European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

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The role of the window-damping test in preoperative decision-making for semicircular canal dehiscence syndrome. 窗阻尼试验在半规管破裂综合征术前决策中的作用。
IF 2.2
Jing Zou, Hongbin Li
{"title":"The role of the window-damping test in preoperative decision-making for semicircular canal dehiscence syndrome.","authors":"Jing Zou, Hongbin Li","doi":"10.1007/s00405-025-09607-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09607-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the utility of a novel window-damping test (WDT), which involves a simple intratympanic injection of fibrin to dampen the movement of the round window membrane and stapedial footplate, in predicting surgical outcomes for round window reinforcement (RWR) in patients with superior semicircular canal dehiscence syndrome (SSCDS).</p><p><strong>Materials and methods: </strong>This retrospective cohort study included 8 patients with clinically suspected SSCDS. Patients underwent pure-tone audiometry, tympanometry, vestibular-evoked myogenic potential (VEMP) testing, and high-resolution CT scans with multiplanar reconstruction. The WDT involved sequential intratympanic injection of fibrin sealant components into the posterior middle ear cavity to simulate RWR, which was achieved by damping the movement of the round window membrane and stapedial footplate. RWR surgery was performed to alleviate symptoms, and symptom changes were compared between WDT and RWR.</p><p><strong>Results: </strong>Although signs of a 'third mobile window' were not universally observed in diagnostic tests, WDT yielded positive results in all patients. The test effectively simulated the biomechanical effects of RWR, demonstrating even greater efficacy than surgery in most cases.</p><p><strong>Conclusions: </strong>The novel WDT is a safe, cost-effective, and valuable preoperative tool for predicting surgical outcomes of RWR in SSCDS.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic sudden sensineural hearing loss: demographic data and treatment in ENT practices in Germany (2014-2023). 特发性突发性感音性听力损失:德国耳鼻喉科的人口统计数据和治疗(2014-2023)。
IF 2.2
David Ulrich Seidel, Simon Bode, Karel Kostev
{"title":"Idiopathic sudden sensineural hearing loss: demographic data and treatment in ENT practices in Germany (2014-2023).","authors":"David Ulrich Seidel, Simon Bode, Karel Kostev","doi":"10.1007/s00405-025-09681-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09681-6","url":null,"abstract":"<p><strong>Objective: </strong>Idiopathic sudden sensorineural hearing loss (ISSNHL) is an acute condition characterized by sudden, usually unilateral hearing loss. This study examines the demographic characteristics and treatment of ISSNHL patients in German ENT practices in the period from 2014 to 2023.</p><p><strong>Methods: </strong>The retrospective analysis is based on data from the IQVIA™ Disease Analyzer database. Patients with a diagnosis of ISSNHL (ICD-10: H91.2) were analyzed with regard to age, sex, patients per practice and the therapies used, including oral corticosteroids, injectable corticosteroids, Ginkgo biloba, pentoxifylline and betahistine.</p><p><strong>Results: </strong>Data were collected on 96,824 patients from 72 ENT practices. The mean percentage of female patients was 56.1%. The mean age remained constant at around 51 years. On average, between 123 and 141 patients with ISSNHL were treated per year per practice. The proportion of patients receiving treatment on the day of diagnosis increased from 41.3% in 2014 to 45.3% in 2023. The majority of patients received oral corticosteroids, the use of which has increased over the years, especially during the COVID-19 pandemic. The use of injectable corticosteroids, ginkgo biloba and betahistine remained stable, while the use of pentoxifylline decreased significantly.</p><p><strong>Conclusions: </strong>The results show a stable demographic distribution and an increasing preference for oral corticosteroids in the treatment of ISSNHL. The decrease in the use of pentoxifylline likely reflects contemporaneous changes in guideline recommendations. These findings highlight an increasing need for evidence-based therapies for ISSNHL in clinical practice.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145067624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The benefit and effectiveness of biodegradable drug-coated stents in treating refractory pediatric laryngotracheal stenosis. 可生物降解药物涂层支架治疗难治性小儿喉气管狭窄的益处和有效性。
IF 2.2
Zhibo Xie, Jiarui Chen, Yangyang Zheng, Xiaoyan Li
{"title":"The benefit and effectiveness of biodegradable drug-coated stents in treating refractory pediatric laryngotracheal stenosis.","authors":"Zhibo Xie, Jiarui Chen, Yangyang Zheng, Xiaoyan Li","doi":"10.1007/s00405-025-09654-9","DOIUrl":"https://doi.org/10.1007/s00405-025-09654-9","url":null,"abstract":"<p><strong>Objectives: </strong>Laryngotracheal stenosis (LTS) is one of the most common causes of pediatric airway obstruction. Patients with LTS who receive multiple treatments but still fail to achieve decannulation are defined as having refractory LTS. Treatments for these patients are especially complicated and unsatisfactory. Biodegradable drug-coated stents (BDCSs) have the advantages of providing stable airway support, not requiring a second operation for removal, and preventing restenosis via the slow-release of a coated drug. We aimed to explore the role of BDCSs in treating refractory LTS.</p><p><strong>Method: </strong>This study enrolled patients with refractory LTS who had undergone previous unsuccessful treatments between 2017 and 2023. Patients were divided into two groups on the basis of whether they received BDCS treatment (BDCS group, n = 30; non-BDCS group, n = 59). Success was defined as achieving decannulation.</p><p><strong>Results: </strong>Among the 89 patients with refractory LTS, 66 patients (74.1%) eventually achieved decannulation. The decannulation rate was significantly greater in the BDCS group (P = 0.020). In patients who achieved decannulation, BDCSs significantly reduced the overall duration (P = 0.044) and total number of interventions (P = 0.029). We observed that 12 patients showed improvement in stenosis within one month after the postoperative follow-up, and those with a BDCS had a greater improvement rate (P = 0.047).</p><p><strong>Conclusion: </strong>BDCSs could be a promising option for patients with severe refractory LTS.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arytenoid prolapse following open airway reconstruction in adults: factors, incidence, and development of a novel grading system. 成人开放气道重建后的杓状体脱垂:因素、发生率和一种新的分级系统的发展。
IF 2.2
Abdullah Sindi, Dana Obaid, Nasser Almutairi, Waleed Alshareef, Khaled Alhussinan, Roqaih Aldueb, Ahmed Alammar
{"title":"Arytenoid prolapse following open airway reconstruction in adults: factors, incidence, and development of a novel grading system.","authors":"Abdullah Sindi, Dana Obaid, Nasser Almutairi, Waleed Alshareef, Khaled Alhussinan, Roqaih Aldueb, Ahmed Alammar","doi":"10.1007/s00405-025-09641-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09641-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to study the correlation and incidence between arytenoid prolapse after open airway surgeries and its risk factors, and to classify the degree of arytenoid prolapse in the adult population.</p><p><strong>Methods: </strong>From 2015 to 2020, we reviewed the charts of adult patients aged > 16 years who had undergone open airway surgeries at our facilities. We excluded patients with pre-existing arytenoid prolapse, limited postoperative endoscopic documentation, or loss to follow-up.</p><p><strong>Results: </strong>The study included 23 patients; most of whom were 40 years (73.91%) and males (65.57%). Subglottic stenosis (SGS) Grade 3 (47.8%) was the most common grade prior to our intervention. No significant association was observed between the degree of SGS, comorbidity, presence of tracheostomized status, operation type (cricotracheal resection or laryngotracheal reconstruction), and the presence of arytenoid prolapse. Patients with bilateral vocal cord immobility were more likely to have arytenoid prolapse compared to those with normal vocal fold mobility (P = 0.045).</p><p><strong>Conclusion: </strong>In adults, open airway surgeries did not correlate with arytenoid prolapse unless the patients had an immobile vocal cord. This may be due to the altered position of the arytenoid cartilage in cases of vocal fold immobility. Moreover, paralysis of the posterior cricoarytenoid muscles can lead to arytenoid apices prolapse anteromedially.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of Sublingual immunotherapy for allergic rhinitis: an overview of systematic reviews and meta analyses. 舌下免疫治疗变应性鼻炎的疗效和安全性:系统综述和荟萃分析。
IF 2.2
Zhuang Wang, Na Wang, Xue Liang, Lina Wei, Yongfu Song, Dongze Li, Yongji Wang
{"title":"Efficacy and safety of Sublingual immunotherapy for allergic rhinitis: an overview of systematic reviews and meta analyses.","authors":"Zhuang Wang, Na Wang, Xue Liang, Lina Wei, Yongfu Song, Dongze Li, Yongji Wang","doi":"10.1007/s00405-025-09664-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09664-7","url":null,"abstract":"<p><strong>Introduction: </strong>Reappraisal of Systematic reviews/Meta analyses on Sublingual Immunotherapy for Allergic Rhinitis: Evidence for Clinical Practice and Decision-Making.</p><p><strong>Methods: </strong>A comprehensive computerized search was conducted across PubMed, Embase, the Cochrane Library, Web of Science, CNKI, VIP, WANFANG, and CBM databases from their inception to June 8, 2025, to systematically identify Systematic reviews and Meta analyses on Sublingual Immunotherapy for allergic rhinitis. A citation overlap matrix was constructed to calculate the corrected covered area, assessing the degree of primary study overlap. The risk of bias, methodological quality, reporting quality, and certainty of evidence in the included Systematic reviews/Meta analyses were evaluated using ROBIS, AMSTAR-2, PRISMA 2020, and GRADE tools, respectively. Both quantitative and qualitative analyses were performed on the primary outcomes to derive a more comprehensive and in-depth understanding.</p><p><strong>Results: </strong>A total of 20 Systematic reviews/Meta analyses were included in this umbrella review. The corrected covered area of 6.391% derived from the citation matrix analysis indicated a modest degree of primary study overlap among the included literature. Risk of bias assessment demonstrated that all incorporated studies exhibited low bias risk. Methodological quality evaluation revealed 2 high-quality, 3 moderate-quality, 14 low-quality, and 1 extremely low-quality study. Reporting quality assessment yielded scores ranging from 22 to 41.5, with 7 studies classified as high-quality, 11 as moderate-quality, and 2 as low-quality reports. The evidence quality assessment revealed that among all evaluated outcomes, 7 were rated as high quality, 19 as moderate quality, 31 as low quality, and 14 as extremely low quality according to the GRADE framework.</p><p><strong>Discussion: </strong>Current evidence demonstrates that Sublingual Immunotherapy exhibits favorable efficacy in improving symptom scores and medication use for allergic rhinitis, with generally acceptable safety profiles despite mild adverse reactions in some cases. Future research should focus on large-scale, real-world studies with diverse outcome measures, investigating variations in regional populations, allergen types, dosage regimens, and treatment durations to further optimize clinical application protocols for Sublingual Immunotherapy.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing retractophilia and retractophobia, and an appreciation of the silent "victims" of retracted papers. 介绍撤稿癖和撤稿恐惧症,以及对撤稿沉默的“受害者”的欣赏。
IF 2.2
Jaime A Teixeira da Silva
{"title":"Introducing retractophilia and retractophobia, and an appreciation of the silent \"victims\" of retracted papers.","authors":"Jaime A Teixeira da Silva","doi":"10.1007/s00405-025-09665-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09665-6","url":null,"abstract":"<p><p>The pressure placed on all stakeholders in academic publishing by post-publication peer review (PPPR), coupled with ethics and structural reforms taking place in journals, are leading to a rise in retractions. It is thus expected that the agents of PPPR (e.g., sleuths) will collide with their targets (e.g., authors, editors, publishers). Those collisions with the status quo and challenges to the published literature may result in conflicts between stakeholders. In the context of PPPR, the outcome of conflict resolution is often the retraction of publications. In this paper, the terms retractophilia and retractophobia are introduced to represent the desire to ensure that retractions occur or the fear that a retraction takes place, respectively. Citations tend to be incremental, so they serve as indirect forms of rewards in a citation-based culture that then feeds bibliometric indicators such as the H-index. Even though a paper is retracted, the citations in its reference list remain standing, i.e., the recipients of a citation, namely the authors of papers that appear in the reference list of a retracted paper, do not suffer an equivalent \"loss\" of a citation, so their H-index is unaffected. Since a negative effect is neither felt nor observed, the recipients of citations, i.e., the authors of papers that appear in the reference lists of retracted papers, are rewarded a citation, but from an \"undesirable\" (i.e., retracted) publication. There are currently no corrective measures in place to formally deal with this situation. However, as more austere measures are put into place to curb \"unfair\" citation practices, metrics, like the H-index, may begin to subtract citations that appear in retracted literature, making those whose work was cited \"silent\" victims. Academics must pay closer attention to the growing culture of retractions, and appreciate its impact on them, their work environment, and careers.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145042915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bi-layered microflap surgery for the treatment of anterior glottic web. 双层显微皮瓣治疗声门前蹼。
IF 2.2
Wei-Chen Hung, Feng-Chuan Lin, Chi-Te Wang
{"title":"Bi-layered microflap surgery for the treatment of anterior glottic web.","authors":"Wei-Chen Hung, Feng-Chuan Lin, Chi-Te Wang","doi":"10.1007/s00405-025-09648-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09648-7","url":null,"abstract":"<p><strong>Introduction: </strong>Anterior glottic webs are epithelium-covered fibrous tissue formations at the anterior commissure, leading to synechiae between the bilateral vocal folds. They manifest with symptoms ranging from hoarseness to airway obstruction. However, treating anterior glottic webs are challenging due to their high recurrence rates. In this study, we report our treatment outcomes using the bi-layered microflap surgery.</p><p><strong>Methods: </strong>This retrospective case series analyzed nine patients with anterior glottic webs from a tertiary medical center. All patients underwent the bi-layered microflap technique for the treatment of anterior glottic webs under the setting as microlaryngeal surgery. The primary treatment outcome was the web length ratio (relative to vocal fold length), while secondary outcomes included the Voice Handicap Index-10 (VHI-10), smoothed Cepstral Peak Prominence (CPPs), and GRB scores.</p><p><strong>Results: </strong>The nine patients comprised five men and four women aged 32 to 71 years, with a mean of 48.6 years. The average web length ratio decreased from 56.9 ± 20.0% to 35.2 ± 13.7%. VHI-10 scores improved from 31.9 ± 7.5 to 16.8 ± 10.1. CPPs increased from 6.4 ± 3.1 to 8.4 ± 3.1, and GRB scores (summation) decreased from 5.4 ± 1.0 to 3.7 ± 1.8 (p < 0.05, Wilcoxon signed-ranks test).</p><p><strong>Conclusion: </strong>The bi-layered microflap technique is an effective method for managing anterior glottic webs. This single-stage, stent-free endoscopic procedure results in a statistically significant decrease in web length ratio, VHI-10, CPPs, and GRB scores.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor "Clinical characteristics and outcomes of positional obstructive sleep apnea: the sleep heart health study". 致编辑的信“体位性阻塞性睡眠呼吸暂停的临床特征和结果:睡眠心脏健康研究”。
IF 2.2
Bao-Rui Lin, Guan-Jiang Huang, Biao-Qing Lu
{"title":"Letter to the editor \"Clinical characteristics and outcomes of positional obstructive sleep apnea: the sleep heart health study\".","authors":"Bao-Rui Lin, Guan-Jiang Huang, Biao-Qing Lu","doi":"10.1007/s00405-025-09594-4","DOIUrl":"https://doi.org/10.1007/s00405-025-09594-4","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply letter: comment on "Treatment package time (TPT) and surgery to post-operative radiotherapy (S-PORT) interval in head and neck cancers: A systematic review and meta-analysis". 复函:关于“头颈部癌症的治疗包时间(TPT)和手术至术后放疗(S-PORT)间隔:系统回顾和荟萃分析”的评论。
IF 2.2
Mario Sanchez-Canteli, Juana M García-Pedrero, Juan P Rodrigo
{"title":"Reply letter: comment on \"Treatment package time (TPT) and surgery to post-operative radiotherapy (S-PORT) interval in head and neck cancers: A systematic review and meta-analysis\".","authors":"Mario Sanchez-Canteli, Juana M García-Pedrero, Juan P Rodrigo","doi":"10.1007/s00405-025-09634-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09634-z","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical heterogeneity and prognostic markers in head and neck Kimura disease: A retrospective study. 头颈部木村病的临床异质性和预后指标:一项回顾性研究
IF 2.2
Yifan Yang, Xue Zhang, Qi Zhong, Yang Zhang, Hongzhi Ma, Lizhen Hou, Shizhi He, Qian Shi, Ru Wang, Jugao Fang, Ling Feng
{"title":"Clinical heterogeneity and prognostic markers in head and neck Kimura disease: A retrospective study.","authors":"Yifan Yang, Xue Zhang, Qi Zhong, Yang Zhang, Hongzhi Ma, Lizhen Hou, Shizhi He, Qian Shi, Ru Wang, Jugao Fang, Ling Feng","doi":"10.1007/s00405-025-09680-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09680-7","url":null,"abstract":"<p><strong>Objective: </strong>Kimura disease (KD) is a rare, chronic inflammatory disorder that is typically located in the head and neck region. It is characterized by subcutaneous nodules, eosinophilia, and elevated IgE levels. Its unclear etiology and similarities to malignancies create diagnostic and therapeutic challenges. The purpose of this study is to share our treatment experience and explore prognostic factors associated with KD.</p><p><strong>Methods: </strong>We collected data on KD patients treated at our hospital between June 2013 and May 2024. The data included the patients' demographics, clinical and laboratory profiles, radiological and pathological findings, treatments, and outcomes. Non-normal variables are presented as medians with ranges, and categorical variables are shown as frequencies. We performed statistical comparisons using Mann-Whitney U tests.</p><p><strong>Results: </strong>This study analyzed 13 KD patients (median age 44 years, male-to-female ratio 9:4). All patients present with had head and neck lesions. 75.0% showed elevated peripheral eosinophilia, 77.8% had increased blood eosinophilia percentages, and all tested patients had elevated IgE levels. Treatments included surgical excision, glucocorticoids, methotrexate, low-dose radiotherapy, and observation. Remission was achieved in 76.9% of patients. Patients with poor outcomes had significantly higher absolute eosinophil counts (median: 1.77 vs. 0.90 × 10⁹/L, p = 0.04) and percentages (median: 21.4% vs. 12.2%, p = 0.03) than those with favorable outcomes. Imaging misdiagnosis occurred in 38.5% of patients, highlighting the superiority of histopathology for diagnosis. Urine abnormalities, mild renal dysfunction, and uncommon lesion sites were also observed.</p><p><strong>Conclusion: </strong>The clinical heterogeneity of KD requires multidisciplinary management. Pre-treatment eosinophilia is emerging as a prognostic marker. Future studies should prioritize the identification of biomarkers, kinetic surveillance, and targeted biologics in order to reduce recurrence and systemic complications.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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