Anatomical record (Hoboken, N.J. : 2007)最新文献

{"title":"Comparative anatomy of the ossified braincase of legless anguine lizard Pseudopus apodus (Pallas, 1775) (Squamata, Anguimorpha).","authors":"Jozef Klembara, Miroslav Hain","doi":"10.1002/ar.25695","DOIUrl":"https://doi.org/10.1002/ar.25695","url":null,"abstract":"<p><p>The braincase and inner ear of the largest species of legless anguine lizards, Pseudopus apodus, are described in detail based on high-resolution x-ray microcomputed tomography. Here, the ontogeny of its braincase is briefly described. The detailed anatomy of the individual braincase bones of P. apodus is presented and compared with those of the modern anguine species Anguis fragilis and species of Ophisaurus, Dopasia, and Hyalosaurus. Because only the extant species of Anguinae are studied and discussed here, the generic names of modern taxa defined genetically-Ophisaurus (North America), Dopasia (Southeast Asia), and Hyalosaurus (North Africa)-are used here. The shape of the supraoccipital in juveniles was similar for all species found in all three geographic territories. During growth, the shape of the supraoccipital changes significantly in Pseudopus, Dopasia, and Ophisaurus, and its shape is very similar to that in adults of the anguine taxon Ophisauriscus quadrupes from the Middle Eocene of Germany. Instead, the shape of the supraoccipital in the adults of Hyalosaurus and Anguis is very similar to that in the juveniles of Pseudopus, Dopasia, and Ophisaurus. This suggests that paedomorphosis probably played a role in the shape formation of the supraoccipital in Hyalosaurus and Anguis. The morphological and proportional changes in several other braincase structures during ontogeny are also described.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of sexual dimorphism of the laryngeal sac in the common minke whale Balaenoptera acutorostrata.","authors":"Gen Nakamura, Hiroko Yamada, Ayumi Hirose, Hikari Maeda, Joy S Reidenberg, Hidehiro Kato, Shinho Park, Yoshihiro Fujise","doi":"10.1002/ar.25681","DOIUrl":"https://doi.org/10.1002/ar.25681","url":null,"abstract":"<p><p>Mysticetes, or baleen whales, have an air sac on the ventral surface of the larynx known as the \"laryngeal sac.\" The primary hypothesis regarding this structure's function is that it is involved in sound production. However, several other functions have been proposed, including air recycling, air storage, and even buoyancy control. In this study, we analyzed ontogenetic development and sexual dimorphism of the laryngeal sac with an aim of elucidating the function of this organ. The larynx of 61 (male: n = 40, female: n = 21) common minke whales Balaenoptera acutorostrata, collected from off the Japanese coast were used for present study. We isolated the larynx, situated between the hyoid bone and the trachea, during the flensing process. Seven linear measurements were taken using calipers, and the weight was obtained using a digital weight scale. Allometric equation and proportions to total body length or weight were used to compare laryngeal morphological differences between sexes and maturity. Measurements of laryngeal sac size were significantly larger in sexually mature males. Furthermore, examination of two male individuals of approximately the same body length but different maturities showed the sexually mature male had a larger laryngeal sac, compared to sexually immature male. The thickness of the laryngeal sac's muscle wall and the volume of the sac's lumen may be related to testes development (sexually mature whales have heavier testes). Only the width of the hyoid bone (basihyal and paired thyrohyals) was proportionally constant within all measurement sites, regardless of sex or maturity. We propose that baleen whales utilize their well muscularly developed laryngeal sac in a manner analogous to the human tongue, actively modifying its shape and volume to influence vocal production. Specifically, this structure may function as a resonance filter that creates a formant structure and contributes to the modification of phonemes generated by the U-folds of the larynx. Furthermore, the ability to produce complex vocalizations through this mechanism may have led to the enlargement of the laryngeal sac in males via sexual selection, where it also serves as a signal of their reproductive status.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping the human face: Periosteal bone modeling across ontogeny.","authors":"Sarah E Freidline, Madison Hubbart, Catherine Shipman, Najielie Burgos, Chiara Villa, Alexandra Schuh","doi":"10.1002/ar.25689","DOIUrl":"https://doi.org/10.1002/ar.25689","url":null,"abstract":"<p><p>Facial morphology is a defining aspect of Homo sapiens that distinguishes our species from fossil ancestors and plays a central role in estimating age, sex, and ancestry in both past and present populations. Understanding how the face develops during postnatal ontogeny is essential for interpreting adult facial variation. Periosteal bone modeling (i.e., patterns of resorption and formation) provides direct evidence of bone growth activity underlying morphological variation. This study quantifies periosteal bone modeling in a cross-sectional ontogenetic sample of individuals ranging from birth to adulthood from three geographical populations: Western Europe, Greenland, and South Africa. Epoxy replicas were analyzed using digital microscopy to quantify bone resorption, and digital maps of the bone modeling patterns were created for each facial region-brow ridge, zygomatic, maxilla, and mandible-and projected onto three-dimensional surface models. In parallel, geometric morphometric and multivariate statistical analyses were used to evaluate ontogenetic patterns. Results highlight a consistent sequence of resorption and deposition during human ontogeny and a strong pattern of covariation between bone modeling and shape for most facial regions. The face is largely resorptive from early ontogeny, with deposition increasing with age; the maxilla is significantly more resorptive than other facial regions. Greater resorption in the midface corresponds to significant facial growth and development in early ontogeny, and a developmental shift around adolescence marks the transition from primarily downward to more forward-oriented growth. Overall, the combined approach underscores the developmental coordination of the face and suggests that the human facial growth pattern reflects the need to maintain a non-projecting face from birth on.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histochemical and Ultrastructural Study of Developing Gonial Bone With Reference to Initial Ossification of the Malleus and Reduction of Meckel's Cartilage in Mice.","authors":"Shunichi Shibata,&nbsp;Masato Takahashi,&nbsp;Kaoru Fujikawa","doi":"10.1002/ar.24201","DOIUrl":"https://doi.org/10.1002/ar.24201","url":null,"abstract":"<p><p>Development of mouse gonial bone and initial ossification process of malleus were investigated. Before the formation of the gonial bone, the osteogenic area expressing alkaline phosphatase and Runx2 mRNA was widely recognized inferior to Meckel's cartilage. The gonial bone was first formed within the perichondrium at E16.0 via intramembranous ossification, surrounded the lower part of Meckel's cartilage, and then continued to extend anteriorly and medially until postnatal day (P) 3.0. At P0, multinucleated chondroclasts started to resorb the mineralized cartilage matrix with ruffled borders at the initial ossification site of the malleus (most posterior part of Meckel's cartilage). Almost all CD31-positive capillaries did not run through the gonial bone but entered the cartilage through the site where the gonial bone was not attached, indicating the forms of the initial ossification site of the malleus are similar to those at the secondary ossification center rather than the primary ossification center in the long bone. Then, the reducing process of the posterior part of Meckel's cartilage with extending gonial bone was investigated. Numerous tartrate-resistant acid phosphatase-positive mononuclear cells invaded the reducing Meckel's cartilage, and the continuity between the malleus and Meckel's cartilage was completely lost by P3.5. Both the cartilage matrix and the perichondrium were degraded, and they seemed to be incorporated into the periosteum of the gonial bone. The tensor tympani and tensor veli palatini muscles were attached to the ligament extending from the gonial bone. These findings indicated that the gonial bone has multiple functions and plays important roles in cranial formation. Anat Rec, 302:1916-1933, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"1916-1933"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37327758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ontogeny of Orbit Orientation in Primates.","authors":"Emily M Nett,&nbsp;Matthew J Ravosa","doi":"10.1002/ar.24193","DOIUrl":"https://doi.org/10.1002/ar.24193","url":null,"abstract":"<p><p>Orbit orientation in primates has been linked to adaptive factors related to activity pattern and size-related variation in structural influences on orbit position. Although differences in circumorbital form between anthropoids and strepsirrhines appear to be related to interspecific disparities in levels of orbital convergence and orbital frontation, there is considerable overlap in convergence between suborders. Unfortunately, putative links between convergence and frontation across primates, and consequent arguments about primate and anthropoid origins, are likely to be influenced by allometry, the size range of a respective sample, and adaptive influences on encephalization and activity patterns. Such a multifarious system is less amenable to interspecific treatment across higher-level clades. An ontogenetic perspective is one way to evaluate transformations from one character state to another, especially as they pertain to allometric effects on phenotypic variation. We characterized the ontogeny of orbital convergence and frontation in 13 anthropoid and strepsirrhine species. In each suborder, correlation and regression analyses were used to test hypotheses regarding the allometric bases of variation in orbital orientation. Growth trajectories were analyzed intra- and inter-specifically. Frontation decreased postnatally in all taxa due to the negative scaling of brain vs. skull size. Further, interspecific variation in relative levels of frontation was linked to corresponding ontogenetic transpositions in encephalization that differed within both suborders. In strepsirrhines, postnatal increases in convergence were largely due to the negative allometry of orbit vs. skull size. In contrast, convergence in anthropoids varied little during growth, being unrelated to ontogenetic variation in either relative orbit or interorbit size. Anat Rec, 302:2093-2104, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"2093-2104"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24193","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40451452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the Superficial Vasculature of the Central Nervous System in Six Laboratory Animals: A Hypothesis About the Role of the \"Circle of Willis\".","authors":"Yoo Yeon Kim,&nbsp;Janet Ren Chao,&nbsp;Chulho Kim,&nbsp;Harry Jung,&nbsp;Boyoung Kim,&nbsp;Tae-Cheon Kang,&nbsp;Jiwon Chang,&nbsp;Hae Sang Park,&nbsp;Jun-Gyo Suh,&nbsp;Jun Ho Lee","doi":"10.1002/ar.24146","DOIUrl":"https://doi.org/10.1002/ar.24146","url":null,"abstract":"<p><p>We provide images of the entire central nervous system vasculature, and compare the anatomical findings in six different laboratory animals. A detailed understanding of the specific anatomy for each is important in the design of experimental modeling and for understanding the specific function of each target organ. Six different types of animals, the Korean wild mouse, C57BL/6J mouse, F344 rat, mongolian gerbil, Syrian hamsters, and guinea pigs, were included. To stain the blood vessels in each of the animals, Alcian blue reagent was used to perfuse each species. The bifurcation and anastomotic patterns of the anterior cerebral arteries differed in each species. The vascular supply to the olfactory nerve was visualized as a single artery supplying both olfactory nerves, and arteries supplying the lateral portion of the olfactory nerves originating from the olfactory bulb area. The posterior communicating arteries of the six animals demonstrated unique morphologies. The shape of the hypophyseal portal system varied by species. Most animals used in this study had a hexagonal Circle of Willis, except for the Korean wild mouse. Using this approach, we successfully mapped the brain vascular system in six different species of animals. This information and the images created can guide other researchers as they design research studies and create experimental models for new surgical procedures and approaches. Anat Rec, 2019. © 2019 Wiley Periodicals, Inc. Anat Rec, 302:2049-2061, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"2049-2061"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24146","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37241537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intussusceptive Lymphangiogenesis in Lymphatic Malformations/Lymphangiomas.","authors":"Lucio Díaz-Flores,&nbsp;Ricardo Gutiérrez,&nbsp;Maria D P García,&nbsp;José L Carrasco,&nbsp;Francisco J Sáez,&nbsp;Lucio Díaz-Flores,&nbsp;Miriam González-Gómez,&nbsp;Juan F Madrid","doi":"10.1002/ar.24204","DOIUrl":"https://doi.org/10.1002/ar.24204","url":null,"abstract":"<p><p>Intussusception in lymphatic vessels has received less attention than in blood vessels. In tumors and pseudotumors of blood vessels with intravascular papillary structures, including sinusoidal hemangioma and intravascular papillary endothelial hyperplasia, we observed exuberant intussusceptive angiogenesis, as well as the similarity between papillae (term used by pathologists) and pillars/folds (hallmarks of intussusceptive angiogenesis). A similar response could be expected in lymphangiomas (lymphatic malformations and reactive processes rather than tumors) with papillae. The aim of this work is to assess whether papillae/pillars/folds and associated structures (vessel loops and septa) are present in lymphangiomas, and to establish the characteristics and formation of these structures. For this purpose, we selected lymphangiomas with intraluminal papillae (n = 18), including cystic, cavernous, circumscriptum, and progressive types, of which two cases of each type with a greater number of papillae were used for serial histologic sections and immunohistochemistry. The studies showed a) dilated lymphatic spaces giving rise to lymphatic-lymphatic vascular loops, which dissected and encircled perilymphatic structures (interstitial tissue structures/ITSs and pillars/posts), b) ITSs and pillars, surrounded by anti-podoplanin-positive endothelial cells, protruding into the lymphatic spaces (papillary aspect), and c) splitting, remodeling, linear arrangement, and fusion of papillae/pillars/folds, forming papillary networks and septa. In conclusion, as occurs in blood vessel diseases, the development of lymphatic vessel loops, papillae/pillars/folds, and septa (segmentation) supports intussusceptive lymphangiogenesis and suggests a piecemeal form of intussusception. This intussusceptive lymphangiogenesis in lymphatic diseases can provide a basis for further studies of lymphatic intussusception in other conditions, with clinical and therapeutic implications. Anat Rec, 302:2003-2013, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"2003-2013"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37352331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microanatomical Record of Cortical Bone Remodeling and High Vascularity in a Fossil Giant Rat Midshaft Femur.","authors":"Justyna J Miszkiewicz,&nbsp;Julien Louys,&nbsp;Sue O'Connor","doi":"10.1002/ar.24224","DOIUrl":"https://doi.org/10.1002/ar.24224","url":null,"abstract":"<p><p>Rat cortical bone does not typically undergo secondary (Haversian) remodeling. Haversian organization of rat bone has been mainly observed in experimental settings following biomechanical or dietary manipulation. Here, we report an observation of cortical secondary osteons within a histological femur cross-section from an extinct (late Quaternary) form of Timorese giant rat (Murinae gen. et sp. indet). The medio-lateral midshaft diameter of its femur, used as a measure of bone size, is 6.15 mm and indicates a heavier than normal skeletal frame. We compare this sample to bone histology in a small rat's midshaft femur of 2.33 mm diameter. A complete lack of Haversian bone remodeling characteristics is noted for the smaller sample, which is dominated by radial vascular canals. The giant rat shows clear secondary osteons and diffuse vascularity mainly composed of tightly packed longitudinal canals across its cortex. It appears that rat cortical bone can undergo bone remodeling, and is organized in a highly vascularized manner, in insular giant cases. Our findings from Timor align with results reported in experimental rat model skeletal biology literature and other insular fossil rat material. Where macroanatomical examination is limited, histological observations on fossil rat limb bones have the potential to aid reconstructions of life history and skeletal growth aspects in these rodents. Anat Rec, 302:1934-1940, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"1934-1940"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24224","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37383970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bufothionine Promotes Apoptosis via Triggering ER Stress and Synergizes with Temozolomide in Glioblastoma Multiforme Cells.","authors":"Yafeng Sun,&nbsp;Xianhong Zhang","doi":"10.1002/ar.24194","DOIUrl":"https://doi.org/10.1002/ar.24194","url":null,"abstract":"<p><p>Glioblastoma multiforme (GBM) is the most common type of malignant glioma. Bufothionine is one of the major active ingredients of Cinobufacini. Although the antitumor activities of bufothionine have been reported, the underlying mechanism remains unclear. The present study showed that bufothionine exhibited antigrowth activities in GBM cell lines U87 and U373. Further investigation showed that bufothionine triggered endoplasmic reticulum (ER) stress to promote apoptosis in U87 and U373 cells. Moreover, our results showed that bufothionine exhibited synergistic activities with Temozolomide (TMZ) to suppress the growth of U87 and U373 cells. The findings in the present study provide basis for further investigation of the therapeutic potential of bufothionine in GBM. Anat Rec, 302:1950-1957, 2019. © 2019 American Association for Anatomy.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"1950-1957"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24194","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37317348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-455-5p Overexpression Reduces Rat Lung Alveolar Type II Cell Proliferation by Downregulating STRA6.","authors":"Jintao Zheng,&nbsp;Qiuming He,&nbsp;Huajian Tang,&nbsp;Huimin Xia","doi":"10.1002/ar.24145","DOIUrl":"https://doi.org/10.1002/ar.24145","url":null,"abstract":"<p><p>miR-455-5p and retinoid signaling pathway and its membrane receptor, STRA6, are associated with lung development. Software copredictions indicate that the miRNA upstream of the STRA6 gene is miR-455-5p. We hypothesized that miR-455-5p participates in rat lung alveolar Type II cell proliferation by targeting STRA6 and designed this study to investigate the effects of miR-455-5p overexpression on rat lung alveolar Type II cells. Dual luciferase reporter gene assay was utilized to confirm the relationship between miR-455-5p and STRA6. An miR-455-5p-expressing adenoviral vector was constructed and transfected into rat lung alveolar Type II cells. STRA6 protein expression was detected in rat lung alveolar Type II cells by Western blotting at 72 hr posttransfection. Retinol concentration was detected by ELISA at 72 hr posttransfection. The cell proliferation was detected by CCK8 assay at 24, 48, and 72 hr posttransfection. Our results showed that STRA6 is a target gene of miR-455-5p. STRA6 protein expression was significantly lower in the miR-455-5p-overexpression group than in the NC group (0.615 ± 0.131 vs. 0.958 ± 0.246, P = 0.029). Similar results were observed for retinol concentration (2.985 ± 0.061 vs. 3.949 ± 0.118, P = 0.000). Rat lung alveolar Type II cell proliferation was lower in the miR-455-5p-overexpression group than in the NC group at 24, 48, and 72 hr posttransfection (24 hr: 0.280 ± 0.184 vs. 1.354 ± 0.169 P = 0.026; 48 hr: 0.881 ± 0.016 vs. 1.992 ± 0.050 P = 0.001; 72 hr: 2.105 ± 0.148 vs. 2.937 ± 0.079 P = 0.016). In summary, miR-455-5p is associated with lung development. miR-455-5p overexpression downregulates STRA6, leading to reduced retinol concentration and rat lung alveolar Type II cell proliferation. Anat Rec, 302:2062-2069, 2019. © 2019 The Authors. The Anatomical Record published by Wiley Periodicals, Inc. on behalf of American Association of Anatomists.</p>","PeriodicalId":520555,"journal":{"name":"Anatomical record (Hoboken, N.J. : 2007)","volume":" ","pages":"2062-2069"},"PeriodicalIF":2.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/ar.24145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37242251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}