Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions最新文献

{"title":"State of the Art: Personalized Antiplatelet Therapy by Genotype and Platelet Function Testing.","authors":"Paul A Gurbel, Young-Hoon Jeong, Eliano Navarese, Jacek Kubica, Bogumil Ramotowski, Udaya S Tantry","doi":"10.1002/ccd.70794","DOIUrl":"10.1002/ccd.70794","url":null,"abstract":"<p><p>The platelet P2Y₁₂ receptor plays a critical role in the genesis of arterial thrombotic events. The demonstration of clopidogrel resistance and the relation of high platelet reactivity to ADP to recurrent ischemic event occurrences in patients with coronary artery disease treated with stents significantly influenced the development of potent P2Y₁₂ receptor inhibitors. A \"one size fits all\" strategy of clopidogrel therapy is associated with a greater risk for recurrent thrombotic events compared to uniform use of potent P2Y₁₂ receptor inhibitors which causes more bleeding. The concept of a therapeutic window for P2Y₁₂ inhibitor therapy that strikes a balance between the attenuation of thrombotic risk and bleeding has been used to personalize antiplatelet therapy. Despite the absence of a strong recommendation in the current guidelines for platelet function testing or genetic testing, the treating interventionalist must rely on the available evidence base, as summarized in this Review, to help decide whether to employ a one-size-fits-all strategy of antiplatelet therapy or one that is personalized by objective testing.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1482-1495"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute and Late Angiographic Lumen Assessment of the Coronary Artery Diameter After Drug Coated Balloon Angioplasty.","authors":"Şi̇şman Uzunoğlan Behice Hande, Uzunoğlan Sezgin, Abanoz Oğuzhan, Danişman Esra, Khanmohammadi Mahsa, Kahraman A Y Nuray, Bacaksiz Ahmet, Açikgöz Nusret, Özdemir Ramazan, Uluganyan Mahmut","doi":"10.1002/ccd.70805","DOIUrl":"10.1002/ccd.70805","url":null,"abstract":"<p><strong>Background: </strong>Drug-coated balloon (DCB) angioplasty has emerged as an alternative strategy. However, data on its mid-term angiographic and clinical outcomes remain limited.</p><p><strong>Methods: </strong>This study included 70 patients who underwent DCB angioplasty. Quantitative coronary angiography (QCA) measurements were obtained before, immediately after, and at follow-up angiography. The primary endpoint was binary restenosis (≥ 50% diameter stenosis), while secondary endpoints included late lumen loss (LLL), late lumen enlargement (LLE), and target lesion revascularization (TLR).</p><p><strong>Aims: </strong>We aimed to evaluate angiographic outcomes of DCB-treated de novo, in-stent restenosis (ISR), and chronic total occlusion (CTO) lesions using follow-up coronary angiography and quantitative coronary angiography (QCA), including acute lumen gain, late lumen loss, late lumen gain, and binary restenosis.</p><p><strong>Results: </strong>Among 70 patients, 25 (35.7%) developed binary restenosis at follow-up. Minimal lumen diameter, minimal lumen area, and percent diameter stenosis showed significant differences across pre-procedure, post-procedure, and follow-up assessments (all p < 0.001). LLL was observed in 72.9% of patients, whereas 27.1% exhibited LLE. Multivariate logistic regression identified active smoking as an independent predictor of binary restenosis (odds ratio [OR]: 9.23, p = 0.019), whereas female sex was associated with a lower risk (OR: 0.07, p = 0.031). No acute thrombosis occurred within 48 h, and one noncardiac death was reported during the first month.</p><p><strong>Conclusion: </strong>DCB angioplasty demonstrated favorable mid-term angiographic efficacy with low rates of binary restenosis and TLR. These findings support DCB therapy as an effective revascularization strategy for selected patients with coronary artery disease.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1564-1571"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148723667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Presentation of Behçet's Disease: Coexistence of Intracardiac Thrombi, Coronary Artery Disease, and Pulmonary Thromboembolism.","authors":"Hakan Yalman, Utku Raimoglu, Damla Raimoglou, Emine Sebnem Durmaz","doi":"10.1002/ccd.70828","DOIUrl":"10.1002/ccd.70828","url":null,"abstract":"<p><p>Behçet's disease (BD) is a rare systemic vasculitis. While pulmonary involvement occurs, severe intracardiac manifestations are exceptional. We report a 44-year-old male presenting with dyspnea and hemoptysis. Multimodality imaging revealed bilateral pulmonary thromboembolism, severe three-vessel and left main coronary artery disease, alongside massive thrombi on the ventricular surface of the tricuspid valve (right ventricle) and at the left ventricular apex. With negative blood cultures, he was diagnosed with BD. Refusing recommended surgical revascularization, he was successfully managed with immunosuppressants (glucocorticoids, cyclophosphamide, infliximab), rivaroxaban, and heart failure therapies. This case underscores the critical role of echocardiography and multimodality imaging in diagnosing life-threatening, multi-system cardiovascular complications of BD.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1591-1594"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conduction Disturbances and Permanent Pacemaker Implantation After TAVR With Self-Expanding Devices: The CONNAVIPRO Study.","authors":"Enrico Poletti, Omar Alessandro Oliva, Ahmad Hassan, Giuseppe Esposito, Mauro Massussi, Valentina Ardizzone, Baydaroglu Nurcan, Antonella Millin, Vittorio Zuccarelli, Andrea Raffaele Munafò, Jacopo Oreglia, Federico De Marco, Marianna Adamo, Didier Tchetché, Andrea Zuffi","doi":"10.1002/ccd.70827","DOIUrl":"10.1002/ccd.70827","url":null,"abstract":"<p><strong>Background: </strong>The Evolut and the Navitor transcatheter heart valves (THVs) represent the most widely used self-expanding implanted valves. Despite a similar implant concept, they markedly differ in design and hemodynamic performance. In both THVs, conduction disturbances following transcatheter aortic valve replacement (TAVR) are reported higher than in balloon-expandable devices. Nevertheless, to date, no direct comparative studies have analyzed their real difference rates.</p><p><strong>Aim: </strong>Aim of the present study was to directly compare the self-expanding Evolut PRO+ and Navitor THVs, with specific focus on the incidence of new permanent pacemaker implantation (PPI) and post-procedural hemodynamic performance.</p><p><strong>Methods: </strong>The CONNAVIPRO registry is an international, multicenter, retrospective study including 880 consecutive patients with severe aortic stenosis treated with Evolut PRO+ (n = 451) or Navitor (n = 429) between May 2022 and December 2024. The primary endpoint was new PPI within 30 days among pacemaker-naïve patients. Secondary endpoints included technical and device success, transprosthetic gradients, and paravalvular leak (PVL). Inverse probability weighting (IPW) was applied to adjust for baseline differences.</p><p><strong>Results: </strong>Procedural success was high with both valves (97.6%), and early safety outcomes were comparable. At 30 days, the Navitor group showed a higher PPI rate than Evolut (23.2% vs. 17.6%), reaching statistical significance after IPW adjustment (OR 1.53, 95% CI 1.08-2.17; p = 0.018). Mean transprosthetic gradients were slightly higher with Navitor (8 vs. 7 mmHg; p = 0.002), whereas moderate or greater PVL was less frequent (2.8% vs. 7.7%; p < 0.001). Variables independently associated with PPI were hypertension, and pre-existing right bundle branch block.</p><p><strong>Conclusions: </strong>Both Evolut PRO+ and Navitor THVs provided excellent safety and hemodynamic outcomes. Navitor may be associated with a higher 30-day PPI rate, a lower incidence of moderate or greater PVL, and clinically non-significant higher gradients. These associations should be interpreted as hypothesis-generating and warrant confirmation in prospective studies.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1630-1639"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148805243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Efficacy and Safety of Tibial-Pedal Artery Access Using a Novel Articulating-Tip Guidewire.","authors":"Ashwani Sastry, Sreejit Nair","doi":"10.1002/ccd.70806","DOIUrl":"10.1002/ccd.70806","url":null,"abstract":"<p><strong>Background: </strong>Retrograde tibial-pedal access is a well-established technique for managing peripheral arterial occlusive disease and its associated ischemic symptoms. While generally considered safe and effective, this method presents notable challenges due to the small caliber and, often, diseased nature of the target vessels, which can complicate entry and cannulation. As a result, multiple access attempts may be necessary, and access-related complications can hinder or even prevent a successful percutaneous intervention.</p><p><strong>Aims: </strong>This report aims to describe a single-center experience utilizing a novel access guidewire featuring a small core diameter and an articulating tip to facilitate tibial-pedal access.</p><p><strong>Methods: </strong>Patients with peripheral vascular disease in whom tibial-pedal access was attempted between January 2, 2024 and September 15, 2025 were included. Real-time ultrasound guidance was used in all cases. Post-procedural ultrasound was performed after hemostasis was achieved with manual compression to evaluate the accessed vessel patency and rule out complications. Study outcomes were first-attempt and overall guidewire insertion success, post-procedural and 30-day patency of the accessed vessel on ultrasound, and incidence of access site complications.</p><p><strong>Results: </strong>Records of 167 access procedures attempted in 133 patients were reviewed (left anterior tibial-76, right anterior tibial-71, right posterior tibial-7, left posterior tibial-4, left dorsalis pedis-1). First-attempt success was 98% (154/157 evaluable records) and all-attempt success was achieved in 100% of the cases. There were no access-site complications, such as occlusion, extravasation, or pseudoaneurysm. Patency was confirmed in all accessed vessels immediately following the procedure and maintained in all but one case at the 30-day mark.</p><p><strong>Conclusions: </strong>Tibial-pedal access was successfully obtained in all cases, demonstrating an exceptionally high nominal first-attempt success rate and no peri-procedural complications. In conjunction with preserved post-procedural vessel patency, these findings support the articulating-tip guidewire's safety and effectiveness for its intended application.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1542-1547"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating HEART Score and Early CT Coronary Angiography in a Chest Pain Hot Clinic-A Safe Alternative to Inpatient Care From UK Tertiary Center Experience.","authors":"Sonny Harvey, Hazem Bashiti, Ayman Helal, Kerron Glean, Preethii Sasikala Palanivel, Sanjana Harish, Shankar Sangaraju","doi":"10.1002/ccd.70780","DOIUrl":"10.1002/ccd.70780","url":null,"abstract":"<p><strong>Background: </strong>Suspected cardiac chest pain is a common cause for hospital admission. In busy acute NHS hospitals, patients with suspected cardiac chest pain, normal Troponin levels, and no evidence of acute coronary syndrome are often admitted for invasive angiography or CT coronary angiography (CTCA). This has a significant impact on the length of stay, patient flow, and bed capacity. A timely ambulatory pathway for these patients to undergo urgent outpatient CTCA would avoid admission.</p><p><strong>Aims: </strong>The aim was to design an ambulatory pathway for rapid investigation of patients with troponin-negative chest pain, as a safe alternative to admission.</p><p><strong>Methods: </strong>A trustwide guideline was implemented, which emphasized the use of the heart score to risk-stratify patients, and determine suitability for referral to our new service. Those scoring 4-6 were deemed appropriate for the pathway and returned within 96 h to undergo CTCA, then attend the chest pain hot clinic for review. In the original HEART pathway trial, these \"moderate risk\" patients were admitted. A unique feature of the pathway was the agreement for non-cardiologists to book the CTCA directly, without cardiology input. This facilitated a very short time to diagnosis from the point of discharge, when compared to similar \"rapid access chest pain\" pathways.</p><p><strong>Results: </strong>A total of 349 patients were reviewed in the hot clinic between July 4, 2024, and December 31, 2024. Of these, 222 met the referral criteria and were included in the per-protocol analysis. A CTCA was performed for 215 patients, with a minority having a valid contraindication. This alone was sufficient to exclude obstructive coronary disease in 99 of those scanned (44.1%). After completion of the investigation, 87 patients (39.2%) received a final diagnosis of angina, whilst 50 patients (22.5%) had coronary disease significant enough to proceed directly to revascularization. With regards to safety outcomes, 20 patients (9.0%) were admitted from the clinic, and there was only one case of a cardiovascular-related admission prior to the appointment (0.4%), with no associated mortality after 6 months.</p><p><strong>Conclusion: </strong>Our center's experience demonstrates the feasibility and safety of managing patients presenting with moderate risk chest pain via an urgent ambulatory care pathway. There are significant benefits to this strategy relating to admission avoidance, and our low adverse event rate suggests that this is a safe model when compared to inpatient investigation.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1445-1451"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Maximum Troponin T Value Correlate With Acute Coronary Occlusion Among Patients Treated as NSTEMI?","authors":"Laou-Abalo Sodou, Mazou Temgoua, Hervé Edorh, Wiyaou Kaziga, Anne Luycx Bore, Koffi Dumessi, Serge Quenum","doi":"10.1002/ccd.70802","DOIUrl":"10.1002/ccd.70802","url":null,"abstract":"<p><strong>Background: </strong>Occlusion myocardial infarction (OMI) is increasingly recognized among NSTEMI patients, yet current diagnostic paradigms may fail to detect coronary occlusion early. In clinical situations, the diagnosis of OMI requires a super electrocardiogram (ECG) expert or use of artificial intelligence like the Queen of hearts. For research purposes, we try to use high-sensitivity cardiac troponin T (hs-cTnT) to help retrospectively classify ECGs as indicating OMI or not among patients treated as NSTEMI.</p><p><strong>Aims: </strong>To evaluate the association between hs-cTnT and angiographic occlusion in patients treated as NSTEMI. The results of this study could help to guide future studies of ECG findings of acute occlusion, with the goal of identifying acute occlusion before troponin results return.</p><p><strong>Methods: </strong>This retrospective, single-center study analyzed data from patients treated as NSTEMI who underwent coronary angiography at Beauvais Hospital, France, between January to December 2024. Among these patients, we initially selected all patients with TIMI flow 0-2, constituting the « OMI » group; subsequently, we included consecutively those patients admitted within the first 3 months with TIMI flow 3, constituting the « NOMI » comparison group. ROC curve analysis was performed to identify hs-cTnT thresholds, and predefined cutoffs (1000 ng/L and 10,000 ng/L) were evaluated. The value of hs-cTnT used was the highest prior to coronary angiography. The setting of hs-cTnT to define coronary occlusion was inspired by previous works in the literature done for research purposes.</p><p><strong>Results: </strong>200 patients were included (31 OMI, 169 NOMI) among patients treated as NSTEMI in 2024. In multivariable analysis, persistent chest pain (OR 2.6; 95% CI: 1.06-6.40; p = 0.037) and de novo wall motion abnormality (OR 3.41; 95% CI: 1.30-8.89; p = 0.012) were independently associated with coronary occlusion. ROC analysis identified 678 ng/L as the optimal threshold of hs-cTnT (AUC = 0.58) with 71% sensitivity (Se) and 65% specificity (Sp). The negative predictive value (NVP) and positive predictive value (PPV) were respectively 91% and 22% in the patient population studied.</p><p><strong>Conclusion: </strong>Coronary occlusion was found in 15% of patients treated as NSTEMI in our cohort. Subject to limitations such as the non-use of peak troponin levels and the exclusion of TIMI-3 flow from the OMI group, which led to an underestimation of prevalence, the hs-cTnT threshold of 678 ng/L was associated with coronary occlusion in patients treated as NSTEMI, with modest sensitivity (Se), good NPV, modest Sp, and poor PPV. As troponin testing is non-specific, the troponin threshold should not be used independently to classify patients treated as NSTEMI into OMI or NOMI. An early ECG interpreted using artificial intelligence is currently the most reliable method for diagnosing OMI.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1467-1472"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Post-Stent Medial Dissection and White Thrombus Using Hybrid IVUS OCT Imaging may Help Guide Management.","authors":"Natali Sorajja, Khady N Fall, Jeffrey W Moses, Megha Prasad","doi":"10.1002/ccd.70821","DOIUrl":"10.1002/ccd.70821","url":null,"abstract":"<p><p>We present a 66-year-old undergoing ostial-to-mid right coronary artery (RCA) percutaneous coronary intervention (PCI) lesion proximal to an existing stent in the mid-to-distal segment. The patient underwent PCI, with intravascular imaging using the Novasight Hybrid IVUS OCT (Conavi, Toronto, CA) which revealed a proximal edge dissection and distal dissection involving the media on OCT, less discernable on IVUS, which required an additional distal stent. Proximally, based on OCT minimal luminal area (MLA) measurements of the dissection, the size of the dissection flap and lack of involvement of the media, a stent was not placed. The patient did well with no periprocedural complications.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1602-1606"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"VERMONT μQFR: Diagnostic Accuracy of Murray Law-Based 2D-μQFR Compared to 3D-μQFR and vFFR.","authors":"Daniel Akrawi, Krishna Kadappu, James Xu, Tamer Yousef Naguib Badie, Oliver Gibbs, Hashim Kachwalla, Phong T D Nguyen, Rahul Kurup, Upul Premawardhana, Justyn Huang, Hao Tran, Kavie Soosapilla, Jim Basilakis, Aiden O'loughlin, Annemarie Hennessy, Giuseppe Femia, Sidney Lo","doi":"10.1002/ccd.70768","DOIUrl":"10.1002/ccd.70768","url":null,"abstract":"<p><strong>Background: </strong>Murray law-based quantitative flow ratio (μQFR) is an angiography-derived physiological index that utilizes a single angiographic projection with artificial intelligence-guided vessel segmentation.</p><p><strong>Aims: </strong>To evaluate the diagnostic accuracy and time efficacy of 2D-μQFR against wire-based fractional flow reserve (FFR ≤ 0.80), compare its performance with 3D-μQFR and vessel-FFR (vFFR), and assess feasibility in lesions excluded from vFFR analysis.</p><p><strong>Methods: </strong>This sub-study of the prospective VERMONT trial analyzed 2D- and 3D-μQFR retrospectively using prospectively acquired angiograms, with wire-based FFR as the reference standard.</p><p><strong>Results: </strong>Among 209 patients with 225 intermediate lesions, 205 lesions were analyzed. 2D-μQFR demonstrated excellent diagnostic accuracy for FFR ≤ 0.80 (AUC 0.95; 95% CI 0.93-0.98), with 93% sensitivity, 92% specificity, 88% positive predictive value (PPV), and 95% negative predictive value (NPV). Inter-observer agreement was excellent (r = 0.94, p < 0.001), and 2D-μQFR analysis was 15.1 min faster than wire-based FFR (1.8 ± 0.7 vs. 16.9 ± 5.4 min, p < 0.001). Diagnostic performance was comparable to that of 3D-μQFR, which achieved an AUC of 0.94 (95% CI 0.91-0.97), with 89% sensitivity, 90% specificity, 86% PPV, and 93% NPV. It was more specific than vFFR, which achieved an AUC of 0.92 (95% CI 0.89-0.96), with 90% sensitivity, 79% specificity, 74% PPV, and 93% NPV. Single-projection analysis was feasible in 85% of lesions excluded from vFFR due to image quality limitations.</p><p><strong>Conclusion: </strong>Single-projection 2D-μQFR provides accurate, rapid, and reproducible physiological assessment comparable to 3D-μQFR with superior specificity to vFFR. These findings support 2D-μQFR as a practical, wire-free alternative to invasive FFR in routine clinical practice.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1256-1267"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13667326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148595442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Risk Identification to Risk Modification in Patients With End-Stage Renal Disease Undergoing Rotational Atherectomy.","authors":"Fahrettin Turna","doi":"10.1002/ccd.70822","DOIUrl":"10.1002/ccd.70822","url":null,"abstract":"","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":"1589-1590"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}