Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie最新文献

{"title":"Minocycline treatment reduces the activation of mononuclear phagocytes and improves retinal function in a mouse model of Leber congenital amaurosis.","authors":"Ettel Bubis, Ifat Sher, Hadas Ketter-Katz, Estela Derzane, Florian Sennlaub, Ygal Rotenstreich","doi":"10.1007/s00417-025-06768-y","DOIUrl":"https://doi.org/10.1007/s00417-025-06768-y","url":null,"abstract":"<p><strong>Purpose: </strong>Leber congenital amaurosis (LCA) is a severe hereditary retinal degeneration characterized by early-onset vision loss. Here, we aimed to characterize the association between retinal mononuclear phagocyte (MP) activation and retinal degeneration in the RPE65/rd12 mouse model of LCA.</p><p><strong>Methods: </strong>Thirty-nine RPE65/rd12 and ten C57BL/6J wild-type mice were used. RPE65/rd12 mice were treated with minocycline by daily intraperitoneal injection (5 mg/kg) for eight weeks starting at age postnatal day 28 (P28). MP cell density in the subretina was determined by choroid-retinal pigment epithelium (RPE) flat mount analysis, and retinal function was determined by electroretinogram (ERG).</p><p><strong>Results: </strong>In wild-type C57BL/6J mice, MPs were exclusively located in the inner retinal layers at ages P28-P84. By contrast, in the RPE65/rd12 mice, MPs migrated into the subretina as early as P56 in a central-to-peripheral gradient. By P84, the density of MPs in the subretina increased by nearly 3-fold, reaching 61.3 ± 6.2 cell/mm² and 33.1 ± 8 cell/mm² in the central and peripheral retina, respectively. Minocycline treatment significantly reduced MP density in the peripheral subretina (16.2 ± 1.8 MP cell/mm²) compared with mice treated with PBS (27.2 ± 2.4 MP cell/mm², respectively, p = 0.006). Maximal electroretinogram b-wave responses were significantly higher in minocycline- vs. PBS-treated mice under light-adapted conditions following eight weeks of treatment (mean ± SE: 199µv ± 28µv vs. 129.8µv ± 9.8µv, p = 0.016).</p><p><strong>Conclusions: </strong>Our data indicates that MP migration into the subretina is associated with retinal degeneration in RPE65/rd12 mice. Inhibiting MP migration into the subretina was associated with improved retinal function. These findings may guide the development of therapies targeting MP activation for neuroprotection in LCA and potentially other retinoid cycle-related retinal degeneration blinding diseases.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting visual outcomes after vitrectomy based on baseline visual acuity and timing of surgery for myopic traction maculopathy (SCHISIS report No.3).","authors":"Masaki Suzue, Taku Wakabayashi, Kentaro Abe, Ryuya Hashimoto, Hisashi Fukuyama, Yuki Yamamoto, Keita Baba, Yuichiro Ishida, Kotaro Tsuboi, Ramesh Venkatesh, Jay Chhablani, Yasushi Ikuno, Bita Momenaei, Motohiro Kamei, Yoshihiro Yonekawa, Yusuke Oshima, Fumi Gomi, Takatoshi Maeno","doi":"10.1007/s00417-025-06865-y","DOIUrl":"https://doi.org/10.1007/s00417-025-06865-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate visual outcomes after vitrectomy based on preoperative visual acuity (VA) in eyes with myopic traction maculopathy (MTM) and explore the optimal timing for surgery.</p><p><strong>Method: </strong>Patients who underwent vitrectomy for MTM were categorized into four groups: preoperative vision of 20/25 or better (V1), worse than 20/25 to 20/50 (V2), 20/60 to 20/200 (V3), and worse than 20/200 (V4). The primary outcome was the postoperative VA at 12 months.</p><p><strong>Results: </strong>We included 193 eyes: V1 (12 eyes), V2 (77 eyes), V3 (83 eyes), and V4 (21 eyes). Postoperative VA significantly correlated with preoperative VA (R² = 0.400, P < 0.001). Postoperative logarithm of the minimum angle of resolution VA was the best in V1 and worst in V4 (V1, 0.10 ± 0.26; V2, 0.19 ± 0.26; V3, 0.54 ± 0.44; and V4, 0.92 ± 0.54; P < 0.001). Visual improvement was highest in V4 and lowest in V1 (V1, 0.04 ± 0.26; V2, -0.12 ± 0.25; V3, -0.18 ± 0.41; and V4, -0.36 ± 0.44; P = 0.001). At 12 months, 83.3% of eyes in V1 achieved a postoperative VA of 20/25 or better, 90.9% of eyes in V2 achieved 20/50 or better, and 88.0% of eyes in V3 achieved 20/200 or better. Overall, 11.4% of eyes experienced a visual deterioration of three lines or more.</p><p><strong>Conclusion: </strong>Vitrectomy generally maintains or improves vision in any group. Early surgery may help preserve good vision in eyes with good baseline vision and worsening symptoms; however, the risk of deterioration suggests it may not always be beneficial. Surgery at moderate visual impairment may offer a balanced benefit-risk ratio, avoiding surgery too early or too late.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the dots: the role of genetics in posterior vitreous detachment.","authors":"Rajya L Gurung, Stewart Lake, Shane Durkin, David Sia, Jagjit Gilhotra, Weng Onn Chan","doi":"10.1007/s00417-025-06869-8","DOIUrl":"https://doi.org/10.1007/s00417-025-06869-8","url":null,"abstract":"<p><p>The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of digital devices screen use on intraocular pressure: A systematic review and meta-analysis.","authors":"Ali Arman, Hadi Vahedi, Ali Jafarizadeh, Reza Moshfeghinia, Mohammadreza Talebnezhad, Mojtaba Heydari, Reza Razeghinejad","doi":"10.1007/s00417-025-06876-9","DOIUrl":"https://doi.org/10.1007/s00417-025-06876-9","url":null,"abstract":"<p><strong>Purpose: </strong>The widespread adoption of digital screens has raised concerns about potential impacts on ocular health, particularly intraocular pressure (IOP). This systematic review and meta-analysis aimed to examine the association between digital screen use and changes in IOP.</p><p><strong>Methods: </strong>We conducted a comprehensive search across multiple electronic databases through January 2024, and reported adhering to PRISMA guidelines. Eligible studies included clinical trials published in English, evaluating the effects of digital screen use on IOP. Statistical analyses were performed with Stata software, calculating the overall effect size using the weighted mean difference (WMD) of IOP changes among healthy and glaucomatous participants before, during (5, 15, 25, 30, 45, and 60 min), and after screen exposure.</p><p><strong>Results: </strong>Nine studies involving 675 eyes were included. Among healthy participants, IOP significantly increased at 25 min, with an increase of 1.53 mmHg [0.83, 2.24] (p = 0.00). Other time intervals (5, 15, 30, 45, and 60 min) showed no significant changes. Post-exposure, IOP returned to baseline levels without any significant change from baseline (p > 0.05). In glaucomatous individuals, IOP rose by 1.13 mmHg [0.46, 1.80] at 5 min (p < 0.001) and 2.49 mmHg [0.33, 4.65] at 25 min (p = 0.02), with no significant changes at other intervals.</p><p><strong>Conclusion: </strong>Screen exposure can lead to temporary IOP increases, especially in individuals with glaucoma. Larger, well-designed clinical trials are necessary to confirm these findings, understand underlying mechanisms, and identify risk factors. This study highlights the potential ocular health risks associated with prolonged screen use.</p><p><strong>Key messages: </strong>What is known Using digital screen has been associated with various ocular effects including eye strain, dry eye, and changes in Intra ocular pressure (IOP). Previous studies have suggested temporary IOP changes with digital screen use, however findings were inconsistent. What is new This systematic review and meta-analysis highlights that digital screen exposure leads to significant IOP increases at specific intervals, in both healthy and glaucomatous individuals. Glaucomatous participants experience more pronounced IOP elevations, emphasizing the need for tailored recommendations for this group. The study identifies potential mechanisms, including accommodation, postural influences, and blue light exposure, that contribute to these changes, underscoring the complexity of digital screen use's impact on ocular health.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular inflammation following intravitreal injections of anti-vascular endothelial growth factor drugs.","authors":"Ana Margarida Ferreira, António Ferrão Mendes, João Nuno Beato, Ana Catarina Pedrosa, Susana Penas, Sónia Torres-Costa, Cláudia Oliveira Ferreira, Carolina Maia, Manuel Falcão, Ângela Carneiro","doi":"10.1007/s00417-025-06875-w","DOIUrl":"https://doi.org/10.1007/s00417-025-06875-w","url":null,"abstract":"<p><strong>Purpose: </strong>To describe cases of infectious and non-infectious intraocular inflammation (NI-IOI) associated with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs in the largest tertiary center with the highest number of IVI in Portugal.</p><p><strong>Methods: </strong>Prospective observational study including all patients diagnosed with infectious endophthalmitis (IE) or NI-IOI after IVI of different anti-VEGF drugs in a total of 83,145 IVI between 2018 and 2023. The most frequent indications for treatment were macular neovascularization or macular edema from different etiologies.</p><p><strong>Results: </strong>Twenty-six eyes developed IE (mean incidence 0.031%) after IVI and 24 eyes were diagnosed with NI-IOI (mean incidence 0.028%), including anterior plus intermediate uveitis (n = 18), only vitritis (n = 4) and retinal vasculitis (n = 2). Regarding NI-IOI, eyes were under treatment with aflibercept (n = 12), bevacizumab (n = 11) and faricimab (n = 1). The most common initial presentation was a painless decrease in visual acuity (VA) at a mean of 8 days [1-20] after IVI in patients with NI-IOI versus red eye, pain and blurry vision, at a mean of 3 days [1-9] after IVI in the IE group. There was a significant improvement in VA between the NI-IOI diagnosis and final visits (35 ± 25 vs. 49 ± 24 ETDRS letters) in the NI-IOI group (p = 0.022), an improvement that occurred over a mean of almost 2 months. There were no significant differences between VA at the time of diagnosis and after treatment (25 ± 28 vs. 26 ± 25 ETDRS letters) in the IE group (p = 0.801).</p><p><strong>Conclusion: </strong>NI-IOI represents an emergent treatment-related adverse event, that can be reversible when adequately managed, contrasting with the sight-threatening severe cases of IE. We emphasize the importance of maintaining active surveillance in patients under intravitreal therapy.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of choriocapillaris perfusion between swept-source optical coherence tomography angiography and spectral-domain optical coherence tomography angiography in five different choriocapillaris slabs in patients with intermediate age-related macular degeneration.","authors":"Nuria Torrell-Belzach, Eric H Souied, Hoang Mai Le, Manal Benlahbib, Zoe Dobbels, Ambroisine Erasti Gounfle, Xavier X Wang, Camille Jung, Alexandra Miere","doi":"10.1007/s00417-025-06874-x","DOIUrl":"https://doi.org/10.1007/s00417-025-06874-x","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze choriocapillaris (CC) perfusion using swept-source optical coherence tomography angiography (SS-OCTA) and spectral-domain optical coherence tomography angiography (SD-OCTA) in five CC slabs in patients with intermediate age-related macular degeneration (iAMD).</p><p><strong>Methods: </strong>This is a cross-sectional study of 23 eyes of 20 patients who underwent three 3 × 3 mm OCTA, one with SS-OCTA and two with SD-OCTA, a non-averaged scan (V1) and a four-scan volume (V4). Percentage of flow deficits (FD%), average size of FD (µm2), total area of FD (mm2) and number of FD were calculated in different CC slabs (automatic, 11-21 μm, 21-31 μm, 31-41 μm, 16-31 μm).</p><p><strong>Results: </strong>There was a statistically significant difference in all parameters and all slabs analyzed, when comparing SS-OCTA versus SD-OCTA V1 and SD-OCTA V1 versus SD-OCTA V4. Nevertheless, when comparing SS-OCTA versus SD-OCTA V4, significant differences were only found for the automatic and the 31-41 μm slab. When comparing the FD% between different slabs on the same device, significant differences were also found.</p><p><strong>Conclusion: </strong>Quantification of CC FD% is impacted by the CC slab, the type of OCTA used, and volume averaging in SD-OCTA. Given the significant impact on quantitative results, comparisons between studies and instruments and/or with/without averaging are difficult, even at the same slab depth.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"STARGUS: a comparative study of a new swept-source biometer and B-mode ultrasound in dense cataracts.","authors":"Héloïse Torres-Villaros, Maté Streho, Didier Hoa, Audrey Giocanti-Aurégan","doi":"10.1007/s00417-025-06863-0","DOIUrl":"https://doi.org/10.1007/s00417-025-06863-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare a new swept-source biometer to the gold standard B-mode ultrasound biometer for measuring the axial length (AL) when standard optical biometers failed due to cataract density.</p><p><strong>Methods: </strong>Patients with advanced cataracts whose AL could not be measured using optical biometers available in our clinics, including the Lenstar LS-900 and IOLMaster 500 and 700, were included. The AL, anterior chamber depth (ACD), and lens thickness (LT) were measured using a new swept-source biometer (SSB) (Argos^®, Alcon) and B-mode ultrasound. The Enhanced Retinal Visualization (ERV) mode of the new SSB was used when the standard mode did not provide reliable AL measurements.</p><p><strong>Results: </strong>AL measurements failed in 183 eyes due to cataract density using available biometers. The new SSB allowed successfully measuring the AL in 89.6% of cases, and the ERV mode was needed in 15.8% of eyes. The ALs measured with the new SSB and B-mode ultrasound were comparable, with an excellent intraclass correlation coefficient (ICC) of 0.99. No significant differences in ACD measurements were observed between new SSB and ultrasound or conventional biometers, with ICC of 0.81 and 0.87, respectively. However, the LT tended to be thinner with the new SSB compared to ultrasound, suggesting a potential source of error, but no significant difference was observed with conventional biometers (ICC of 0.88).</p><p><strong>Conclusions: </strong>The new SSB Argos^®, in particular when the ERV mode is used, could be a reliable alternative to B-mode ultrasound for measuring AL in eyes with dense cataracts. It is as effective as ultrasound in measuring the AL, and it could help to improve cataract surgery planning and outcomes.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual and surgical outcomes of retinal detachment after Lens removal for ectopia lentis in pediatric patients with Marfan syndrome.","authors":"Costanza Barresi, Thibaut Chapron, Ismael Chehaibou, Florence Metge, Georges Caputo, Youssef Abdelmassih","doi":"10.1007/s00417-025-06871-0","DOIUrl":"https://doi.org/10.1007/s00417-025-06871-0","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate surgical and visual outcomes following retinal detachment (RD) repair after lensectomy in pediatric patients with Marfan syndrome.</p><p><strong>Methods: </strong>This retrospective cohort study included patients under 21 years of age with Marfan syndrome who RD following lensectomy for ectopia lentis between January 2011 and January 2024. All patients underwent a comprehensive ophthalmologic assessment at baseline, defined as the visit at which RD was diagnosed, as well as at follow-up visits. Data were collected on clinical features of RD, anatomical success rates, complications, and changes in visual outcomes after surgery.</p><p><strong>Results: </strong>A total of 33 eyes from 25 patients (18 males, 72%) with a mean age at presentation of 12.6 ± 4.7 years were included. The mean axial length was 27.8 ± 2.8 mm, and the mean postoperative follow-up duration was 6.1 ± 5.8 years. The most common RD mechanisms were horseshoe tears (33%), retinal holes (33%), and giant retinal tears (15%). Fifteen eyes underwent scleral buckle (SB) surgery as the initial procedure (45.5%), 10 underwent pars plana vitrectomy (PPV) alone (30.3%), and 8 underwent combined PPV and SB surgery (24.2%). Complete anatomical success was achieved in 73.0% (24 eyes) of cases: after one surgery in 16 eyes (67%), two surgeries in 6 eyes (25%), and three surgeries in 2 eyes (8%). An additional 12% (4 eyes) remained attached under silicone oil tamponade at final follow-up. Only the presence of proliferative vitreoretinopathy (PVR) was associated with a lower success rate (p = 0.001). Visual acuity significantly improved after surgery (1.7 ± 1.3 LogMAR vs. 0.8 ± 1.1; p < 0.001). Postoperative complications included ocular hypertension (27.3%), corneal edema (18.2%), and cystoid macular edema (9.1%).</p><p><strong>Conclusions: </strong>Surgical management of RD following lensectomy in pediatric patients with Marfan syndrome remains challenging but is indicated, as it can provide meaningful visual improvement and anatomical stabilization in a subset of cases. The presence of PVR affects both surgical outcomes and the number of surgeries required.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of autologous serum in corneal healing following metallic foreign body injuries.","authors":"Levent Doğan, Ömer Özer, Zeki Baysal, Özer Dursun","doi":"10.1007/s00417-025-06866-x","DOIUrl":"https://doi.org/10.1007/s00417-025-06866-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of topical autologous serum (AS) on corneal healing following metallic corneal foreign body (CFB) trauma.</p><p><strong>Method: </strong>Following the removal of CFBs with a 26-gauge needle, patients were randomly divided into two groups. Group 1 patients received topical moxifloxacin and preservative- free artificial tears, while Group 2 participants used these drops in addition to AS five times a day. Patients were followed until their corneal epithelial defects were closed. The baseline size of the epithelial defects was measured, and corneal densitometry measurements using Pentacam HR (Oculus, Wetzlar, Germany) were obtained before treatment. Epithelial healing rates and post-treatment corneal densitometric measurements were compared.</p><p><strong>Results: </strong>Group 1 comprised 41 male participants with a mean age of 36.1 ± 13.3 years, and Group 2 consisted of 42 male participants with a mean age of 34.9 ± 11.5 years. No statistically significant difference in age distribution was observed between the groups (p = 0.229). Complete epithelial closure occurred within 3.51 ± 1.03 days for Group 1 participants, whereas Group 2 participants achieved complete closure within 2.19 ± 1.10 days. A significantly faster rate of epithelial closure and a notably shorter duration were observed in Group 2 (p = 0.002 and p < 0.001, sincerely). Post-epithelial healing corneal densitometry measurements revealed significantly lower values in participants utilizing AS (p = 0.007).</p><p><strong>Conclusion: </strong>The use of AS accelerated corneal defect healing following metallic CFB removal and resulted in a greater reduction in corneal densitometry values compared with standard treatment with topical antibiotics and artificial tears.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allogeneic fresh frozen plasma eye drops for the treatment of ocular Graft-versus-Host disease: prospective open-label study.","authors":"Yoav Nahum, Noa Golomb, Ronit Goldman-Levi, Michael Mimouni, Eitan Livny, Mali Rubinstein, Irit Bahar, Liat Shargian, Pia Raanani, Vered Yahalom, Moshe Yeshurun","doi":"10.1007/s00417-025-06870-1","DOIUrl":"https://doi.org/10.1007/s00417-025-06870-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the safety and efficacy of allogeneic fresh frozen plasma drops for the treatment of chronic ocular graft-versus-host disease (oGVHD).</p><p><strong>Methods: </strong>In this prospective open-label institutional study, adult oGVHD patients were administered allogeneic fresh frozen 100% plasma (FFP) eye drops QID or more for 3 months, in addition to the patients' usual treatment. The drops were prepared using a closed sterile tubing system (COL© System, Biomed Device Srl., Italy). The main outcome measures included the Ocular Surface Disease Index (OSDI), corneal fluorescein staining National Eye Institute (NEI) scale, basal tear secretion test, and functional assessment of cancer therapy-bone marrow transplant (FACT-BMT) questionnaire.</p><p><strong>Results: </strong>This study included 25 patients (49 eyes). OSDI scores decreased from 53 ± 26 at baseline to 32 ± 22 after 1 month and 30 ± 23 after 3 months (P < 0.0001), and fluorescein staining NEI grade decreased from 7.04 ± 3.51 at baseline to 5.5 ± 3.1 after 1 month (P < 0.0001) and 5.3 + 3.1 after 3 months (baseline to 3 months, P < 0.0001; one month to 3 months, P = 0.64). Mean basal tear secretion was 4.65 ± 3.4 mm at baseline and 6.5 ± 4.7 mm after 3 months (P = 0.002). The FACT-BMT scores did not change significantly from baseline to 3 months (106.3 ± 22 vs. 112 ± 20, P = 0.08). A subset of eight patients who were using scleral or bandage contact lenses concurrently showed significant improvement, and four of them were managed without lenses during the study period. No significant adverse events were noted.</p><p><strong>Conclusion: </strong>Allogeneic FFP eye drops are safe and effective in the treatment of chronic oGVHD.</p><p><strong>Trial registration: </strong>The trial is listed from 10/2020 in the Israeli Ministry of Health Clinical Trials Registry (MOH_2021-09-30_010276).</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}