International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group最新文献

{"title":"Factors associated with ablation zone resorption after microwave ablation in solitary T1aN0M0 papillary thyroid carcinoma: baseline lesion volume and microcalcification.","authors":"Quan Wen, Qianwen Wang, Zhanxiong Yi, Ying Feng, Linxue Qian, Yuan Zu","doi":"10.1080/02656736.2026.2750644","DOIUrl":"https://doi.org/10.1080/02656736.2026.2750644","url":null,"abstract":"<p><strong>Objectives: </strong>To identify preoperative factors associated with ablation zone resorption after microwave ablation (MWA) in patients with solitary T1aN0M0 papillary thyroid carcinoma (PTC), and to explore their association with energy density.</p><p><strong>Materials and methods: </strong>This retrospective study enrolled patients with solitary T1aN0M0 PTC who underwent MWA in our institution between September 2013 and January 2021. Ablation zone volume was measured at 1, 3, 6, 12, and 24 months post-ablation, and annually thereafter. Cox proportional hazards regression was performed to identify independent factors associated with ablation zone resorption. Kaplan-Meier analysis compared cumulative resorption rates among subgroups. Energy density was compared across subgroups.</p><p><strong>Results: </strong>A total of 296 patients were included, with an overall complete resorption rate of 73.6%. Multivariable Cox analysis identified baseline lesion volume (HR per IQR: 0.788, 95% CI: 0.678-0.917, <i>p</i> = 0.002) and microcalcification (HR: 0.669, 95% CI: 0.508-0.881, <i>p</i> = 0.004) as independent factors associated with delayed ablation zone resorption. Both factors were significantly correlated with energy density: the large-volume group (>52.1 mm³) received lower energy density than the small-volume group (≤52.1 mm³) (median 18.3 vs. 60.5 J/mm³, <i>p</i> < 0.001), and energy density was also lower in the microcalcification group than in those without (median 25.6 vs. 35.2 J/mm³, <i>p</i> = 0.030).</p><p><strong>Conclusion: </strong>MWA is an effective and safe treatment for solitary T1aN0M0 PTC. Baseline lesion volume and microcalcification are independent factors associated with delayed ablation zone resorption, and their correlation with energy density provides a rationale for optimizing energy delivery strategies to facilitate resorption.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2750644"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149241193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and outcomes of microwave ablation for solid benign thyroid nodules (>10mL): a retrospective study.","authors":"Liu Gong, Shiyan Guo, Jinguang Zhou, Jiale Li, Ping Zhou","doi":"10.1080/02656736.2026.2659372","DOIUrl":"10.1080/02656736.2026.2659372","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the safety and effectiveness of microwave ablation (MWA) in treating solid benign thyroid nodules (BTNs, >10mL) and to identify factors influencing volume reduction rate (VRR).</p><p><strong>Methods: </strong>This retrospective study included 123 patients with 123 solid BTNs greater than 10 mL in size who underwent ultrasound-guided MWA between March 2019 and May 2024. Conventional ultrasound (US) examinations were performed at 1,3,6,12 months after ablation and annually thereafter. Outcomes measures included VRR, symptom and cosmetic scores, complications, and factors affecting VRR. High-risk surgical and low-risk surgical subgroups were compared.</p><p><strong>Results: </strong>The median initial volume was 14.59 mL, final VRR reached 80.73% (mean follow-up 28.32 ± 7.91 months), with 91.87% achieving >50% VRR at 12th month. Comparing to pre-ablation, symptom scores significantly decreased from 3.20 ± 2.75 to 0.76 ± 1.15 (<i>p</i> < 0.001), and cosmetic scores from 3.34 ± 0.85 to 1.97 ± 0.84 (<i>p</i> < 0.001) at 12th month post-ablation. The major complication rate was 4.88%, with no cases of permanent sequelae. No significant differences were observed in outcomes between high-risk surgical and low-risk surgical groups (VRR: 68.72% vs 69.96%, <i>p</i> = 0.57, complications: 26.67% vs 18.52%, <i>p</i> = 0.49). Baseline nodule volume showed a significant negative correlation with VRR (β = -0.82, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>MWA is an effective minimally invasive approach with an excellent safety for controlling the volume of solid BTNs greater than 10 mL in size and providing symptomatic relief, and it represents a valuable treatment alternative for patients at high risk of surgery.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2659372"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced magnetic hyperthermia using anti-PD-L1 antibody-conjugated magnetoliposomes in a murine subcutaneous bladder cancer model.","authors":"Masakazu Gonda, Noriyasu Kawai, Daiki Ishikawa, Maria Aoki, Toshiharu Morikawa, Nobuhiko Shimizu, Takashi Nagai, Toshiki Etani, Taku Naiki, Shuzo Hamamoto, Atsushi Okada, Rintaro Saito, Masahiro Kaneko, Akira Ito, Takahiro Yasui","doi":"10.1080/02656736.2026.2645413","DOIUrl":"10.1080/02656736.2026.2645413","url":null,"abstract":"<p><strong>Background/objectives: </strong>Bladder cancer (BC) often arises in an immunosuppressive tumor microenvironment that limits responses to immune checkpoint inhibitors. Magnetic hyperthermia therapy (MHT) can induce immunogenic cell death, but its value as an immunotherapeutic remains insufficient.</p><p><strong>Methods: </strong>We conjugated anti-programmed death-ligand 1 (PD-L1) antibody (αPD-L1) with magnetite cationic liposomes (MCL) and developed αPD-L1@MCL for MHT in an MB49 murine subcutaneous BC model. Mice received a single or triple exposure of αPD-L1@MCL-mediated MHT (P-MHT) at 43 °C or 46 °C (<i>n</i> = 5 per group), then we assessed tumor growth and CD8⁺ T-cell infiltration.</p><p><strong>Results: </strong>Without αPD-L1, triple MHT at 46 °C induced complete tumor regression, whereas a single exposure 43 °C was insufficient. A single exposure 43 °C P-MHT achieved complete regression in four out of five mice. Flow cytometry revealed an increase in CD8⁺ T cells in tumors treated with P-MHT.</p><p><strong>Conclusions: </strong>Our αPD-L1@MCL enables hyperthermia with magnetic nanoparticles and immunotherapy with an anti-PD-L1 antibody. These findings support further development of hyperthermia mediated by anti-PD-L1 antibody-conjugated magnetic nanoparticles as a promising therapeutic strategy for BC.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2645413"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147523840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity thermal stress enhances adoptive NK-cell cytotoxicity in poorly differentiated hepatocellular carcinoma.","authors":"Po-Chun Chen, Janet Pham, Sara Huerta-Yepez, Tiran Sargsyan, Jillian Poulsen, Sonia Virk, Tu Nguyen, Steven S Raman, Anahid Jewett, Jason Chiang","doi":"10.1080/02656736.2026.2685850","DOIUrl":"https://doi.org/10.1080/02656736.2026.2685850","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous thermal ablation is used to treat early-stage, non-resectable hepatocellular carcinoma (HCC). NK-cell immunotherapy has been studied as an adjuvant treatment, but the efficacy remains unclear when combined with ablation.</p><p><strong>Purpose: </strong>To evaluate the potential of peri-ablational, high-intensity thermal stress to augment adoptive NK-cell cytotoxicity in HCC.</p><p><strong>Methods: </strong>HCC cells were exposed to 37, 43, and 47 °C in water baths to recapitulate peri-ablational heat stress before delivering NK-cell therapy. <i>In vitro</i> cytolysis was measured using chromium release and live-cell imaging assays. An orthotopic mouse model of poorly differentiated HCC was used to evaluate the therapeutic effect of combined microwave ablation (MWA) and adoptive NK-cell therapy. Tumor burden was compared via tumor weight, Gaussia luciferase levels, and immunohistochemistry.</p><p><strong>Results: </strong>NK-cell cytotoxicity increased against poorly differentiated HCC cells pretreated at 47 °C compared with 37 °C controls (<i>p</i> < 0.001). <i>In vivo</i>, MWA+NK-cell therapy reduced poorly differentiated HCC weight (1.53 ± 0.44 g) compared to monotherapy groups (MWA: 2.06 ± 0.61; NK: 1.92 ± 0.75 g), although the difference was only found to be significant when compared to untreated tumor group (2.89 ± 0.92 g, <i>p</i> < 0.01). Additionally, MWA+NK-cell therapy significantly decreased Gaussia luciferase level (<i>p</i> < 0.05) and Ki-67 expression (<i>p</i> < 0.01), while increasing tumor necrosis (<i>p</i> < 0.05) in tumors when compared to tumor control.</p><p><strong>Conclusion: </strong>High intensity thermal stress increased susceptibility of poorly differentiated HCC to NK-cell-mediated cytotoxicity <i>in vitro</i> and <i>in vivo</i> when compared to untreated controls. The combination of thermal ablation and adoptive NK-cell therapy should be further investigated in clinically relevant sub-lethal ablation settings and broader ablation-time combinations to support future clinical studies.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2685850"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148274572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative study on the effects of high-intensity focused ultrasound (HIFU) and laparoscopic myomectomy on ovarian function and endometrial receptivity in patients with uterine fibroids.","authors":"Rui Huang, Yangyang Wang, Yuying Song, Xiangling Duan, Shanshan Wu, Xian Zhang, Susu Wu, Haichun Guo","doi":"10.1080/02656736.2026.2703617","DOIUrl":"https://doi.org/10.1080/02656736.2026.2703617","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effects of high-intensity focused ultrasound (HIFU) ablation and laparoscopic myomectomy on ovarian function and endometrial receptivity in patients with uterine fibroids.</p><p><strong>Materials and methods: </strong>In this prospective, non-randomized cohort study, 60 patients with uterine fibroids were either treated with HIFU (<i>n</i> = 30) or laparoscopic myomectomy (<i>n</i> = 30) based on patient preference after standardized counseling. Ovarian function and endometrial receptivity were evaluated preoperatively and at 1, 3, and 6 months post‑treatment. Ovarian reserve was assessed using anti‑Müllerian hormone (AMH), sex hormone levels of luteinizing hormone (LH), follicle‑stimulating hormone (FSH), estradiol (E2), and antral follicle count (AFC). Endometrial receptivity was evaluated using endometrial thickness and vascular indices, including endometrial artery resistance index (RI), pulsatility index (PI), and the systolic/diastolic velocity ratio (S/D).</p><p><strong>Results: </strong>Regarding endometrial receptivity, the HIFU group exhibited significantly greater endometrial thickness at the 1‑month follow‑up compared to the laparoscopic group (mean difference: 1.5 mm, 95% CI: 0.6 to 2.4 mm; Cohen's <i>d</i> = 0.72, <i>p</i> < 0.05). Both groups showed a reduction in PI after treatment, though the change was not statistically significant. RI and S/D ratios were comparable between the two groups at any time point (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>Both HIFU and laparoscopic myomectomy preserved ovarian function in patients with uterine fibroids. HIFU was associated with faster short-term endometrial recovery at 1 month post-treatment, but no differences in ovarian function or other receptivity markers were observed between the two groups of patients. Randomized trials with pregnancy outcomes are needed before clinical recommendations can be made.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2703617"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148665590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 International expert consensus on ultrasound-guided thermal ablation for secondary and tertiary hyperparathyroidism.","authors":"Ying Wei, Shu-Rong Wang, Jennifer H Kuo, Bülent Çekiç, Lin-Xue Qian, Hossam Arafa Ghazi, Ying Che, Gerardo Amabile, Song-Song Wu, Ajit Yadav, Gang Dong, Ingo Janssen, Bo-Qiang Fan, Nobuhiro Fukunari, Jun-Feng He, Le Thanh Dung, Song-Yuan Yu, Sum Leong, Jian-Jun Yu, Yi-Hong Chou, Rafael De Cicco, Shu-Hang Xu, Kai-Lun Cheng, Emad Kandil, Wei-Che Lin, Dong Xu, Jonathon Russell, Man Lu, Ralph P Tufano, Lei Liang, Gregory W Randolph, Jian-Qiao Zhou, Giovanni Mauri, Hong-Hui Su, Marika Russell, Amr H Abdelhamid, Kaustubh Patel, Li Zhuo, Ya-Jun Zhang, Yun Niu, Zhen-Long Zhao, Ming-An Yu","doi":"10.1080/02656736.2025.2606698","DOIUrl":"10.1080/02656736.2025.2606698","url":null,"abstract":"<p><p>Treatments for secondary and tertiary hyperparathyroidism (SHPT/THPT) remain significant challenges in patients with end-stage renal disease. Thermal ablation (TA) has emerged as a minimally invasive, safe, and effective alternative to surgical resection (SR). However, technical variations and a lack of standardization have limited its widespread adoption. To address these challenges, an international expert panel developed consensus recommendations using a modified Delphi method, integrated with a systematic literature review. As a result, sixteen recommendations were formulated, addressing diagnosis, preoperative preparation, technical procedures, postoperative management, follow-up strategies, efficacy assessment, and complications associated with TA for SHPT/THPT. These recommendations aim to promote standardized treatment protocols, improve procedural safety, and provide evidence-based guidance for clinical practice and future research in ultrasound-guided TA for SHPT/THPT management.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2606698"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of locally applied water-filtered infrared a irradiation adjunctive to iloprost and carbon dioxide hand baths in patients with systemic sclerosis and severe Raynaud's phenomenon - a randomized controlled trial.","authors":"Nils Schulz, Priyanka Boettger, Joachim Bär, Tim Wilhelmi, Pascal van Wijnen, Ulf Müller-Ladner, Uwe Lange, Philipp Klemm","doi":"10.1080/02656736.2026.2653012","DOIUrl":"10.1080/02656736.2026.2653012","url":null,"abstract":"<p><strong>Background: </strong>Almost all patients with systemic sclerosis (SSc) experience Raynaud's phenomenon (RP) with risk of digital ulcers (DU). In severe RP, intravenous iloprost is standard, yet additive hyperthermic therapy may enhance vasodilation and microcirculation. However, whether more intensive or alternative hyperthermic modalities offer benefits beyond commonly used CO₂ hand baths remains unclear.</p><p><strong>Methods: </strong>In this randomized, controlled trial, all patients received a baseline therapy of iloprost plus CO₂ hand baths. The intervention group (IG) received additional water-filtered infrared-A (wIRA; 2 × 30 min/day, 8 days), while the control group (CG) received baseline therapy alone. The primary endpoint was the difference in RP-associated pain (VAS 0-100 mm) after treatment. Secondary outcomes included changes in RP duration, frequency, and intensity, Health Assessment Questionnaire (HAQ), serum interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF).</p><p><strong>Results: </strong>Of 46 randomized patients, 38 (IG = 19, CG = 19) completed the study. Pain decreased from 70.4 ± 27.8 to 56.7 ± 21.4 mm with wIRA and from 73.9 ± 27.5 to 65.3 ± 26.8 mm in controls. Multivariable ANCOVA showed a mean difference of -14.7, 95% CI [-28.8;-0.7], <i>p</i> = 0.041 in favor of wIRA. RP duration improved more in the wIRA group (day 23: β = -3.8, 95% CI [-7.4;-0.2], <i>p</i> = 0.041), while RP frequency, intensity, HAQ, IL-6, and VEGF showed no significant differences (all <i>p</i> > 0.05). No adverse events occurred.</p><p><strong>Conclusions: </strong>Adjunctive wIRA during iloprost therapy was safe and yielded modest, short-term improvements in pain and RP duration. These exploratory effects warrant confirmation in larger controlled trials.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2653012"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable radiopaque targets for cone-beam CT guided histotripsy.","authors":"Katrina L Falk, Michael A Speidel, Grace M Minesinger, Gretchen M Foltz, Fred T Lee, Timothy J Ziemlewicz, Martin G Wagner, Paul F Laeseke","doi":"10.1080/02656736.2026.2642172","DOIUrl":"10.1080/02656736.2026.2642172","url":null,"abstract":"<p><strong>Background: </strong>Cone-beam CT (CBCT) guided histotripsy is being developed as a supplemental image guidance technique for histotripsy. The goal of this work is to present a percutaneously injectable, radiopaque target that can be used in preclinical testing of CBCT-guided histotripsy.</p><p><strong>Methods: </strong>Livers of five <i>in vivo</i> swine were percutaneously injected with a mixture of barium paste diluted with saline or autologous blood to a concentration of 4:1. Post-injection CBCT images were used to analyze radiographic differences in injected volume; temporal stability of the injection (intensity, volume, and sphericity); and presence of image artifacts. Four injections were targeted and treated <i>in vivo</i> using a clinical histotripsy system. Injectate volume and intensity, and treatment zone size and contrast-to-noise ratio (CNR) were compared to control treatments.</p><p><strong>Results: </strong>There was no significant difference in imaged volume or intensity between the 100 or 200 µL(<i>p</i> = 0.384) injection. Over the analyzed 5-206 min, the barium-saline and barium-blood injections had similar ranges of imaged volume and intensity, both changing during the first 30 min then were stable. The image artifact was reported as none to moderate in 5/6 cases for both injections. The CNR of the treatment zones and difference in diameters (planned versus actual) were 5.9 ± 1.8, 3.7 ± 1.3, and 5.9 ± 1.0 and 8.1 ± 4.0 mm, 15.9 ± 11.4 mm, and 7.6 ± 2.2 mm for the barium-saline, barium-blood and control groups respectively. The barium-saline injectate was not visible after treatment while the barium-blood was visible but dispersed.</p><p><strong>Conclusion: </strong>Percutaneously injectable, radiopaque barium-based targets were acutely safe, targetable and treatable on CBCT and did not alter histotripsy treatment zone size <i>in vivo</i>.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2642172"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13072709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI radiomics combined with clinical features for predicting initial dose in focused ultrasound ablation surgery for uterine fibroids.","authors":"Lina Zhao, Guangbo Li, Qingyue Chen, Min He, Zongjiu Zhang","doi":"10.1080/02656736.2026.2719927","DOIUrl":"https://doi.org/10.1080/02656736.2026.2719927","url":null,"abstract":"<p><strong>Objective: </strong>To develop and validate a radiomics-clinical model for individualized prediction of the initial treatment dose in focused ultrasound ablation surgery (FUAS) for uterine fibroids.</p><p><strong>Methods: </strong>This retrospective study included 210 patients with solitary uterine fibroids who underwent FUAS and were randomly divided into training and testing cohorts (7:3). The outcome variable was defined as the total sonication energy delivered to the initial treatment layer. Regions of interest were manually delineated on preoperative T2-weighted MRI, and radiomics features were extracted using PyRadiomics. After feature selection, multiple machine-learning algorithms were evaluated, and the optimal radiomics model was combined with independent clinical predictors to construct a radiomics-clinical model. Model performance was assessed using receiver-operating-characteristic analysis and decision curve analysis (DCA).</p><p><strong>Results: </strong>A total of 1,223 radiomics features were extracted, of which 10 were retained for model construction. Body mass index (BMI), rectus abdominis thickness, and preoperative surgical score were identified as independent clinical predictors. The combined radiomics-clinical model demonstrated the best predictive performance, with an AUC of 0.862 (95% CI, 0.821-0.898) in the training cohort and 0.803 (95% CI, 0.756-0.845) in the testing cohort. DCA demonstrated greater clinical net benefit for the combined model compared with either the radiomics or clinical model alone.</p><p><strong>Conclusions: </strong>MRI-based radiomics combined with clinical variables may provide a useful approach for individualized prediction of the initial FUAS treatment dose for uterine fibroids.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2719927"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy and safety of cervical pregnancy treated with high-intensity focused ultrasound versus uterine artery embolization prior to ultrasound-guided suction curettage: a retrospective study.","authors":"Yan Peng, Yu Dai, Cuili Wen, Guiyuan Yu, Ping Jin","doi":"10.1080/02656736.2026.2616375","DOIUrl":"10.1080/02656736.2026.2616375","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to retrospectively evaluate the efficacy and safety of high-intensity focused ultrasound (HIFU) versus uterine artery embolization (UAE) as pretreatment prior to ultrasound-guided suction curettage in the management of cervical pregnancy.</p><p><strong>Methods: </strong>A retrospective review was conducted on 41 patients diagnosed with cervical pregnancy. Among them, 20 patients underwent UAE and 21 received HIFU treatment, both followed by ultrasound-guided suction curettage.</p><p><strong>Results: </strong>None of the 41 patients required additional interventions due to active uterine bleeding following curettage. No significant differences were observed between the two groups in terms of age, number of previous abortions, days of amenorrhea, pretreatment serum β-hCG levels, average diameter of the gestational sac/mass, or blood loss during curettage (<i>p</i> > .05). Compared to the UAE group, the HIFU group exhibited significantly lower hospitalization costs, shorter hospital stays, and less pain intensity (<i>p</i> < .05). In the UAE group, 7 out of 20 patients experienced reduced menstrual flow; among them, 5 patients with fertility intentions underwent hysteroscopic adhesiolysis, resulting in 2 successful pregnancies. Of the remaining 13 patients in the UAE group without menstrual changes, 2 patients with fertility intentions achieved pregnancy. In the HIFU group, no patients reported alterations in menstrual volume. Among 10 patients with fertility intentions, 9 patients had pregnancies.</p><p><strong>Conclusions: </strong>In this pilot retrospective study, both UAE and HIFU demonstrated efficacy as pretreatment modalities prior to ultrasound-guided suction curettage for cervical pregnancy. HIFU showed potential advantages in pain reduction, hospitalization days, hospitalization expenses, and fertility preservation. These preliminary findings warrant validation in larger, prospective, multi-center trials.</p>","PeriodicalId":520653,"journal":{"name":"International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group","volume":"43 1","pages":"2616375"},"PeriodicalIF":3.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}