Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology最新文献

{"title":"The Role of Rurality, Travel Time, and Neighborhood Socioeconomics on Patterns of Adjuvant Therapy Receipt Among Endometrial Cancer Patients.","authors":"Victoria M Petermann, Stephanie B Wheeler, Jennifer L Lund, Ashley Leak Bryant, Bradford E Jackson, Benjamin B Albright, Thom J Worm, Jennifer Leeman","doi":"10.1158/1055-9965.EPI-24-1201","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1201","url":null,"abstract":"<p><strong>Background: </strong>Rural endometrial cancer (EC) patients are more likely to receive lower quality treatment compared to their urban peers. We evaluated the role of contextual factors (rurality, distance to care, community socioeconomics) on receipt of adjuvant therapy (AT): vaginal brachytherapy (VBT), external beam radiation (EBRT), and chemotherapy.</p><p><strong>Methods: </strong>We analyzed SEER-Medicare and included stages IB grade 3 and stages II-IV. We used county-level rural-urban continuum codes to define rurality, the Yost index to measure community socioeconomics (SES) and measured of average driving time to gynecologic-oncology care. Multivariable logistic regression was used to estimate Odds Ratios (aOR) and 95% confidence intervals (CI) evaluating AT receipt adjusting for patient-level clinical and demographic characteristics.</p><p><strong>Results: </strong>A total of 7,572 individuals met inclusion criteria; 15% were rural residing. Rurality was only associated with lower odds any adjuvant therapy receipt among patients with stage IB EC (aOR 0.62, 95%CI 0.46-0.83). Increasing travel time was associated with lower odds of VBT (aOR 0.89, 95%CI 0.84-0.95). Residence in a low SES neighborhood was associated with lower odds of chemotherapy (aOR 0.79, 95%CI 0.67-0.92) and VBT (aOR 0.81, 0.69-0.95); however, associations were no longer significant adjusting for individual SES.</p><p><strong>Conclusions: </strong>Travel time to gynecologic oncology care negatively impacts receipt of treatment regardless of rural or urban residence. Travel time may be a proxy for access to brachytherapy services and may explain the associations between travel and receipt of VBT.</p><p><strong>Impact: </strong>Factors characterizing place of residence beyond rural/urban residence are important for predicting inequitable access to AT.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interrelationship between Preconception Folate Nutritional Intake and Child Genetic Liability in the Risk of Childhood Acute Lymphoblastic Leukemia.","authors":"Yijin Xiang, Catherine Metayer, Scott C Kogan, Xiaomei Ma, Eric Nickels, Joseph L Wiemels","doi":"10.1158/1055-9965.EPI-25-0154","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0154","url":null,"abstract":"<p><strong>Background: </strong>Prenatal maternal folate intake is associated with reduced risk of childhood acute lymphoblastic leukemia (ALL), but how this interacts with children's genetic predisposition to folate deficiency remains unclear.</p><p><strong>Methods: </strong>We used Mendelian randomization (MR) to investigate the causal link between serum folate, total homocysteine (tHcy) and B vitamins on ALL using independent genetic instruments. These were evaluated in two independent childhood ALL GWASs, the California Childhood Cancer Record Linkage Project and California Childhood Leukemia Study, the latter with available self-reported periconceptional nutrition data. Logistic regressions assessed the interrelationship between maternal nutrition and children's folate metabolism-related polygenic risk score (PRS) and MTHFR rs1801133 genotype.</p><p><strong>Results: </strong>MR analyses showed that higher genetically predicted serum folate was associated with reduced ALL risk (meta-analysis OR = 0.58; 95% CI: 0.34-0.97). In Latinos, higher periconceptional folate intake from food mitigated and reversed the elevated risk associated with low folate PRS and the rs1801133 T allele. As the total folate intake increased, the odds of ALL shifted from 1.31 (95% CI: 1.01-1.69) to 0.53 (95% CI: 0.30-0.91) per 0.05-unit decrease in folate PRS, and from 1.71 (95% CI: 1.02-2.88) to 0.24 (95% CI: 0.07-0.79) per T allele. In contrast, among non-Latino Whites (NLWs), the corresponding ORs remained at 1.24 (95% CI: 1.07-1.43) and 1.40 (95% CI: 1.04-1.91).</p><p><strong>Conclusions: </strong>Maternal folate intake mitigated genetic liability against ALL in Latinos only, while genetic liability persisted in NLWs.</p><p><strong>Impact: </strong>This study highlights the need for personalized approaches to maximize the benefits of folic acid supplementation programs.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the metagenomic performance of stools collected from custom cards and 95% ethanol in epidemiologic studies.","authors":"Thomas M Kuntz, Ling Liu, Kai Wang, Christine Everett, A Heather Eliassen, Walter C Willett, Rashmi Sinha, Andrew T Chan, Eric B Rimm, Wendy S Garrett, Nicola Segata, Gianmarco Piccinno, Curtis Huttenhower, Xochitl Morgan, Mingyang Song","doi":"10.1158/1055-9965.EPI-25-0157","DOIUrl":"10.1158/1055-9965.EPI-25-0157","url":null,"abstract":"<p><p>Background Stool cards have been used for microbiome assessment in epidemiological studies. Methods We compared shotgun metagenomic sequencing from 32 participants who self-collected stool samples from the same bowel movement using a custom stool card vs. a collection tube with 95% ethanol fixative in the Nurses' Health Study II. We evaluated the agreement between methods at both the whole-community and individual species levels. To contextualize the comparison for disease association studies, we assessed the performance of the two collection methods for differentiating colorectal cancer-associated taxa. Results Overall, metagenomes from cards and 95% ethanol were highly correlated within individuals. No difference was found in alpha diversity and only ~1% of variation in beta diversity was explained by the collection method. At the species level, while the relative abundances were highly correlated between card and ethanol sample pairs (Spearman rho = 0.96), 10 (out of 239) species showed a differential abundance in paired samples, including overrepresentation of Escherichia coli and underrepresentation of three Streptococcus species in cards compared with ethanol. Among a set of 99 colorectal cancer-associated species, 4 showed differential abundances between collection methods; however, this number was consistent with what would be expected by chance. Conclusions Metagenomic sequencing using stool samples self-collected using stool cards or 95% ethanol yielded largely consistent results, although differential abundances were observed for a small number of individual species. Impact Stool cards can be a cost-effective alternative to collect stool samples for metagenomic sequencing in epidemiologic studies but warrant additional considerations for data analysis.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors Associated with Gastroenteropancreatic and Lung Neuroendocrine Tumors: A Nested Case-Control Study from The All of Us Research Program.","authors":"Tao Xu, Joseph S Dillon, Dawn E Quelle, Sarah H Nash, Hyunkeun Cho, Michael A O'Rorke","doi":"10.1158/1055-9965.EPI-25-0155","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0155","url":null,"abstract":"<p><strong>Background: </strong>The incidence of neuroendocrine tumors (NETs), which arise primarily in lung and gastroenteropancreatic (GEP) tissues, has risen dramatically in the past fifty years. However, the etiology of NETs remains inconclusive.</p><p><strong>Methods: </strong>We conducted a nested case-control study using data from the All of Us research program (version 7; index dates [2000-2022]) to compare the odds of diagnosed GEP or lung NETs in the presence or absence of various potential risk factors. One case was matched to five controls without cancer diagnoses by age at consent and sex. We used piecewise structural equation modeling to generate effect estimates.</p><p><strong>Results: </strong>Of 2,180 individuals (including 366 with NETs), most were non-Hispanic White (62.8%) and female (61.0 %). Individuals with a family history of any cancer (odds ratios (OR), 1.43; 95% confidence intervals (CI), 1.06 to 1.95, P=0.021), a past diagnosis of type 2 diabetes (OR, 1.46; 95% CI, 1.09 to 1.96, P=0.012) and any immune-mediated disease (OR, 1.40; 95% CI, 1.11 to 1.76, P=0.004) had higher odds of developing GEP or lung NETs.</p><p><strong>Conclusions: </strong>This study confirms prior evidence in less diverse cohorts that the risk of developing GEP or lung NETs is significantly associated with having a first-degree relative with any cancer or previous diagnosis of type 2 diabetes.</p><p><strong>Impact: </strong>Our findings are the first to demonstrate that a pre-existing diagnosis of any immune-mediated disease is a risk factor for developing NETs. Together, our findings suggest that NET development may be influenced by non-modifiable factors as well as modifiable conditions.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of stem cell markers with lobular involution in benign breast tissue.","authors":"Lusine Yaghjyan, Rulla M Tamimi, Gabrielle M Baker, Yujing J Heng","doi":"10.1158/1055-9965.EPI-25-0097","DOIUrl":"10.1158/1055-9965.EPI-25-0097","url":null,"abstract":"<p><strong>Background: </strong>Terminal duct lobular unit (TDLU) involution has been linked to decreased breast cancer (BCa) risk in some studies. Whether the number/activity of breast stem cells (SCs) in non-cancerous tissue may influence TDLU involution is unknown. We examined the associations of CD44, CD24, and ALDH1A1 SC markers with TDLU involution.</p><p><strong>Methods: </strong>We included 309 cancer-free women with biopsy-confirmed benign breast disease. Immunohistochemistry (IHC) was performed using tissue microarrays. For each core, IHC expression was assessed using a semi-automated software as % of positively stained cells for each marker. Eight TDLU involution measures were assessed with an established computational pathology algorithm. Generalized linear regression was used to examine the associations of each marker (≥10% vs. <10%) with each TDLU involution measure (log-transformed), adjusted for BCa risk factors.</p><p><strong>Results: </strong>CD44 was positively associated with acini counts per non-adipose tissue area (epithelial: β=0.307, 95% Confidence Interval [CI 0.072,0.542]; stromal: β=0.249 [ 0.005,0.494]) and median acini density (epithelial: β=0.127 [0.025,0.229]; stromal: β=0.143, [0.037,0.249). Epithelial ALDH1A1 was positively associated with median acini density (β=0.161, [0.045, 0.278]) and stromal ALDH1A1 was positively associated with median acini counts per TDLU (β=0.145, [0.018,0.273]).</p><p><strong>Conclusions: </strong>Higher CD44 and ALDH1A1 expressions in epithelial and stromal regions were associated with lower TDLU involution.</p><p><strong>Impact: </strong>We present the first epidemiological evidence on association of SC markers with TDLU involution.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability and Variability of the Human Fecal Microbiome Over Two Years in the Multiethnic Cohort Study: A Metagenomic Analysis.","authors":"Darya Moosavi, Keith R Curtis, Timothy W Randolph, Orsalem J Kahsai, Hamza Ammar, Unhee Lim, Iona Cheng, Lynne R Wilkens, Loïc Le Marchand, Johanna W Lampe, Meredith A J Hullar","doi":"10.1158/1055-9965.EPI-24-1770","DOIUrl":"10.1158/1055-9965.EPI-24-1770","url":null,"abstract":"<p><strong>Background: </strong>Understanding the longitudinal variability of the gut microbiome is essential for advancing microbiome-based measurements and designing robust sampling protocols in observational and intervention studies of cancer and other health outcomes. The aim of this study was to explore the temporal variability and stability of the fecal microbiome over a 2-year period, using intraclass correlation (ICC) analysis of metagenomic sequencing data.</p><p><strong>Methods: </strong>We studied 25 older adults from the Multiethnic Cohort Adiposity Phenotype Study (MEC-APS, 2013-2016). Stool samples were collected every six months over a two-year period (5 samples) and analyzed using metagenomic sequencing. The temporal stability was evaluated using ICCs across taxonomic levels, diversity, and functional genes and pathways.</p><p><strong>Results: </strong>The microbial community showed stability in alpha diversity and overall structure, with no significant changes across time points (Shannon diversity, p = 0.95). Taxonomic composition showed strong reliability over time, with median ICCs of 0.7 at the genus level and 0.75 at species level. Functional genes also demonstrated good stability (median ICC = 0.68). However, microbial pathways were more variable, with a fair median ICC of 0.49.</p><p><strong>Conclusion: </strong>While the fecal microbiome was generally stable, some taxa and functions were more dynamic and responsive to external influences.</p><p><strong>Impact: </strong>Findings highlight the need for reliable microbiome measurements and sampling strategies to reduce bias in studies of the microbiome and cancer.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12247528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic risk prediction models for upper gastrointestinal cancers: A systematic review.","authors":"Tyler Seyhan Saunders, Pawandeep Virpal, Maria Andreou, Asha Parmar, Christina Derksen, Oleg Blyuss, Fiona M Walter, Garth Funston","doi":"10.1158/1055-9965.EPI-24-1714","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1714","url":null,"abstract":"<p><p>Upper gastrointestinal (UGI) cancers are often detected late. Risk prediction models could facilitate earlier detection by identifying patients at risk for further investigation. We systematically reviewed evidence on UGI diagnostic risk prediction models. A search of MEDLINE, Embase, and CENTRAL was conducted for studies reporting on the development and/or validation of diagnostic risk prediction models for UGI cancers (pancreatic, gastric, oesophageal, gallbladder, and/or biliary tract). Studies had to report at least one quantitative measure of model performance to be eligible for inclusion. A total of 82 studies describing 162 UGI risk models were included. Models predicted gallbladder (n=6), gastric (n=25), oesophageal (n=34), gastro-oesophageal (n=14), and pancreatic (n=83) cancers. Most models used logistic regression, but machine learning was increasingly used from 2019. In total, 366 unique variables were incorporated across models. Only 33 models were externally validated, with 15 achieving an AUC ≥0.80. This review highlights that several models perform well in predicting UGI cancers on external validation. Future research is needed to compare the best performing models and assess their clinical utility, acceptability and cost effectiveness. Given the significant overlap in at risk populations and predictors across UGI cancers, there may also be scope to develop UGI 'multi-cancer' models.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Cancer History with COVID-19 Risk and Outcomes Among Older Postmenopausal Women: Results from the Women's Health Initiative.","authors":"Chloe M Hery, Xiaochen Zhang, Eric McLaughlin, Diane Von Ah, Garnet L Anderson, Holly R Harris, Trang VoPham, Lorena Garcia, Aladdin H Shadyab, Shawna Follis, Electra D Paskett","doi":"10.1158/1055-9965.EPI-24-1682","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1682","url":null,"abstract":"<p><strong>Background: </strong>Several studies early in the COVID-19 pandemic suggested those with a cancer history had higher risk of COVID-19 infections and complications. However, few prospective studies evaluated the association of cancer with COVID-19 in older women. We aimed to examine the association of cancer history with risk of COVID-19 and various COVID-19 outcomes among older women.</p><p><strong>Methods: </strong>The Women's Health Initiative (WHI) is an ongoing cohort study that recruited 161,808 postmenopausal women aged 50-79 from 1993-1998. Those who completed the COVID-19 survey (2021-2022) were included (n=35,623). Multivariable linear and logistic regression were used to examine COVID-19 positivity, symptoms severity, long COVID, and COVID concerns/anxiety outcomes.</p><p><strong>Results: </strong>28% (n=9,901) of participants had a history of cancer. Cancer history was not significantly associated with COVID-19 positivity (OR: 0.94, 95% CI: 0.81-1.08), COVID-19 hospitalization (OR: 1.21, 95% CI: 0.85-1.72), number of symptoms (LS Mean: 0.33, 95% CI: -0.20, 0.85), and long COVID (OR: 1.18, 95% CI: 0.88-1.58).</p><p><strong>Conclusions: </strong>History of cancer was not associated with most COVID-19 outcomes. Future studies should continue to examine physiological mechanisms contributing to differences within cancer survivors and prioritize the inclusion of underserved populations to identify strategies to address the impact of COVID-19.</p><p><strong>Impact: </strong>These findings may assure cancer survivors their diagnosis alone does not increase their risk of COVID-19 and suggests older women with a history of cancer may have similar risk of COVID-19 outcomes compared to their non-cancer counterparts.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"State-Specific Incidence of Endometrial Cancer in the U.S. by Histologic Subtype Corrected for Hysterectomy Prevalence, 2010 to 2019.","authors":"Megan A Clarke, Jared A Fisher, Nicolas Wentzensen, Akemi T Wijayabahu, Rebecca C Arend, Rena R Jones, Britt K Erickson","doi":"10.1158/1055-9965.EPI-25-0057","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0057","url":null,"abstract":"<p><strong>Background: </strong>Accurate reporting of state-specific endometrial cancer incidence is important for informing cancer control efforts and may lead to new hypotheses regarding environmental and/or geographic risk factors. Previous studies have demonstrated the importance of accounting for hysterectomy prevalence when estimating state-level endometrial cancer incidence rates, as hysterectomy prevalence varies by geographic region.</p><p><strong>Methods: </strong>We used the Cancer in North America Public Use Dataset produced by the North American Association of Central Cancer Registries to identify incident endometrial cancer cases among women aged ≥20 years diagnosed from 2010 to 2019. We estimated state-specific hysterectomy-corrected, age-adjusted incidence rates overall and by histology. State-specific hysterectomy prevalence data were obtained from the Behavioral Risk Factor Surveillance System.</p><p><strong>Results: </strong>Hysterectomy prevalence was highest in Southern and Midwestern states and lowest in the Northeast. While uncorrected endometrial cancer incidence rates were highest in the Northeast, hysterectomy-corrected rates were highest in states within the Midwest and Appalachia. Geographic patterns of hysterectomy-corrected incidence of endometrioid cancer resembled those of endometrial cancer overall. In contrast, corrected rates of non-endometrioid cancer were highest in the South and in certain states within the Northeast and Midwest. There was no overlap in the top 10 states with the highest rates of endometrioid and non-endometrioid cancers, respectively.</p><p><strong>Conclusions: </strong>State-specific, hysterectomy-corrected incidence rates of endometrial cancer vary by histology, suggesting potential differences in behavioral, sociodemographic, and/or environmental exposures at the state level.</p><p><strong>Impact: </strong>This study presents an accurate assessment of U.S. endometrial cancer rates and emphasize the importance of hysterectomy correction for geographic comparisons.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Post-Diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analyses.","authors":"Oliver Wa Wilson, Charles E Matthews, Kaitlyn M Wojcik, Yelena N Tarasenko, Gisela Butera, Jessica Gorzelitz, Clyde Schechter, Jennifer Y Sheng, Jinani Jayasekera","doi":"10.1158/1055-9965.EPI-24-1798","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1798","url":null,"abstract":"<p><p>We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence and mortality to support individualized breast cancer survivorship care plans in clinical settings. Seven databases were searched to identify observational studies that examined the effects of exercise on recurrence, breast cancer-specific mortality (BCSM), and all-cause mortality (ACM) among female breast cancer survivors. Fully adjusted hazard ratios, and 95% confidence intervals were extracted for comparisons reported in relation to no/minimal exercise (reference). Dose-response relationships between exercise and events were examined using restricted cubic splines. Under half (44.3%, n=50,689) met aerobic exercise guidelines for health (≥~2.5hrs/wk). Meeting guidelines was associated with a ~50% reduction in the hazard ratio for ACM, with further reductions up to ~4.5hrs/wk. A ~25% reduction in the hazard ratio for ACM was associated with ~1hr/wk. The 5-year (unadjusted) ACM rates were 11% for no/minimal exercise, 4% for insufficient exercise, and 3% for meeting exercise guidelines (n=5 studies). There were limited data for subgroups. Similar patterns were observed for recurrence and BCSM. Exercise may lower the risk of recurrence and mortality among breast cancer survivors. Though meeting guidelines for health offers the greatest benefits, exercise below guidelines is also beneficial.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}