Simultaneous treatment of pulmonary ground-glass opacity nodules with microwave ablation and coaxial puncture biopsy.

Abstract

Objective: To explore the feasibility of microwave ablation combined with coaxial biopsy in the simultaneous treatment of malignant-prone pulmonary ground-glass opacity (GGO) nodules, the advantages and disadvantages of different sequences, and differences in curative efficacy.

Methods: We retrospectively analyzed 45 patients (46 lesions) who received microwave ablation combined with coaxial puncture biopsy for pulmonary GGO nodules, with 24 patients (25 lesions) in Group A having biopsies taken after microwave ablation and 21 patients (21 lesions) in Group B having biopsies taken before microwave ablation. By comparing the clinical data, technical success rate, complications, and positive pathological diagnosis rate of the two groups, the advantages and disadvantages of different sequences of puncture biopsy and microwave ablation treatment and their respective efficacies were discussed.

Results: The pathological positive diagnosis rates of the two groups were 64.00% and 80.95%, respectively. The pneumothorax rates were 36.00% (9/25) and 33.33% (7/21), respectively, and there were no statistical differences between the two groups (p > 0.05). The incidence rates of intrapulmonary oozing blood in the two groups were 4.00% (3/25) and 28.57% (9/21), respectively, with a statistically significant difference between the two groups (p < 0.05). The rates of complete ablation of the pulmonary nodules at the recent follow-up were 84.00% (21/25) and 71.43% (15/21) in both groups, respectively.

Conclusion: Microwave ablation combined with coaxial biopsy is safe, feasible, and effective for treating malignant-prone pulmonary GGO nodules. Sequencing of ablations and biopies has advantages and disadvantages in the diagnosis and treatment of pulmonary GGO.