European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Reappraising the TNM staging system for oral cavity squamous cell carcinoma.","authors":"Xiao-Xue Lin, Guan-Jiang Huang, Biao-Qing Lu","doi":"10.1007/s00405-025-09488-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09488-5","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ultra-high frequency ultrasound (UHF-US) in the study of early stages of squamous cell carcinoma of the tongue.","authors":"Gabriele Monarchi, Margherita Gobbo, Luca Guarda Nardini","doi":"10.1007/s00405-025-09484-9","DOIUrl":"https://doi.org/10.1007/s00405-025-09484-9","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the prognostic value of ultra-high frequency ultrasonography (UHF-US) in assessing the depth of invasion (DOI) in early-stage tongue squamous cell carcinoma (OSCC). Given the limitations of traditional imaging techniques such as magnetic resonance (MRI) and computed tomography (CT), UHF-US offers a high-resolution alternative for preoperative DOI estimation.</p><p><strong>Results: </strong>UHF-US demonstrated in literature a high level of accuracy in preoperative DOI measurement, offering improved precision over MRI and CT. The study findings reinforce the clinical importance of DOI as a predictor of nodal metastasis risk and patient outcomes. UHF-US exhibited strong sensitivity and specificity, supporting its role as a valuable tool in guiding surgical decisions.</p><p><strong>Conclusion: </strong>The study confirms the prognostic significance of DOI in early-stage tongue OSCC and highlights UHF-US as a highly accurate imaging modality for preoperative DOI assessment. UHF-US could play a crucial role in surgical decision-making and patient selection for elective neck dissection. Further research will be needed to validate these findings and explore their practical application in the management of as many oral malignant lesions as possible.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of 11 staging classifications in carcinoma of the external auditory canal.","authors":"Aniwat Berpan","doi":"10.1007/s00405-025-09489-4","DOIUrl":"https://doi.org/10.1007/s00405-025-09489-4","url":null,"abstract":"<p><strong>Background and purpose: </strong>To compare overall survival (OS) differences across 11 different staging classifications.</p><p><strong>Materials and methods: </strong>Patient data were retrospectively collected. OS curves were estimated by Kaplan-Meier method. Hazard ratios (HR) were calculated by Cox regression. Concordance between HR of each system was evaluated by C-index. Absolute net reclassification improvement (NRI) was performed.</p><p><strong>Results: </strong>Thirty-five patients fitted study criteria with median follow-up of 27.3 months. 80% were diagnosed with squamous cell carcinoma. 14.3% had ECOG > 1. Eighteen patients underwent surgery, while 31 patients received radiotherapy. For AJCC 8th edition cutaneous carcinoma of the head and neck, 3-year OS of stage 1-3 and 4 was 26.7% (median OS of 0.8 years) and 64.1% (median OS of 4.3 years) (HR 0.33; 95%CI 0.09-1.2). 3-year OS of T1-3 and T4 in modified Pittsburgh classification were 65% and 55.4% with median OS of not reached and 3.1 years (HR 1.86; 95%CI 0.66-5.23). Regarding Kinney system, patients with stage 1-2 and 3 had 3-year OS of 67.1% and 45.5%, while median OS was 4.7 years and 1 year (HR 1.94; 95%CI 0.75-4.97). C-indices were 0.577, 0.523 and 0.569. NRI comparing Kinney with modified Pittsburgh classifications was 2.86%.</p><p><strong>Conclusion: </strong>Kinney's may offer improved prognostic accuracy compared to other classifications.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Feasibility of improving vocal fold pathology image classification with synthetic images generated by DDPM-based GenAI: a pilot study\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1007/s00405-025-09496-5","DOIUrl":"https://doi.org/10.1007/s00405-025-09496-5","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of camrelizumab plus apatinib in treating recurrent/metastatic nasopharyngeal carcinoma: a single-arm meta-analysis.","authors":"Yanmei Li, Yongfu Liang, Peichang Ye, Guoan Chen, Yimin Zhang, Meixia Chen, Wenhua Xiong, Xiuhao Yang, Xiaowen Zhang","doi":"10.1007/s00405-025-09482-x","DOIUrl":"https://doi.org/10.1007/s00405-025-09482-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of camrelizumab combined with apatinib in the treatment of recurrent/metastatic nasopharyngeal carcinoma (RM-NPC) and provide a basis for clinical application.</p><p><strong>Methods: </strong>PubMed, Cochrane Library, Embase, and Web of Science databases were searched until July 19, 2024 for relevant studies. Data extraction and risk of bias assessment were conducted. Meta-analysis was performed using R software.</p><p><strong>Results: </strong>Four single-arm trials with a total of 205 patients were included, with an overall survival rate of 78%, a progression-free survival rate of 45%, an objective response rate of 60%, and a disease control rate of 76%. Common adverse reactions were anemia (45%), leukopenia (46%), and fatigue (53%). The incidence of grade 3 or above adverse reactions was less than 10%, except for hypertension (16%).</p><p><strong>Conclusion: </strong>Camrelizumab combined with apatinib showed favorable efficacy and safety in the treatment of RM-NPC, providing an important reference for clinical treatment strategies.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IgG4-related disease involving distinctive areas of skull base: our experience.","authors":"Sharmistha Chakravarty, Kritika Bhardwaj","doi":"10.1007/s00405-025-09479-6","DOIUrl":"https://doi.org/10.1007/s00405-025-09479-6","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin G4-related disease (IgG4-RD) is a rare, systemic fibro-inflammatory condition characterized by lymphoplasmacytic infiltration with IgG4-positive plasma cells, storiform fibrosis, and elevated serum IgG4 levels. It can affect multiple organ systems, often mimicking malignancies or infections. Skull base involvement in IgG4-RD is uncommon and presents diagnostic and therapeutic challenges. We present three topographically distinct areas of skull base involvement patterns in IgG4-RD.</p><p><strong>Case presentation: </strong>This case series describes three patients with IgG4-RD affecting distinct skull base regions. The first case involves a 57-year-old female presenting with chief complaint of headache, sudden deterioration of vision in the right eye over the past two months, with ptosis and saddle nose deformity. Imaging revealed a heterogeneous multiloculated cystic lesion in intraconal compartment of right orbital apex with polypoidal mucosal thickening in ethmoid and sphenoid sinus. Biopsy done from posterior ethmoid and sphenoid mass confirmed IgG4-RD. The patient improved with corticosteroid therapy. The second case is a 50-year-old male with right-sided ear pain, decreased hearing, hoarseness of voice and facial nerve palsy for 3 months. Imaging showed a heterogeneous, enhancing soft tissue lesion involving right parotid, carotid, masticator, parapharyngeal and pharyngeal mucosal space with few lytic lesions involving petrous part of right temporal bone with adjacent sclerosis. Biopsy from nasopharynx confirmed IgG4-RD and corticosteroid therapy led to clinical improvement. Our third case is a 60-year-old male with IgG4-RD Oof nasopharynx, nasal obstruction and discharge for 3 months. Imaging revealed an ill defined soft tissue thickening in nasopharynx, bilateral Fossa of Rosenmuller and disease spreading to clivus. Biopsy from nasopharynx confirmed the diagnosis and patient started on oral corticosteroids, initially improved but the disease progressed, leading to multiorgan failure and death.</p><p><strong>Conclusion: </strong>These cases highlight the diverse clinical presentations and outcomes of IgG4-RD involving the skull base. Early diagnosis through histopathology and initiation of corticosteroid therapy is critical for improving outcomes. However, refractory cases may require immunosupressive therapies.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking remission in CRSwNP: The olfaction paradox.","authors":"Diego Marcelo Conti, Eduardo Javier Correa","doi":"10.1007/s00405-025-09472-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09472-z","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phoneme discrimination and localization performance in children with cochlear implants and contralateral auditory brainstem implants with inner ear malformations.","authors":"Erva Degirmenci Uzun, Merve Ozbal Batuk, Gonca Sennaroglu, Levent Sennaroglu","doi":"10.1007/s00405-025-09474-x","DOIUrl":"https://doi.org/10.1007/s00405-025-09474-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study compares unilateral and bilateral phoneme discrimination (PD) and azimuth localization abilities in children with severe inner ear malformations and cochlear nerve deficiencies who use a cochlear implant (CI) and a contralateral auditory brainstem implant (ABI).</p><p><strong>Methods: </strong>A total of 17 children between the ages of 7 and 18 years with CI and contralateral ABI were included in the study. PD and localization tests were evaluated in three conditions: CI only, ABI only, and bilateral. All subjects completed a self-report Hearing-Related Quality of Life (HRQoL) scale.</p><p><strong>Results: </strong>Statistical analysis revealed that PD scores were significantly higher in the bilateral condition than in the ABI condition alone (p = 0.003). However, no significant differences were found between the CI and ABI or between the CI and bilateral conditions. Similarly, no statistically significant differences in localization performance were found between the three conditions (p > 0.05). Regression analysis identified HRQoL as a significant predictor of bilateral PD (p < 0.05), while ABI localization was a significant predictor of bilateral localization (p < 0.05). Additionally, bilateral PD was found to be a significant predictor of HRQoL (p = 0.001).</p><p><strong>Conclusion: </strong>While the performance of CI alone and bilateral PD is similar, there is a significant difference between the performance of ABI alone and bilateral PD. Therefore, in cases with an ABI, bilateral stimulation should be maintained by continued use of a CI in the contralateral ear, even in the presence of severe inner ear malformation and/or cochlear nerve deficiencies. In the long term, comparable levels of PD discrimination and localization performance can be achieved by using two different modalities.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and classification of posterior semicircular canal dehiscence in HRCTs of the petrous part of the temporal bone : High-resolution computed tomography of posterior semicircular canal dehiscence in combination with conductive or sensorineural hearing loss.","authors":"Sandra Schmidt, Daniel Overhoff, Christian von Falck, Marc Brockmann, Christoph Matthias, Stephan Waldeck","doi":"10.1007/s00405-025-09439-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09439-0","url":null,"abstract":"<p><strong>Background and purpose: </strong>The complex anatomy of the petrous part of the temporal bone (or petrous temporal bone) is difficult to understand and constitutes a challenge in the daily diagnostic routine even for experienced neuroradiologists. High-resolution computed tomography (HRCT) is an integral part of equipment-based diagnostics of the rare entity of posterior semicircular canal dehiscence (PSCD). PSCD is characterised by an absence of the bony cover of the posterior semicircular canal in the petrous temporal bone. The aim of this study is to verify the prevalence of PSCD in a group of patients with residual hearing. Furthermore, it is our intention to clarify which location types of dehiscence are possible and which reconstructions are necessary correspondingly.</p><p><strong>Study design and setting: </strong>We evaluated 1370 scans of the petrous part of the temporal bone of patients with residual hearing which were conducted at the participating hospitals of Koblenz, Mainz and Hanover between 2008 and 2016. We verified 37 cases of posterior semicircular canal dehiscence (PSCD). We conducted a sub-group analysis of these 37 HRCT scans including age group correlation and introduced a classification of PSCD.</p><p><strong>Results: </strong>In 2.7% of the individuals (n = 37), PSCD was detected on at least one side. Furthermore, it was shown that the prevalence of PSCD increases relative to age.</p><p><strong>Conclusion: </strong>In total, PSCD was detected in 2.7% of the individuals. Posterior dehiscence can be divided into an external and an internal location type. This distinction is crucial for the surgical procedure.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auricular cartilage flap for device salvage in revision cochlear implant surgery.","authors":"Emirhan Ceviken, Serdal Celik, Merve Torun Topcu, Mahmut Tayyar Kalcioglu","doi":"10.1007/s00405-025-09491-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09491-w","url":null,"abstract":"<p><p>Although the number of cochlear implant surgeries performed to restore hearing in people with hearing loss is increasing with the expansion of indications, the likelihood of complications and revision surgeries is decreasing proportionally as surgical techniques and device technology have evolved over the years. In this case, a cartilage-reinforced flap approach was used to solve the problem of a patient whose implant electrode became visible under the skin five years after the initial surgery. Since it was not possible to replace the implant during revision surgery due to financial reasons, this surgical approach was preferred to preserve the device. In certain situations it may be necessary to develop solutions outside of established protocols. In this case, while the standard approach would be to remove the implant, create a new implant bed and perform a revision surgery with a new implant, the patient's inability to obtain a new device necessitated the preservation of the existing implant. This approach successfully resolved the problem and prevented the patient from losing access to sound.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}