European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Dutch translation and validation of the Visual Vertigo Analogue Scale (VVAS).","authors":"Marie Reynders, Wilfried Cools, Kelsey Van Den Houte, Elke Lichtert, Ina Foulon","doi":"10.1007/s00405-025-09455-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09455-0","url":null,"abstract":"<p><strong>Background: </strong>Visual vertigo (VV) is dizziness triggered by visually complex environments and is common in vestibular disorders such as Persistent Postural Perceptual Dizziness (PPPD). The Visual Vertigo Analogue Scale (VVAS) is a validated tool for assessing VV severity, but no Dutch version is currently available.</p><p><strong>Objective: </strong>This study involved translating the original English version of the VVAS into Dutch, followed by adaptation and validation to ensure reliability and consistency with the source version.</p><p><strong>Methods: </strong>The VVAS was translated using forward-backward translation. The final version was tested in 104 participants (PPPD patients and healthy controls). Internal consistency (Cronbach's alpha), test-retest reliability (Intraclass Correlation Coefficient), and construct validity (factor analysis and regression modeling) were assessed.</p><p><strong>Results: </strong>The Dutch VVAS showed high internal consistency (Cronbach's alpha = 0.93), comparable to the original version. Test-retest reliability was adequate (ICC = 0.67). VVAS scores were significantly higher in PPPD patients compared to healthy controls (p < 0.001), controlling for age and gender.</p><p><strong>Conclusion: </strong>The Dutch VVAS is a reliable and valid tool for assessing VV in Dutch-speaking populations, making it suitable for clinical and research applications.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of EAONO/JOS and ChOLE Classifications in Cholesteatoma in Terms of Intraoperative Findings and Postoperative Results.","authors":"Esra Aydin Sudabatmaz, Mehmet Akif Abakay, Filiz Gulustan, Zahide Mine Yazici","doi":"10.1007/s00405-025-09423-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09423-8","url":null,"abstract":"<p><strong>Purpose: </strong>In recent years, various classifications have been proposed for cholesteatoma staging, including the European Academy of Otology and Neurotology and the Japanese Society of Otology (EAONO/JOS) system and the ChOLE system. The objective of our study is to compare these two staging systems in terms of surgical technique, intraoperative findings, postoperative results, and recidivism.</p><p><strong>Methods: </strong>Patients aged 18 and above who underwent surgery at our hospital for chronic otitis media with histopathologically confirmed cholesteatoma between January 2016 and January 2021 were included in the study. The cholesteatoma stage was retrospectively determined using the EAONO/JOS and ChOLE systems. Surgical techniques, intraoperative findings, presence of recidivism within one year, pre- and postoperative air and bone conduction thresholds (ACT and BCT) and air-bone gap (ABG) were examined.</p><p><strong>Results: </strong>As the ChOLE stage increases, the frequency of each of the intraoperative findings (facial canal dehiscence, LSSK fistula, tegmen defect, external auditory canal erosion) increases. As the EAONO/JOS stage increases, only the incidence of facial canal dehiscence and external auditory canal erosion increases. As the EAONO/JOS stage increases, ACT and BCT and ABG increase. As the ChOLE stage increases, ACT and BCT values increase. Additionally, as the stage increased in both systems, CWD techniques were performed more frequently in surgery.</p><p><strong>Conclusion: </strong>According to our study, ChOLE is more correlated with intraoperative findings and EAONO/JOS is more correlated with audiological results. Although there is no correlation between these stagings and recidivism, both staging systems are related to surgical technique.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BDNF as a biomarker for evaluating clinical response in allergic rhinitis patients undergoing allergen-specific immunotherapy.","authors":"Hongping Zhang, Yiran Zang, Xu Li, Hongyang Zhang, Xiaoxue Zi, Peng Jin, Lili Zhi","doi":"10.1007/s00405-025-09498-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09498-3","url":null,"abstract":"<p><strong>Objective: </strong>The present study aimed to compare the correlation between serum brain-derived neurotrophic factor (BDNF) level and clinical, immunological parameters in patients receiving allergen-specific subcutaneous immunotherapy (SCIT) for 3 years duration.</p><p><strong>Methods: </strong>Comparing serum BDNF levels in AR patients and healthy controls, the correlation between serum BDNF level and clinical parameters in AR patients was analyzed further. Immunological parameters, including total IgE, d1 sIgE and d2 sIgE, serum BDNF levels, and the clinical parameters were evaluated at the 4-time points that including before immunotherapy, the end of the 1st, 2nd, and 3rd year during the SCIT treatment for AR patients who received immunotherapy.</p><p><strong>Results: </strong>We found a significantly elevated expression level of serum BDNF levels in AR patients and it also showed a significant correlation with nasal symptom score that included itching score, nasal obstruction score, runny nose, total nasal symptom score, and peripheral parameters including eosinophil percent and eosinophil count. For AR patients who received immunotherapy, a good response was shown, the expression of serum BDNF levels showed a downward trend during 3 years of SCIT, and it significantly positively correlated with the improvement of nasal symptoms including nasal obstruction, nasal itching, and medicine score.</p><p><strong>Conclusion: </strong>Serum BDNF level was associated with clinical severity in AR patients and clinical parameters in AR patients in SCIT duration, which should be considered as a response evaluation biomarker to monitor clinical efficacy in allergen-specific immunotherapy.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of metastasis in lymph nodes posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma.","authors":"Huan-Rong Cao, Wen-Jin Lin, You-Jia Lin, Yu Chen, Rong-Xi Liang","doi":"10.1007/s00405-025-09503-9","DOIUrl":"https://doi.org/10.1007/s00405-025-09503-9","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to determine the risk factors associated with lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) metastasis in patients with papillary thyroid carcinoma (PTC).</p><p><strong>Method: </strong>A total of 1381 patients diagnosed with PTC who underwent right or total thyroidectomy were included in this retrospective study. The relationship between clinicopathological variables and metastasis to lymph nodes posterior to the right recurrent laryngeal nerve was evaluated using both univariate and multivariate analyses.</p><p><strong>Results: </strong>Right-sided Central Lymph Node (CLN) positivity was detected in 42.8% (591/1381) of patients.The metastasis rates for LN-arRLN and LN-prRLN were 36.5% (504/1381) and 17.89% (247/1381), respectively. Simultaneous metastasis to both LN-arRLN and LN-prRLN was present in 11.59% (160/1381) of patients. Furthermore, among patients without LN-arRLN metastasis, the metastasis rate for LN-prRLN was 9.8% (87/887). Factors associated with an increased risk of LN-arRLN metastasis include gender, age, maximum tumor diameter, microcalcification, thyroid capsule invasion, prelaryngeal lymph node metastasis, pretracheal lymph node metastasis, and lateral neck lymph node metastasis. Furthermore, maximum tumor diameter, proximity to the posterior medial capsule, prelaryngeal lymph node metastasis, LN-arRLN metastasis, left central lymph node metastasis, and lateral neck lymph node metastasis were identified as independent predictors of LN-prRLN metastasis(P<0.001).</p><p><strong>Conclusion: </strong>In conclusion, LN-prRLN metastasis is relatively common in patients with PTC. For those undergoing central lymph node dissection (CLND), LN-prRLN dissection should be considered when high-risk features are present, including maximum tumor diameter > 1 cm, proximity to the posterior medial capsule, prelaryngeal lymph node metastasis, LN-arRLN metastasis, left central lymph node metastasis, and lateral neck lymph node metastasis.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining swallowing parameters of the Yale Swallow Protocol in healthy individuals: Establishing Normative Data.","authors":"Angela Van Sickle, Ed M Bice, Abdul Awal, Debra Suiter","doi":"10.1007/s00405-025-09483-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09483-w","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, the Yale Swallow Protocol overidentifies prandial aspiration. The current investigation aimed to establish normative data for the number of swallows, average volume per swallow, time to complete, and integrated surface electromyography signal (area under the curve) for the consumption of 3 oz (90 mL) of water.</p><p><strong>Methods: </strong>Participants were divided into three groups: younger adults (n = 65, = 22.8 years), middle-aged adults (n = 62, = 53.2 years), and older adults (n = 65, = 81.5 years). Participants consumed 3 oz (90 mL) of water while connected to a surface electromyography device. Descriptive statistics and the main effects of age were computed.</p><p><strong>Results: </strong>Data for the number of swallows, average volume per swallow, time to complete, and integrated surface electromyography signal (area under the curve) were reported. For the 3-oz (90 mL) task, the number of swallows consistently increased as age increased. Younger and middle-aged adults consumed 3 oz of water with a statistically significant fewer number of swallows when compared to older adults (younger p = 0.008 and middle-aged p = 0.017). Although it did not reach statistical significance, younger adults swallowed fewer times than middle-aged adults (p = 0.822). The average volume per swallow decreased as age increased. Although younger and middle-aged adults consumed similar average volumes per swallow, younger adults swallowed a statistically significant greater average amount per swallow than older adults (p = 0.001) as did middle-aged adults (p = 0.001). The time to complete increased as age increased. Although there were no statistically significant differences between younger and middle-aged adults, older adults took significantly more time to consume 3 oz of water than middle-aged adults (p = 0.004) and younger adults (p = 0.001). The middle-aged adults had the smallest, and younger adults had the largest area under the curve. There were significant differences between younger and middle-aged adults (p = 0.004) and middle-aged and older adults (p = 0.043).</p><p><strong>Conclusion: </strong>The study provided normative data for number of swallows, average volume per swallow, time to complete, and integrated surface electromyography signal or area under the curve while consuming 3 oz (90 mL) of water. Data from the current study provides a foundation for future research to examine the sensitivity and specificity of the YSP using additional parameters.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of metformin on hypoxia-associated gene expression in oral cavity squamous cell carcinoma in non-diabetic patients - a prospective window of opportunity study.","authors":"Simon A Mueller, Olgun Elicin, Bastien Monney, Tilman Rau, Alan Dal Pra, Ludwig Sachs, Irene Centeno Ramos, Erik Vassella, Florian Dammann, Francesca Caparrotti, Andreas Limacher, Lluís Nisa, Matthias S Dettmer, Roland Giger","doi":"10.1007/s00405-025-09493-8","DOIUrl":"https://doi.org/10.1007/s00405-025-09493-8","url":null,"abstract":"<p><strong>Purpose: </strong>Research suggests that metformin may reduce tumor hypoxia, rendering it a potential radiosensitizer. This study investigated metformin's effect on hypoxia-associated gene expression in oral cavity squamous cell carcinoma (OCSCC).</p><p><strong>Methods: </strong>In this prospective trial, non-diabetic patients with OCSCC scheduled for curative surgery received preoperative metformin for 10 to 14 days. Tumor biopsies were taken before and after metformin treatment. Gene expression profiling was performed using RNASeq, emphasizing on hypoxia-associated signaling pathways.</p><p><strong>Results: </strong>Fifteen patients of 25 enrolled patients completed the study protocol and passed quality checks. No significant difference in gene expression was observed after adjustment for multiple testing. No significant changes were found in the hypoxia-associated hypoxia-inducible factor 1- alpha (HIF1A) pathway or in other signaling pathways associated with metformin reported in the literature.</p><p><strong>Conclusion: </strong>This study does not support the hypothesis that metformin improves tumor hypoxia in OCSCC after 10 to 14 days of treatment.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of matrix metalloproteinase expression levels in the pathogenesis of tympanosclerosis.","authors":"Semih Van, Doğukan Özdemir, Seda Koç Şahin, Şule Öztürk, Dursun Mehmet Mehel, Ayşe Çeçen","doi":"10.1007/s00405-025-09509-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09509-3","url":null,"abstract":"<p><strong>Purpose: </strong>Tympanosclerosis is a disease characterized by the accumulation of hyaline calcareous deposits in the tympanic membrane, tympanic cavity, ossicular chain, ligaments, and rarely, in the mastoid. Matrix metalloproteinases, which are involved in physiological and pathologic processes, are also likely to play a role in tympanosclerosis. In our study, we aimed to investigate the presence of MMP 2 and 9 in patients with chronic otitis media with tympanosclerosis and its possible effect on tympanosclerosis severity and prognosis.</p><p><strong>Methods: </strong>In our study, 45 patients with myringosclerosis or myringosclerosis and intratympanic sclerosis who underwent endoscopic transcanal tympanoplasty due to COM (chronic otitis media) were included in the study group, and 35 patients with only COM, without tympanosclerosis, were included in the control group. Immunohistochemical staining of the mucosa samples of the eardrum and middle ear were compared with MMP-2 and MMP-9 in the study and control groups.</p><p><strong>Results: </strong>The rate of MMP-2 staining (64.3%) was higher than the control group (42.9%), and the rate of MMP-9 staining (16.7%) was lower than the control group (51.4%) (p < 0.05). The rate of MMP-9 staining in the middle ear mucosa samples (31.0%) was statistically lower than the control group (57.1%) (p < 0.05).</p><p><strong>Conclusion: </strong>In our study, high levels of MMP-2 staining in the study group and low levels of MMP-9 staining in the control group help to elucidate the complex relationship between both metalloproteinases. Compared with the inadequacy of animal models of tympanosclerosis to mimic the chronic process, our study reveals the late results of MMP-2 and MMP-9 in patients with tympanosclerosis.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep endoscopy in obstructive sleep apnea: analysis of pharyngeal collapse patterns and correlation with body mass index.","authors":"Dalila Mota Schudt, Marcia Jacomelli, Victor Arthur Ohannesian, Marcelo Gervilla Gregório, Addy Lidvina Mejia Palomino, Altair da Silva Costa","doi":"10.1007/s00405-025-09499-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09499-2","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluated the impact of Body Mass Index (BMI) on upper airway obstruction severity in Obstructive Sleep Apnea (OSA) patients using sleep endoscopy.</p><p><strong>Method: </strong>Retrospective analysis of OSA patients undergoing propofol-sedated sleep endoscopy. Obstruction patterns were classified using the VOTE protocol, analyzing collapse location, type, and severity. Patients were grouped by BMI: normal, overweight, and obese. The influence of age and gender was also analyzed.</p><p><strong>Results: </strong>210 patients (72.9% male, mean age 45.1 ± 11.1 years, mean BMI 27.06 ± 3.91) were analyzed. The velopharynx was the most frequently affected site (74.8%), followed by the tongue base (60%), epiglottis (55%), and oropharynx (40.5%). Anteroposterior collapse predominated at the tongue base (91.4%), while lateral collapse was most common in the oropharynx (68.1%). Obese patients had significantly higher rates of complete obstruction in the velopharynx (p = 0.023), oropharynx (p < 0.001), and multilevel obstruction (p = 0.049). Significant gender differences were observed in VOTE classification, with males exhibiting more circumferential, lateral, and multilevel collapses. Females had more anteroposterior collapse in the velopharynx and epiglottis. Complete obstruction was more prevalent in patients aged ≥ 45 years, particularly at the tongue base (p = 0.007).</p><p><strong>Conclusion: </strong>The velopharynx was the primary obstruction site in OSA patients. BMI, gender, and age significantly influenced airway collapse patterns, with obese patients demonstrating increased multilevel and complete obstruction. These findings support sleep endoscopy for personalized OSA management.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does obstructive sleep apnoea surgery improve perceived insomnia severity in patients suffering from co-morbid insomnia and sleep apnoea (COMISA)?","authors":"Mohamed S Rashwan, Aranee Thirukketheesparan, Katherine Haworth, Asma Awad, Aaron Trinidade, Amro Hassaan","doi":"10.1007/s00405-025-09495-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09495-6","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of obstructive sleep apnoea (OSA) surgery on insomnia in patients with co-morbid insomnia and sleep apnoea (COMISA).</p><p><strong>Methods: </strong>A retrospective interventional study was conducted on fifty consecutive adult patients with OSA who underwent surgery for OSA. Outcome measures included the Insomnia Severity Index (ISI) and the following polysomnography (PSG) indices: apnoea-hypopnea index (AHI), oxygen saturation index (ODI), lowest oxygen saturation (LOS) and Epworth Sleepiness Score (ESS) before treatment and at 4 months post-operatively.</p><p><strong>Results: </strong>In our study, 36% of the patients had clinical insomnia (ISI score > 15) prior to surgery. Following OSA surgery, there was an average improvement in the total ISI scores from 19.82 to 5.65 (p < 0.05). One patient continued to have moderate to severe clinical insomnia. Overall OSA parameters following surgery showed AHI decreased from 33.38 ± 23.76 to 18.37 ± 22.94 (p < 0.05); ODI reduced from 30.85 ± 22.37 to 16.77 ± 21.73 (p < 0.05); LOS significantly increased from 74.42 ± 11.93 to 87.70 ± 7.59 (p < 0.05); ESS showed significant reduction from 10 ± 5.9 to 6.55 ± 5.18 (p < 0.05).</p><p><strong>Conclusion: </strong>Our results showed a reduction in the insomnia scores of our COMISA subgroup and a significant post-operative improvement in ambulatory polysomograph variables. OSA and insomnia are strongly correlated and surgical treatment of OSA appears to be effective in reducing the insomnia burden in COMISA patients.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting surgical intervention in paediatric cervical abscesses using machine learning: a comparative analysis.","authors":"Ryota Koshu, Masao Noda, Haruna Nakamoto, Takahiro Fukuhara, Makoto Ito","doi":"10.1007/s00405-025-09505-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09505-7","url":null,"abstract":"<p><strong>Background: </strong>Paediatric cervical abscesses necessitate careful assessment to determine appropriate treatment strategies. Some patients require surgical intervention, although conservative management is effective. However, the criteria for the surgical indications remain unclear. Machine learning models have demonstrated promise in improving diagnostic accuracy across different medical fields.</p><p><strong>Objective: </strong>This study aimed to assess the use of machine learning models in predicting the requirement for surgical intervention in paediatric cervical abscesses and compare their performance with that of traditional logistic regression.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 55 paediatric patients diagnosed with cervical abscesses between 2010 and 2024. The patient demographics, clinical findings, laboratory data, and imaging characteristics were examined. Six predictive models were developed: logistic regression, Random Forest, Lasso regression, Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine. Model performance was evaluated using the area under the curve (AUC), accuracy, precision, recall, and F1-score. Feature importance was examined to identify the main predictive factors.</p><p><strong>Results: </strong>Among all the factors, abscess size was the most significant predictor of surgical intervention. Machine-learning models, especially XGBoost, outperformed logistic regression, achieving the highest AUC, accuracy, and recall. Inflammatory markers, including neutrophil-to-lymphocyte ratio and neutrophil count, also substantially contributed to the prediction accuracy.</p><p><strong>Conclusion: </strong>Machine learning models, particularly XGBoost, provide superior predictive performance compared with logistic regression, providing a valuable tool for optimising treatment decisions in paediatric cervical abscesses. These models improve clinical decision-making by integrating multiple factors, decreasing unnecessary surgeries, and enhancing patient outcomes.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}