlin Shi, Miao Zhang, Xiaohong Gong, Li Luo, Honggui Zhou","doi":"10.1080/02656736.2025.2570825","DOIUrl":"https://doi.org/10.1080/02656736.2025.2570825","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of focused ultrasound (FUS) and loop electrosurgical excision procedure (LEEP) on cervical morphology and elasticity after treatment of cervical squamous intraepithelial lesions (SILs).</p><p><strong>Methods: </strong>Eighty-one patients with histologically confirmed SILs (42 FUS <i>vs</i>. 39 LEEP) were prospectively evaluated. FUS ablation was performed using the CZF-2 device (Haifu^® Medical, 3.5 MHz). LEEP followed ASCCP guidelines with resection margins ≥5 mm beyond lesions. Serial transvaginal ultrasound measurements (cervical length/width/volume) were conducted at baseline and 3/6 months postoperatively.</p><p><strong>Results: </strong>At 3-6 months after surgery, the high-risk human papilloma virus (HR-HPV) clearance rate and high-grade SIL cure rate were similar in the FUS and LEEP groups (<i>p</i> > 0.05). Cervical length, width, anterior-posterior diameter, and volume did not significantly change after FUS (<i>p</i> > 0.003125). All 4 dimensions were significantly reduced after LEEP (<i>p</i> < 0.003125). These morphological alterations were greater in the LEEP group (<i>p</i> < 0.05). Strain rates at the internal and external os, and anterior-posterior lips did not significantly change after FUS (<i>p</i> > 0.05). After LEEP, strain rates slightly decreased at the internal and external os (1.02 ± 1.00 <i>vs</i>. 0.79 ± 0.69, <i>p</i> > 0.05) and significantly decreased at the anterior-posterior lips (1.43 ± 1.34 <i>vs</i>. 0.97 ± 0.93; <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>FUS and LEEP demonstrate comparable efficacy in treating HR-HPV-associated SILs. Initial observations suggest that FUS impacts cervical morphology and elasticity less than does LEEP, implying an advantage of FUS for fertility preservation, although the long-term fertility outcomes require further investigation.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2570825"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of modified fluid isolation on the recurrent laryngeal nerve in ablative treatment of thyroid nodules.","authors":"Bingcheng Chen, Minhua Huang, Ziying Jiang, Yi Cao, Waner Zou, Liping Lu","doi":"10.1080/02656736.2025.2566279","DOIUrl":"https://doi.org/10.1080/02656736.2025.2566279","url":null,"abstract":"<p><strong>Background: </strong>Real-time ultrasound-guided radiofrequency ablation (RFA) is a widely used technique for the treatment of thyroid nodules. Liquid isolation methods are often employed frequently utilized to augment the safety of RFA. However, recurrent laryngeal nerve injury (RLN) has still been reported in clinical practice. We developed a modified liquid isolation method to reduce the occurrence of RLN injury. This study aims to evaluate the protective effect of the modified isolation technique on the RLN during thermal ablation of thyroid nodules.</p><p><strong>Methods: </strong>This study included patients who underwent RFA with a liquid isolation method. Patients were divided into two groups according to the liquid isolation technique: modified or traditional. Univariate and multivariate logistic regression analyses were further performed to evaluate whether the type of liquid isolation method had an impact on the occurrence of RLN injury.</p><p><strong>Results: </strong>A total of 196 patients were included in the study. Hoarseness occurred in 2 cases (2.2%) in the modified liquid isolation group, compared with 10 cases (9.4%) in the traditional liquid isolation group (<i>p</i> = 0.036). Patients in the modified group had a higher proportion with a history of thyroid surgery. Further multivariate regression analysis indicated that the modified liquid isolation technique was associated with a significantly lower risk of RLN injury (OR: 0.18; 95% CI: 0.04-0.89; <i>p</i> = 0.036).</p><p><strong>Conclusion: </strong>The modified liquid isolation method has a better protective effect on RLN in the ablative treatment of thyroid nodules.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2566279"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modeling the involution of microwave liver ablation zones.","authors":"William B N Weston, Owen A White, Ruby Callister, Nicos Fotiadis, Joshua Shur, S Nahum Goldberg, Edward W Johnston","doi":"10.1080/02656736.2025.2525422","DOIUrl":"https://doi.org/10.1080/02656736.2025.2525422","url":null,"abstract":"<p><strong>Background: </strong>The post-ablation involution of microwave liver ablation zones (AZs) remains poorly understood. This study develops mathematical models to characterize AZ involution and identifies key predictors influencing its dynamics.</p><p><strong>Materials and methods: </strong>Fifty-four patients (mean age 61 ± 10 years (standard deviation), 33 men) underwent microwave liver ablation (MWA) of 76 liver tumors and follow-up contrast enhanced CT (CECT) imaging in this retrospective single-center cohort study. AZs were segmented on intraprocedural post-ablation portal-venous phase CECT and all available subsequent postprocedural follow-up scans, or until local tumor progression (LTP). Volumetric AZ involution was modeled using non-linear regression methods and correlated with initial tumor and ablation parameters.</p><p><strong>Results: </strong>In total, 366 AZ segmentations were performed over median 304 days CECT-follow-up (range 21-741). Involution was best modeled by mono-exponential decay (SSE = 4.64, RMSE = 0.11). AZs shrank to one-third of baseline volume within a year, with a half-life of 158 days. At 6 weeks, relative volume was 0.81 of baseline (95% prediction interval 0.59-1.04, 95% confidence interval 0.80-0.83). Variables with a significant effect on involution included initial tumor diameter (<i>p</i> = 0.03), initial AZ volume (<i>p</i> < 0.01), and tumor:AZ volume ratio (<i>p</i> = 0.04).</p><p><strong>Conclusions: </strong>Microwave ablation zones rapidly involute and stabilize at approximately one-third of their baseline volume within a year. The involution process is best modeled by mono-exponential decay and influenced by the type of tissue ablated. These findings highlight the potential need for predictive models to adjust for involution for follow-up imaging-based margin assessment to optimize accuracy and ablation outcomes.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2525422"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144645203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound radiomics-based nomogram to predict the non-perfused volume ratio of breast fibroadenomas treated with ultrasound-guided high-intensity focused ultrasound: a multicenter study.","authors":"De Zhou, Dewu Mu, Zhiqin Lin, Yijie Ren, Ye Zhou, Huan Liu, Leilei Zhu, Jie Luo, Meifang Li, Chenghai Li, Faqi Li","doi":"10.1080/02656736.2025.2568624","DOIUrl":"https://doi.org/10.1080/02656736.2025.2568624","url":null,"abstract":"<p><strong>Object: </strong>To develop and validate an ultrasound radiomics-based nomogram for the preoperative prediction of the non-perfused volume ratio of Ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for fibroadenomas.</p><p><strong>Methods: </strong>This multicenter retrospective study included 156 patients from two institutions, comprising a total of 200 breast fibroadenomas. Data from one center (<i>n</i> = 140) were used for the training cohort, and data from the other center (<i>n</i> = 60) served as the test cohort. Radiomics features were extracted from preoperative US images. Feature selection was performed sequentially using Student's <i>t</i>-test or the Mann-Whitney U-test, followed by the least absolute shrinkage and selection operator (LASSO) regression. LightGBM was applied to build the radiomics and clinical models, and a combined model was then developed using the multivariate logistic regression, <i>that is</i> US radiomics-based nomogram. The performance of the models was evaluated based on area under the curve (AUC), calibration, and clinical applicability.</p><p><strong>Result: </strong>Model evaluation showed that the nomogram outperformed both the clinical model (training set AUC = 0.696; test set AUC = 0.689) and the radiomics model (training set AUC = 0.898; test set AUC = 0.805), with an AUC of 0.896 in the training set and 0.830 in the test set. Calibration and decision curve analysis indicated that the nomogram exhibited good calibration and clinical utility.</p><p><strong>Conclusion: </strong>The nomogram model provides an effective prediction of the non-perfused volume ratio (NPVR) in breast fibroadenomas treated with HIFU.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2568624"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145260482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent thrombocytopaenia as an independent risk factor for 28-day mortality and multiorgan failure in exertional heatstroke: a retrospective study of 217 patients.","authors":"Li Zhong, Yan Liu, Conglin Wang, Zheying Liu, Lei Su, Zhifeng Liu, Ming Wu","doi":"10.1080/02656736.2025.2535730","DOIUrl":"https://doi.org/10.1080/02656736.2025.2535730","url":null,"abstract":"<p><strong>Background: </strong>Thrombocytopaenia is a known predictor of poor outcomes in trauma and sepsis patients, its prognostic role in exertional heatstroke (EHS) remains underexplored. This study aimed to evaluate the association between persistent thrombocytopaenia and mortality in critically ill EHS patients.</p><p><strong>Methods: </strong>In this retrospective cohort study, we analyzed data from 217 EHS patients admitted to the intensive care unit (ICU) between November 2009 and October 2023. Demographic, biochemical (baseline, 24 h, and 48 h), and inflammatory marker data were collected. Persistent thrombocytopaenia was defined as a platelet count <100 × 10⁹/L at both 24 h and 48 h postadmission. Multivariate logistic regression identified predictors of 28-day mortality, and Kaplan-Meier survival curves with log-rank tests were used to compare outcomes between groups.</p><p><strong>Results: </strong>Among the 217 patients, 19 (8.8%) patients died within 28 days. Nonsurvivors presented significantly worse liver/kidney function, coagulopathy (DIC incidence: 89.5% vs. 26.8%, <i>p</i> < 0.001), and AKI incidence (100% vs. 38.4%, <i>p</i> < 0.01). The platelet counts in nonsurvivors were markedly lower than those in survivors at admission (71 vs. 166 × 10⁹/L), 24 h (49 vs. 134 × 10⁹/L), and 48 h (56 vs. 131 × 10⁹/L) (all <i>p</i> < 0.001). Persistent thrombocytopaenia (63 patients, 29.0%) independently predicted mortality (adjusted OR = 17.44, 95% CI: 4.76-63.86; <i>p</i> < 0.001) and was correlated with higher DIC (84.1% vs. 11.0%, <i>p</i> < 0.001) and AKI (63.5% vs. 35.7%, <i>p</i> < 0.001) rates. Survival analysis confirmed significantly increased 28-day mortality in thrombocytopaenia patients (25.4% vs. 1.9%, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Persistent thrombocytopaenia within 48 h of ICU admission is a robust predictor of mortality and multiorgan dysfunction in patients with EHS.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2535730"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High intensity focused ultrasound serves as a salvage treatment for uterine arteriovenous fistula when uterine artery embolization fails and pregnancy outcomes: a case report and literature review.","authors":"Shanyu Huang, Mingzhu Ye, Xiaoxiao Xi, Waixing Li, Xiaogang Zhu, Xin Sun","doi":"10.1080/02656736.2025.2519347","DOIUrl":"10.1080/02656736.2025.2519347","url":null,"abstract":"<p><p>Uterine arteriovenous fistula (UAVF) is an abnormal connection formed between the branches of the uterine artery and the venous plexus, accounting for 1%-2% of all reproductive system and abdominal bleeding. In recent years, the incidence has been gradually increasing due to acquired causes such as uterine surgery and pregnancy. The common clinical symptom is painless and irregular vaginal bleeding, which can lead to hemorrhagic shock. There is no standardized and unified treatment for UAVF. At present, uterine artery embolization (UAE) is considered the first-choice treatment for UAVF in clinical practice, but it is prone to treatment failure due to various potential complications. HIFU, as a noninvasive treatment, is currently used in a limited number of cases for the treatment of UAVF, and a few literature reports have shown clinical effects after high-intensity focused ultrasound (HIFU) treatment. This paper reports a case that HIFU was successfully used to treat UAVF after the failure of UAE, and the patient successfully became pregnant, indicating that HIFU can be used as an alternative after the failure of UAE treatment for UAVF, without affecting subsequent pregnancy.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2519347"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144629261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary comparative study of three different microwave ablation methods for cystic-solid thyroid nodules.","authors":"Xiang-Rong Xie, Yu-Fan Wu, Geng-Biao Zhang, Dong-Ming Guo, Chuang-Yu Ma, Wei-Jian Luo, Jin-Mei Pan, Yan-Ping Wu, Hong-Hui Su","doi":"10.1080/02656736.2025.2557954","DOIUrl":"10.1080/02656736.2025.2557954","url":null,"abstract":"<p><strong>Objective: </strong>This preliminary comparative study assessed the effectiveness of three microwave ablation (MWA) techniques in managing cystic-solid thyroid nodules.</p><p><strong>Methods: </strong>Patients who underwent MWA from January 2018 to October 2021 at the Second Affiliated Hospital of Shantou University Medical College were divided into three groups: Simple Aspiration Group (SAG) (cyst fluid drained before direct ablation), Epinephrine Solution Immersion Group (ESIG) (cyst fluid drained followed by soaking in epinephrine), and High-Power Ablation Group (HPAG) (immediate high-power ablation after drainage). Twenty patients were retrospectively analyzed in each group, comparing intraoperative intracapsular bleeding, ablation time of cystic-solid nodules, 12th-month nodule volume reduction rate (VRR), preoperative cosmetic and symptom scores, and postoperative scores.</p><p><strong>Results: </strong>Significant differences were observed in intraoperative intracapsular rebleeding (≥50% cyst cavity volume) between ESIG and SAG (<i>p</i> = 0.029) and HPAG and SAG (<i>p</i> = 0.008), but not between ESIG and HPAG (<i>p</i> = 0.602). The ablation time for cystic-solid nodules was shorter in ESIG and HPAG compared to SAG (<i>p</i> = 0.003 and <i>p</i> = 0.006, respectively), with no significant difference between ESIG and HPAG (<i>p</i> = 0.689). However, the 12th-month outcomes-VRRs, symptom scores, and cosmetic scores-showed no statistical significance among the groups (<i>p</i> = 0.634, <i>p</i> = 0.329, and <i>p</i> = 0.717, respectively).</p><p><strong>Conclusion: </strong>ESIG and HPAG significantly reduced intraoperative intracapsular bleeding and ablation time of solid-cystic nodules compared with SAG, indicating enhanced procedural efficiency. Nevertheless, the long-term therapeutic outcomes (nodule shrinkage, symptom relief, and cosmesis) were similar across all methods. These findings underscore the potential of epinephrine immersion and high-power ablation in optimizing MWA for cystic-solid nodules.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"42 1","pages":"2557954"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}