Oliver Wa Wilson, Charles E Matthews, Kaitlyn M Wojcik, Yelena N Tarasenko, Gisela Butera, Jessica Gorzelitz, Clyde Schechter, Jennifer Y Sheng, Jinani Jayasekera
{"title":"诊断后娱乐性有氧运动对乳腺癌幸存者的影响:一项系统综述/ meta分析","authors":"Oliver Wa Wilson, Charles E Matthews, Kaitlyn M Wojcik, Yelena N Tarasenko, Gisela Butera, Jessica Gorzelitz, Clyde Schechter, Jennifer Y Sheng, Jinani Jayasekera","doi":"10.1158/1055-9965.EPI-24-1798","DOIUrl":null,"url":null,"abstract":"<p><p>We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence and mortality to support individualized breast cancer survivorship care plans in clinical settings. Seven databases were searched to identify observational studies that examined the effects of exercise on recurrence, breast cancer-specific mortality (BCSM), and all-cause mortality (ACM) among female breast cancer survivors. Fully adjusted hazard ratios, and 95% confidence intervals were extracted for comparisons reported in relation to no/minimal exercise (reference). Dose-response relationships between exercise and events were examined using restricted cubic splines. Under half (44.3%, n=50,689) met aerobic exercise guidelines for health (≥~2.5hrs/wk). Meeting guidelines was associated with a ~50% reduction in the hazard ratio for ACM, with further reductions up to ~4.5hrs/wk. A ~25% reduction in the hazard ratio for ACM was associated with ~1hr/wk. The 5-year (unadjusted) ACM rates were 11% for no/minimal exercise, 4% for insufficient exercise, and 3% for meeting exercise guidelines (n=5 studies). There were limited data for subgroups. Similar patterns were observed for recurrence and BCSM. Exercise may lower the risk of recurrence and mortality among breast cancer survivors. Though meeting guidelines for health offers the greatest benefits, exercise below guidelines is also beneficial.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":3.4000,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effects of Post-Diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analyses.\",\"authors\":\"Oliver Wa Wilson, Charles E Matthews, Kaitlyn M Wojcik, Yelena N Tarasenko, Gisela Butera, Jessica Gorzelitz, Clyde Schechter, Jennifer Y Sheng, Jinani Jayasekera\",\"doi\":\"10.1158/1055-9965.EPI-24-1798\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence and mortality to support individualized breast cancer survivorship care plans in clinical settings. Seven databases were searched to identify observational studies that examined the effects of exercise on recurrence, breast cancer-specific mortality (BCSM), and all-cause mortality (ACM) among female breast cancer survivors. Fully adjusted hazard ratios, and 95% confidence intervals were extracted for comparisons reported in relation to no/minimal exercise (reference). Dose-response relationships between exercise and events were examined using restricted cubic splines. Under half (44.3%, n=50,689) met aerobic exercise guidelines for health (≥~2.5hrs/wk). Meeting guidelines was associated with a ~50% reduction in the hazard ratio for ACM, with further reductions up to ~4.5hrs/wk. A ~25% reduction in the hazard ratio for ACM was associated with ~1hr/wk. The 5-year (unadjusted) ACM rates were 11% for no/minimal exercise, 4% for insufficient exercise, and 3% for meeting exercise guidelines (n=5 studies). There were limited data for subgroups. Similar patterns were observed for recurrence and BCSM. Exercise may lower the risk of recurrence and mortality among breast cancer survivors. 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The Effects of Post-Diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analyses.
We aimed to estimate the incremental effects of post-diagnosis recreational aerobic exercise, and possible variations in effects, on recurrence and mortality to support individualized breast cancer survivorship care plans in clinical settings. Seven databases were searched to identify observational studies that examined the effects of exercise on recurrence, breast cancer-specific mortality (BCSM), and all-cause mortality (ACM) among female breast cancer survivors. Fully adjusted hazard ratios, and 95% confidence intervals were extracted for comparisons reported in relation to no/minimal exercise (reference). Dose-response relationships between exercise and events were examined using restricted cubic splines. Under half (44.3%, n=50,689) met aerobic exercise guidelines for health (≥~2.5hrs/wk). Meeting guidelines was associated with a ~50% reduction in the hazard ratio for ACM, with further reductions up to ~4.5hrs/wk. A ~25% reduction in the hazard ratio for ACM was associated with ~1hr/wk. The 5-year (unadjusted) ACM rates were 11% for no/minimal exercise, 4% for insufficient exercise, and 3% for meeting exercise guidelines (n=5 studies). There were limited data for subgroups. Similar patterns were observed for recurrence and BCSM. Exercise may lower the risk of recurrence and mortality among breast cancer survivors. Though meeting guidelines for health offers the greatest benefits, exercise below guidelines is also beneficial.