Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions最新文献

{"title":"Interaction Between Guiding-Extension Catheter and Drug-Eluting Stents: Always Safe or Sometimes Harmful?","authors":"Salvatore Colangelo, Riccardo Mangione, Mario Iannaccone, Francesco Colombo, Giacomo Giovanni Boccuzzi","doi":"10.1002/ccd.70035","DOIUrl":"https://doi.org/10.1002/ccd.70035","url":null,"abstract":"<p><strong>Background: </strong>Guiding-extension catheters (GECs) provide enhanced support to guiding catheter (GC) during complex percutaneous coronary intervention (PCI). However, by reducing the inner cross-sectional diameter, they can create high friction between the GEC and the drug-eluting stents (DES), potentially causing abrasion and damage to the abluminal struts.</p><p><strong>Aim: </strong>This study aims to compare the performances of the Amphilimus Cre8 EVO polymer-free DES with all the other surface-coated DES. The abluminal grooves of this polymer-free DES, which contain the drug and avoid any risk of its abrasion and detachment (abluminal reservoir technology), may offer a protective effect during stent advancement within the GEC.</p><p><strong>Methods: </strong>Between January 2019 and April 2024, 218 patients who underwent complex PCI procedures with the insertion of a DES and the use of GEC were enrolled in the study. They were divided into Group A (39 patients) received the Amphilimus polymer-free DES, while Group B (179 patients) received other types of DES. To evaluate the efficacy and safety of the DES used, a device-oriented composite endpoint (DoCE) was assessed at one year of follow-up. This composite endpoint included Cardiovascular Death, Target Vessel Myocardial Infarction, and Clinically and Physiologically indicated Target Lesion Revascularization.</p><p><strong>Results: </strong>At the one-year follow-up, the primary endpoint demonstrated a statistically significant difference between the two groups. Event-free survival from DoCE was 97.4% in Group A compared to 85.5% in Group B (Log rank = 0.027). Additionally, there was a significant difference in mean stent length between the groups: Group A had a longer mean stent length of 52.4 ± 38.6 mm, while Group B had a mean length of 40.4 ± 22.6 mm, with a p-value of 0.01. All other clinical and procedural variables were similar between the two groups.</p><p><strong>Conclusion: </strong>Our findings suggest that the polymer-free DES tested in this study appears to be the most effective option when using GECs, as it may help prevent negative interactions between the inner surface of GEC and the abluminal struts of the DES.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Vascular Response of a Biodegradable Polymer-Coated Sirolimus-Eluting Stent in Patients With ST-Segment Elevation Myocardial Infarction-The OCIMI Study.","authors":"Atul Abhyankar, Bhargav Patel, Ankit Jain, Vikas Patel, Yamunesh Patel, Kan Saito, Akihiro Yoshida, Yasuhiro Honda, Krishnankutty Sudhir","doi":"10.1002/ccd.70046","DOIUrl":"https://doi.org/10.1002/ccd.70046","url":null,"abstract":"<p><strong>Background: </strong>Few studies have addressed the early healing pattern of ultrathin strut drug-eluting stents implanted specifically for the treatment of acute myocardial infarction.</p><p><strong>Aims: </strong>This study employed optical coherence tomography (OCT) to assess neointimal coverage and vascular healing following implantation of ultrathin biodegradable polymer-coated sirolimus-eluting stents (SES) in patients with ST-segment elevation myocardial infarction (STEMI).</p><p><strong>Methods: </strong>The OCIMI study was a prospective, single-center investigation of 23 STEMI patients treated with Supraflex Cruz SES (Sahajanand Medical Technologies Ltd., Surat, India) during primary PCI between September 2019 and June 2020. All patients underwent OCT imaging at 3-month follow-up, and images were analyzed at an independent core laboratory by analysts blinded to clinical and procedural data.</p><p><strong>Results: </strong>At the 3-month follow-up, no clinical events were reported. The analyzed stent length was 28.4 ± 12.0 mm, with a stent diameter of 2.70 ± 0.46 mm and a reference lumen diameter of 2.46 ± 0.44 mm. OCT demonstrated nearly complete stent strut coverage (99.94%), with uncovered struts observed in 0.06 ± 0.16% of total struts per stent. Incomplete stent apposition was present in 0.14 ± 0.37% of struts. The mean neointimal hyperplasia (NIH) area and thickness were 0.81 ± 0.40 mm² and 110 ± 40 µm, respectively, with a mean NIH unevenness score of 1.74 ± 0.19.</p><p><strong>Conclusion: </strong>Primary PCI performed with Supraflex Cruz SES demonstrated excellent early vascular healing at the 3-month OCT follow-up. The extremely low incidence of uncovered struts may have implications for abbreviated dual antiplatelet therapy in high-bleeding risk STEMI patients.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Femoropopliteal Drug-Coated Balloon Use on Clinical Outcomes in Patients With Chronic Limb-Threatening Ischemia.","authors":"Haruya Yamane, Yosuke Hata, Osamu Iida, Yasunori Ueda, Kuniyasu Ikeoka, Taku Toyoshima, Motoki Yasunaga, Hiroaki Nohara, Akito Kawamura, Sho Nakao, Yohei Sotomi, Yasushi Sakata","doi":"10.1002/ccd.70033","DOIUrl":"https://doi.org/10.1002/ccd.70033","url":null,"abstract":"<p><strong>Background: </strong>Drug-coated balloons (DCBs) for femoropopliteal (FP) lesions have demonstrated superiority over standard percutaneous transluminal angioplasty (PTA) in maintaining vessel patency. However, data on whether the good durability of DCBs translates into improved wound outcome in chronic limb-threatening ischemia (CLTI) patients are limited.</p><p><strong>Aims: </strong>The aim of this study was to compare the effectiveness of FP-DCBs with that of standard PTA in achieving superior wound healing outcomes in CLTI patients.</p><p><strong>Methods: </strong>This was a sub-analysis of the multicenter, retrospective, observational SAPLING (SAtellite database of Patients with chronic Limb-threateniNG Ischemia) registry. CLTI patients with tissue loss who underwent endovascular therapy for FP lesions with either DCBs or PTA were analyzed using propensity score matching. Patients were classified into the DCB group or the PTA group. The primary outcome measure was 2-year wound healing.</p><p><strong>Results: </strong>A total of 701 limbs were included in this study. After propensity score matching, the 2-year cumulative incidence of wound healing was not significantly different between the DCB and PTA group (76.7% vs. 67.5%; hazard ratio: 1.129; 95% confidence interval: 0.861-1.480, p = 0.382). Interaction analysis demonstrated that DCB use was associated with a higher wound healing rate in patients with Wound grade 2 or 3 (p for interaction = 0.002) and foot Infection grade 2 or 3 (p for interaction = 0.03) in the Wound, Ischemia, and foot Infection classification.</p><p><strong>Conclusions: </strong>DCB use for FP lesions was not significantly associated with superior wound healing in patients with CLTI. However, DCB may offer benefits for patients with higher wound and foot infection grades.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular Ultrasound-Detected Layered Plaque Mimicking Spontaneous Coronary Artery Dissection.","authors":"Hideaki Suwa, Keisuke Yasumura, Samin K Sharma, Annapoorna S Kini","doi":"10.1002/ccd.70054","DOIUrl":"https://doi.org/10.1002/ccd.70054","url":null,"abstract":"<p><p>Diagnosing ambiguous culprit lesions by coronary angiography is challenging, particularly in the presence of vessel overlap, tortuosity, or eccentric lesions. In such cases, intravascular imaging provides critical diagnostic insights. We present the case of a 55-year-old female with recurrent chest pain, initially suspected to have spontaneous coronary artery dissection (SCAD) based on clinical context. Coronary angiography was inconclusive; however, intravascular ultrasound (IVUS) revealed distinct plaque layers with varying echogenicity separated by clear borders-findings more consistent with a layered plaque than SCAD. This case highlights the value of intravascular imaging in accurately characterizing ambiguous coronary lesions and guiding appropriate management.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical Rotational Intravascular Ultrasound Catheter Suicide: A Word of Caution.","authors":"Juan Del Cid Fratti, Reza Masoomi, Ladan Masoumi, Kathleen E Kearney, William L Lombardi, Lorenzo Azzalini","doi":"10.1002/ccd.70032","DOIUrl":"https://doi.org/10.1002/ccd.70032","url":null,"abstract":"<p><p>Intravascular ultrasound (IVUS) is a critical adjunct in percutaneous coronary intervention (PCI), improving clinical outcomes. While generally safe, mechanical IVUS systems carry a rare risk of catheter entrapment. We report a case of IVUS catheter entrapment during percutaneous intervention of a heavily calcified lesion. Entrapment occurred when the imaging function was activated during catheter advancement through a tight lesion, leading to sheath compression, torsional distortion, and knotting. The catheter was successfully retrieved using balloon-assisted modification. The patient later underwent staged PCI without complication. This case highlights a unique entrapment mechanism specific to mechanical IVUS systems, emphasizing the importance of avoiding early imaging activation and forceful advancement through stenotic lesions. Understanding IVUS mechanics and available bailout techniques is critical for management of this complication. Awareness of this underrecognized complication and adherence to proper protocols can help prevent mechanical IVUS entrapment and ensure safe PCI outcomes.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Ultrasound-Guided Closure of Perimembranous Ventricular Septal Defects in Children Using Bioabsorbable Occluders-Feasibility and 1-Year Follow-Up.","authors":"Liu Liu Huang, Mai Chen, De Cai Zeng, Chun Lan Jiang, Guo Xing Ling, Chun Xiao Su, Bao Shi Zheng, Ji Wu","doi":"10.1002/ccd.70022","DOIUrl":"https://doi.org/10.1002/ccd.70022","url":null,"abstract":"<p><strong>Background: </strong>To reduce complications associated with metal occluders, bioabsorbable occluders have been implanted for perimembranous ventricular septal defects (VSDs) via transthoracic approach. This study investigates the feasibility of echocardiography-guided percutaneous closure of perimembranous VSDs in children using bioabsorbable occluders, along with its 1-year follow-up outcomes.</p><p><strong>Aims: </strong>To evaluate the feasibility and 1-year outcomes of echocardiography-guided percutaneous closure of perimembranous VSDs using bioabsorbable occluders in children.</p><p><strong>Methods: </strong>Between April 2023 and March 2024, consecutive children with perimembranous VSDs underwent percutaneous closure using bioabsorbable occluders under echocardiography guidance alone were enrolled. Procedural success was defined as percutaneous device implantation under sole ultrasound guidance with residual shunt ≤ 2 mm and no severe in-hospital complications. Preoperative, intraoperative, and follow-up data were prospectively collected and analyzed.</p><p><strong>Results: </strong>The study cohort comprised 14 children, including three with a subaortic rim ≤ 3 mm and one with a distance of ≤ 1 mm between the VSD and the tricuspid septal leaflet. All procedures were successful. Vascular access was via the femoral artery in six patients (42.9%) and femoral vein in eight patients (57.1%). No major complications occurred. A 2 mm residual shunt was noted in one patient (7.1%) and remained unchanged during the follow-up period. While new-onset mild/moderate tricuspid regurgitation occurred in three patients (21.4%), all cases showed improvement over time. At 1 year, no new onset aortic regurgitation or complete heart block were reported, and the occluders were largely absorbed.</p><p><strong>Conclusion: </strong>Percutaneous closure of perimembranous VSDs in children using bioabsorbable occluders under echocardiography guidance is feasible, with promising 1-year outcomes.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Exploration of CBCT in IVCFT Patient Filter Retrieval.","authors":"Jiahao Zhu, Yang Geng, Zengqiang Xu, Mengxin Jiang, Yingjiang Xu","doi":"10.1002/ccd.70048","DOIUrl":"https://doi.org/10.1002/ccd.70048","url":null,"abstract":"<p><strong>Background: </strong>Inferior vena cava filter related thrombosis (IVCFT) poses significant challenges in patients undergoing mechanical thromboembolic prophylaxis, often leading to filter retrieval failure and recurrent pulmonary embolism. Current diagnostic modalities, including ultrasound, CT venography, and digital subtraction angiography (DSA), suffer from limitations such as operator dependency, ferromagnetic interference, patient transfer risks, and suboptimal multiplanar reconstruction capabilities. Cone-beam computed tomography (CBCT), offering real-time three-dimensional vascular imaging within the angiography suite, holds promise for overcoming these barriers. However, its diagnostic accuracy and clinical utility in characterizing IVCFT morphology, thrombus burden, and filter-device interactions remain unestablished. This study aimed to evaluate CBCT's role in optimizing filter retrieval decision-making by integrating preprocedural thrombus phenotyping with intraoperative guidance, thereby establishing a personalized management framework for IVCFT.</p><p><strong>Aims: </strong>To evaluate the diagnostic efficacy of cone-beam CT (CBCT) in IVCFT retrieval and analyze thrombus characteristics affecting retrieval outcomes.</p><p><strong>Methods: </strong>This prospective study enrolled 20 patients undergoing prophylactic filter placement (August 2024-March 2025) for \"one-stop\" assessment using intraoperative CBCT 3D rotational angiography combined with DSA. Multidimensional 3D reconstructions were analyzed for thrombus morphology, spatial distribution, and filter-thrombus integration. Diagnostic accuracy was validated through post-retrieval macroscopic examination. Retrieval success rates and contributing factors were statistically analyzed.</p><p><strong>Results: </strong>Among 16 confirmed IVCFT cases, CBCT demonstrated 100% diagnostic concordance. Thrombus morphology distribution revealed mural (81.3%) versus free-floating (18.7%) patterns. The overall retrieval success rate was 87.5% (14/16). Subanalysis demonstrated 100% success (10/10) with ≤ 60% cross-sectional thrombus burden versus 66.7% (4/6) with > 60% occupancy (p = 0.125). Filters with transaxial thrombus penetration showed lower success rates compared to localized thrombi (75.0% vs. 100%, p = 0.467). Bedridden patients exhibited significantly higher rates of > 60% thrombus burden compared to ambulatory counterparts (83.3% vs. 10.0%, p = 0.008).</p><p><strong>Conclusion: </strong>CBCT provides precise three-dimensional characterization of IVCFT morphology and spatial relationships. Critical thrombus burden ( > 60%) and transfilter penetration emerge as key risk factors for retrieval failure. The CBCT-DSA integrated protocol establishes an optimized decision-making framework for personalized endovascular management.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convolutional Neural Network Fused With Recurrent Network for ECG-Based Detection of Hypertrophic Cardiomyopathy.","authors":"Yogalakshmi V, Manikandan T","doi":"10.1002/ccd.70041","DOIUrl":"https://doi.org/10.1002/ccd.70041","url":null,"abstract":"<p><strong>Background: </strong>Hypertrophic Cardiomyopathy (HCM) affects the left ventricle of the heart, leading to thickening of the ventricular wall and potentially life-threatening conditions, such as atrial fibrillation, cardiac failure, and sudden death. Early and accurate detection of HCM from Electrocardiogram (ECG) signals is critical for reducing mortality risk. However, most existing methods fail to simultaneously capture spatial and temporal patterns in ECG data, resulting in reduced diagnostic reliability.</p><p><strong>Method: </strong>This paper proposes a hybrid Deep Learning (DL) network for detecting HCM using the ECG. Initially, input ECG signals are forwarded for pre-processing by Kalman filter. Then, processed signal is fed to feature extraction phase for extracting Empirical Mode Decomposition (EMD), statistical and medical features, which is followed by feature fusion, wherein the optimal feature is merged by Deep Belief Network (DBN) with Jensen-Shannon distance. Moreover, Convolutional Neural Network Fused with Recurrent Network (CNNFRN) performs HCM detection and final detected output is effectively achieved. The proposed CNNFRN combines Kalman Neural Network (CNN) and Recurrent Neural Network (RNN) based on regression modelling. Finally, the model is trained under a supervised framework using the Adam optimizer.</p><p><strong>Results: </strong>The proposed model is validated using the PTB Diagnostic ECG Database and Shaoxing and Ningbo Hospital ECG Database. The results show that the proposed CNNFRN model achieved an accuracy of 0.940, sensitivity of 1.000, specificity of 0.913, and an F1-score of 0.956. These findings confirm the model's effectiveness in robust and early detection of HCM, offering significant clinical value.</p><p><strong>Conclusion: </strong>The proposed model accurately detects HCM by combining advanced feature extraction and a hybrid deep learning approach that captures both spatial and temporal ECG patterns. It also shows strong performance and reliability across multiple databases, making it valuable for early and effective clinical diagnosis.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Link Between Gut Microbiota and Arterial Occlusive Diseases: Insights From Mendelian Randomization and Bioinformatics Analysis.","authors":"Xin Lin, Kangdi Xu","doi":"10.1002/ccd.70047","DOIUrl":"https://doi.org/10.1002/ccd.70047","url":null,"abstract":"<p><strong>Background: </strong>Arterial occlusive diseases (AOD), including peripheral artery disease (PAD), are significant causes of morbidity and mortality worldwide. Emerging evidence suggests that gut microbiota may play a crucial role in the pathogenesis of PAD. However, causal relationships remain unclear due to limitations in observational studies.</p><p><strong>Aims: </strong>This study aims to investigate the causal relationship between gut microbiota and PAD.</p><p><strong>Methods: </strong>This study employed a two-sample Mendelian randomization (MR) approach using genome-wide association study (GWAS) summary statistics to investigate the causal relationship between gut microbiota and PAD. Genetic variants associated with gut microbiota were used as instrumental variables. Sensitivity analyses were performed to assess pleiotropy and heterogeneity, and results were validated in independent datasets.</p><p><strong>Results: </strong>We identified significant causal associations between specific gut microbiota and PAD. Notably, Candidatus Soleaferrea and Ruminococcaceae UCG005 were positively associated with PAD risk. Validation analyses across diverse populations confirmed the robustness of these associations. Pathway enrichment analysis highlighted potential mechanisms, including inflammatory and metabolic pathways such as TNF signaling and AMPK signaling pathway.</p><p><strong>Conclusion: </strong>This study provides strong evidence of a causal relationship between gut microbiota and AOD, particularly PAD. The findings highlight the potential of gut microbiota as biomarkers and therapeutic targets in managing vascular diseases. Further research is warranted to explore microbiota-targeted interventions and their clinical applications.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the V-RESOLVE Score for Side Branch Occlusion in the PROGRESS-BIFURCATION Registry.","authors":"Dimitrios Strepkos, Michaella Alexandrou, Deniz Mutlu, Pedro E P Carvalho, Ozgur S Ser, Oleg Krestyaninov, Dimitri Khelimskii, Barkin Kultursay, Ali Karagoz, Ufuk Yildirim, Korhan Soylu, Mahmut Uluganyan, Olga Mastrodemos, Bavana V Rangan, Sandeep Jalli, Konstantinos Voudris, M Nicholas Burke, Yader Sandoval, Emmanouil S Brilakis","doi":"10.1002/ccd.70023","DOIUrl":"https://doi.org/10.1002/ccd.70023","url":null,"abstract":"<p><strong>Background: </strong>We validated the Visual estimation for Risk prEdiction of Side branch OccLusion in coronary bifurcation interVEntion (V-RESOLVE) score for predicting side branch occlusion (SBO) in an independent registry.</p><p><strong>Aims: </strong>We sought to evaluate the predictive performance of the V-RESOLVE score.</p><p><strong>Methods: </strong>We compared the characteristics, V-RESOLVE scores, and outcomes of 791 patients (937 bifurcation PCIs) who underwent provisional bifurcation PCI performed at five centers between 2014 and 2024 from the PROGRESS-BIFURCATION registry.</p><p><strong>Results: </strong>The incidence of SBO was 13% (n = 124). SBO patients had lower rates of hypertension, diabetes, prior coronary artery bypass graft surgery (CABG), and prior PCI but higher angiographic complexity, with higher left anterior descending artery stenoses, lower side branch diameter, higher side branch diameter stenoses, and lower rates of ostial lesions. SBO patients had higher median V-RESOLVE scores (16 vs. 12, p < 0.001) and were more likely to convert from provisional to two-stent strategies (21.0% vs. 5.8%, p < 0.001) and to require plaque modification (37.9% vs. 18.9%, p < 0.001). SBO patients had lower technical (76.6% vs. 95.9%, p < 0.001) and procedural (72.8% vs. 92.6%, p < 0.001) success and similar in-hospital major adverse cardiovascular events (MACE) (6.1% vs. 3.8%, p = 0.306). The quartile cutoffs for V-RESOLVE scores were 9 for the first quartile of patients, 12 for the second, and 18 for the third with a maximum of 43. SBO rates were 7.5%, 9.8%, 17.5%, and 15.3% for each quartile (p < 0.001). Using the cutoff values used to develop the score (0-3, 4-7, 8-11, 12-43), the SBO rates were 7.0%, 7.0%, 8.6%, 15.7%, respectively (p < 0.001). The area under the curve (AUC) of the V-RESOLVE score for predicting SBO was 0.61 (95% confidence intervals 0.56-0.66).</p><p><strong>Conclusions: </strong>The predictive value of the V-RESOLVE score for SBO in the PROGRESS-BIFURCATION registry was modest.</p>","PeriodicalId":520583,"journal":{"name":"Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}