Eye and vision (London, England)最新文献

{"title":"Validity of the French version of Catquest-9SF and use of an electronic notepad for entering patient-reported outcome measures.","authors":"Gregory Katz,&nbsp;Alexandra Rouquette,&nbsp;François Lignereux,&nbsp;Thierry Mourgues,&nbsp;Michel Weber,&nbsp;Mats Lundström","doi":"10.1186/s40662-021-00233-7","DOIUrl":"https://doi.org/10.1186/s40662-021-00233-7","url":null,"abstract":"<p><strong>Background: </strong>The Catquest-9SF questionnaire is a patient reported outcome measure that quantifies the visual benefits from cataract surgery. The purpose of this study was to translate and adapt the Catquest-9SF questionnaire for France, to assess its psychometric properties via Rasch analysis, and to assess its validity when completed using an electronic notepad.</p><p><strong>Methods: </strong>The Catquest-9SF questionnaire was translated following the guidelines of the International Society for Pharmacoeconomics and Outcomes Research. Catquest-9SF and clinical data were collected from patients before and after routine cataract surgery. All questionnaire data were collected via an electronic notepad. Rasch analysis was performed to assess psychometric properties, and sensitivity to change was analysed for patients with complete paired pre- and post-operative questionnaires.</p><p><strong>Results: </strong>A complete filled-in preoperative questionnaire was obtained for 848 patients. Rasch analysis showed good precision (person separation: 2.32, person reliability: 0.84), ordered category probability curves, no item misfit, and unidimensionality. The respondents were slightly more able than the level of item difficulty (targeting: -1.12 logits). Sensitivity was analysed on 211 paired questionnaires, and the postoperative questionnaires showed a clear ceiling effect. The effect size was 2.6. The use of an electronic notepad for completing the questionnaire worked out very well after some adjustments.</p><p><strong>Conclusions: </strong>The French version of Catquest-9SF has good psychometric properties and is suitable for use in French-speaking patients. The use of the Catquest-9SF questionnaire in an electronic format showed good validity.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"11"},"PeriodicalIF":4.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00233-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25550160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The number of intracorneal ring segments in asymmetric and central cones.","authors":"Canan Asli Utine,&nbsp;Denizcan Özizmirliler,&nbsp;Mustafa Kayabaşı,&nbsp;Üzeyir Günenç","doi":"10.1186/s40662-021-00234-6","DOIUrl":"https://doi.org/10.1186/s40662-021-00234-6","url":null,"abstract":"<p><strong>Background: </strong>To compare the results of single versus double intracorneal ring segment (ICRS) (KeraRing) implantation in keratoconus with respect to different cone locations.</p><p><strong>Methods: </strong>Twenty-two eyes of 18 patients with totally asymmetric cones (20-80% or 0-100% distribution along steep axis) were implanted with single ICRS (Group 1), 38 eyes of 32 patients with central or partially asymmetric cones (50-50% or 40-60% distribution along steep axis) were implanted with double ICRS (Group 2), at a depth of 80% of the site of implantation, in channels created with femtosecond laser device. All patients had uncorrected and corrected distance visual acuities (UDVA and CDVA, respectively) of ≤ 0.3 Snellen lines.</p><p><strong>Results: </strong>In both groups, patients had median UDVA and CDVA gain of 3 Snellen lines (P > 0.05). Postoperative improvement in indices of vertical asymmetry and height decentration in Group 1; simulated keratometry, corneal astigmatism and anterior corneal asphericity values in Group 2 were greater (P < 0.05). A total of 10 eyes (45.5%) in Group 1 were recommended double ring implantation by the manufacturer's nomogram, but underwent single ICRS implantation and achieved visual, refractive, tomographic outcomes comparable to that in Group 2, although corneal cylindrical correction was less and final topographic astigmatism was greater.</p><p><strong>Conclusion: </strong>Double ICRS implantation seems to be superior in terms of keratometry, corneal astigmatism and anterior corneal asphericity improvement. Single ICRS implantation in totally asymmetric cones seems to provide satisfactory visual, refractive and tomographic results, similar to double ICRS implantation in central and partially asymmetric cones, by inducing central shift of the cone.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"10"},"PeriodicalIF":4.2,"publicationDate":"2021-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00234-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25531248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unintended changes in ocular biometric parameters during a 6-month follow-up period after FS-LASIK and SMILE.","authors":"Junjie Wang,&nbsp;Bernardo T Lopes,&nbsp;Hechen Li,&nbsp;Riccardo Vinciguerra,&nbsp;Si Cao,&nbsp;Songan Wu,&nbsp;Rong Zhu,&nbsp;Qinmei Wang,&nbsp;Xiaobo Zheng,&nbsp;Fangjun Bao,&nbsp;Ahmed Elsheikh","doi":"10.1186/s40662-021-00232-8","DOIUrl":"https://doi.org/10.1186/s40662-021-00232-8","url":null,"abstract":"<p><strong>Background: </strong>Corneal refractive surgery has become reliable for correcting refractive errors, but it can induce unintended ocular changes that alter refractive outcomes. This study is to evaluate the unintended changes in ocular biometric parameters over a 6-month follow-up period after femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK) and small incision lenticule extraction (SMILE).</p><p><strong>Methods: </strong>156 consecutive myopic patients scheduled for FS-LASIK and SMILE were included in this study. Central corneal thickness (CCT), mean curvature of the corneal posterior surface (K_pm), internal anterior chamber depth (IACD) and the length from corneal endothelium to retina (ER) were evaluated before and after surgery over a 6-month period.</p><p><strong>Results: </strong>Both the FS-LASIK and SMILE groups (closely matched at the pre-surgery stage) experienced flatter K_pm, shallower IACD and decreased ER 1 week post-surgery (P < 0.01), and these changes were larger in FS-LASIK than in SMILE group. During the 1 week to 6 months follow up period, K_pm, IACD and ER remained stable unlike CCT which increased significantly (P < 0.05), more in the FS-LASIK group.</p><p><strong>Conclusions: </strong>During the follow up, the posterior corneal surface became flatter and shifted posteriorly, the anterior chamber depth and the length from the corneal endothelium to retina decreased significantly compared with the pre-surgery stage. These unintended changes in ocular biometric parameters were greater in patients undergoing FS-LASIK than SMILE. The changes present clear challenges for IOL power calculations and should be considered to avoid affecting the outcome of cataract surgery.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"9"},"PeriodicalIF":4.2,"publicationDate":"2021-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00232-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25507222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of corneal topographic and densitometric properties of Wilson's disease patients with or without a Kayser-Fleischer ring.","authors":"Mehmet Fuat Alakus,&nbsp;Mehtap Caglayan,&nbsp;Nazım Ekin,&nbsp;Hasan Oncul,&nbsp;Esref Arac,&nbsp;Umut Dag,&nbsp;Halit Diri","doi":"10.1186/s40662-021-00231-9","DOIUrl":"https://doi.org/10.1186/s40662-021-00231-9","url":null,"abstract":"<p><strong>Background: </strong>To investigate the topographic measurements and densitometry of corneas in Wilson's disease (WD) patients with or without a Kayser-Fleischer ring (KF-r) compared to healthy individuals.</p><p><strong>Methods: </strong>This cross-sectional study included 20 WD patients without a KF-r (group I), 18 WD patients with a KF-r (group II), and 20 age-matched controls (group III). The Pentacam high resolution imaging system is used to determine corneal topographic measurements and densitometry.</p><p><strong>Results: </strong>Mean age for groups I, II and III was 25.40 ± 6.43 years (14-36 years), 25.38 ± 6.96 years (16-39 years), 23.60 ± 6.56 years (17-35 years), respectively (P = 0.623). There was no significant difference between the groups in terms of the anterior corneal densitometry values (P > 0.05), while the 6-10 mm and 10-12 mm mid stroma and the 2-6 mm, 6-10 mm, and 10-12 mm posterior corneal densitometry values in group II were significantly higher than those in groups I and III (for all values, P <  0.05). However, the 10-12 mm posterior corneal densitometry values in group I were also significantly higher than those in group III (P = 0.038). The central corneal thickness (CCT), thinnest corneal thickness (tCT), and corneal volume (CV) values in groups I and II were significantly lower than those in group III (for CCT values, P = 0.011 and P = 0.009; for tCT values, P = 0.010 and P = 0.005; for CV values, P = 0.043 and P = 0.029).</p><p><strong>Conclusion: </strong>In WD patients with a KF-r, corneal transparency decreased in the peripheral posterior and mid stromal corneal layers; for these patients, corneal transparency may be impaired not only in the peripheral cornea but also in the paracentral cornea.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"8"},"PeriodicalIF":4.2,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00231-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25466205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cosmetic outcome of femtosecond laser-assisted pterygium surgery.","authors":"Darren Shu Jeng Ting,&nbsp;Yu-Chi Liu,&nbsp;Yi Fang Lee,&nbsp;Angel Jung Se Ji,&nbsp;Tien-En Tan,&nbsp;Hla M Htoon,&nbsp;Jodhbir S Mehta","doi":"10.1186/s40662-021-00230-w","DOIUrl":"https://doi.org/10.1186/s40662-021-00230-w","url":null,"abstract":"<p><strong>Background: </strong>To examine the cosmetic outcome of femtosecond laser-assisted pterygium surgery (FLAPS) with conjunctival autograft (CAG) and its potential predictive factors.</p><p><strong>Methods: </strong>This was a prospective interventional case series (NCT02866968). We included 29 patients (29 eyes) with primary pterygium who underwent FLAPS. Cosmetic outcome was graded by two graders (an ophthalmology resident and an experienced ophthalmologist) using Hirst classification system (1-4 = excellent-poor). Weighted Cohen's kappa analysis was performed to examine the intra- and inter-rater reliability. The relationship between cosmetic outcome and various factors were determined by Spearman's correlation coefficients (r).</p><p><strong>Results: </strong>The preoperative severity of pterygium (Tan grading system) was mild/atrophic (7%), moderate/intermediate (62%), and severe/fleshy (31%). An ultrathin CAG (mean thickness of 74.5 ± 9.8 μm) was fashioned intraoperatively. An excellent cosmetic outcome of FLAPS (median ± IQR) was observed at 3 months (1.0 ± 1.0) and remained similar at 6 months (1.0 ± 0.0) and 12 months (1.0 ± 0.0) postoperatively. At final follow-up, 27 (93%) patients achieved good-to-excellent cosmetic outcome, with 1 (3%) patient having a poor outcome due to incomplete pterygium removal. Weighted kappa analysis of Hirst grading system showed excellent intra-rater (κ = 0.86-0.95) and inter-rater reliability (κ = 0.84-0.88). There was a weak and borderline significant correlation between good cosmetic outcome and reduced postoperative CAG thickness (r = 0.38, P = 0.06) but not with age, gender, preoperative pterygium severity, or intraoperative CAG thickness.</p><p><strong>Conclusions: </strong>FLAPS can result in an excellent cosmetic outcome, which may be attributed to the beneficial effect of an ultrathin CAG.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov , NCT02866968 . Registered in July 2016.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"7"},"PeriodicalIF":4.2,"publicationDate":"2021-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00230-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25439220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strain heterogeneity, cooccurrence network, taxonomic composition and functional profile of the healthy ocular surface microbiome.","authors":"Yutong Kang,&nbsp;Shudan Lin,&nbsp;Xueli Ma,&nbsp;Yanlin Che,&nbsp;Yiju Chen,&nbsp;Tian Wan,&nbsp;Die Zhang,&nbsp;Jiao Shao,&nbsp;Jie Xu,&nbsp;Yi Xu,&nbsp;Yongliang Lou,&nbsp;Meiqin Zheng","doi":"10.1186/s40662-021-00228-4","DOIUrl":"https://doi.org/10.1186/s40662-021-00228-4","url":null,"abstract":"<p><strong>Background: </strong>There is growing evidence indicating that the microbial communities that dwell on the human ocular surface are crucially important for ocular surface health and disease. Little is known about interspecies interactions, functional profiles, and strain heterogeneity across individuals in healthy ocular surface microbiomes.</p><p><strong>Methods: </strong>To comprehensively characterize the strain heterogeneity, cooccurrence network, taxonomic composition and functional profile of the healthy ocular surface microbiome, we performed shotgun metagenomics sequencing on ocular surface mucosal membrane swabs of 17 healthy volunteers.</p><p><strong>Results: </strong>The healthy ocular surface microbiome was classified into 12 phyla, 70 genera, and 140 species. The number of species in each healthy ocular surface microbiome ranged from 6 to 47, indicating differences in microbial diversity among individuals. The species with high relative abundances and high positivity rates were Streptococcus pyogenes, Staphylococcus epidermidis, Propionibacterium acnes, Corynebacterium accolens, and Enhydrobacter aerosaccus. A correlation network analysis revealed a competitive interaction of Staphylococcus epidermidis with Streptococcus pyogenes in ocular surface microbial ecosystems. Staphylococcus epidermidis and Streptococcus pyogenes revealed phylogenetic diversity among different individuals. At the functional level, the pathways related to transcription were the most abundant. We also found that there were abundant lipid and amino acid metabolism pathways in the healthy ocular surface microbiome.</p><p><strong>Conclusion: </strong>This study explored the strain heterogeneity, cooccurrence network, taxonomic composition, and functional profile of the healthy ocular surface microbiome. These findings have important significance for the future development of probiotic-based eye therapeutic drugs.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"6"},"PeriodicalIF":4.2,"publicationDate":"2021-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40662-021-00228-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25396873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirius Scheimpflug-Placido versus ultrasound pachymetry for central corneal thickness: meta-analysis.","authors":"Yili Jin,&nbsp;Colm McAlinden,&nbsp;Yong Sun,&nbsp;Daizong Wen,&nbsp;Yiran Wang,&nbsp;Jinjin Yu,&nbsp;Ke Feng,&nbsp;Benhao Song,&nbsp;Qinmei Wang,&nbsp;Shihao Chen,&nbsp;Jinhai Huang","doi":"10.1186/s40662-021-00227-5","DOIUrl":"https://doi.org/10.1186/s40662-021-00227-5","url":null,"abstract":"<p><strong>Background: </strong>To compare the difference in central corneal thickness (CCT) measurements in normal eyes between a rotating Scheimpflug camera combined with a Placido-disk corneal topographer (Sirius, CSO, Italy) and ultrasound pachymetry (USP).</p><p><strong>Methods: </strong>A systematic literature search was conducted for relevant studies published on PubMed, Medline, EMBASE, and the Cochrane Library and ClinicalTrials.gov from inception to August 1st, 2019. Primary outcome measures were CCT measurements between Sirius and USP. A random effects model was used to pool CCT measurements.</p><p><strong>Results: </strong>A total of twelve studies involving 862 eyes were included in this meta-analysis. The meta-analysis found CCT measurements between Sirius and USP to be statistically significantly different (P < 0.0001). The mean difference between Sirius and USP was -11.26 μm with a 95% confidence interval (CI) (-16.92 μm, -5.60 μm). The heterogeneity was I² = 60% (P = 0.004).</p><p><strong>Conclusion: </strong>CCT measurements with the Sirius Scheimpflug-Placido topographer were statistically significantly lower than USP. However, it may be argued that the mean difference of 11.26 μm is not a clinically significant difference.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"5"},"PeriodicalIF":4.2,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7891160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25380491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of hypothermia on the biomechanical effect of epithelium-off corneal cross-linking.","authors":"Hormoz Abdshahzadeh,&nbsp;Reyhaneh Abrishamchi,&nbsp;Emilio A Torres-Netto,&nbsp;Sabine Kling,&nbsp;Nikki L Hafezi,&nbsp;Mark Hillen,&nbsp;Farhad Hafezi","doi":"10.1186/s40662-021-00229-3","DOIUrl":"https://doi.org/10.1186/s40662-021-00229-3","url":null,"abstract":"<p><strong>Background: </strong>The corneal cross-linking (CXL) photochemical reaction is essentially dependent on oxygen and hypothermia, which usually leads to higher dissolved oxygen levels in tissues, with potentially greater oxygen availability for treatment. Here, we evaluate whether a reduction of corneal temperature during CXL may increase oxygen availability and therefore enhance the CXL biomechanical stiffening effect in ex vivo porcine corneas.</p><p><strong>Methods: </strong>One hundred and twelve porcine corneas had their epithelium manually debrided before being soaked with 0.1% hypo-osmolaric riboflavin. These corneas were equally assigned to one of four groups. Groups 2 and 4 underwent accelerated epithelium-off CXL using 9 mW/cm² irradiance for 10 min, performed either in a cold room temperature (group 2, 4 °C) or at standard room temperature (group 4, 24 °C). Groups 1 and 3 served as non-cross-linked, temperature-matched controls. Using a stress-strain extensometer, the elastic moduli of 5-mm wide corneal strips were analyzed as an indicator of corneal stiffness.</p><p><strong>Results: </strong>Accelerated epithelium-off CXL led to significant increases in the elastic modulus between 1 and 5% of strain when compared to non-cross-linked controls (P < 0.05), both at 4 °C (1.40 ± 0.22 vs 1.23 ± 0.18 N/mm) and 24 °C (1.42 ± 0.15 vs 1.19 ± 0.11 N/mm). However, no significant difference was found between control groups (P = 0.846) or between groups in which CXL was performed at low or standard room temperature (P = 0.969).</p><p><strong>Conclusions: </strong>Although initial oxygen availability should be increased under hypothermic conditions, it does not appear to play a significant role in the biomechanical strengthening effect of epithelium-off CXL accelerated protocols in ex vivo porcine corneas.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"4"},"PeriodicalIF":4.2,"publicationDate":"2021-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7871403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25349523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of cytomegalovirus corneal endotheliitis.","authors":"Angela H Y Wong,&nbsp;Wee Nie Kua,&nbsp;Alvin L Young,&nbsp;Kelvin H Wan","doi":"10.1186/s40662-020-00226-y","DOIUrl":"https://doi.org/10.1186/s40662-020-00226-y","url":null,"abstract":"<p><strong>Background: </strong>Cytomegalovirus (CMV) can manifest as corneal endotheliitis in immunocompetent individuals. Early diagnosis is prudent to prevent endothelial cell loss, which could ultimately lead to corneal decompensation. CMV DNA was first detected in an eye with corneal endotheliitis in 2006; since then, clinical evidence from numerous case reports and case series have accumulated.</p><p><strong>Main text: </strong>In this narrative review, we identified several drugs, including ganciclovir, valganciclovir, and their combination in oral, intravenous, intravitreal, and topical forms in different concentrations, together with the judicious use of topical steroids, have reported variable success. There has yet to be any prospective comparative study evaluating the efficacy and safety of these assorted forms of treatment; clinical evidence is based on case reports and case series. CMV endotheliitis presenting with corneal edema can masquerade as other corneal diseases and thus poses a great challenge especially in post-keratoplasty eyes. Heightened awareness is needed before and after keratoplasty to start prompt prophylaxis and treatment.</p><p><strong>Conclusion: </strong>There is no consensus on the management of CMV endotheliitis. Further studies are much needed to elucidate the optimal treatment modality, regime, and duration in the treatment and prophylaxis of CMV endotheliitis.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"3"},"PeriodicalIF":4.2,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7807491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39152988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between corneal biomechanical parameters and corneal sublayer thickness measured by Corvis ST and UHR-OCT in keratoconus and normal eyes.","authors":"Yong Li,&nbsp;Zhiqiang Xu,&nbsp;Qiaoli Liu,&nbsp;Yuzhou Wang,&nbsp;Kan Lin,&nbsp;Jiahui Xia,&nbsp;Shihao Chen,&nbsp;Liang Hu","doi":"10.1186/s40662-020-00225-z","DOIUrl":"https://doi.org/10.1186/s40662-020-00225-z","url":null,"abstract":"<p><strong>Background: </strong>To explore the relationship between corneal biomechanical parameters and corneal sublayer thickness using corneal visualization Scheimpflug technology (Corvis ST) and ultrahigh-resolution optical coherence tomography (UHR-OCT) in clinical and suspected keratoconus and normal eyes.</p><p><strong>Methods: </strong>Cross-sectional prospective study. A total of 94 eyes of 70 participants were recruited. Twenty five eyes of 19 keratoconus patients, 52 eyes of 34 patients showing high risk of developing keratoconus according to the Belin/Ambrosio Enhanced Ectasia Display, and each eye of 17 normal subjects were enrolled. All participants underwent Corvis ST, Pentacam, and UHR-OCT examinations at the same time. Stiffness parameter A1 (SP-A1), deformation amplitude ratio (DA ratio), and other biomechanical parameters were recorded using Corvis ST. The vertical and horizontal thickness profiles of central 3 mm corneal epithelium, Bowman's layer, and stroma as measured by the perpendicular distance between the neighboring interfaces were generated using UHR-OCT. The flat keratometry and steep keratometry were obtained using Pentacam. Analysis of correlation was applied to explore the association between variables.</p><p><strong>Results: </strong>Most of the biomechanical parameters and corneal sublayer thickness profiles showed statistical differences among three groups. A statistically significant linear relationship was noted between SP-A1 and DA ratio in all three groups. SP-A1 was found to be positively correlated with epithelial and Bowman's layer thickness in the keratoconus (KC) group, and with stromal thickness in all three groups. In the normal and suspected keratoconus (SKC) groups, only stromal thickness was included in the stepwise linear regression to predict SP-A1, whereas in the KC group, steep keratometry and Bowman's layer thickness were included.</p><p><strong>Conclusions: </strong>Significant and different correlations were noted between corneal stiffness and corneal sublayer thickness in different groups, indicating that corneal sublayers may play different roles in maintaining corneal biomechanical stability between keratoconus and normal eyes.</p>","PeriodicalId":520624,"journal":{"name":"Eye and vision (London, England)","volume":" ","pages":"2"},"PeriodicalIF":4.2,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38799693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}