Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie最新文献

{"title":"Leveraging retrieval-augmented large language models for patient education in ophthalmology.","authors":"Karthik Reddy, Yannis M Paulus","doi":"10.1007/s00417-025-06877-8","DOIUrl":"https://doi.org/10.1007/s00417-025-06877-8","url":null,"abstract":"","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography angiography measurements in patients with HIV: a systematic review and meta-analysis.","authors":"Mohammad Reza Abdol Homayuni, Sepideh Poshtdar, Reza Sadeghi, Seyed Behnam Jazayeri, Helia Ashourizadeh, Nazanin Ebrahimiadib","doi":"10.1007/s00417-025-06860-3","DOIUrl":"https://doi.org/10.1007/s00417-025-06860-3","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the evidence for alterations of blood flow, vascular and perfusion densities in the macula, and peripapillary region in patients with Human Immunodeficiency Virus (HIV) based on changes of OCTA parameters.</p><p><strong>Methods: </strong>A systematic review of PubMed, Scopus, WOS, and Embase databases, including quality assessment of published studies, investigating the alterations of OCTA parameters in HIV patients was conducted. The outcomes of interest comprised changes of perfusion and Vascular Densities (VD) in Superficial and Deep capillary plexus (SCP and DCP), Foveal Avascular Zone (FAZ) area, and Retinal Nerve Fiber Layer (RNFL).</p><p><strong>Results: </strong>From the total of 322 articles obtained from the databases, the meta-analysis included six studies, including 270 patients with HIV and 275 healthy controls for SCP and DCP vascular densities, as well as 216 cases and 214 controls for RNFL thickness. The aggregated investigation revealed markedly lower foveal SCP (Hedge's g: -0.45; 95% CI [-0.86 to -0.04], p = 0.03) and DCP (Hedges' g: -0.31; 95% CI [-0.50 to -0.24], p < 0.001) vascular densities, as well as diminished temporal (Hedges' g: -0.97; 95% CI [-1.48 to -0.46], p < 0.001) and nasal parafoveal SCP (Hedges' g: -0.74; 95% CI [-1.14 to -0.35], p < 0.001) and DCP ( (Hedges' g: -0.40; 95% CI [-0.76 to -0.04], p = 0.03) and (Hedges' g: -0.29; 95% CI [-0.60 to 0.02], p = 0.07)) vascular densities in HIV-positive patients compared to healthy controls. No significant differences were observed in parafoveal nasal, superior, or inferior vascular densities at the DCP and SCP levels, nor in RNFL thickness between the two groups. The FAZ extent at SCP showed no significant changes in HIV-positive patients. The findings highlight retinal microvascular alterations in HIV patients, particularly in specific regions of the fovea and parafovea.</p><p><strong>Conclusion: </strong>In this systematic review and meta-analysis, our goal was to examine the changes in the retinal vasculature in HIV patients and assess how well OCTA, an advanced diagnostic technique, works to identify these alterations. Our findings suggest significant reductions in parameters such as foveal SCP and DCP VD, as well as temporal and nasal parafoveal SCP and DCP VD in HIV patients compared to healthy controls. While these changes offer valuable insights into HIV-associated retinal microvasculopathy, their utility as potential diagnostic biomarkers requires further validation.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of anterior chamber stability with a cohesive ophthalmic viscosurgical device versus the soft-shell technique.","authors":"Daniel M Handzel, Chiraz Ben Abdallah, Markus S Ladewig, Walter Sekundo","doi":"10.1007/s00417-025-06867-w","DOIUrl":"10.1007/s00417-025-06867-w","url":null,"abstract":"<p><strong>Purpose: </strong>To study the properties of different ophthalmic viscosurgical devices (OVD) in respect of their ability to create and maintain high intraocular pressure (IOP) during the creation of a continuous curvilinear capsulorhexis (CCC).</p><p><strong>Methods: </strong>In this randomized interventional study IOP was measured using rebound tonometry with sterilized probes immediately before the beginning of the CCC and immediately afterwards during cataract surgery. The study included 177 eyes in four groups using two different OVD - hyaluronic acid (HA) and a combination of HA and hydroxy propylmethylcellulosis (HPMC) according to the soft shell-technique (SST) - and two different instruments, Utrata forceps (UF) and 26 g cystotome (RN).</p><p><strong>Results: </strong>The drop in intraocular pressure (IOP) during capsulorhexis was measured at 57.0 ± 12.2 mmHg in eyes treated with HA (90) and 63.1 ± 13.4 mmHg in eyes treated with SS (87). The difference in IOP reduction between HA and SS did not reach statistical significance (p = 0.060).</p><p><strong>Conclusions: </strong>The use of different OVD did not result in a significant difference in IOP drop. As the soft shell-technique has shown superiority in respect of endothelial protection, these results should encourage cataract surgeon to resort to the soft shell-technique more often if not use it as a standard technique.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of minor fluorophores on the detection of macular atrophy using fundus autofluorescence in patients with pathologic myopia.","authors":"Cristina Novarese, Guglielmo Parisi, Michele Reibaldi, Enrico Borrelli","doi":"10.1007/s00417-025-06879-6","DOIUrl":"https://doi.org/10.1007/s00417-025-06879-6","url":null,"abstract":"","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minocycline treatment reduces the activation of mononuclear phagocytes and improves retinal function in a mouse model of Leber congenital amaurosis.","authors":"Ettel Bubis, Ifat Sher, Hadas Ketter-Katz, Estela Derzane, Florian Sennlaub, Ygal Rotenstreich","doi":"10.1007/s00417-025-06768-y","DOIUrl":"https://doi.org/10.1007/s00417-025-06768-y","url":null,"abstract":"<p><strong>Purpose: </strong>Leber congenital amaurosis (LCA) is a severe hereditary retinal degeneration characterized by early-onset vision loss. Here, we aimed to characterize the association between retinal mononuclear phagocyte (MP) activation and retinal degeneration in the RPE65/rd12 mouse model of LCA.</p><p><strong>Methods: </strong>Thirty-nine RPE65/rd12 and ten C57BL/6J wild-type mice were used. RPE65/rd12 mice were treated with minocycline by daily intraperitoneal injection (5 mg/kg) for eight weeks starting at age postnatal day 28 (P28). MP cell density in the subretina was determined by choroid-retinal pigment epithelium (RPE) flat mount analysis, and retinal function was determined by electroretinogram (ERG).</p><p><strong>Results: </strong>In wild-type C57BL/6J mice, MPs were exclusively located in the inner retinal layers at ages P28-P84. By contrast, in the RPE65/rd12 mice, MPs migrated into the subretina as early as P56 in a central-to-peripheral gradient. By P84, the density of MPs in the subretina increased by nearly 3-fold, reaching 61.3 ± 6.2 cell/mm² and 33.1 ± 8 cell/mm² in the central and peripheral retina, respectively. Minocycline treatment significantly reduced MP density in the peripheral subretina (16.2 ± 1.8 MP cell/mm²) compared with mice treated with PBS (27.2 ± 2.4 MP cell/mm², respectively, p = 0.006). Maximal electroretinogram b-wave responses were significantly higher in minocycline- vs. PBS-treated mice under light-adapted conditions following eight weeks of treatment (mean ± SE: 199µv ± 28µv vs. 129.8µv ± 9.8µv, p = 0.016).</p><p><strong>Conclusions: </strong>Our data indicates that MP migration into the subretina is associated with retinal degeneration in RPE65/rd12 mice. Inhibiting MP migration into the subretina was associated with improved retinal function. These findings may guide the development of therapies targeting MP activation for neuroprotection in LCA and potentially other retinoid cycle-related retinal degeneration blinding diseases.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting visual outcomes after vitrectomy based on baseline visual acuity and timing of surgery for myopic traction maculopathy (SCHISIS report No.3).","authors":"Masaki Suzue, Taku Wakabayashi, Kentaro Abe, Ryuya Hashimoto, Hisashi Fukuyama, Yuki Yamamoto, Keita Baba, Yuichiro Ishida, Kotaro Tsuboi, Ramesh Venkatesh, Jay Chhablani, Yasushi Ikuno, Bita Momenaei, Motohiro Kamei, Yoshihiro Yonekawa, Yusuke Oshima, Fumi Gomi, Takatoshi Maeno","doi":"10.1007/s00417-025-06865-y","DOIUrl":"https://doi.org/10.1007/s00417-025-06865-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate visual outcomes after vitrectomy based on preoperative visual acuity (VA) in eyes with myopic traction maculopathy (MTM) and explore the optimal timing for surgery.</p><p><strong>Method: </strong>Patients who underwent vitrectomy for MTM were categorized into four groups: preoperative vision of 20/25 or better (V1), worse than 20/25 to 20/50 (V2), 20/60 to 20/200 (V3), and worse than 20/200 (V4). The primary outcome was the postoperative VA at 12 months.</p><p><strong>Results: </strong>We included 193 eyes: V1 (12 eyes), V2 (77 eyes), V3 (83 eyes), and V4 (21 eyes). Postoperative VA significantly correlated with preoperative VA (R² = 0.400, P < 0.001). Postoperative logarithm of the minimum angle of resolution VA was the best in V1 and worst in V4 (V1, 0.10 ± 0.26; V2, 0.19 ± 0.26; V3, 0.54 ± 0.44; and V4, 0.92 ± 0.54; P < 0.001). Visual improvement was highest in V4 and lowest in V1 (V1, 0.04 ± 0.26; V2, -0.12 ± 0.25; V3, -0.18 ± 0.41; and V4, -0.36 ± 0.44; P = 0.001). At 12 months, 83.3% of eyes in V1 achieved a postoperative VA of 20/25 or better, 90.9% of eyes in V2 achieved 20/50 or better, and 88.0% of eyes in V3 achieved 20/200 or better. Overall, 11.4% of eyes experienced a visual deterioration of three lines or more.</p><p><strong>Conclusion: </strong>Vitrectomy generally maintains or improves vision in any group. Early surgery may help preserve good vision in eyes with good baseline vision and worsening symptoms; however, the risk of deterioration suggests it may not always be beneficial. Surgery at moderate visual impairment may offer a balanced benefit-risk ratio, avoiding surgery too early or too late.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connecting the dots: the role of genetics in posterior vitreous detachment.","authors":"Rajya L Gurung, Stewart Lake, Shane Durkin, David Sia, Jagjit Gilhotra, Weng Onn Chan","doi":"10.1007/s00417-025-06869-8","DOIUrl":"https://doi.org/10.1007/s00417-025-06869-8","url":null,"abstract":"<p><p>The vitreous is a transparent homogenous gel comprised predominantly of water. It is firmly attached to the internal limiting membrane in young healthy individuals. As part of the physiological aging process, the separation of the posterior vitreous cortex from the internal limiting membrane is called physiological posterior vitreous detachment (PVD), which usually occurs without ocular complications. On the contrary, anomalous PVD can have various sight-threatening complications. The cause of this difference is poorly understood and is a topic of future research. Further, newer evidence indicates that anomalous PVD may be genetically influenced.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of digital devices screen use on intraocular pressure: A systematic review and meta-analysis.","authors":"Ali Arman, Hadi Vahedi, Ali Jafarizadeh, Reza Moshfeghinia, Mohammadreza Talebnezhad, Mojtaba Heydari, Reza Razeghinejad","doi":"10.1007/s00417-025-06876-9","DOIUrl":"https://doi.org/10.1007/s00417-025-06876-9","url":null,"abstract":"<p><strong>Purpose: </strong>The widespread adoption of digital screens has raised concerns about potential impacts on ocular health, particularly intraocular pressure (IOP). This systematic review and meta-analysis aimed to examine the association between digital screen use and changes in IOP.</p><p><strong>Methods: </strong>We conducted a comprehensive search across multiple electronic databases through January 2024, and reported adhering to PRISMA guidelines. Eligible studies included clinical trials published in English, evaluating the effects of digital screen use on IOP. Statistical analyses were performed with Stata software, calculating the overall effect size using the weighted mean difference (WMD) of IOP changes among healthy and glaucomatous participants before, during (5, 15, 25, 30, 45, and 60 min), and after screen exposure.</p><p><strong>Results: </strong>Nine studies involving 675 eyes were included. Among healthy participants, IOP significantly increased at 25 min, with an increase of 1.53 mmHg [0.83, 2.24] (p = 0.00). Other time intervals (5, 15, 30, 45, and 60 min) showed no significant changes. Post-exposure, IOP returned to baseline levels without any significant change from baseline (p > 0.05). In glaucomatous individuals, IOP rose by 1.13 mmHg [0.46, 1.80] at 5 min (p < 0.001) and 2.49 mmHg [0.33, 4.65] at 25 min (p = 0.02), with no significant changes at other intervals.</p><p><strong>Conclusion: </strong>Screen exposure can lead to temporary IOP increases, especially in individuals with glaucoma. Larger, well-designed clinical trials are necessary to confirm these findings, understand underlying mechanisms, and identify risk factors. This study highlights the potential ocular health risks associated with prolonged screen use.</p><p><strong>Key messages: </strong>What is known Using digital screen has been associated with various ocular effects including eye strain, dry eye, and changes in Intra ocular pressure (IOP). Previous studies have suggested temporary IOP changes with digital screen use, however findings were inconsistent. What is new This systematic review and meta-analysis highlights that digital screen exposure leads to significant IOP increases at specific intervals, in both healthy and glaucomatous individuals. Glaucomatous participants experience more pronounced IOP elevations, emphasizing the need for tailored recommendations for this group. The study identifies potential mechanisms, including accommodation, postural influences, and blue light exposure, that contribute to these changes, underscoring the complexity of digital screen use's impact on ocular health.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular inflammation following intravitreal injections of anti-vascular endothelial growth factor drugs.","authors":"Ana Margarida Ferreira, António Ferrão Mendes, João Nuno Beato, Ana Catarina Pedrosa, Susana Penas, Sónia Torres-Costa, Cláudia Oliveira Ferreira, Carolina Maia, Manuel Falcão, Ângela Carneiro","doi":"10.1007/s00417-025-06875-w","DOIUrl":"https://doi.org/10.1007/s00417-025-06875-w","url":null,"abstract":"<p><strong>Purpose: </strong>To describe cases of infectious and non-infectious intraocular inflammation (NI-IOI) associated with intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) drugs in the largest tertiary center with the highest number of IVI in Portugal.</p><p><strong>Methods: </strong>Prospective observational study including all patients diagnosed with infectious endophthalmitis (IE) or NI-IOI after IVI of different anti-VEGF drugs in a total of 83,145 IVI between 2018 and 2023. The most frequent indications for treatment were macular neovascularization or macular edema from different etiologies.</p><p><strong>Results: </strong>Twenty-six eyes developed IE (mean incidence 0.031%) after IVI and 24 eyes were diagnosed with NI-IOI (mean incidence 0.028%), including anterior plus intermediate uveitis (n = 18), only vitritis (n = 4) and retinal vasculitis (n = 2). Regarding NI-IOI, eyes were under treatment with aflibercept (n = 12), bevacizumab (n = 11) and faricimab (n = 1). The most common initial presentation was a painless decrease in visual acuity (VA) at a mean of 8 days [1-20] after IVI in patients with NI-IOI versus red eye, pain and blurry vision, at a mean of 3 days [1-9] after IVI in the IE group. There was a significant improvement in VA between the NI-IOI diagnosis and final visits (35 ± 25 vs. 49 ± 24 ETDRS letters) in the NI-IOI group (p = 0.022), an improvement that occurred over a mean of almost 2 months. There were no significant differences between VA at the time of diagnosis and after treatment (25 ± 28 vs. 26 ± 25 ETDRS letters) in the IE group (p = 0.801).</p><p><strong>Conclusion: </strong>NI-IOI represents an emergent treatment-related adverse event, that can be reversible when adequately managed, contrasting with the sight-threatening severe cases of IE. We emphasize the importance of maintaining active surveillance in patients under intravitreal therapy.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of choriocapillaris perfusion between swept-source optical coherence tomography angiography and spectral-domain optical coherence tomography angiography in five different choriocapillaris slabs in patients with intermediate age-related macular degeneration.","authors":"Nuria Torrell-Belzach, Eric H Souied, Hoang Mai Le, Manal Benlahbib, Zoe Dobbels, Ambroisine Erasti Gounfle, Xavier X Wang, Camille Jung, Alexandra Miere","doi":"10.1007/s00417-025-06874-x","DOIUrl":"https://doi.org/10.1007/s00417-025-06874-x","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze choriocapillaris (CC) perfusion using swept-source optical coherence tomography angiography (SS-OCTA) and spectral-domain optical coherence tomography angiography (SD-OCTA) in five CC slabs in patients with intermediate age-related macular degeneration (iAMD).</p><p><strong>Methods: </strong>This is a cross-sectional study of 23 eyes of 20 patients who underwent three 3 × 3 mm OCTA, one with SS-OCTA and two with SD-OCTA, a non-averaged scan (V1) and a four-scan volume (V4). Percentage of flow deficits (FD%), average size of FD (µm2), total area of FD (mm2) and number of FD were calculated in different CC slabs (automatic, 11-21 μm, 21-31 μm, 31-41 μm, 16-31 μm).</p><p><strong>Results: </strong>There was a statistically significant difference in all parameters and all slabs analyzed, when comparing SS-OCTA versus SD-OCTA V1 and SD-OCTA V1 versus SD-OCTA V4. Nevertheless, when comparing SS-OCTA versus SD-OCTA V4, significant differences were only found for the automatic and the 31-41 μm slab. When comparing the FD% between different slabs on the same device, significant differences were also found.</p><p><strong>Conclusion: </strong>Quantification of CC FD% is impacted by the CC slab, the type of OCTA used, and volume averaging in SD-OCTA. Given the significant impact on quantitative results, comparisons between studies and instruments and/or with/without averaging are difficult, even at the same slab depth.</p>","PeriodicalId":520634,"journal":{"name":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}